This document provides guidance on how to build a successful neurointervention program. It recommends having a clear vision with a team of experts available round-the-clock to handle at least 250 cases per year and provide a full range of high-quality interventions. Clinical outcomes depend on coordinated service across specialties. It also stresses the importance of effective communication, transparent teamwork, and publishing academic work and outcomes to establish a strong reputation and attract more patients and referrals. Building a like-minded team through win-win relationships and sharing responsibilities is key to long-term success.