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SORT-OUT III: A Prospective Randomized Comparison of Zotarolimus-Eluting and Sirolimus-Eluting Stents in Patients with Coronary Artery Disease Michael Maeng , Klaus Rasmussen, Per Thayssen, Henning Kelbæk, Jan Ravkilde, Ulrik Abildgaard, Lisette O. Jensen, Evald H. Christiansen, Knud N. Hansen, Hans-Henrik Tilsted, Peter R. Hansen, Lars R. Krusell, Thomas Engstrøm, Jens Aarøe, Jan S. Jensen, Hans E. Bøtker, Steen D. Kristensen, Steen Z. Abildstrøm, Anne Kaltoft, Morten Madsen, Søren P. Johnsen, Henrik T. Sørensen, Leif Thuesen & Jens F. Lassen
Conflicts of interests for Michael Maeng, M.D. Cordis, Johnson & Johnson: Speaker fees. Medtronic: Consultant fee SORT-OUT III: A Prospective Randomized Comparison of Zotarolimus-Eluting and Sirolimus-Eluting Stents in Patients with Coronary Artery Disease
Background ,[object Object]
Purpose To compare the clinical outcome in routine clinical care (“all-comer”) patients randomized to Endeavor or Cypher stent implantation
PCI Organization in Denmark Population of 5,5 million inhabitants 5 high volume PCI centers 12-month dual anti-platelet therapy is recommended PCI center 100 US miles
Methods ,[object Object],[object Object],[object Object]
Methods ,[object Object],[object Object],[object Object],[object Object],[object Object]
Endpoints ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Results ,[object Object],[object Object]
Selected Patient Characteristics 26 21 7 70 54 15 73 64 1.162 END CYP No of patients 1.170 Age (yrs) 64 Male (%) 72 Diabetes (%) 14 Hypertension (%) 51 Lipid-lowering therapy (%) 68 Previous CABG (%) 7 Previous PCI (%) 17 Previous MI (%) 27
PCI Indication END CYP Stable angina (%) 53 51 NSTEMI/UAP (%) 38 38 STEMI (%) 6 9 Other (%) 4 3
Selected Lesion Characteristics 1.5 1.6 No of lesions/patient 1.7 1.8 Stents/patient 36 45 20 3.2 18 13 END CYP Lesion length (mm) 14 Stent length (mm) 18 Stent diameter (mm) 3.2 Lesion type A (%) 18 Lesion type B (%) 48 Lesion type C (%) 35
MACE HR = 2.19 (1.58 – 3.04) P < 0.0001 END : 9.7% CYP : 4.5%
All Cause Mortality HR = 1.61 (1.03 – 2.50) P = 0.035 END : 4.4% CYP : 2.7%
Cardiac Death HR = 1.51 (0.73 – 3.14) P = 0.27 END : 1.6% CYP : 1.0%
Myocardial Infarction HR = 2.22 (1.09 – 4.53) P = 0.029 END : 2.1% CYP : 0.9%
Definite Stent Thrombosis HR = 2.19 (0.83 – 5.77) P = 0.13 END : 1.1% CYP : 0.5%
Target Vessel Revascularization HR = 2.42 (1.67 – 3.52) P<0.0001 END : 7.9% CYP : 3.3%
Target Lesion Revascularization HR = 3.66 (2.23 – 6.01) P < 0.0001 END : 6.1% CYP : 1.7%
Conclusion ,[object Object]
For further details ….. ,[object Object],Thank you for your attention

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Sort out iii

  • 1. SORT-OUT III: A Prospective Randomized Comparison of Zotarolimus-Eluting and Sirolimus-Eluting Stents in Patients with Coronary Artery Disease Michael Maeng , Klaus Rasmussen, Per Thayssen, Henning Kelbæk, Jan Ravkilde, Ulrik Abildgaard, Lisette O. Jensen, Evald H. Christiansen, Knud N. Hansen, Hans-Henrik Tilsted, Peter R. Hansen, Lars R. Krusell, Thomas Engstrøm, Jens Aarøe, Jan S. Jensen, Hans E. Bøtker, Steen D. Kristensen, Steen Z. Abildstrøm, Anne Kaltoft, Morten Madsen, Søren P. Johnsen, Henrik T. Sørensen, Leif Thuesen & Jens F. Lassen
  • 2. Conflicts of interests for Michael Maeng, M.D. Cordis, Johnson & Johnson: Speaker fees. Medtronic: Consultant fee SORT-OUT III: A Prospective Randomized Comparison of Zotarolimus-Eluting and Sirolimus-Eluting Stents in Patients with Coronary Artery Disease
  • 3.
  • 4. Purpose To compare the clinical outcome in routine clinical care (“all-comer”) patients randomized to Endeavor or Cypher stent implantation
  • 5. PCI Organization in Denmark Population of 5,5 million inhabitants 5 high volume PCI centers 12-month dual anti-platelet therapy is recommended PCI center 100 US miles
  • 6.
  • 7.
  • 8.
  • 9.
  • 10. Selected Patient Characteristics 26 21 7 70 54 15 73 64 1.162 END CYP No of patients 1.170 Age (yrs) 64 Male (%) 72 Diabetes (%) 14 Hypertension (%) 51 Lipid-lowering therapy (%) 68 Previous CABG (%) 7 Previous PCI (%) 17 Previous MI (%) 27
  • 11. PCI Indication END CYP Stable angina (%) 53 51 NSTEMI/UAP (%) 38 38 STEMI (%) 6 9 Other (%) 4 3
  • 12. Selected Lesion Characteristics 1.5 1.6 No of lesions/patient 1.7 1.8 Stents/patient 36 45 20 3.2 18 13 END CYP Lesion length (mm) 14 Stent length (mm) 18 Stent diameter (mm) 3.2 Lesion type A (%) 18 Lesion type B (%) 48 Lesion type C (%) 35
  • 13. MACE HR = 2.19 (1.58 – 3.04) P < 0.0001 END : 9.7% CYP : 4.5%
  • 14. All Cause Mortality HR = 1.61 (1.03 – 2.50) P = 0.035 END : 4.4% CYP : 2.7%
  • 15. Cardiac Death HR = 1.51 (0.73 – 3.14) P = 0.27 END : 1.6% CYP : 1.0%
  • 16. Myocardial Infarction HR = 2.22 (1.09 – 4.53) P = 0.029 END : 2.1% CYP : 0.9%
  • 17. Definite Stent Thrombosis HR = 2.19 (0.83 – 5.77) P = 0.13 END : 1.1% CYP : 0.5%
  • 18. Target Vessel Revascularization HR = 2.42 (1.67 – 3.52) P<0.0001 END : 7.9% CYP : 3.3%
  • 19. Target Lesion Revascularization HR = 3.66 (2.23 – 6.01) P < 0.0001 END : 6.1% CYP : 1.7%
  • 20.
  • 21.

Editor's Notes

  1. Ascertained from