The document describes a study evaluating the "straight left heart border" (SLHB) radiological sign for detecting hemopericardium after penetrating chest trauma. The study prospectively analyzed 162 patients over 8 years, finding the SLHB sign had low sensitivity (40%) but high specificity (84%) for detecting hemopericardium identified by surgical window. While an absent SLHB does not rule out cardiac injury, its presence should alert surgeons to potential hemopericardium.
Conferencia magistral "20 años de Angioplastia Primaria para el tratamiento del Infarto. Experiencia y evolución de las redes de infarto" del Dr. Petr Widimsky durante la XXV Reunión Anual de la Sección de Hemodinámica y Cardiología Intervencionista (SHCI) de 2014 en Córdoba.
Conferencia magistral "20 años de Angioplastia Primaria para el tratamiento del Infarto. Experiencia y evolución de las redes de infarto" del Dr. Petr Widimsky durante la XXV Reunión Anual de la Sección de Hemodinámica y Cardiología Intervencionista (SHCI) de 2014 en Córdoba.
Patients with Chronic stable angina and unstable angina also present a dilemma for further management based on results of coronary angiography alone. Estimation of Fractional flow reserve (FFR) allows to identify ischemia producing lesions in coronary tree. It has been proved beyond doubt that interventions for the lesions causing ischemia improves morbidity and mortality.
Chest X-Ray for CT Surgeons | IACTS SCORE 2020IACTSWeb
This presentation was prepared by Dr. Anil G. Tendolkar for the student-participants of IACTS SCORE 2020, which was held between 7-8 March 2020 at SSSIHMS, Whitefield, Bengaluru.
This presentation eludes to the basics of imaging, views, signs and must-knows for preliminary diagnosis of various anomalies of the heart that represent themselves either discreetly or thoroughly on the scan.
These are the slides from a presentation I recently gave at work. It demonstrates two fascinating cases [one massive & one submassive PE] & lends itself to a review of the literature assessing the roles and evidence behind thrombolysis for pulmonary embolism.
Covered includes the MAPPET-3, MOPPET & PEITHO trials.
[Paper Report] Coronary Artery Bypass Graft versus Percutaneous Coronary In...Hao-Chen Ke
[Paper Report]
CABG與 PCI兩種術式用於急性心臟衰竭之比較
Reference:
Coronary Artery Bypass Graft versus Percutaneous Coronary Intervention in Acute Heart Failure
Lee SE, et al. Heart 2018;0:1–8. doi:10.1136/heartjnl-2018-313242
Heart: first published as 10.1136/heartjnl-2018-313242 on 12 September 2018. Downloaded from http://heart.bmj.com/ on 10 October 2018 by guest. Protected by copyright.
Jill Blumenthal, MD of the UC San Diego AntiViral Research Center presents "Cryptococcal Meningitis with Cranial Nerve Neuropathies: Predictors of Outcome and Review of ART Initiation"
Dr. Sharfuddin Chowdhury: Tranexamic Acid administration in traumaShakila Rifat
Time since injury is the major factor in preventing Tranexamic Acid (TXA) use in the trauma setting: An observational cohort study from a major trauma centre in a middle income country.
Patients with Chronic stable angina and unstable angina also present a dilemma for further management based on results of coronary angiography alone. Estimation of Fractional flow reserve (FFR) allows to identify ischemia producing lesions in coronary tree. It has been proved beyond doubt that interventions for the lesions causing ischemia improves morbidity and mortality.
Chest X-Ray for CT Surgeons | IACTS SCORE 2020IACTSWeb
This presentation was prepared by Dr. Anil G. Tendolkar for the student-participants of IACTS SCORE 2020, which was held between 7-8 March 2020 at SSSIHMS, Whitefield, Bengaluru.
This presentation eludes to the basics of imaging, views, signs and must-knows for preliminary diagnosis of various anomalies of the heart that represent themselves either discreetly or thoroughly on the scan.
These are the slides from a presentation I recently gave at work. It demonstrates two fascinating cases [one massive & one submassive PE] & lends itself to a review of the literature assessing the roles and evidence behind thrombolysis for pulmonary embolism.
Covered includes the MAPPET-3, MOPPET & PEITHO trials.
[Paper Report] Coronary Artery Bypass Graft versus Percutaneous Coronary In...Hao-Chen Ke
[Paper Report]
CABG與 PCI兩種術式用於急性心臟衰竭之比較
Reference:
Coronary Artery Bypass Graft versus Percutaneous Coronary Intervention in Acute Heart Failure
Lee SE, et al. Heart 2018;0:1–8. doi:10.1136/heartjnl-2018-313242
Heart: first published as 10.1136/heartjnl-2018-313242 on 12 September 2018. Downloaded from http://heart.bmj.com/ on 10 October 2018 by guest. Protected by copyright.
Jill Blumenthal, MD of the UC San Diego AntiViral Research Center presents "Cryptococcal Meningitis with Cranial Nerve Neuropathies: Predictors of Outcome and Review of ART Initiation"
Dr. Sharfuddin Chowdhury: Tranexamic Acid administration in traumaShakila Rifat
Time since injury is the major factor in preventing Tranexamic Acid (TXA) use in the trauma setting: An observational cohort study from a major trauma centre in a middle income country.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
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ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
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Straight Left Heart Border-Dr. Sharfuddin Chowdhury
1. The Straight Left Heart Border :
A new radiological sign for detection of a
hemopericardium after penetrating chest trauma
Andrew Nicol
Sharfuddin Chowdhury
Delawir Kahn
Sorin Edu
Pradeep Navsaria
Trauma Centre
Department of Surgery
Groote Schuur Hospital and University of Cape Town
SRS 2012
2. Background
The chest radiograph is not considered to be
particularly useful in the diagnosis of a
penetrating cardiac injury.
At GSH Trauma Centre, the straight left heart
border, is a newly described radiological sign
associated with the presence of blood in the
pericardial sac.
3. Aim
The aim of this study was to determine the
sensitivity and specificity of the SLHB in
the diagnosis of a hemopericardium in
stable patients after penetrating chest
trauma
4. Methods
Prospective study – 8 year period. (2001-2009).
All patients admitted to the GSH Trauma Centre
following penetrating chest trauma who did not
have an indication for emergency surgery.
An erect CXR was done.
5. Methods
A true positive was the presence of a SLHB
sign on the CXR and hemopericardium found at
subxiphoid pericardial window (SPW).
A false positive was defined as the presence of
a SLHB sign on the CXR but the SPW was
negative for blood.
A P value < 0.05 was considered to be significant.
8. Results
SLHB sign SPW positive SPW negative Total
Positive 49 6 55
Negative 75 32 107
Total 124 38 162
No. of patients 162
Mean age 27.7 (r 13 – 62)
No. of patients with SLHB 55 (34%)
True positive 49
False positive 75
Sensitivity 40%
Specificity 84%
P - value 0.005 (Chi-square)
9. Conclusion
SLHB is not a very sensitive sign for the
presence of a hemopericardium (40%) .
Although the absence of a SLHB does not
exclude a cardiac injury, it is highly specific (84%)
P = 0.005
When SLHB sign is present on CXR, it should alert
the surgeon about the possibility of a
hemopericardium.