This document discusses physics-based failure analysis using Virtual Life Management (VLM) simulation to predict reliability and lifetime of components before they are built. VLM creates a "Virtual Twin" of a component by simulating its material microstructure and service conditions. It has been shown to reduce testing time by factors of 20 and costs by factors of 13 compared to physical testing, while providing high statistical confidence. VLM has applications across industries for design optimization, failure analysis, and maintenance planning. Case studies demonstrate its use in predicting turbine blade and bearing lifetimes in aircraft engines, assessing steel grades for oil pipelines, and optimizing turbocharger design.