This document discusses key events and innovations in science, technology, and culture that have occurred in and around San Antonio, Texas over the past century. It mentions the first personal computer, Wi-Fi, largest telecom company in the US, sequencing the human genome, LASIK eye surgery, and the first US astronaut to walk in space. It then provides more details on aviation pioneers, early aerospace research facilities, development of integrated circuits, and growth of technology companies in San Antonio through the 20th and into the 21st century.