1. MS-325 is an albumin-targeted gadolinium contrast agent that highlights inflamed vessel walls and facilitates plaque imaging. It provides prolonged enhancement of the vessel wall and lumen, allowing for high resolution detection of plaque burden.
2. Studies show strong vessel wall enhancement with MS-325 due to increased capillary volume and binding to extravasated albumin in the vessel wall of patients with atherosclerosis. This may help identify stenosis and quantify plaque.
3. Experimental models demonstrate MS-325 can improve visualization of vulnerable plaque features like lipid cores and thin fibrous caps, as well as directly detect thrombus formation during plaque rupture.
This document discusses two MRI contrast agents - MS-325 and EP-1873. MS-325 is an albumin-binding agent that enhances the vessel wall in patients with atherosclerosis by binding to extravasated albumin, allowing visualization of plaque. It also prolongs the enhancement of the vessel wall and lumen, enabling high-resolution measurement of plaque burden. EP-1873 is a fibrin-targeted agent that makes thrombotic consequences of plaque rupture directly visible on standard MR scans, with potential applications in assessing thromboembolic risk and monitoring clot resolution after treatment.
134 mr contrast agents for vulnerable plaque imagingSHAPE Society
1. MS-325 is an albumin-targeted gadolinium contrast agent that highlights inflamed vessel walls and facilitates plaque imaging. It provides prolonged enhancement of the vessel wall and lumen, allowing for high resolution detection of plaque burden.
2. Studies show MS-325 provides strong enhancement of vessel walls adjacent to plaques due to increased capillary volume and binding to extravasated albumin in the vessel wall. This allows for detection and potential quantification of atherosclerotic plaques.
3. Experimental fibrin-targeted contrast agents EP-1242 and EP-1873 rapidly enhance arterial and venous blood clots in animal models, demonstrating potential for assessing thromboembolic risk and monitoring clot resolution with
039 mr contrast agents for vulnerable plaque imagingSHAPE Society
1. MS-325 is an albumin-targeted gadolinium contrast agent that highlights inflamed vessel walls and facilitates plaque imaging. It provides prolonged enhancement of the vessel wall and lumen, allowing for high resolution detection of plaque burden.
2. Studies show strong vessel wall enhancement with MS-325 due to increased capillary volume and binding to extravasated albumin in the vessel wall of patients with atherosclerosis. This may help identify stenosis and quantify plaque.
3. Experimental models demonstrate MS-325 can improve visualization of vulnerable plaque features like lipid cores and thin fibrous caps, as well as directly detect thrombus formation during plaque rupture.
1) The document discusses the impeachment process of South Korean President Park Geun-hye due to her involvement in a corruption scandal with her close friend Choi Soon-sil.
2) Key figures involved include President Park, Choi Soon-sil and her family members, senior presidential aides, and the heads of Samsung and other major Korean companies.
3) The impeachment process requires a majority vote in parliament to impeach the president and a two-thirds majority vote plus a Supreme Court ruling to formally remove the president from office.
Neuro-ophthalmic Complications in Multiple SclerosisJessica Griego
This document discusses neuro-ophthalmic complications in multiple sclerosis (MS), including the disease mechanisms, diagnostic criteria, imaging findings, and ophthalmic manifestations. Key points include:
- MS is an immune-mediated demyelinating disease that causes focal lesions in the central nervous system, affecting sensory and motor functions.
- McDonald criteria uses MRI to document dissemination of lesions in time and space for formal diagnosis of MS.
- Common ophthalmic manifestations include demyelinating optic neuritis (DON), eye movement palsies, nystagmus, and uveitis.
- Treatment for DON includes intravenous steroids, with oral steroids and immunomodulatory
MS Dynamics CRM consultant at Cynoteck provide complete CRM customization, Integration, and support in both MS Dynamics CRM System and Salesforce solutions.
The document summarizes proposed updates to MRI criteria for diagnosing multiple sclerosis (MS) by the MAGNIMS group in 2016. The updates aim to 1) expand the definition of dissemination in space to include more lesion locations, 2) revise lesion count requirements, and 3) remove the distinction between symptomatic and asymptomatic lesions. The changes also broaden the criteria's applicability to more age groups and ethnicities. Key revisions include requiring 3+ periventricular lesions instead of 1, considering lesions in the optic nerves, and applying the same dissemination standards to both relapsing-remitting and primary progressive MS. The updates are meant to improve sensitivity while maintaining specificity in MS diagnosis.
1. MS-325 is an albumin-targeted gadolinium contrast agent that highlights inflamed vessel walls and facilitates plaque imaging. It provides prolonged enhancement of the vessel wall and lumen, allowing for high resolution detection of plaque burden.
2. Studies show strong vessel wall enhancement with MS-325 due to increased capillary volume and binding to extravasated albumin in the vessel wall of patients with atherosclerosis. This may help identify stenosis and quantify plaque.
3. Experimental models demonstrate MS-325 can improve visualization of vulnerable plaque features like lipid cores and thin fibrous caps, as well as directly detect thrombus formation during plaque rupture.
This document discusses two MRI contrast agents - MS-325 and EP-1873. MS-325 is an albumin-binding agent that enhances the vessel wall in patients with atherosclerosis by binding to extravasated albumin, allowing visualization of plaque. It also prolongs the enhancement of the vessel wall and lumen, enabling high-resolution measurement of plaque burden. EP-1873 is a fibrin-targeted agent that makes thrombotic consequences of plaque rupture directly visible on standard MR scans, with potential applications in assessing thromboembolic risk and monitoring clot resolution after treatment.
134 mr contrast agents for vulnerable plaque imagingSHAPE Society
1. MS-325 is an albumin-targeted gadolinium contrast agent that highlights inflamed vessel walls and facilitates plaque imaging. It provides prolonged enhancement of the vessel wall and lumen, allowing for high resolution detection of plaque burden.
2. Studies show MS-325 provides strong enhancement of vessel walls adjacent to plaques due to increased capillary volume and binding to extravasated albumin in the vessel wall. This allows for detection and potential quantification of atherosclerotic plaques.
3. Experimental fibrin-targeted contrast agents EP-1242 and EP-1873 rapidly enhance arterial and venous blood clots in animal models, demonstrating potential for assessing thromboembolic risk and monitoring clot resolution with
039 mr contrast agents for vulnerable plaque imagingSHAPE Society
1. MS-325 is an albumin-targeted gadolinium contrast agent that highlights inflamed vessel walls and facilitates plaque imaging. It provides prolonged enhancement of the vessel wall and lumen, allowing for high resolution detection of plaque burden.
2. Studies show strong vessel wall enhancement with MS-325 due to increased capillary volume and binding to extravasated albumin in the vessel wall of patients with atherosclerosis. This may help identify stenosis and quantify plaque.
3. Experimental models demonstrate MS-325 can improve visualization of vulnerable plaque features like lipid cores and thin fibrous caps, as well as directly detect thrombus formation during plaque rupture.
1) The document discusses the impeachment process of South Korean President Park Geun-hye due to her involvement in a corruption scandal with her close friend Choi Soon-sil.
2) Key figures involved include President Park, Choi Soon-sil and her family members, senior presidential aides, and the heads of Samsung and other major Korean companies.
3) The impeachment process requires a majority vote in parliament to impeach the president and a two-thirds majority vote plus a Supreme Court ruling to formally remove the president from office.
Neuro-ophthalmic Complications in Multiple SclerosisJessica Griego
This document discusses neuro-ophthalmic complications in multiple sclerosis (MS), including the disease mechanisms, diagnostic criteria, imaging findings, and ophthalmic manifestations. Key points include:
- MS is an immune-mediated demyelinating disease that causes focal lesions in the central nervous system, affecting sensory and motor functions.
- McDonald criteria uses MRI to document dissemination of lesions in time and space for formal diagnosis of MS.
- Common ophthalmic manifestations include demyelinating optic neuritis (DON), eye movement palsies, nystagmus, and uveitis.
- Treatment for DON includes intravenous steroids, with oral steroids and immunomodulatory
MS Dynamics CRM consultant at Cynoteck provide complete CRM customization, Integration, and support in both MS Dynamics CRM System and Salesforce solutions.
The document summarizes proposed updates to MRI criteria for diagnosing multiple sclerosis (MS) by the MAGNIMS group in 2016. The updates aim to 1) expand the definition of dissemination in space to include more lesion locations, 2) revise lesion count requirements, and 3) remove the distinction between symptomatic and asymptomatic lesions. The changes also broaden the criteria's applicability to more age groups and ethnicities. Key revisions include requiring 3+ periventricular lesions instead of 1, considering lesions in the optic nerves, and applying the same dissemination standards to both relapsing-remitting and primary progressive MS. The updates are meant to improve sensitivity while maintaining specificity in MS diagnosis.
Postinflammatory hyperpigmentation,by Dr Mohammad BaghaeiMohammad Baghaei
بروز لک بعد از التهاب یا افزایش رنگدانه های پوستی پس از التهاب Postinflammatory hyperpigmentation (PIH) ازعوارض و درگیری های متداول و نسبتا شایع پوست به واسطه بروز برخی بیماریها یا اقدامات درمانی است.
Brain MRI biomarkers for improved follow up of people with Multiple Sclerosis...Wim Van Hecke
MRI is increasingly used for the diagnosis and follow-up of people with Multiple Sclerosis (MS). However, there is a need for objective MRI biomarkers that can be used in clinical practice. This is now possible. By sending MRI data to a icometrix, reliable and objective reports of brain atrophy and lesion load can be obtained.
The document contains a student registration form listing student names, registration numbers, and assigned slide numbers. It then discusses the key differences between Microsoft Office 2010 and 2007. Some of the main improvements in Office 2010 include a more intuitive ribbon interface with a home menu system, enhanced digital signatures and paste preview options, and the backstage view which combines printing tools. For PowerPoint 2010, improvements include separate transitions and animations tabs, more animation effects, and the ability to broadcast slideshows online. Excel 2010 allows for more customization of ribbons and defines conditional formatting, while Access 2010 provides improved database management tools.
The document summarizes the radiological anatomy of the knee joint. It describes the various ligaments, tendons, bones and cartilage that make up the knee, including the medial and lateral menisci, anterior and posterior cruciate ligaments, patellar tendon, and surrounding muscles. It provides imaging protocols for MRI of the knee, covering positioning, slice thickness, pulse sequences and imaging planes used to visualize the different knee structures. Common anatomical variations and pitfalls in interpretation are also discussed.
This document provides an overview of multiple sclerosis (MS). It begins by defining MS as a disease of the central nervous system involving destruction of myelin. It then discusses who is most likely to get MS, noting it occurs most often in Caucasians between ages 20-50 and more frequently in women than men. The document explains that in MS the immune system mistakenly attacks myelin. It describes the different types of MS and common symptoms. Diagnosis involves MRI, neurological tests, and spinal fluid examination. Treatment aims to reduce inflammation and immune system activity. The role of the immune system and proteins like GM-CSF and perforin in the development and progression of MS lesions is also summarized.
MRI provides detailed images of the brain without exposing patients to radiation. It is useful for evaluating conditions like tumors, strokes, and multiple sclerosis. The document describes the MRI procedure for brain imaging including patient preparation, head coils, sequences, and protocols. Key sequences discussed are T1-weighted, T2-weighted, FLAIR, diffusion weighted, MR angiography, and MR venography.
MRI sequences utilize the magnetic spin property of hydrogen protons to generate images. T1-weighted images highlight fat and tissues with slow-flowing blood while T2-weighted images highlight edema, inflammation and fluid. FLAIR sequences suppress the signal from cerebrospinal fluid to improve detection of lesions near CSF-containing spaces such as in multiple sclerosis or mesial temporal sclerosis. Choosing the appropriate sequence depends on the desired tissue contrast and abnormalities being evaluated.
Postinflammatory hyperpigmentation,by Dr Mohammad BaghaeiMohammad Baghaei
بروز لک بعد از التهاب یا افزایش رنگدانه های پوستی پس از التهاب Postinflammatory hyperpigmentation (PIH) ازعوارض و درگیری های متداول و نسبتا شایع پوست به واسطه بروز برخی بیماریها یا اقدامات درمانی است.
Brain MRI biomarkers for improved follow up of people with Multiple Sclerosis...Wim Van Hecke
MRI is increasingly used for the diagnosis and follow-up of people with Multiple Sclerosis (MS). However, there is a need for objective MRI biomarkers that can be used in clinical practice. This is now possible. By sending MRI data to a icometrix, reliable and objective reports of brain atrophy and lesion load can be obtained.
The document contains a student registration form listing student names, registration numbers, and assigned slide numbers. It then discusses the key differences between Microsoft Office 2010 and 2007. Some of the main improvements in Office 2010 include a more intuitive ribbon interface with a home menu system, enhanced digital signatures and paste preview options, and the backstage view which combines printing tools. For PowerPoint 2010, improvements include separate transitions and animations tabs, more animation effects, and the ability to broadcast slideshows online. Excel 2010 allows for more customization of ribbons and defines conditional formatting, while Access 2010 provides improved database management tools.
The document summarizes the radiological anatomy of the knee joint. It describes the various ligaments, tendons, bones and cartilage that make up the knee, including the medial and lateral menisci, anterior and posterior cruciate ligaments, patellar tendon, and surrounding muscles. It provides imaging protocols for MRI of the knee, covering positioning, slice thickness, pulse sequences and imaging planes used to visualize the different knee structures. Common anatomical variations and pitfalls in interpretation are also discussed.
This document provides an overview of multiple sclerosis (MS). It begins by defining MS as a disease of the central nervous system involving destruction of myelin. It then discusses who is most likely to get MS, noting it occurs most often in Caucasians between ages 20-50 and more frequently in women than men. The document explains that in MS the immune system mistakenly attacks myelin. It describes the different types of MS and common symptoms. Diagnosis involves MRI, neurological tests, and spinal fluid examination. Treatment aims to reduce inflammation and immune system activity. The role of the immune system and proteins like GM-CSF and perforin in the development and progression of MS lesions is also summarized.
MRI provides detailed images of the brain without exposing patients to radiation. It is useful for evaluating conditions like tumors, strokes, and multiple sclerosis. The document describes the MRI procedure for brain imaging including patient preparation, head coils, sequences, and protocols. Key sequences discussed are T1-weighted, T2-weighted, FLAIR, diffusion weighted, MR angiography, and MR venography.
MRI sequences utilize the magnetic spin property of hydrogen protons to generate images. T1-weighted images highlight fat and tissues with slow-flowing blood while T2-weighted images highlight edema, inflammation and fluid. FLAIR sequences suppress the signal from cerebrospinal fluid to improve detection of lesions near CSF-containing spaces such as in multiple sclerosis or mesial temporal sclerosis. Choosing the appropriate sequence depends on the desired tissue contrast and abnormalities being evaluated.
اساسا هر گونه اقدام در درمان ریزش یا تحریک رشد موی سر باید بر پایه یک یا چند مورد از مکانیسم های زیر باشد:
• مهار آنزیم 5 آلفا ردوکتاز
• افزایش گردش خونی محیطی و وازودیلیتوری
• بهسازی تغذیه ای سلولهای درمال پاپیلا وسلولهای بنیادی مو
• کاهش التهاب اطراف فولیکولها
Approach and management of COVID-19 patients in AfghanistanJawad Haqbeen
Approach and management of COVID-19 patients in Afghanistan
Lecture 1-7
All Slides of Dr. Saba
درسگفتار راهکار و مدیریت بیماران کوید-۱۹ در افغانستان
با تشکر
برگزار کننده
مركز اموزشي طبي دريچه موفقيت
حمایت کننده تخنیکی
دی اگری افغانستان