This document provides an overview of SNC-Lavalin Pharma and its areas of expertise. SNC-Lavalin Pharma is a global engineering and construction firm specializing in the life sciences sector, with over 400 personnel across several centers of excellence. It offers a wide range of process engineering services for sectors such as sterile products, biotechnology, solid dosage forms, and bulk pharmaceutical chemicals. The document outlines SNC-Lavalin Pharma's technological and unit operations expertise across areas like biopharmaceutical processes, sterile manufacturing, and solid dosage forms. It also lists the company's international offices and contact information.

1. SECTORS OF EXPERTISE
Sterile Products
Biotechnology
Solid Dosage Forms and Liquids
Bulk Pharmaceutical Chemicals
Medical Devices
Support Services
PROCESS ENGINEERING
SOLUTIONS THROUGH
PARTNERING

2. IN NOVATION WITH G LOBAL REACH
SNC-Lavalin is one of the leading groups of engineering and construction
companies in the world, and a global leader in the ownership and manage-
ment of infrastructure. Founded in 1911, SNC-Lavalin is acknowledged for
its world class technical expertise, project and construction management,
and procurement and financial arrangement services – all delivered locally
to clients anywhere in the world through its extensive international network
of offices, partners and suppliers.
SNC-Lavalin Pharma
SNC-Lavalin Pharma, a member of the teams of experts carry out all stages of project
SNC-Lavalin Group, has over 15 years of global execution, and supply specialized expertise for
experience and is one of the world’s leading any challenge in the industry.
engineering and construction firms in the life SNC-Lavalin Pharma’s services, combined
sciences sector. Its experienced team of over with its expertise, allow it to deliver personalized
400 personnel has met tight deadlines and solutions to its clients. Add to this the innovation
technical challenges for companies of all sizes, and creativity that SNC-Lavalin Pharma’s teams
including most of the world’s pharmaceutical bring to each mandate and clients can be
giants. assured of customized, leading-edge solutions
SNC-Lavalin Pharma has a firm that meet their highest expectations.
understanding of the global market and From traditional fee-per-service to turnkey
maintains a broad base of expertise in order to mandates, SNC-Lavalin Pharma meets all its
be a true single source solution for its clients. clients’ needs.
Working from Centres of Excellence in Canada,
the United States, Belgium, France and India, its
PROCESS E NG I N E E R I NG SERVICES
 Facility Master Planning  Space requirements for each process
 Material balances  Production line and traffic models
 Process Flow Diagrams (PFDs)  Analysis of environmental and safety requirements
 Process and Instrumentation Diagrams (P&IDs)  Analysis of personnel segregation requirements
for process utilities  Risk review, identification of risk factors
 Process automation  Estimate of procurement, installation and servicing of
 Process description and philosophy production equipment
 Process Architecture:  Development of Project Charter : The Project Charter
 detailed process room layout and definition describes clearly and precisely what the system, the
 integration of all process equipment into the layout project, is supposed to do and should include all essential
requirements (musts) and, if possible, a prioritized set of
 personnel process flow
desirable requirements (wants).
 material and waste flows  Preparation of :
 room classification and pressurization  User Requirements Specification (URS)

Functional description of equipment  Functional Requirements Specification (FRS)
 Functional relationships  Detail Design Specification (DDS)

3. TECHNOLOG ICAL AN D UN IT OPERATIONS EXPERTISE
Biopharmaceutical Processes Sterile Manufacturing Processes
 Raw materials storage/handling  Dispensing
 Weighing/dispensing  Compounding
 Liquid media/buffer/component preparation  Sterile filtration
 Inoculum preparation  Container washing
 Fermentation/cell culture  Container sterilization and depyrogenation
 Batch process  Stopper preparation
 Fed-batch process  Filling/stoppering
 Continuous process  Lyophilization
 Perfusion process  Capping
 Suspension cell growth  Terminal sterilization
 Anchorage dependent cell growth  Alternative technologies
 Stirred tank reactor  Blow-fill-seal
 Airlift reactor  Barrier isolators
 Packed bed reactor
 Hollow flow reactor
 Recovery and harvest Solid Dosage Forms Processes
 Centrifugation
 Cell disruption  Weighing and dispensing
 Micro filtration  Blending
 Depth filtration  Shell
 Extraction  Blade
 Refold  Bin/tote
 Expanded bed chromatography  Milling
 Inactivation  Granulation
 Purification and column packing  Planetary
 Ion exchange chromatography  High shear
 Affinity chromatography  Fluidization
 Hydrophobic interaction  Spray bar
 Size exclusion  Densification
 HPLC  Drying
 Precipitation  Tray
 Chemical treatment  Fluidization
 Ultra-filtration / Dia-filtration  Microwave
 Nano-filtration  Finishing
 Bulk filling  Compression
 Bio-waste deactivation  Encapsulation
 BL1/BL2/BL3 containment systems  Coating
 Filling
 Alternative technologies
 Tote system
 Vacuum transfer system
Bulk Pharmaceutical Chemicals Processes
 Reactor
 Filtration
 Crystallization
 Centrifugation
 Drying
Specialized Utility Systems
 PW (Purified Water) USP system
 WFI (Water For Injection) system
 Clean steam system
 CIP/SIP systems
 Nitrogen and other process gases

4. www.snclavalin.com/pharma
Head Office
Telephone :
1-800-505-5651
email : slp@snclavalin.com
NORTH AMERICA EUROPE ASIA
ALLENTOWN MONTREAL QUEBEC CITY BRUSSELS MUMBAI
SNC-Lavalin 8000 Decarie Blvd. 5500 des Galeries Blvd. S.A. Coppée-Courtoy N.V. /ICCE SNC-Lavalin
5012 Medical Center Circle 3rd Floor Suite 200 Avenue Louise 251 Engineering & Technology Pvt. Ltd.
Allentown, PA 18106 Montreal, Quebec Quebec City, Quebec Box 16 Mirchandani Business Park
USA Canada H4P 2S4 Canada G2K 2E2 B-1050 Brussels 6th Floor, Sakinaka, Andheri (East)
Belgium Mumbai - 400 072
Telephone: 610-391-1037 Telephone: 514-735-5651 Telephone: 418-621-5500 India
Telephone: (32-2) 643.15.11
Telephone: + 91 22 6720 7000
CALGARY PHILADELPHIA TORONTO LYON SNC-LAVALIN INT’L
Wiebe Forest Engineering SNC-Lavalin 789 Don Mills Road Sogequip S.A./Qualifarm AND PROCUREMENT
3613 - 33rd Street NW 436 Creamery Way, Suite 100 10th Floor C.D.12 Beijing, China
Calgary, Alberta Exton, PA 19341 Toronto, Ontario 69360 Solaize Shanghai, China
Canada T2L 2A7 USA Canada M3C 1T5 France Kuala Lumpur, Malaysia
Jakarta, Indonesia
Telephone: 403-670-7300 Telephone: 610-524-5920 Telephone: 416-422-4056 Telephone: 33 (0) 4 78 02 77 44