Autonomic Nervous Sytem and neurohumoral transmission-Dr.Jibachha Sah,M.V.Sc,...Dr. Jibachha Sah
The document provides an introduction to the autonomic nervous system and neurohumoral transmission. It discusses that the autonomic nervous system controls involuntary functions and is divided into the sympathetic and parasympathetic divisions. The sympathetic division is associated with the fight or flight response while the parasympathetic promotes rest and digestion. Neurotransmission in the autonomic nervous system involves the release of acetylcholine at neuromuscular junctions and the release of acetylcholine or norepinephrine at effector cells, depending on if the transmission is parasympathetic or sympathetic. Receptors on effector cells are nicotinic, muscarinic, alpha-adrenergic, or beta-adrenergic depending on the neurotransmit
This document provides an overview of the anatomy and pharmacology of the autonomic nervous system (ANS). It describes the ANS as having two divisions - the sympathetic and parasympathetic nervous systems. It outlines the pre- and post-ganglionic fibers, neurotransmitters, and target tissues of each division. It also discusses the receptors, signal transmission, and mechanisms of neurotransmitter synthesis, release, and removal involved in the ANS.
Complex Regional Pain Syndrome (CRPS) is classified as a Somatic Symptom Disorder characterized by extreme pain, swelling, and changes in skin temperature and color in one or more limbs. It commonly develops after an injury or trauma and is thought to involve dysfunction of the sympathetic nervous system. Symptoms range from mild to severe pain, sensory abnormalities and trophic skin changes. Diagnosis is based on patient history and ruling out other conditions, with no single diagnostic test. Treatment involves a multidisciplinary approach including physical therapy, medications, sympathetic nerve blocks, and spinal cord stimulation for severe cases. Prognosis varies but many patients improve over time with treatment.
CRPS I (RSD) with pictures. Differential DiagnosisNelson Hendler
This presentation is a summary of several lectures given by the past president of the Reflex Sympathetic Dystrophy of America. The Power Point presents the appropriate way to diagnose CRPS (RSD), and has pictures of CRPS compared to nerve entrapment syndromes, mistakenly diagnosed as CRPS. A list of appropriate medical testing is included, as is an explanation of the pathophysiology. See www.DiagnoseMyPain.com to take a test to clarify the diagnosis.
Complex Regional Pain Syndrome (CRPS) is a debilitating painful condition affecting a limb. It is associated with sensory, motor, autonomic, skin and bone abnormalities. The leading symptom is pain, which is often associated with limb dysfunction and psychological distress. CRPS arises after an injury to a limb and is classified into two types depending on whether there is a major nerve lesion present. Management involves a multidisciplinary approach with four pillars - pain relief through medications, procedures, physical and vocational therapy, and psychological therapy. Early diagnosis and treatment are important to help patients.
The document summarizes the assessment and treatment approaches for complex regional pain syndrome (CRPS). It describes CRPS as an abnormal neurologic processing of pain that causes disproportionate pain to the initial injury. Symptoms may include allodynia, hyperalgia, swelling and abnormal hair/nail growth. Treatment involves a multidisciplinary approach between occupational therapy and physical therapy, focusing on reducing pain and swelling, improving range of motion and function through desensitization and stress loading techniques. While no single protocol works for all patients, early intervention generally leads to quicker improvement. Further research is still needed to determine the most effective CRPS treatments.
This document provides an overview of Complex Regional Pain Syndrome (CRPS). It defines CRPS as a multi-symptom syndrome affecting one or more extremities that is usually out of proportion to the inciting cause. CRPS involves pain, changes in skin temperature or color, swelling, or restricted joint movement. It discusses the stages of CRPS from initial pain and swelling to potential long-term tissue damage. The document also outlines medical and surgical treatment options.
Autonomic Nervous Sytem and neurohumoral transmission-Dr.Jibachha Sah,M.V.Sc,...Dr. Jibachha Sah
The document provides an introduction to the autonomic nervous system and neurohumoral transmission. It discusses that the autonomic nervous system controls involuntary functions and is divided into the sympathetic and parasympathetic divisions. The sympathetic division is associated with the fight or flight response while the parasympathetic promotes rest and digestion. Neurotransmission in the autonomic nervous system involves the release of acetylcholine at neuromuscular junctions and the release of acetylcholine or norepinephrine at effector cells, depending on if the transmission is parasympathetic or sympathetic. Receptors on effector cells are nicotinic, muscarinic, alpha-adrenergic, or beta-adrenergic depending on the neurotransmit
This document provides an overview of the anatomy and pharmacology of the autonomic nervous system (ANS). It describes the ANS as having two divisions - the sympathetic and parasympathetic nervous systems. It outlines the pre- and post-ganglionic fibers, neurotransmitters, and target tissues of each division. It also discusses the receptors, signal transmission, and mechanisms of neurotransmitter synthesis, release, and removal involved in the ANS.
Complex Regional Pain Syndrome (CRPS) is classified as a Somatic Symptom Disorder characterized by extreme pain, swelling, and changes in skin temperature and color in one or more limbs. It commonly develops after an injury or trauma and is thought to involve dysfunction of the sympathetic nervous system. Symptoms range from mild to severe pain, sensory abnormalities and trophic skin changes. Diagnosis is based on patient history and ruling out other conditions, with no single diagnostic test. Treatment involves a multidisciplinary approach including physical therapy, medications, sympathetic nerve blocks, and spinal cord stimulation for severe cases. Prognosis varies but many patients improve over time with treatment.
CRPS I (RSD) with pictures. Differential DiagnosisNelson Hendler
This presentation is a summary of several lectures given by the past president of the Reflex Sympathetic Dystrophy of America. The Power Point presents the appropriate way to diagnose CRPS (RSD), and has pictures of CRPS compared to nerve entrapment syndromes, mistakenly diagnosed as CRPS. A list of appropriate medical testing is included, as is an explanation of the pathophysiology. See www.DiagnoseMyPain.com to take a test to clarify the diagnosis.
Complex Regional Pain Syndrome (CRPS) is a debilitating painful condition affecting a limb. It is associated with sensory, motor, autonomic, skin and bone abnormalities. The leading symptom is pain, which is often associated with limb dysfunction and psychological distress. CRPS arises after an injury to a limb and is classified into two types depending on whether there is a major nerve lesion present. Management involves a multidisciplinary approach with four pillars - pain relief through medications, procedures, physical and vocational therapy, and psychological therapy. Early diagnosis and treatment are important to help patients.
The document summarizes the assessment and treatment approaches for complex regional pain syndrome (CRPS). It describes CRPS as an abnormal neurologic processing of pain that causes disproportionate pain to the initial injury. Symptoms may include allodynia, hyperalgia, swelling and abnormal hair/nail growth. Treatment involves a multidisciplinary approach between occupational therapy and physical therapy, focusing on reducing pain and swelling, improving range of motion and function through desensitization and stress loading techniques. While no single protocol works for all patients, early intervention generally leads to quicker improvement. Further research is still needed to determine the most effective CRPS treatments.
This document provides an overview of Complex Regional Pain Syndrome (CRPS). It defines CRPS as a multi-symptom syndrome affecting one or more extremities that is usually out of proportion to the inciting cause. CRPS involves pain, changes in skin temperature or color, swelling, or restricted joint movement. It discusses the stages of CRPS from initial pain and swelling to potential long-term tissue damage. The document also outlines medical and surgical treatment options.
The autonomic nervous system regulates involuntary functions through two divisions - the sympathetic and parasympathetic nervous systems. The sympathetic system uses norepinephrine as a neurotransmitter and activates the fight or flight response. The parasympathetic system uses acetylcholine and activates rest and digest functions. Both systems target glands, muscles and organs through nicotinic and muscarinic receptors. Acetylcholinesterase terminates the action of acetylcholine at synapses.
Neurohumoral transmission in ans final fully1cl frahulsharma3589
1) Neurohumoral transmission involves the release of neurotransmitters from nerve terminals that activate specialized receptors on target cells, eliciting physiological responses.
2) Key events in neurohumoral transmission include axonal conduction, neurotransmitter release, receptor activation, post-junctional signal propagation, and neurotransmitter destruction.
3) The autonomic nervous system relies on neurohumoral transmission, using acetylcholine at parasympathetic nerve endings and norepinephrine at most sympathetic nerve endings.
The document discusses the central nervous system, peripheral nervous system, and autonomic nervous system. It describes the sympathetic and parasympathetic divisions of the autonomic nervous system. It provides details on the neurotransmitters, receptors, and typical locations involved in neurotransmission within the sympathetic and parasympathetic systems. It also lists some common effector organs and the actions mediated by stimulation or blockade of receptors in these divisions.
CGRP is a 37 amino acid neuropeptide derived from the calcitonin gene that is widely distributed throughout the body. It was discovered in 1980 when the calcitonin gene was cloned and further research in 1982 revealed CGRP. It exists in two forms, alpha and beta, and binds to a receptor composed of CLR and RAMP1. CGRP is involved in many physiological functions as it is found in the central nervous system, peripheral nervous system, and cardiovascular system. It acts as a vasodilator and plays a role in migraine headaches and nociception.
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
Discover the benefits of homeopathic medicine for irregular periods with our guide on 5 common remedies. Learn how these natural treatments can help regulate menstrual cycles and improve overall menstrual health.
Visit Us: https://drdeepikashomeopathy.com/service/irregular-periods-treatment/
Giloy in Ayurveda - Classical Categorization and SynonymsPlanet Ayurveda
Giloy, also known as Guduchi or Amrita in classical Ayurvedic texts, is a revered herb renowned for its myriad health benefits. It is categorized as a Rasayana, meaning it has rejuvenating properties that enhance vitality and longevity. Giloy is celebrated for its ability to boost the immune system, detoxify the body, and promote overall wellness. Its anti-inflammatory, antipyretic, and antioxidant properties make it a staple in managing conditions like fever, diabetes, and stress. The versatility and efficacy of Giloy in supporting health naturally highlight its importance in Ayurveda. At Planet Ayurveda, we provide a comprehensive range of health services and 100% herbal supplements that harness the power of natural ingredients like Giloy. Our products are globally available and affordable, ensuring that everyone can benefit from the ancient wisdom of Ayurveda. If you or your loved ones are dealing with health issues, contact Planet Ayurveda at 01725214040 to book an online video consultation with our professional doctors. Let us help you achieve optimal health and wellness naturally.
Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
The autonomic nervous system regulates involuntary functions through two divisions - the sympathetic and parasympathetic nervous systems. The sympathetic system uses norepinephrine as a neurotransmitter and activates the fight or flight response. The parasympathetic system uses acetylcholine and activates rest and digest functions. Both systems target glands, muscles and organs through nicotinic and muscarinic receptors. Acetylcholinesterase terminates the action of acetylcholine at synapses.
Neurohumoral transmission in ans final fully1cl frahulsharma3589
1) Neurohumoral transmission involves the release of neurotransmitters from nerve terminals that activate specialized receptors on target cells, eliciting physiological responses.
2) Key events in neurohumoral transmission include axonal conduction, neurotransmitter release, receptor activation, post-junctional signal propagation, and neurotransmitter destruction.
3) The autonomic nervous system relies on neurohumoral transmission, using acetylcholine at parasympathetic nerve endings and norepinephrine at most sympathetic nerve endings.
The document discusses the central nervous system, peripheral nervous system, and autonomic nervous system. It describes the sympathetic and parasympathetic divisions of the autonomic nervous system. It provides details on the neurotransmitters, receptors, and typical locations involved in neurotransmission within the sympathetic and parasympathetic systems. It also lists some common effector organs and the actions mediated by stimulation or blockade of receptors in these divisions.
CGRP is a 37 amino acid neuropeptide derived from the calcitonin gene that is widely distributed throughout the body. It was discovered in 1980 when the calcitonin gene was cloned and further research in 1982 revealed CGRP. It exists in two forms, alpha and beta, and binds to a receptor composed of CLR and RAMP1. CGRP is involved in many physiological functions as it is found in the central nervous system, peripheral nervous system, and cardiovascular system. It acts as a vasodilator and plays a role in migraine headaches and nociception.
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
Discover the benefits of homeopathic medicine for irregular periods with our guide on 5 common remedies. Learn how these natural treatments can help regulate menstrual cycles and improve overall menstrual health.
Visit Us: https://drdeepikashomeopathy.com/service/irregular-periods-treatment/
Giloy in Ayurveda - Classical Categorization and SynonymsPlanet Ayurveda
Giloy, also known as Guduchi or Amrita in classical Ayurvedic texts, is a revered herb renowned for its myriad health benefits. It is categorized as a Rasayana, meaning it has rejuvenating properties that enhance vitality and longevity. Giloy is celebrated for its ability to boost the immune system, detoxify the body, and promote overall wellness. Its anti-inflammatory, antipyretic, and antioxidant properties make it a staple in managing conditions like fever, diabetes, and stress. The versatility and efficacy of Giloy in supporting health naturally highlight its importance in Ayurveda. At Planet Ayurveda, we provide a comprehensive range of health services and 100% herbal supplements that harness the power of natural ingredients like Giloy. Our products are globally available and affordable, ensuring that everyone can benefit from the ancient wisdom of Ayurveda. If you or your loved ones are dealing with health issues, contact Planet Ayurveda at 01725214040 to book an online video consultation with our professional doctors. Let us help you achieve optimal health and wellness naturally.
Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
Are you looking for a long-lasting solution to your missing tooth?
Dental implants are the most common type of method for replacing the missing tooth. Unlike dentures or bridges, implants are surgically placed in the jawbone. In layman’s terms, a dental implant is similar to the natural root of the tooth. It offers a stable foundation for the artificial tooth giving it the look, feel, and function similar to the natural tooth.
Nano-gold for Cancer Therapy chemistry investigatory projectSIVAVINAYAKPK
chemistry investigatory project
The development of nanogold-based cancer therapy could revolutionize oncology by providing a more targeted, less invasive treatment option. This project contributes to the growing body of research aimed at harnessing nanotechnology for medical applications, paving the way for future clinical trials and potential commercial applications.
Cancer remains one of the leading causes of death worldwide, prompting the need for innovative treatment methods. Nanotechnology offers promising new approaches, including the use of gold nanoparticles (nanogold) for targeted cancer therapy. Nanogold particles possess unique physical and chemical properties that make them suitable for drug delivery, imaging, and photothermal therapy.