англ конференция
•Download as PPTX, PDF•
0 likes•236 views
This document summarizes Turnina Tanya's postgraduate research on investigating new catalyst systems for phenol alkylation with terpenes under the supervision of Irina U. Chukicheva at the Institute of Chemistry. The objectives are to study original sources on phenol alkylation, investigate heterogeneous acid catalysts for phenol alkylation, and select catalytic systems. Phenolic compounds produced from alkylation have applications as antioxidants, stabilizers, surfactants, plasticizers, inhibitors and in medical equipment and food. Experimental conditions and product distributions are shown for resorcinol alkylation with β-pinene using (PhO)3AI catalyst. The major alkylation product is a chroman ether derivative that does not depend
Report
Share
Report
Share
Recommended
англ конференция
This document summarizes Turnina Tanya's postgraduate research on investigating a new catalyst system for the phenol alkylation reaction with terpenes. The research objectives are to study original sources on phenol alkylation, investigate heterogeneous acid catalysts for this reaction, and select catalytic systems. The document outlines potential applications of phenolic compounds and shows the alkylation of resorcinol by β-pinene using (PhO)3AI as a catalyst. It presents the reaction conditions, conversions, and product distributions. The major alkylation product is a chroman ether that does not depend on initial reactant ratios or temperature.
7.linalool
Linalool is a colorless liquid that is stable and naturally occurs as a minor constituent in roses, rosewood, and lavender. It is an optically active acyclic oxygenated monoterpenoid with a boiling point of 198-199C and molecular formula of C10H18O. It contains two double bonds, as indicated by its reaction with bromine to form tetra bromine. It contains a tertiary alcohol functional group, as shown by its reaction with PCl5. Linalool is isomeric with geraniol and can be synthesized by steam distillation from natural sources.
Terpene
1. Terpenes are a large class of natural products composed of isoprene units. There are over 30,000 terpenes that have various uses as perfumes, medicines, and flavorings.
2. Terpenes are biosynthesized from the building blocks isopentyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) through two pathways, the mevalonate pathway and the deoxyxylulose pathway.
3. The document provides an overview of terpene chemistry and classifications as well as commercially available terpene building blocks.
Preparetion of asprine
Salicylic acid can be synthesized into aspirin through an acid-catalyzed reaction with acetic anhydride. In this experiment, students reacted 1g of salicylic acid with 2.5mL of acetic anhydride using sulfuric acid as a catalyst. This produced 0.68g of aspirin, with a percent yield of 52.12%. Tests on the product showed the presence of unreacted salicylic acid, indicating impurities. The synthesis of aspirin provides an example of organic synthesis and students can analyze reaction yields and purities.
Synthesis of benzocaine
1) The document describes an experiment to synthesize benzocaine from p-amino benzoic acid through an esterification reaction.
2) P-amino benzoic acid, ethanol, sulfuric acid, and sodium carbonate are reacted through refluxing.
3) Thin layer chromatography is used to analyze the reaction product and confirms benzocaine formation by its different Rf value from the starting material p-amino benzoic acid.
Aspirin
This document provides information on the synthesis, purification, characterization, and analysis of aspirin. It begins with background on aspirin and its biological activity. The document then reviews the relevant organic chemistry concepts and outlines the procedure for synthesizing aspirin through the esterification of salicylic acid and acetic anhydride. Methods for purifying the product include recrystallization and testing purity through analysis of physical properties, solubility, melting point, IR spectroscopy, percent yield, and chemical tests.
Synthesis of Coumarins
This document summarizes the synthesis of 7-Hydroxy-4-Methyl Coumarin via the Pechmann condensation reaction of resorcinol and ethyl acetoacetate in the presence of concentrated sulfuric acid. Coumarins are an important class of compounds that are found in plants and have various medical applications such as antimicrobial and antitumor properties. The procedure involves cooling concentrated sulfuric acid to below 5°C and adding a solution of resorcinol and ethyl acetoacetate dropwise, followed by workup to obtain an impure product that is recrystallized from ethanol.
Deepak nagargoje rc
This document summarizes a method for the one-step synthesis of xanthones catalyzed by a highly efficient copper-based magnetically recoverable nanocatalyst. Key points include:
- Xanthones provide pharmacological properties and this method uses a copper nanoparticle catalyst to efficiently synthesize various xanthones from aryl aldehydes and phenols in just 2 hours.
- Screening showed copper nanoparticles supported on magnetic silica (CuNPs/MagSilica) was the most effective copper-based catalyst.
- The optimal reaction conditions were identified as using 1 mmol of aldehyde and 1.1 mmol of phenol with 0.9 mol% CuNPs/Mag
Recommended
англ конференция
This document summarizes Turnina Tanya's postgraduate research on investigating a new catalyst system for the phenol alkylation reaction with terpenes. The research objectives are to study original sources on phenol alkylation, investigate heterogeneous acid catalysts for this reaction, and select catalytic systems. The document outlines potential applications of phenolic compounds and shows the alkylation of resorcinol by β-pinene using (PhO)3AI as a catalyst. It presents the reaction conditions, conversions, and product distributions. The major alkylation product is a chroman ether that does not depend on initial reactant ratios or temperature.
7.linalool
Linalool is a colorless liquid that is stable and naturally occurs as a minor constituent in roses, rosewood, and lavender. It is an optically active acyclic oxygenated monoterpenoid with a boiling point of 198-199C and molecular formula of C10H18O. It contains two double bonds, as indicated by its reaction with bromine to form tetra bromine. It contains a tertiary alcohol functional group, as shown by its reaction with PCl5. Linalool is isomeric with geraniol and can be synthesized by steam distillation from natural sources.
Terpene
1. Terpenes are a large class of natural products composed of isoprene units. There are over 30,000 terpenes that have various uses as perfumes, medicines, and flavorings.
2. Terpenes are biosynthesized from the building blocks isopentyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) through two pathways, the mevalonate pathway and the deoxyxylulose pathway.
3. The document provides an overview of terpene chemistry and classifications as well as commercially available terpene building blocks.
Preparetion of asprine
Salicylic acid can be synthesized into aspirin through an acid-catalyzed reaction with acetic anhydride. In this experiment, students reacted 1g of salicylic acid with 2.5mL of acetic anhydride using sulfuric acid as a catalyst. This produced 0.68g of aspirin, with a percent yield of 52.12%. Tests on the product showed the presence of unreacted salicylic acid, indicating impurities. The synthesis of aspirin provides an example of organic synthesis and students can analyze reaction yields and purities.
Synthesis of benzocaine
1) The document describes an experiment to synthesize benzocaine from p-amino benzoic acid through an esterification reaction.
2) P-amino benzoic acid, ethanol, sulfuric acid, and sodium carbonate are reacted through refluxing.
3) Thin layer chromatography is used to analyze the reaction product and confirms benzocaine formation by its different Rf value from the starting material p-amino benzoic acid.
Aspirin
This document provides information on the synthesis, purification, characterization, and analysis of aspirin. It begins with background on aspirin and its biological activity. The document then reviews the relevant organic chemistry concepts and outlines the procedure for synthesizing aspirin through the esterification of salicylic acid and acetic anhydride. Methods for purifying the product include recrystallization and testing purity through analysis of physical properties, solubility, melting point, IR spectroscopy, percent yield, and chemical tests.
Synthesis of Coumarins
This document summarizes the synthesis of 7-Hydroxy-4-Methyl Coumarin via the Pechmann condensation reaction of resorcinol and ethyl acetoacetate in the presence of concentrated sulfuric acid. Coumarins are an important class of compounds that are found in plants and have various medical applications such as antimicrobial and antitumor properties. The procedure involves cooling concentrated sulfuric acid to below 5°C and adding a solution of resorcinol and ethyl acetoacetate dropwise, followed by workup to obtain an impure product that is recrystallized from ethanol.
Deepak nagargoje rc
This document summarizes a method for the one-step synthesis of xanthones catalyzed by a highly efficient copper-based magnetically recoverable nanocatalyst. Key points include:
- Xanthones provide pharmacological properties and this method uses a copper nanoparticle catalyst to efficiently synthesize various xanthones from aryl aldehydes and phenols in just 2 hours.
- Screening showed copper nanoparticles supported on magnetic silica (CuNPs/MagSilica) was the most effective copper-based catalyst.
- The optimal reaction conditions were identified as using 1 mmol of aldehyde and 1.1 mmol of phenol with 0.9 mol% CuNPs/Mag
MCR
The document summarizes the Passerini reaction and its use in synthesizing α-hydroxy-β-amino acid derivatives and related compounds. It describes how treating α-amino aldehydes with trifluoroacetic acid (TFA) and a pyridine-type base generates α-hydroxy-β-amino amide products in good yields with retention of stereochemistry. A variety of amino acid derivatives have been synthesized using this method. The products have applications as protease inhibitors, natural products, and imaging agents.
Partial thesis defence presentation
This document summarizes research on the structural biology of cytochrome P450 monooxygenases in the phenylpropanoid pathway of Arabidopsis thaliana. It discusses homology modeling and protein engineering methods used to study the structures of phenylpropanoid P450s. It also describes efforts to develop X-ray crystallography and NMR techniques to determine the crystal structures of these P450s to better understand their functions in metabolic pathways.
IFT_PAH
This document summarizes the analysis of polycyclic aromatic hydrocarbons (PAHs) and aliphatic hydrocarbons (AHCs) in seafood using gas chromatography/mass spectrometry (GC/MS). Key points include:
- PAHs and AHCs were analyzed in seafood samples from the Gulf of Mexico following the 2010 Deepwater Horizon oil spill.
- Sample preparation included extraction, column cleanup, and GPC cleanup before analysis by GC/MS.
- 16 priority PAHs were analyzed using GC/MS along with internal standards for quantification.
- Data analysis involved checking ion ratios, retention times and calibration curves to ensure method validity.
- The summary describes the sample
Hydroxyapatite synthesis and its chromatographic properties
The document summarizes the chemical synthesis of hydroxyapatite (HAP) for use in chromatography. HAP was synthesized through a wet chemical precipitation method involving calcium nitrate, ammonium phosphate, and ammonium hydroxide solutions. The resulting HAP powder was characterized using FTIR spectroscopy and formed into pellets for use as a chromatographic matrix. Bovine serum albumin was separated on a column packed with the HAP pellets, demonstrating the potential of synthesized HAP for protein chromatography applications.
Presentation anam
The document discusses the synthesis of various oxacyclic derivatives such as furan, pyran, coumarins, and dioxanes using ionic liquids as reaction media. Ionic liquids offer advantages over traditional organic solvents as they are non-volatile, thermally stable, and recyclable. The synthesis of oxacyclic derivatives in ionic liquid media results in improved yields and reduced reaction times. Ionic liquids provide a more environmentally friendly approach for synthesizing important compounds like pharmaceuticals, agrochemicals, and fragrances.
B030510 559
This document describes a study analyzing benzo(a)pyrene (BaP) and its metabolites in biological samples using high performance liquid chromatography with fluorescence detection and gas chromatography mass spectrometry. The researchers developed a sensitive method to detect and quantify BaP and four of its hydroxylated metabolites (1-OHBaP, 3-OHBaP, 4,5-diolBaP, and 7,8-diolBaP) in rat urine and plasma. They found that derivatization of the metabolites with alkyl iodide improved their resolution and detection, allowing separation of 1-OHBaP and 3-OHBaP which previously co-eluted. The method was validated and successfully
Asymmetric synthesis
Asymmetric synthesis (As per new syllabus of PCI)
Methods of asymmetric synthesis using chiral pool
Chiral auxiliaries and catalytic asymmetric synthesis
Enantiopure seperation
Stereoselective synthesis
Recent advances
References
Synopsis of Research
This document summarizes research on phosphorylating functionalized alcohols and diols using a Lewis acid catalyst. It describes how the Sculimbrene lab has overcome limitations of previous phosphorylation techniques by using pyrophosphates instead of phenyl protecting groups. The lab has successfully phosphorylated amino acids, allylic alcohols, and developed an analogue of the drug FTY720. For diol phosphorylation, the lab studied factors that control selectivity for mono- vs diphosphorylation. Future work aims to develop a chiral Lewis acid catalyst for asymmetric phosphorylation, such as of the immunosuppressant FTY720.
Flavonoids
it contains flavonoids chemisytry classification and structure elucidation of flavones and isoflavones
Phenol & it's Compounds
Phenol is an organic compound used widely in industry. It is produced at over 7 billion kg per year mainly through cumene synthesis from benzene, propene and oxygen. Its major uses are in producing plastics, resins, nylon and non-ionic detergents. Phenol is slightly acidic and is a precursor to many drugs, herbicides and pharmaceuticals. Exposure to phenol can cause skin and eye burns and internal organ damage. It is toxic in high doses and was even used for executions during WWII. Regulations control phenol levels in wastewater, drinking water and hazardous waste due to its toxicity.
Chem 116 Presentation
The document summarizes an exploration of using selective aerobic oxidation reactions to convert ethylbenzene to acetophenone. A series of metal activators including Mn, Pt, Co were screened to control the reactivity of O2. The best results were obtained using Co(OAc)2 with MCBA as an activator, achieving nearly quantitative yields of acetophenone. While some success was seen with new activators, literature methods using Mn still performed the best. The goal of controlling O2 reactivity through the use of catalysts was partially achieved.
Beta-OH-5-HT-AminoAcids-2014
This document describes the synthesis and characterization of beta-hydroxy-serotonin (β-OH-5-HT), a derivative of the neurotransmitter serotonin. β-OH-5-HT was successfully synthesized from serotonin using the enzyme tryptophan side chain oxidase type I (TSOI) from Pseudomonas. Structural analysis using NMR and mass spectrometry confirmed the identity of β-OH-5-HT. Interestingly, β-OH-5-HT was found to readily racemize and react with nucleophiles like alcohols and thiols, which is unusual behavior that has not been observed for related compounds. The rapid racemization mechanism of β-OH-5-HT
Biomimetic hplc methods to predict in vivo drug distribution
This document discusses how biomimetic HPLC methods can be used to predict in vivo drug distribution and improve drug candidate quality. It provides three key points:
1) HPLC retention times measured using stationary phases that mimic human serum albumin (HSA), alpha-1-acid glycoprotein (AGP), and artificial membranes can be used to estimate binding to these biomolecules and predict tissue distribution.
2) Chromatographic hydrophobicity indices (CHIs) measured at different pH values reveal a compound's acid/base properties without structural information.
3) HPLC methods allow rapid measurement of various physicochemical properties like lipophilicity, permeability, and solubility which influence drug absorption and efficacy.
phenol ppt 7718.pptx
This document discusses phenols and their properties. It defines phenols as compounds containing a hydroxyl group attached directly to a benzene ring. It describes the acidity of phenols and how substituents can affect acidity. It provides examples of monohydric, dihydric, and trihydric phenols and discusses the structures and properties of phenol, cresols, resorcinol, and naphthols. It also outlines several qualitative tests and reactions of phenols and their uses in products like soaps, plastics, and herbicides.
suzuki coupling and its kinetics
The document discusses the use of a Herrmann palladacycle catalyst for Suzuki coupling reactions to synthesize biaryls. It examines the effects of various reaction parameters on the coupling. The catalyst is thermally stable, easily synthesized, and provides high catalytic activity and selectivity for biaryl formation. Applications of biaryls include use in pharmaceuticals, agrochemicals, polymers, and liquid crystals.
Microwave Assisted Synthesis and Characterisation of Ofloxacin Carboxamide De...
Tuberculosis (TB) remains a significant global health threat, especially with
the emergence of drug-resistant strains. In this study, we aimed to address
the pressing need for novel antitubercular agents targeting multidrug-
resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB). The
quinoxaline nucleus was selected for its unique mechanism of binding with
nucleic acid residues and lower reported toxicity. Seven quinoxaline
derivatives were synthesized through eight synthetic schemes and
screened for antimycobacterial activity against Mycobacterium tuberculosis
using the microplate Alamar Blue Assay (MABA) method. Standard strains
and concentrations were utilized for comparison: Pyrazinamide
(3.125µg/mL), Ciprofloxacin (3.125µg/mL), and Streptomycin (6.25µg/mL).
Our results indicate that all synthesized compounds, including derivatives
of Histidine, Glutamic Acid, Glycine, Valine, Alanine, Aspartic Acid, and
Cysteine, exhibited potent antimycobacterial activity at concentrations as
low as 0.8µg/mL, surpassing the efficacy of standard drugs. Particularly,
synthetic derivatives of ofloxacin demonstrated significant inhibition against
drug-resistant Mycobacterium tuberculosis, highlighting their potential as
promising candidates for further investigation. This study underscores the
importance of exploring novel chemical entities, such as ofloxacin
derivatives with amino acids, to combat the escalating threat of drug-
resistant tuberculosis. Further research in this direction holds promise for
the development of more effective treatments against virulent TB strains.
Chromatofocusing
Chromatofocusing is a technique that separates proteins based on their isoelectric point (pI). It uses buffers like Polybuffer 74 or 96 to generate a linear pH gradient within an ion exchange column containing beads like PBE 94. Proteins are separated as they elute from the column based on their net charge, with more acidic proteins eluting first when the pH is below their pI and more basic proteins eluting later when the pH exceeds their pI. Chromatofocusing can resolve small differences in pI and is useful for analytical separations and purification of proteins.
khairia-m-youssef-future-university-egypt.ppt
This document discusses curcumin and curcumin analogs as potential anti-cancer agents. It first provides background on curcumin, noting that it is the main constituent in turmeric and has demonstrated antioxidant and anti-cancer properties. It then describes several synthetic methods that have been used to produce curcumin analogs, with modified chemical structures. Several curcumin analogs are presented that were synthesized using these methods. The document discusses in vitro tests of the antioxidant and anti-cancer effects of curcumin and its analogs, including their ability to inhibit tubulin polymerization. It concludes that the synthetic analogs demonstrated improved antioxidant and anti-cancer activity compared to curcumin itself, with effects related to their
Biocatalytic properties of a recombinant aldo keto reductase with broad subst...
Biocatalytic properties of a recombinant aldo keto reductase with broad substrate spectrum and excellent stereoselectivity
SYNTHESIS, SPECTRAL CHARACTERIZATION AND BIOACTIVITY OF NOVEL
This document summarizes the synthesis and characterization of novel organophosphorus compounds and their biological evaluation. Eight α-hydroxyphosphonate compounds were synthesized using an Abramov reaction involving various aldehydes and diphenyl phosphite. The compounds were characterized using techniques like IR spectroscopy and melting point determination. Their antibacterial activity was tested against four bacterial strains using MIC and MBC assays, with some compounds showing activity. The anticancer potential was evaluated using an acetylcholinesterase inhibition assay, with some compounds exhibiting inhibition of the enzyme. In conclusion, a convenient method for synthesizing α-hydroxyphosphonates was developed and some of the compounds demonstrated selected biological activities.
How to Fix the Import Error in the Odoo 17
An import error occurs when a program fails to import a module or library, disrupting its execution. In languages like Python, this issue arises when the specified module cannot be found or accessed, hindering the program's functionality. Resolving import errors is crucial for maintaining smooth software operation and uninterrupted development processes.
More Related Content
Similar to англ конференция
MCR
The document summarizes the Passerini reaction and its use in synthesizing α-hydroxy-β-amino acid derivatives and related compounds. It describes how treating α-amino aldehydes with trifluoroacetic acid (TFA) and a pyridine-type base generates α-hydroxy-β-amino amide products in good yields with retention of stereochemistry. A variety of amino acid derivatives have been synthesized using this method. The products have applications as protease inhibitors, natural products, and imaging agents.
Partial thesis defence presentation
This document summarizes research on the structural biology of cytochrome P450 monooxygenases in the phenylpropanoid pathway of Arabidopsis thaliana. It discusses homology modeling and protein engineering methods used to study the structures of phenylpropanoid P450s. It also describes efforts to develop X-ray crystallography and NMR techniques to determine the crystal structures of these P450s to better understand their functions in metabolic pathways.
IFT_PAH
This document summarizes the analysis of polycyclic aromatic hydrocarbons (PAHs) and aliphatic hydrocarbons (AHCs) in seafood using gas chromatography/mass spectrometry (GC/MS). Key points include:
- PAHs and AHCs were analyzed in seafood samples from the Gulf of Mexico following the 2010 Deepwater Horizon oil spill.
- Sample preparation included extraction, column cleanup, and GPC cleanup before analysis by GC/MS.
- 16 priority PAHs were analyzed using GC/MS along with internal standards for quantification.
- Data analysis involved checking ion ratios, retention times and calibration curves to ensure method validity.
- The summary describes the sample
Hydroxyapatite synthesis and its chromatographic properties
The document summarizes the chemical synthesis of hydroxyapatite (HAP) for use in chromatography. HAP was synthesized through a wet chemical precipitation method involving calcium nitrate, ammonium phosphate, and ammonium hydroxide solutions. The resulting HAP powder was characterized using FTIR spectroscopy and formed into pellets for use as a chromatographic matrix. Bovine serum albumin was separated on a column packed with the HAP pellets, demonstrating the potential of synthesized HAP for protein chromatography applications.
Presentation anam
The document discusses the synthesis of various oxacyclic derivatives such as furan, pyran, coumarins, and dioxanes using ionic liquids as reaction media. Ionic liquids offer advantages over traditional organic solvents as they are non-volatile, thermally stable, and recyclable. The synthesis of oxacyclic derivatives in ionic liquid media results in improved yields and reduced reaction times. Ionic liquids provide a more environmentally friendly approach for synthesizing important compounds like pharmaceuticals, agrochemicals, and fragrances.
B030510 559
This document describes a study analyzing benzo(a)pyrene (BaP) and its metabolites in biological samples using high performance liquid chromatography with fluorescence detection and gas chromatography mass spectrometry. The researchers developed a sensitive method to detect and quantify BaP and four of its hydroxylated metabolites (1-OHBaP, 3-OHBaP, 4,5-diolBaP, and 7,8-diolBaP) in rat urine and plasma. They found that derivatization of the metabolites with alkyl iodide improved their resolution and detection, allowing separation of 1-OHBaP and 3-OHBaP which previously co-eluted. The method was validated and successfully
Asymmetric synthesis
Asymmetric synthesis (As per new syllabus of PCI)
Methods of asymmetric synthesis using chiral pool
Chiral auxiliaries and catalytic asymmetric synthesis
Enantiopure seperation
Stereoselective synthesis
Recent advances
References
Synopsis of Research
This document summarizes research on phosphorylating functionalized alcohols and diols using a Lewis acid catalyst. It describes how the Sculimbrene lab has overcome limitations of previous phosphorylation techniques by using pyrophosphates instead of phenyl protecting groups. The lab has successfully phosphorylated amino acids, allylic alcohols, and developed an analogue of the drug FTY720. For diol phosphorylation, the lab studied factors that control selectivity for mono- vs diphosphorylation. Future work aims to develop a chiral Lewis acid catalyst for asymmetric phosphorylation, such as of the immunosuppressant FTY720.
Flavonoids
it contains flavonoids chemisytry classification and structure elucidation of flavones and isoflavones
Phenol & it's Compounds
Phenol is an organic compound used widely in industry. It is produced at over 7 billion kg per year mainly through cumene synthesis from benzene, propene and oxygen. Its major uses are in producing plastics, resins, nylon and non-ionic detergents. Phenol is slightly acidic and is a precursor to many drugs, herbicides and pharmaceuticals. Exposure to phenol can cause skin and eye burns and internal organ damage. It is toxic in high doses and was even used for executions during WWII. Regulations control phenol levels in wastewater, drinking water and hazardous waste due to its toxicity.
Chem 116 Presentation
The document summarizes an exploration of using selective aerobic oxidation reactions to convert ethylbenzene to acetophenone. A series of metal activators including Mn, Pt, Co were screened to control the reactivity of O2. The best results were obtained using Co(OAc)2 with MCBA as an activator, achieving nearly quantitative yields of acetophenone. While some success was seen with new activators, literature methods using Mn still performed the best. The goal of controlling O2 reactivity through the use of catalysts was partially achieved.
Beta-OH-5-HT-AminoAcids-2014
This document describes the synthesis and characterization of beta-hydroxy-serotonin (β-OH-5-HT), a derivative of the neurotransmitter serotonin. β-OH-5-HT was successfully synthesized from serotonin using the enzyme tryptophan side chain oxidase type I (TSOI) from Pseudomonas. Structural analysis using NMR and mass spectrometry confirmed the identity of β-OH-5-HT. Interestingly, β-OH-5-HT was found to readily racemize and react with nucleophiles like alcohols and thiols, which is unusual behavior that has not been observed for related compounds. The rapid racemization mechanism of β-OH-5-HT
Biomimetic hplc methods to predict in vivo drug distribution
This document discusses how biomimetic HPLC methods can be used to predict in vivo drug distribution and improve drug candidate quality. It provides three key points:
1) HPLC retention times measured using stationary phases that mimic human serum albumin (HSA), alpha-1-acid glycoprotein (AGP), and artificial membranes can be used to estimate binding to these biomolecules and predict tissue distribution.
2) Chromatographic hydrophobicity indices (CHIs) measured at different pH values reveal a compound's acid/base properties without structural information.
3) HPLC methods allow rapid measurement of various physicochemical properties like lipophilicity, permeability, and solubility which influence drug absorption and efficacy.
phenol ppt 7718.pptx
This document discusses phenols and their properties. It defines phenols as compounds containing a hydroxyl group attached directly to a benzene ring. It describes the acidity of phenols and how substituents can affect acidity. It provides examples of monohydric, dihydric, and trihydric phenols and discusses the structures and properties of phenol, cresols, resorcinol, and naphthols. It also outlines several qualitative tests and reactions of phenols and their uses in products like soaps, plastics, and herbicides.
suzuki coupling and its kinetics
The document discusses the use of a Herrmann palladacycle catalyst for Suzuki coupling reactions to synthesize biaryls. It examines the effects of various reaction parameters on the coupling. The catalyst is thermally stable, easily synthesized, and provides high catalytic activity and selectivity for biaryl formation. Applications of biaryls include use in pharmaceuticals, agrochemicals, polymers, and liquid crystals.
Microwave Assisted Synthesis and Characterisation of Ofloxacin Carboxamide De...
Tuberculosis (TB) remains a significant global health threat, especially with
the emergence of drug-resistant strains. In this study, we aimed to address
the pressing need for novel antitubercular agents targeting multidrug-
resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB). The
quinoxaline nucleus was selected for its unique mechanism of binding with
nucleic acid residues and lower reported toxicity. Seven quinoxaline
derivatives were synthesized through eight synthetic schemes and
screened for antimycobacterial activity against Mycobacterium tuberculosis
using the microplate Alamar Blue Assay (MABA) method. Standard strains
and concentrations were utilized for comparison: Pyrazinamide
(3.125µg/mL), Ciprofloxacin (3.125µg/mL), and Streptomycin (6.25µg/mL).
Our results indicate that all synthesized compounds, including derivatives
of Histidine, Glutamic Acid, Glycine, Valine, Alanine, Aspartic Acid, and
Cysteine, exhibited potent antimycobacterial activity at concentrations as
low as 0.8µg/mL, surpassing the efficacy of standard drugs. Particularly,
synthetic derivatives of ofloxacin demonstrated significant inhibition against
drug-resistant Mycobacterium tuberculosis, highlighting their potential as
promising candidates for further investigation. This study underscores the
importance of exploring novel chemical entities, such as ofloxacin
derivatives with amino acids, to combat the escalating threat of drug-
resistant tuberculosis. Further research in this direction holds promise for
the development of more effective treatments against virulent TB strains.
Chromatofocusing
Chromatofocusing is a technique that separates proteins based on their isoelectric point (pI). It uses buffers like Polybuffer 74 or 96 to generate a linear pH gradient within an ion exchange column containing beads like PBE 94. Proteins are separated as they elute from the column based on their net charge, with more acidic proteins eluting first when the pH is below their pI and more basic proteins eluting later when the pH exceeds their pI. Chromatofocusing can resolve small differences in pI and is useful for analytical separations and purification of proteins.
khairia-m-youssef-future-university-egypt.ppt
This document discusses curcumin and curcumin analogs as potential anti-cancer agents. It first provides background on curcumin, noting that it is the main constituent in turmeric and has demonstrated antioxidant and anti-cancer properties. It then describes several synthetic methods that have been used to produce curcumin analogs, with modified chemical structures. Several curcumin analogs are presented that were synthesized using these methods. The document discusses in vitro tests of the antioxidant and anti-cancer effects of curcumin and its analogs, including their ability to inhibit tubulin polymerization. It concludes that the synthetic analogs demonstrated improved antioxidant and anti-cancer activity compared to curcumin itself, with effects related to their
Biocatalytic properties of a recombinant aldo keto reductase with broad subst...
Biocatalytic properties of a recombinant aldo keto reductase with broad substrate spectrum and excellent stereoselectivity
SYNTHESIS, SPECTRAL CHARACTERIZATION AND BIOACTIVITY OF NOVEL
This document summarizes the synthesis and characterization of novel organophosphorus compounds and their biological evaluation. Eight α-hydroxyphosphonate compounds were synthesized using an Abramov reaction involving various aldehydes and diphenyl phosphite. The compounds were characterized using techniques like IR spectroscopy and melting point determination. Their antibacterial activity was tested against four bacterial strains using MIC and MBC assays, with some compounds showing activity. The anticancer potential was evaluated using an acetylcholinesterase inhibition assay, with some compounds exhibiting inhibition of the enzyme. In conclusion, a convenient method for synthesizing α-hydroxyphosphonates was developed and some of the compounds demonstrated selected biological activities.
Similar to англ конференция (20)
Hydroxyapatite synthesis and its chromatographic properties
Hydroxyapatite synthesis and its chromatographic properties
Biomimetic hplc methods to predict in vivo drug distribution
Biomimetic hplc methods to predict in vivo drug distribution
Microwave Assisted Synthesis and Characterisation of Ofloxacin Carboxamide De...
Microwave Assisted Synthesis and Characterisation of Ofloxacin Carboxamide De...
Biocatalytic properties of a recombinant aldo keto reductase with broad subst...
Biocatalytic properties of a recombinant aldo keto reductase with broad subst...
SYNTHESIS, SPECTRAL CHARACTERIZATION AND BIOACTIVITY OF NOVEL
SYNTHESIS, SPECTRAL CHARACTERIZATION AND BIOACTIVITY OF NOVEL
Recently uploaded
How to Fix the Import Error in the Odoo 17
An import error occurs when a program fails to import a module or library, disrupting its execution. In languages like Python, this issue arises when the specified module cannot be found or accessed, hindering the program's functionality. Resolving import errors is crucial for maintaining smooth software operation and uninterrupted development processes.
Chapter wise All Notes of First year Basic Civil Engineering.pptx
Chapter wise All Notes of First year Basic Civil Engineering
Syllabus
Chapter-1
Introduction to objective, scope and outcome the subject
Chapter 2
Introduction: Scope and Specialization of Civil Engineering, Role of civil Engineer in Society, Impact of infrastructural development on economy of country.
Chapter 3
Surveying: Object Principles & Types of Surveying; Site Plans, Plans & Maps; Scales & Unit of different Measurements.
Linear Measurements: Instruments used. Linear Measurement by Tape, Ranging out Survey Lines and overcoming Obstructions; Measurements on sloping ground; Tape corrections, conventional symbols. Angular Measurements: Instruments used; Introduction to Compass Surveying, Bearings and Longitude & Latitude of a Line, Introduction to total station.
Levelling: Instrument used Object of levelling, Methods of levelling in brief, and Contour maps.
Chapter 4
Buildings: Selection of site for Buildings, Layout of Building Plan, Types of buildings, Plinth area, carpet area, floor space index, Introduction to building byelaws, concept of sun light & ventilation. Components of Buildings & their functions, Basic concept of R.C.C., Introduction to types of foundation
Chapter 5
Transportation: Introduction to Transportation Engineering; Traffic and Road Safety: Types and Characteristics of Various Modes of Transportation; Various Road Traffic Signs, Causes of Accidents and Road Safety Measures.
Chapter 6
Environmental Engineering: Environmental Pollution, Environmental Acts and Regulations, Functional Concepts of Ecology, Basics of Species, Biodiversity, Ecosystem, Hydrological Cycle; Chemical Cycles: Carbon, Nitrogen & Phosphorus; Energy Flow in Ecosystems.
Water Pollution: Water Quality standards, Introduction to Treatment & Disposal of Waste Water. Reuse and Saving of Water, Rain Water Harvesting. Solid Waste Management: Classification of Solid Waste, Collection, Transportation and Disposal of Solid. Recycling of Solid Waste: Energy Recovery, Sanitary Landfill, On-Site Sanitation. Air & Noise Pollution: Primary and Secondary air pollutants, Harmful effects of Air Pollution, Control of Air Pollution. . Noise Pollution Harmful Effects of noise pollution, control of noise pollution, Global warming & Climate Change, Ozone depletion, Greenhouse effect
Text Books:
1. Palancharmy, Basic Civil Engineering, McGraw Hill publishers.
2. Satheesh Gopi, Basic Civil Engineering, Pearson Publishers.
3. Ketki Rangwala Dalal, Essentials of Civil Engineering, Charotar Publishing House.
4. BCP, Surveying volume 1
The Diamonds of 2023-2024 in the IGRA collection
A review of the growth of the Israel Genealogy Research Association Database Collection for the last 12 months. Our collection is now passed the 3 million mark and still growing. See which archives have contributed the most. See the different types of records we have, and which years have had records added. You can also see what we have for the future.
How to deliver Powerpoint Presentations.pptx
"How to make and deliver dynamic presentations by making it more interactive to captivate your audience attention"
ANATOMY AND BIOMECHANICS OF HIP JOINT.pdf
it describes the bony anatomy including the femoral head , acetabulum, labrum . also discusses the capsule , ligaments . muscle that act on the hip joint and the range of motion are outlined. factors affecting hip joint stability and weight transmission through the joint are summarized.
The History of Stoke Newington Street Names
Presented at the Stoke Newington Literary Festival on 9th June 2024
www.StokeNewingtonHistory.com
Main Java[All of the Base Concepts}.docx
This is part 1 of my Java Learning Journey. This Contains Custom methods, classes, constructors, packages, multithreading , try- catch block, finally block and more.
BBR 2024 Summer Sessions Interview Training
Qualitative research interview training by Professor Katrina Pritchard and Dr Helen Williams
Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...
Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...Dr. Vinod Kumar Kanvaria
Exploiting Artificial Intelligence for Empowering Researchers and Faculty,
International FDP on Fundamentals of Research in Social Sciences
at Integral University, Lucknow, 06.06.2024
By Dr. Vinod Kumar KanvariaPengantar Penggunaan Flutter - Dart programming language1.pptx
Pengantar Penggunaan Flutter - Dart programming language1.pptx
How to Manage Your Lost Opportunities in Odoo 17 CRM
Odoo 17 CRM allows us to track why we lose sales opportunities with "Lost Reasons." This helps analyze our sales process and identify areas for improvement. Here's how to configure lost reasons in Odoo 17 CRM
Reimagining Your Library Space: How to Increase the Vibes in Your Library No ...
Librarians are leading the way in creating future-ready citizens – now we need to update our spaces to match. In this session, attendees will get inspiration for transforming their library spaces. You’ll learn how to survey students and patrons, create a focus group, and use design thinking to brainstorm ideas for your space. We’ll discuss budget friendly ways to change your space as well as how to find funding. No matter where you’re at, you’ll find ideas for reimagining your space in this session.
Pollock and Snow "DEIA in the Scholarly Landscape, Session One: Setting Expec...
Pollock and Snow "DEIA in the Scholarly Landscape, Session One: Setting Expec...National Information Standards Organization (NISO)
This presentation was provided by Steph Pollock of The American Psychological Association’s Journals Program, and Damita Snow, of The American Society of Civil Engineers (ASCE), for the initial session of NISO's 2024 Training Series "DEIA in the Scholarly Landscape." Session One: 'Setting Expectations: a DEIA Primer,' was held June 6, 2024.Hindi varnamala | hindi alphabet PPT.pdf
हिंदी वर्णमाला पीपीटी, hindi alphabet PPT presentation, hindi varnamala PPT, Hindi Varnamala pdf, हिंदी स्वर, हिंदी व्यंजन, sikhiye hindi varnmala, dr. mulla adam ali, hindi language and literature, hindi alphabet with drawing, hindi alphabet pdf, hindi varnamala for childrens, hindi language, hindi varnamala practice for kids, https://www.drmullaadamali.com
clinical examination of hip joint (1).pdf
described clinical examination all orthopeadic conditions .
Recently uploaded (20)
Film vocab for eal 3 students: Australia the movie
Film vocab for eal 3 students: Australia the movie
Chapter wise All Notes of First year Basic Civil Engineering.pptx
Chapter wise All Notes of First year Basic Civil Engineering.pptx
Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...
Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...
Liberal Approach to the Study of Indian Politics.pdf
Liberal Approach to the Study of Indian Politics.pdf
Pengantar Penggunaan Flutter - Dart programming language1.pptx
Pengantar Penggunaan Flutter - Dart programming language1.pptx
How to Manage Your Lost Opportunities in Odoo 17 CRM
How to Manage Your Lost Opportunities in Odoo 17 CRM
Reimagining Your Library Space: How to Increase the Vibes in Your Library No ...
Reimagining Your Library Space: How to Increase the Vibes in Your Library No ...
Pollock and Snow "DEIA in the Scholarly Landscape, Session One: Setting Expec...
Pollock and Snow "DEIA in the Scholarly Landscape, Session One: Setting Expec...
англ конференция
- 1. Postgraduate: Turnina Tanya Scientific supervisor: Irina U. Chukicheva Institute of Chemistry
- 2. The purpose: investigation the new catalyst system by phenol alkylation with terpenes . Objectives: To study original sources on phenols alkylation. To investigate heterogeneous acid catalysts in phenols alkylation. To select catalytic systems for phenols alkylation.
- 3. Application of phenolic antioxidants Stabilizers of polymers Medical equipment. Surfactants Food antioxidants Plasticizers Inhibitors thermopolymeriza tion OH R
- 4. Alkylation resorcinol by β-pinene HO O HO O O O O O 3 4 5 6 OH + cat OH 1 2 OR OR OH OR R OH OH 7 8 9 Cat= (PhO)3 AI H R= a) b)
- 5. Conditions and Products of Rresorcinol Alkylation by β-Pinene in the Presence Rresorcinol- β –Pinene ratio Conversion, % of Al(OPh)3 Reaction products composition, % 3 4 5 6 7a 8a 9a 9b (PhO)3Al, 160 °С, 12 ч 1:1 100 22 21 15 13 5 11 4 0,5 1:2 100 23 6 - - 23 4 21 5 2:1 100 32 9 9 3 5 2 11 - (PhO)3Al, 120 °С, 30 ч 1:1 100 16 13 11 - 22 12 8 - 1:2 100 15 3 3 - 37 - 13 10 2:1 100 26 3 21 2 16 8 7 - O OH H 7a HO O 3
- 6. Conclusions Major alkylation products: HO O 3 O Does not depend on the ratio of the initial reactants and the temperature OH H 7a Chroman ether 1) 2)
- 7. Thank you for your attention!