The Center for Science in the Public Interest is downgrading Splenda (sucralose) from "safe" to "caution" based on a recent Italian study. The study found that lifetime consumption of sucralose in mice was linked to an increased risk of leukemia, and the more sucralose they consumed the higher their risk. The study's lead researcher recommended that similar studies be urgently repeated in rats and large observational studies be set up to monitor potential cancer risks in humans. Currently, CSPI advises avoiding saccharin, aspartame, and acesulfame potassium, and that more testing is needed on rebiana.