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Presented By:
Chukwuma I. Onyeije, M.D.
Atlanta Perinatal Associates
Clinical Associate Professor,
Morehouse School of Medicine
Specific FHR abnormalities
are related to cerebral palsy
and neurologic injury in the
fetus
The 1970s
CLINICAL OBSTETRICS AND GYNECOLOGY
Volume 54, Number 1, 56–65
r 2011, Lippincott Williams & Wilkins
Intrapartum EFM associated
with decreased perinatal
mortality due to fetal hypoxia
but also with higher rates of
surgical intervention for
suspected fetal distress.
Vintzeleos et al, Obstet Gynecol. 1993 Jun;81(6):899-907.
Compared to
Auscultation, EFM
results in higher
operative delivery rates
without significant
lowering of perinatal
mortality.
Conclusion:
Auscultation…. The winner!
Scalp pH  Pulse Oximetry
 Scalp pH largely abandoned in the United
States 2 decades ago.
 Fetal pulse oximetry did NOT reduce
cesarean delivery rates for ‘nonreassuring’’ FHR
patterns in NICHD trial.
 The fetal ST interval changes in the fetus suffering
from oxygen deficiency.
 ST Analysis (STAN) consists of highlighting
theses changes.
For a fetus, the birth is the treadmill.
 STAN begins with conventional EFM (FHR +
UCs) and adds automated ST Analysis
 Comprehensive and mandatory education prior
to introduction of STAN
Showed that hypoxia
was associated with a
significant elevation of
the T-wave in the
fECG.
Am J Obstet Gynecol.
1984;149:190–195.
 Increased myocardial glycogen
breakdown
 Liberation of potassium
 Increased local catecholamines
 The increase in T-wave height relative to the
amplitude of the QRS complex was identified
when the fetus transitions from aerobic to
anaerobic metabolism.
 The T:QRS ratio measures of myocardial
metabolic status
 Other changes in the ST-segment identified
fetuses with chronic oxygen deprivation were
subjected to acute hypoxic stress.
Baseline T :QRS ratio
Appearance of ST segment
waveforms
 Hypoxic fetuses
 Fetuses with
myocardial
dysfunction
 Chronically hypoxic
fetuses with acute
insults
BEFORE using STAN
 >36+0 gestational weeks
 Ruptured membranes
 No contraindication for scalp electrode or STAN
 First stage, no active or involuntary pushing
At onset of STAN
 Classify the FHR.
 Check for FHR reactivity
 Confirm nondeteriorating fetal state
 Check for normal ECGwaveform
 Confirm sufficient signal quality
 Confirm baseline T:QRS ratio
 Any contraindication to
invasive monitoring
◦ active maternal herpes
◦ HIV
◦ Hepatitis
STAN
determines baseline
T:QRS ratio over
20 T :QRS ratios
and then tracks for
changes over
time.
T:QRS Ratio
EVENT LOG
AVERAGE T:QRS
ST ALRETS
 Episodic rise in T:QRS ratio
◦ (greater than 0.10 for less than 10 min);
 Baseline rise in T :QRS ratio
◦ (greater than 0.05 for more than 10 min); and
 Recurrent biphasic ST segments
FHR
CLASSIFICATIO
N
BASELINE FHR VARIABILITY DECELERTION
S
GREEN
110 - 160 MODERATE
(+)ACCELERATIONS
EARLY
VARIABLE (LESS
THAN 60 x 60)
YELLO
W
BRADY <110
TACHY > 160
> 150 WITH
MINIMAL
VARIABILITY
MINIMAL FOR
> 40 MIN
MARKED FOR
> 40 MIN
VARIABLE
GREATER THAN
60 x 60
RECURRENT
LATE
PROLONGED
RED SINUSOIDAL OR ABSENT VARIABILITY REGARDLESS
OF FHR PATTERN
STAN’s FHR Clinical
Management Protocol
FHR CLASSIFICATION NO ST EVENTS ST EVENTS
PRESENT
GREEN EXPECTANT MANAGEMENT
CONTINUED OBSERVATION
YELLOW
EXPECTANT
MANAGEMENT
DIRECT PHYSICIAN
ASSESSMENT OF
FETAL STATE IF > 60
MINUTES
DIRECT PHYSICIAN
ASSESSMENT
INTRAUTERINE
RESUSCITATION
EXPEDITED DELIVERY
IF NO IMPROVEMENT
RED EXPEDITIOUS
DELIVERY / RESUSCITATION (?)
 Main outcome of interest was a reduction in
cord artery metabolic acidosis (pH <7.05
and base deficit >12 mmol/L) with the addition of
STAN data.
U.K. – Am J Obstet Gynecol. 1993;169:1151–1160.
Sweden - Lancet. 2001;358:534–538.
UNITED KINGDOM: 1993 SWEDEN: 2001
 Significant reduction in fetal metabolic acidosis
AND reduction in operative delivery.
 Follow-up studies of the neonates showed a
significant reduction in neonatal encephalopathy
 Standard EFM is very good at
detecting the very healthy and very
sick fetus.
 STAN allows us to grade fetuses
between the extremes
 STAN combined with EFM provides more
accurate information about the fetus during labor
than EFM alone.
 STAN is automatic, continuous and has been
proven to be effective in large randomized trials.
 Information from STAN provides precise
information about the fetal state during labor to
detect fetuses at risk and avoid unnecessary
interventions.
 CLINICAL OBSTETRICS AND GYNECOLOGY Vol.54, Number 1, 56–65. 2011,
 Am J Obstet Gynecol. 1993;169:1151–1160.
 Lancet. 2001;358:534–538.
 Am J Obstet Gynecol.1984;149:190–195.
 Obstet Gynecol. 1993 Jun;81(6):899-907
 http://www.neoventa.com/INT/Articles/Products/Goldtrace_INT.html

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STAN

  • 1. Presented By: Chukwuma I. Onyeije, M.D. Atlanta Perinatal Associates Clinical Associate Professor, Morehouse School of Medicine
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  • 3. Specific FHR abnormalities are related to cerebral palsy and neurologic injury in the fetus
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  • 8. The 1970s CLINICAL OBSTETRICS AND GYNECOLOGY Volume 54, Number 1, 56–65 r 2011, Lippincott Williams & Wilkins
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  • 10. Intrapartum EFM associated with decreased perinatal mortality due to fetal hypoxia but also with higher rates of surgical intervention for suspected fetal distress. Vintzeleos et al, Obstet Gynecol. 1993 Jun;81(6):899-907.
  • 11. Compared to Auscultation, EFM results in higher operative delivery rates without significant lowering of perinatal mortality.
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  • 14. Scalp pH  Pulse Oximetry
  • 15.  Scalp pH largely abandoned in the United States 2 decades ago.  Fetal pulse oximetry did NOT reduce cesarean delivery rates for ‘nonreassuring’’ FHR patterns in NICHD trial.
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  • 17.  The fetal ST interval changes in the fetus suffering from oxygen deficiency.  ST Analysis (STAN) consists of highlighting theses changes.
  • 18. For a fetus, the birth is the treadmill.
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  • 20.  STAN begins with conventional EFM (FHR + UCs) and adds automated ST Analysis  Comprehensive and mandatory education prior to introduction of STAN
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  • 22. Showed that hypoxia was associated with a significant elevation of the T-wave in the fECG. Am J Obstet Gynecol. 1984;149:190–195.
  • 23.  Increased myocardial glycogen breakdown  Liberation of potassium  Increased local catecholamines
  • 24.  The increase in T-wave height relative to the amplitude of the QRS complex was identified when the fetus transitions from aerobic to anaerobic metabolism.
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  • 29.  The T:QRS ratio measures of myocardial metabolic status  Other changes in the ST-segment identified fetuses with chronic oxygen deprivation were subjected to acute hypoxic stress.
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  • 31. Baseline T :QRS ratio Appearance of ST segment waveforms
  • 32.  Hypoxic fetuses  Fetuses with myocardial dysfunction  Chronically hypoxic fetuses with acute insults
  • 33. BEFORE using STAN  >36+0 gestational weeks  Ruptured membranes  No contraindication for scalp electrode or STAN  First stage, no active or involuntary pushing
  • 34. At onset of STAN  Classify the FHR.  Check for FHR reactivity  Confirm nondeteriorating fetal state  Check for normal ECGwaveform  Confirm sufficient signal quality  Confirm baseline T:QRS ratio
  • 35.  Any contraindication to invasive monitoring ◦ active maternal herpes ◦ HIV ◦ Hepatitis
  • 36. STAN determines baseline T:QRS ratio over 20 T :QRS ratios and then tracks for changes over time.
  • 38.  Episodic rise in T:QRS ratio ◦ (greater than 0.10 for less than 10 min);  Baseline rise in T :QRS ratio ◦ (greater than 0.05 for more than 10 min); and  Recurrent biphasic ST segments
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  • 42. FHR CLASSIFICATIO N BASELINE FHR VARIABILITY DECELERTION S GREEN 110 - 160 MODERATE (+)ACCELERATIONS EARLY VARIABLE (LESS THAN 60 x 60) YELLO W BRADY <110 TACHY > 160 > 150 WITH MINIMAL VARIABILITY MINIMAL FOR > 40 MIN MARKED FOR > 40 MIN VARIABLE GREATER THAN 60 x 60 RECURRENT LATE PROLONGED RED SINUSOIDAL OR ABSENT VARIABILITY REGARDLESS OF FHR PATTERN
  • 43. STAN’s FHR Clinical Management Protocol FHR CLASSIFICATION NO ST EVENTS ST EVENTS PRESENT GREEN EXPECTANT MANAGEMENT CONTINUED OBSERVATION YELLOW EXPECTANT MANAGEMENT DIRECT PHYSICIAN ASSESSMENT OF FETAL STATE IF > 60 MINUTES DIRECT PHYSICIAN ASSESSMENT INTRAUTERINE RESUSCITATION EXPEDITED DELIVERY IF NO IMPROVEMENT RED EXPEDITIOUS DELIVERY / RESUSCITATION (?)
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  • 45.  Main outcome of interest was a reduction in cord artery metabolic acidosis (pH <7.05 and base deficit >12 mmol/L) with the addition of STAN data. U.K. – Am J Obstet Gynecol. 1993;169:1151–1160. Sweden - Lancet. 2001;358:534–538.
  • 46. UNITED KINGDOM: 1993 SWEDEN: 2001
  • 47.  Significant reduction in fetal metabolic acidosis AND reduction in operative delivery.  Follow-up studies of the neonates showed a significant reduction in neonatal encephalopathy
  • 48.  Standard EFM is very good at detecting the very healthy and very sick fetus.  STAN allows us to grade fetuses between the extremes
  • 49.  STAN combined with EFM provides more accurate information about the fetus during labor than EFM alone.  STAN is automatic, continuous and has been proven to be effective in large randomized trials.
  • 50.  Information from STAN provides precise information about the fetal state during labor to detect fetuses at risk and avoid unnecessary interventions.
  • 51.  CLINICAL OBSTETRICS AND GYNECOLOGY Vol.54, Number 1, 56–65. 2011,  Am J Obstet Gynecol. 1993;169:1151–1160.  Lancet. 2001;358:534–538.  Am J Obstet Gynecol.1984;149:190–195.  Obstet Gynecol. 1993 Jun;81(6):899-907  http://www.neoventa.com/INT/Articles/Products/Goldtrace_INT.html