This document discusses non-covalent bonding interactions such as halogen bonding, dipole-dipole interactions, and π-π interactions. It describes how these interactions can form supramolecular complexes through host-guest interactions or polymerization. Applications of supramolecular chemistry include materials science, fabrication, optoelectronics, drug delivery, and metal extraction. The document presents examples of halogen-bonded supramolecular assemblies and π-stacked complexes that form through orthogonal interactions in water. It also shows molecular structures of pyridyl-functionalized naphthalene monoimide acceptors and iodotetrafluorophenoxy donors that assemble through halogen bonding and dipole interactions.

1.  Halogen bonding
 Dipole-Dipole interaction
 Π-Π interaction
Non- Covalent Bonding:
Co-polymerization
Homo - Polymerization Hetro - Polymerzation
Supra Molecular Bonding
(A)
(B)
(A-A)
(A-B)
Figure1:interaction can hold
a host-guest complex
Figure2: Π-Π stacking face to face
Figure3 : Homo and Hetro Polymerzation

2. Introduction
• Noncovalent interactions, primarily p–p stacking, van der Waals
forces and hydrogen (H)-bonding, are critical in maintaining the
three-dimensional structure of biomolecules, such as proteins and
nucleic acids
What is supramolecules : Organized system of two or more molecules held together by intermolecular forces
Figure 4 : Supramolecular chemistry group
Application
fabrication
materials science
and biology
various
optoelectronic
device
Synergistic use of
p-stacking and H-
bonding
Metal Extraction from
Ores and Nuclear
Waste
Drug Delivery
Metal
Extraction
Application:-

3. Halogen Bonded Supra –Π- Amphiphiles
Figure(5): . Structure of XB Acceptor (NMI-Py),
XB Donors (PEG-I/TEG-I), and Their Proposed
Co-assembly by X bonding
Figure(6): Orthogonal dipole−dipole
interaction and π-stacking of the NMI- PY
fluorophore
• The ability of NMI-PY and PEG-I to form supra-π-
amphiphile by X-bonding.
• NMI-PY was sparingly soluble in water, while becoming
readily soluble in the presence of 1 equiv of PEG-I
• A hydrophobic pyridyl functionalized naphthalene monoimide (NMI-Py)
based X-bond acceptor and hydrophilic iodotetrafluorophenyl
functionalized polyethylene glycol (PEG-I) or triethylene glycol (TEG-I)
based X-bond donors.

4. Molecular structure of M1, M2, and M3
Figure (7) :Molecular structure of M1, M2, and M3
a pyridyl-functionalized NMIbased halogen bond (XB)
acceptor (M1) with complementary hydrophilic XB donors
equipped with an XB-donating iodotetrafluorophenoxy (ITFP)
moiety through orthogonal halogen bonding and dipole–
dipole interactions in water

5. Homo - Polymerization
• Parallel
• Slipped J-shaped
• Π-Π stacking
• Parallel (3.371)
• Anti-parallel (3.487)
• Parallel

7. M1 M2 M3