A teenager is admitted to the psychiatry unit with signs of depression and self-harm behavior. Depression is a mood disorder characterized by intense sadness or loss of interest in activities. It is diagnosed when a low mood and other symptoms persist for at least two weeks. Treatment involves psychotherapy, reducing stress, ensuring safety, and antidepressant medication such as SSRIs or TCAs. Nursing care includes monitoring, education, and preventing suicide risk. Left untreated, depression can lead to further issues like anxiety, substance abuse, or suicide.
If you're feeling down most of the time and your symptoms don't quite match those typically associated with depression, you may be suffering from atypical depression. Here are more details to help you recognize the condition and be aware of effective treatment.
https://pathwaysreallife.com/atypical-depression-treatment-in-utah/
If you're feeling down most of the time and your symptoms don't quite match those typically associated with depression, you may be suffering from atypical depression. Here are more details to help you recognize the condition and be aware of effective treatment.
https://pathwaysreallife.com/atypical-depression-treatment-in-utah/
Presented by: Dr. Melissa Graham, SAPD Psychologist
Jeanie Paradise, Clinical Director Crisis Care Center
Lt. Teri Neal, Director SAPD Communications Unit
Emile Clede, SAPD Communications Training Coordinator
Depression is a psychological state of mind. It is a major problem faced by most of the people especially the youths. all the reasons why depression is caused what are it's symptoms signs how must the person be treated is explained in this slide
A mental health disorder characterised by persistently depressed mood or loss of interest in activities, causing significant impairment in daily life.
Possible causes include a combination of biological, psychological and social sources of distress. Increasingly, research suggests that these factors may cause changes in brain function, including altered activity of certain neural circuits in the brain.
The persistent feeling of sadness or loss of interest that characterises major depression can lead to a range of behavioural and physical symptoms. These may include changes in sleep, appetite, energy level, concentration, daily behaviour or self-esteem. Depression can also be associated with thoughts of suicide
Do you really want to understand what doctors mean when they talk about depression? Do you know that in everyone on earth, 2 out of 3 suffers depression on a daily basis.
TalkToAngel can help with teen depression. TalkToAngel is an online counseling platform that provides access to licensed therapists who specialize in treating mental health issues, including depression. Teen depression is a serious mental health concern that can affect a young person's emotional, social, and academic functioning.
Millions of people worldwide suffer from the mental health illness known as depression. It is marked by enduring melancholy, pessimism, and a lack of interest in once-pleasant pursuits.
https://www.talktoangel.com/area-of-expertise/depression
You know someone who gets irritated without reason? remains sad? talks about suicide? has not been sleeping well? has problems like headaches, pains?
he might be suffering from clinical depression. see the following presentation..
ARE YOU NEURO-PROTECTED?
CLINICAL DEPRESSION is the MOST under treated and under diagnosed medical disorder of modern times.
Its responsible for upto 40-60% decrease in sense of fullfillment, productivity and happiness.
It affects 1 in ever 5 persons in the world.
Depression
Background
Pathophysiology
• The monoamine theory of depression is that it results from a central deficit in the monoamine neurotransmitters serotonin (5-HT) and norepinephrine.
• Other reported physiological features include ↑cortisol and a blunted TSH response.
• However, there is no widely accepted and definitively proven biological model of depression.
Epidemiology
• Time course: for most it is an episodic illness, but for other it follows a more chronic course.
• Incidence: 5% annual risk, 20% lifetime risk.
Presentation
DSM and NICE criteria
These are based on DSM-4, though DSM-5 does not significantly differ.
Major depressive disorder is ≥2 weeks of low mood and/or anhedonia, and at least 4 symptoms out of:
• ↓Energy or fatigue.
• ↓Concentration
• ↓Weight/appetite.
• Disturbed sleep, which commonly includes early waking. Diurnal pattern to symptoms also seen, with symptoms often worse in the morning.
• Slowing of thought and movements (psychomotor slowing) or agitation.
• Ideas of worthlessness or guilt.
• Recurrent thoughts of death or suicide.
• All but the last 2 are considered 'biological' symptoms.
Presented by: Dr. Melissa Graham, SAPD Psychologist
Jeanie Paradise, Clinical Director Crisis Care Center
Lt. Teri Neal, Director SAPD Communications Unit
Emile Clede, SAPD Communications Training Coordinator
Depression is a psychological state of mind. It is a major problem faced by most of the people especially the youths. all the reasons why depression is caused what are it's symptoms signs how must the person be treated is explained in this slide
A mental health disorder characterised by persistently depressed mood or loss of interest in activities, causing significant impairment in daily life.
Possible causes include a combination of biological, psychological and social sources of distress. Increasingly, research suggests that these factors may cause changes in brain function, including altered activity of certain neural circuits in the brain.
The persistent feeling of sadness or loss of interest that characterises major depression can lead to a range of behavioural and physical symptoms. These may include changes in sleep, appetite, energy level, concentration, daily behaviour or self-esteem. Depression can also be associated with thoughts of suicide
Do you really want to understand what doctors mean when they talk about depression? Do you know that in everyone on earth, 2 out of 3 suffers depression on a daily basis.
TalkToAngel can help with teen depression. TalkToAngel is an online counseling platform that provides access to licensed therapists who specialize in treating mental health issues, including depression. Teen depression is a serious mental health concern that can affect a young person's emotional, social, and academic functioning.
Millions of people worldwide suffer from the mental health illness known as depression. It is marked by enduring melancholy, pessimism, and a lack of interest in once-pleasant pursuits.
https://www.talktoangel.com/area-of-expertise/depression
You know someone who gets irritated without reason? remains sad? talks about suicide? has not been sleeping well? has problems like headaches, pains?
he might be suffering from clinical depression. see the following presentation..
ARE YOU NEURO-PROTECTED?
CLINICAL DEPRESSION is the MOST under treated and under diagnosed medical disorder of modern times.
Its responsible for upto 40-60% decrease in sense of fullfillment, productivity and happiness.
It affects 1 in ever 5 persons in the world.
Depression
Background
Pathophysiology
• The monoamine theory of depression is that it results from a central deficit in the monoamine neurotransmitters serotonin (5-HT) and norepinephrine.
• Other reported physiological features include ↑cortisol and a blunted TSH response.
• However, there is no widely accepted and definitively proven biological model of depression.
Epidemiology
• Time course: for most it is an episodic illness, but for other it follows a more chronic course.
• Incidence: 5% annual risk, 20% lifetime risk.
Presentation
DSM and NICE criteria
These are based on DSM-4, though DSM-5 does not significantly differ.
Major depressive disorder is ≥2 weeks of low mood and/or anhedonia, and at least 4 symptoms out of:
• ↓Energy or fatigue.
• ↓Concentration
• ↓Weight/appetite.
• Disturbed sleep, which commonly includes early waking. Diurnal pattern to symptoms also seen, with symptoms often worse in the morning.
• Slowing of thought and movements (psychomotor slowing) or agitation.
• Ideas of worthlessness or guilt.
• Recurrent thoughts of death or suicide.
• All but the last 2 are considered 'biological' symptoms.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
2. CASE SCENARIO
A teenager is admitted to the psychiatry
unit with signs of depression and self
harm behavior. How would you assess
and provide therapeutic support for this
adolescent?
4. Depression
Depression is a mood disorder characterized by a
feeling of intense sadness or loss of interest in
pleasurable activities.
It may follow a recent loss or other sad event but it is
out of proportion to that event and persists beyond an
appropriate length of time.
6. Aetiology
The causes of depression are not fully understood but a number of factors
may make a person more likely to experience depression.
Heredity or genetic predisposition
Emotional upsetting events e.g. poverty, bereavement etc.
Physical illnesses e.g. AIDS, Tuberculosis, Syphilis, cancers,
hypothyroidism etc.
Secondary to another psychiatric disorder e.g. Schizophrenia.
Medication e.g. steroids, antipsychotics, contraceptives, cimetidine etc.
Abuse of substances e.g. alcohol.
7. Signs and Symptoms
Person may appear slow and sad or irritable and anxious.
Person may withdraw, speak little, stop eating with poor
sleep (vegetative depression) or a person may be very
restless, over talkative, wringing hands (agitated
depression).
Loss of interest in the formally pleasurable activities.
Feeling of worthless, useless, guilt and self blame.
Loss of energy and unexplained body weakness
8. Loss of interest in sexual activity.
Reduced concentration, attention and poor decision
making.
Recurrent death wishes and acts of self harm or suicide.
Low self esteem
It may present with psychotic features; hallucinations,
hearing voices telling him bad things. Delusions e.g.
believing he is not worth living.
9. Diagnosis
To make a diagnosis of depression the
patient should have had a persistent low
mood, loss of interest in the formally
pleasurable activities for at least two weeks
accompanied by at least four other signs and
symptoms of depression.
11. Medication
Generic name and
class
Trade name Dose Side Effects
Amitriptyline
(TCAs)
Laroxyl 50mg-100mg nocte
(Max 300mg)
Sedation, dry mouth,
constipation, blurring of vision,
palpitations and dizziness
Imipramine (TCAs) Tofranil 50mg-100mg nocte
(Max 300mg)
See above
Fluoxetine (SSRIs) Prozac, Trizac,
Nuzac
20-60mg mane Insomnia and anxiety
Sertraline(SSRIs) Zoloft 50mg mane
12. Nursing Care
Admit patients with severe depression on an open ward for easy
monitoring.
Establish good nurse-patient relationship
Psychotherapy to the patient and relatives is very important.
Educate patient and family about depression as being a sickness like any
other and effective treatment is available
In the course of treatment patient should not take any alcoholic drink
Assess for the risk of suicide and if present admit and put on caution card.
Help the patient come out of the stressor or cope with it.
13. Points to note
It is very important to know what types of depression you are dealing with. If you
are treating depression secondary to general medical condition or substance abuse
or another psychiatric disorder, its important to address these issues.
If it is psychotic depression you may use an antipsychotic.
If it is bipolar depression a combination of a mood stabilizer and anti depressant
may be more use full.
Depression due to stress can be treated by psychotherapy.
Depressive episodes have a tendency to re-occur and all patients who have had two
or more episodes may require maintenance treatment to prevent recurrence.
14. Complications
Depression if not properly managed can result into;
Suicide and homicides
Comorbid Anxiety disorders
Psychotic features
Alcohol and drug abuse
REFERENCES
1. The Diagnostic and statistical manual of Mental Disorders (DSM-5) by
American Psychiatric Association.
2. Kaplan and Sadock’s Comprehensive Textbook of Psychiatry by
Benjamin J. Sadock, Virginia A. Sadock, and Pedro Ruiz.
3. Basic and Clinical Pharmacolgy by Bertram G. Katzung 15th Edition