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- For drug approval, the primary endpoint must be statistically significant in the intention-to-treat population. Significance in a prespecified subgroup is not sufficient.
- Subgroup analyses may raise multiplicity issues if multiple subgroups are tested, similar to multiple comparisons issues. Controlling the family-wise error rate is important.
- An example is presented of a trial testing efficacy in both the overall population and an African subgroup. Different statistical conclusions could arise from these tests.
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This document summarizes key points from a conference on multiple comparisons in clinical trials:
- The FDA acknowledges the need for subgroup analyses but provides little methodological guidance. Subgroup analyses are considered exploratory.
- For drug approval, the primary endpoint must be statistically significant in the intention-to-treat population. Significance in a prespecified subgroup is not sufficient.
- Subgroup analyses may raise multiplicity issues if multiple subgroups are tested, similar to multiple comparisons issues. Controlling the family-wise error rate is important.
- An example is presented of a trial testing efficacy in both the overall population and an African subgroup. Different statistical conclusions could arise from these tests.
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The rising cost of healthcare can equally come from the marked increase in pollution. We don' need to wait for the 4 Horsemen of the Apocalypse.
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The document summarizes the stages of language acquisition in infants and young children. It discusses how the infant vocal tract develops, the stages of cooing and babbling that begin around 4-8 months, the emergence of first words between 12-18 months, telegraphic speech at age 2, and the achievement of normal speech by ages 5-6. It also provides tips for caregivers to support language development, such as using full sentences, reading books, and expanding the child's vocabulary through descriptive language.
Lilia explains how she got her name from her mother watching TV and seeing a character named Lilia. She has a brother and parents, with her brother able to make her laugh, her father enjoying exercise, and her mother being nice. Lilia is of mixed Chinese and Australian heritage from her father and mother. She enjoys sports like kickball and soccer, getting her athletic side from her father. Overall, Lilia loves her life in Japan and would like to remain there as long as possible.
Two individuals, Ta-Chi A.K.A. Mando and Onayski A.K.A. Evrydayok, are having a conflict. Both individuals are from Bulacan but represent different clans, Mendoza and Gallardo respectively.
The rising cost of healthcare can equally come from the marked increase in pollution. We don' need to wait for the 4 Horsemen of the Apocalypse.
We are the 4 Horsemen.
2012 Volkswagen Beetle review from edmundsCourtney Boone
The 2012 Volkswagen Beetle was completely redesigned, ditching the "New" from its name. It has a more functional design that is longer, wider and lower than previous models. This provides more interior space. It is available with different engine options, including a base 2.5-liter 5-cylinder or a turbocharged 2.0-liter 4-cylinder in higher trim levels. The Beetle retains its retro styling cues but has a more modern interior. While less cute than past models, it offers more usability than competitors like the Mini Cooper or Fiat 500.
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This document discusses key aspects to consider for a successful SharePoint 2013 migration. It outlines steps to learn about new capabilities, prepare by documenting the environment and customizations, test using real data, implement with minimal downtime while monitoring progress, and validate by troubleshooting issues. Migration options like database attach and in-place upgrades are described. Risks include refactoring for .NET 4.0, changes to search, authentication, design elements, and Outlook Web Access.
המצגת מציעה רעיון להקמת פלטפורמה אזרחית המבוססת על הפרויקטים של "הסדנה לידע ציבורי" לצורך הקמת מערכת פוליטית אזרחית שתחליף בסופו של דבר את המערכת הפוליטית הקיימת
מיפוי ארגונים חברתיים לפיתוח יכולות ארגוניות - ממצאי סקירה של קרן אבי חיmushu
בשנתיים האחרונות אנו עדים להתעניינות הולכת וגוברת בנושאים שונים הקשורים לפיתוח יכולות ארגוניות וניהוליות בעמותות.
התמקצעות המגזר השלישי בכלל והמשבר הכלכלי האחרון בפרט גרם להצפה בהיצע מחד ולביקוש הולך וגובר של העמותות במגוון השירותים מאידך.
זירה זו, שבעבר היתה נחלתם של נותני שירות מעטים, הפכה לאחרונה לזירה צפופה של ארגונים, חברות ויועצים המבקשים לסייע לפיתוח המקצועי של המגזר השלישי.
כדי שנוכל כולנו לבחון באופן מושכל יותר את המצאי ביצענו לאחרונה בסיוע אורטל שמלץ מיפוי של ארגונים חברתיים (שאינם למטרות רווח) העוסקים בפיתוח יכולות ארגוניות במגוון תחומים:
ניהול, פיתוח ארגוני ותכנון אסטרטגי, פיתוח משאבים ניהול פיננסי, טכנולוגיה, שיווק ויח"צ, פיתוח ועד מנהל, התנדבות, הערכה ומדידה וניהול משאבי אנוש.
מיפוי זה אינו כולל חברות עסקיות ויועצים פרטיים.
עשינו את מירב המאמצים למפות את כלל הארגונים התחום אולם ברור לנו שאין בידנו את כל המידע.
במידה ויש בידכם מידע על ארגונים נוספים, שאינם למטרות רווח, נשמח לקבלו מכם.
שימו לב! אם תרצו להפיץ את המידע לשותפיכם, אנא עשו זאת עם ציון הקרדיט לקרן אבי חי.
אנו מקווים שהמיפוי המצורף יסייע בידכם בשעת הצורך לעשות שימוש מושכל בשפע ההיצע הקיים ולצרוך באופן המיטבי את השירותים המוצעים.
בברכה,
צוות קרן אבי חי
פורום רובינגר:
החזית החברתית. מעבדות לחירות 2012
בקיץ 2011 גילינו שאנו יכולים להיות טובים יותר. בקיץ 2012 נהפוך לטובים יותר, את מדינתנו ואת החברה שבה אנו חיים.
by Boaz Gaon on Apr 05, 2012
בקיץ 2011 גילינו שאנו יכולים להיות טובים יותר. בקיץ 2012 נהפוך לטובים יותר, את מדינתנו ואת החברה שבה אנו חיים. ברוכים הבאים לחזית החברתית - עתיד לישראל.
Designing mobile learning activities for outdoor learninghagitmt
This document discusses a study that explored using mobile devices like iPads and smartphones for outdoor learning. The study examined students' attitudes towards mobile learning and had students design mobile learning activities. Students participated in a workshop over 4 days that covered exposure to mobile learning, hands-on experience, and pedagogical design. Students' activities made use of mobile apps for measurement, documentation and location-based learning. The findings showed that while students saw benefits of mobile technologies for learning, they also had concerns about issues like connectivity, battery life and distraction. Overall, students were able to design effective mobile learning activities for outdoor contexts.
3. למה צריך מתווך ?
• יכולת ההפצה דורשת משאבים כלכליים
וטכנולוגיים: אולפנים, מערכות עיתונים וכד'
• הפקת התכנים דורשת מיומנות ומקצועיות: צילום,
כתיבה, הגשה, דיווח וכד'
4. מה המחיר של התווך?
• יצירת מוקד כח בידי אמצעי התקשורת
• שליטה על תכני המידע וסדר היום הציבורי
"אם אתה לא שם אתה לא קיים"
5. סוגי התווך של התקשורת פסיבי
כלי: משמשת עבור הממשל כלי להעברת מסרים, •
השמעת דעות והעברת מסרים (תעמולה, יחסי ציבור)
מראה/צינור: מדווחת ומסקרת על ארועים ומידע שיש •
בו ענין ציבורי לאזרחים
חוקרת: "כלב השמירה של הדמוקרטיה", משמשת •
כמגן על הפרט ועל הכלל מפני סכנה אפשרית, חושפת
עוולות ציבוריות, מצביעה על כשלים, שחיתויות,
מבקרת את הממשל והתהליך הדמוקרטי
משפיעה: יוצרת דעת קהל/משפיעה על דעת הקהל, •
בוחרת מה לדווח, מפרשת ומתווכת בין הארוע
החדשותי ובין האזרח, יוצרת סדר יום ציבורי
אקטיבי
6. האם התקשורת המסורתית באמת יכולה/ראויה
להיות אקטיביסטית?
חורגת מסמכותה ותפקידה כמדווחת, שופטת ו/או •
משפיעה על הרשות השופטת
כפופה ללחצים ופיקוח מצד הממשל, אינה אוטונומית •
כפופה לאינטרסים של בעלי ההון / הבעלים של •
אמצעי התקשורת , תרבות רייטינג ושיקולי צריכה
כפופה למגבלות רבות מבחינה חוקית (הזכות •
לבטחון, הזכות לפרטיות, צנעת הפרט)
מציגה את הנרטיב של ה"מיינסטרים", של האליטות •
החברתיות, של הרוב, אינה מציגה את נקודת המבט
של המיעוטים
7. תוצאות הביקורת שמועלית כנגד התקשורת
המסורתית
דרך ב' דרך א'
• מינוף הכח של התקשורת • הקמת אמצעי תקשורת
המסורתית לקידום אינטרסים עצמאיים, בעלי אג'נדה
של קבוצות ותנועות מוגדרת, שיוצאים נגד
חברתיות הקונצנזוס החברתי , קוראים
• ניהול "קמפיינים ציבוריים", לשינוי רדיקלי של החברה
השתתפות בתקשורת, ומוסדותיה.
העלאת ביקורת, העלאת
מודעות, שכלול מערכת יחסי • התפתחות העיתונות
הציבור והדוברות של ארגוני מקומית/מגזרית, רדיו פיראטי,
החברה האזרחית, נסיון ערוצי טלויזיה עצמאיים
"לתפוס" את עיני התקשורת.
