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ABOUT TERUMO BCT



CORPORATE PRESENTATION
2012
Terumo BCT is the world leader in blood
             component technologies.

      We believe in the potential of blood to do
      even more for patients than it does today.
     This belief unites our organization, inspires
         our innovation and strengthens our
            collaboration with customers.
               ll b ti      ith    t

    Terumo BCT
    Unlocking the Potential of Blood



2
Unlocking the Potential of Blood

                             Our focus, working with one of the world’s
                             most vital resources to ensure the lifesaving
                             gift of blood is available to p
                             g                             patients g
                                                                    globally
                                                                           y

            Our future together, to think new and differently, to strive
            for higher levels of performance to ensure our products
                                 performance,
            and services enable customers to reap new benefits and
            outcomes

 Our scientific insight, engineering abilities and manufacturing in
 collaboration with customers to innovate technologies and discover new
 ways t use current technologies t i
       to             t t h l i to increase productivity, efficiency and
                                                    d ti it    ffi i   d
 patient care
Looking at Terumo BCT at a glance


            Parent company:       Terumo Corporation
                     Division:    Blood Management Business
                   Chairman:      David Perez
                  Revenues:       In excess of $875M in FY2011
          President and CEO:      David Perez
                 Associates:      More than 2,500 globally
               Classification:    Medical Device Manufacturer
                    Industry:     Blood Banking, Transfusion Medicine,
                                  Cell Therapies and Cell Processing
         Customer segments:       Blood Centers Hospitals and Therapeutic Apheresis
                                        Centers,
                                  Centers, and Biotech and Cell Processing
        Global headquarters:      Lakewood, Colorado, United States
      Regional headquarters:      Brussels, Buenos Aires, Hong Kong, Tokyo
Major manufacturing facilities:   China, India, Japan, Northern Ireland, United States




 4
Working to satisfy customer needs wherever
    customers are l
       t           located
                       t d




                    Terumo BCT does business in more than 120 countries
                  ▲ Terumo BCT has manufacturing locations in 5 countries
                    This map is a symbolic representation
                       s ap s sy bo c ep ese a o



5
Listening to our customers inspires our
     commitment to innovation and our quest to deliver
     higher levels of quality, safety and efficiency
                    COBE® SSpectra
                                t       Trima
                   Apheresis System   Collection                                               Atreus®      Spectra Optia®
                                       System IMUFLEX® In-Line                               Whole Blood      Apheresis                             TACSI®
                                                                                          Processing System    System                                WB
                                                 Filter System
                                                                                                                                                   Est. 2012
                                                                        T-ACE II                                                        T-RAC II
                                                                                                                          Mirasol®
                                                                                                                          System
                                                                                                                          Manager                 Reveos
                                                                                                                                                Automated
   TERUFLEX® HEMOQUICK                        T-ACE
                                                                                  TSCD® II                                                         Blood
Blood Bag System
                                                                                                                                                Processing
                               Invented                                                                                                           System
                                                                Vista®                               Atreus®                         Mirasol
                                 LRS®                                                                                                            Est. 2012
                                                             Information                             System                          Platelet
                              technology
                                                               System                                Manager      TACSI              in PAS


 1969                                                                                                                                              2012

                                                                                                                               Atreus
                                                                                                                             Components
                                                                                                                              Protocol
                           Double                                                                      Mirasol®   Cadence Data         Trima
    IMUGARD               Platelet                                                                    Pathogen     Collection        Automated
                          Products                                                                 Reduction System System                     Quantum®
                                                                                                                                     Red Cells
                                                                                                                                                  Cell
               COBE®                       TERUSYS Trima Accel® OrbiSac                Elutra® Cell (Plasma and
                                                                                                      Platelets)                               Expansion
              2991 Cell                     System    Automated     System             Separation
                                                                                                                                                System
              Processor                            Blood Collection                      System
                                                       System
                                                                                                          T-SEAL II
    6                                                   Product availability varies by country.
Providing a comprehensive product portfolio to
meet the needs of our customers
                  o r c stomers

    Blood
    Bl d                           Hospitals and
                                   H    it l   d                    Biotech d
                                                                    Bi t h and
    Centers                        Therapeutic Apheresis            Cell Processing
                                   Centers
    Striving to make even safer,   Helping our customers bring      Supporting researchers in
    higher-quality transfusions    even more treatment options to   developing cell therapies that
    available to more patients     patients                         may fundamentally improve
    globally                                                        health care




7
Focusing on adding value at every step in                              Blood
                                                                       Centers



Blood C t
Bl d Center operations
                  ti




                   Donor Management: Matching each donor to better
                   collection options

                   Collections: Enhancing efficiency and flexibility
                   for in-center and mobile blood drives

                   Processing: Improving lab efficiency, blood component
                              g    p     g             y          p
                   quality and process control through automation

                   Pathogen Reduction: Working toward safer blood for
                   p
                   patients, with safe and simple p
                           ,                  p procedures for operators
                                                                p




8                    Product availability varies by country.
Offering the most comprehensive                                                          Blood
                                                                                         Centers



product range f Bl d C t
   d t        for Blood Centers


                     Donor Management                                   DonorMAX
                     DonorMAX Program │Trima for Prediction
                                    g   │
                     of Donation (T-POD)│Productivity Tools

                                                                                                     Trima Accel
                                                                                                       System
                     Collections
                     Trima Accel System │ Cadence Data Collection System │
                     O t      R i │Vi t Information S t │
                     Outcome Review│Vista I f       ti System│
                     Trima Accel Reporter│TOMEs Data Management Software│
                     T-RAC II System │IMUFLEX In-Line Filter System│
                                                                                                     TERUFLEX/
                     TERUFLEX Blood Bag System│Atreus Whole Blood Processing System                   IMUFLEX
                     Disposables │ Blood Collection Accessories │Solutions


                     Processing
                     Atreus System │TACSI System│OrbiSac System │T-ACE II+ Blood
                     Component Expressor │T-SEAL II and Teruseal Tube Sealers│
                     TSCD II, TSCD and SCD II B Sterile Tube Welders│            Reveos System
                                                                                   (Est. 2012)
                     Atreus System Manager│Cadence Data Collection System


                                                                                                   TACSI System
                     Pathogen Reduction
                     Mirasol System │Mirasol Manager


                                                                        Mirasol System



9                 Product availability varies by country.
Helping Blood Centers diversify                                                Blood
                                                                               Centers



and grow in new di
  d      i      directions
                     ti

                                     Offering therapeutic apheresis:
                                      Expands treatment options for patients
                                      Includes plasmapheresis, cytapheresis and red
                                       blood cell exchange
                                      Is possible in freestanding clinics, dedicated
                                       centers or in conjunction with l
                                           t      i      j   ti    ith local h
                                                                            l hospitals
                                                                                  it l
                                     Expanding into cell therapy:
                                      Has the potential to fundamentally change the
                                       way many diseases are treated
                                      Includes cell collections, secondary processing
                                       and expansion
                                      Enables scalable production of cell therapies




                   Product availability varies by country.
10
Terumo BCT is the only company leveraging unique technology
                                                       technology,
     innovation and core competencies in therapeutic apheresis, cell
     collections and cell processing

       Hospitals and Therapeutic
          Apheresis Centers                                                 Biotech and Cell Processing

 Improving the lives of patients with powerful                      Providing devices that wash, separate,
and flexible platforms to treat multiple disease                  concentrate and culture cells for research,
                     states                                    industry and clinical use as well as dependable
                                                                                     use,
                                                                  tools for supporting sterile lab applications




                                                      Sterile Connection
                                                            Devices                                 Elutra
                                                                                                    El t     Quantum
                                                                                   COBE 2991
Spectra Optia System   COBE Spectra System                                                         System    System
                                                                                  Cell Processor

11                                           Product availability varies by country.
Biotech and

Supporting the cell processing value                                                                                            Cell Processing




chain f
      from end to end
          Cell           Cell              Cell                   Cell                    Washing and                Cell                g
                                                                                                                                    Storage
       collection      isolation         analysis              expansion                  concentration            analysis           and
                                                                                                                                  distribution

     Activity:

    Cells
    C ll are          Cells are
                      C ll            Cell
                                      C ll population
                                                l ti             Cells
                                                                 C ll are                    Cells are
                                                                                              C ll            Cell
                                                                                                              C ll population
                                                                                                                        l ti    Cells
                                                                                                                                C ll are stored
                                                                                                                                            t   d
 collected from     separated and      is analyzed              expanded                    washed or          is analyzed       prior to patient
 bone marrow,          sorted               and                 (cultured)                concentrated              and          administration
  cord blood,                         characterized               and/or                  prior to storage    characterized
    tissue or                                                    modified                         or
   p p
   peripheral                                                                             administration
      blood




Products:

COBE Spectra
      p             COBE 2991 cell                               Quantum                    COBE 2991 cell                             TSCD II
  system              processor                                    system                     processor
                                                              (cell expansion)
 Spectra Optia       Elutra system                                                           Elutra system
   system             (elutriation)                                 TSCD II                   (elutriation)

                        TSCD II


12                                                      Product availability varies by country.
Enabling scalable production of                                                                  Biotech and
                                                                                                 Cell Processing



cell th
  ll therapies
           i
      Traditional methods of cell expansion may be cost prohibitive to scale, and require:
         A skilled labor force
         Expensive equipment and facilities
         Complex requirements and manual processes, which may compromise commercial viability



      Our automated cell expansion provides scalability, which:
         Is relevant for pre-clinical research through large-scale manufacturing
         Minimizes the need to revalidate or revisit manufacturing methods later
         Potentially
          P t ti ll accelerates ti
                        l t time t market
                                    to     k t
         Complements well-established, closed secondary processing technologies



      We d li
      W deliver well-established solutions for related cell processes, such as:
                  ll t bli h d l ti        f     l t d ll                 h
        Washing
         Concentration
         Enrichment
         Depletion


      Our fast, strong, sterile welds are critical to establishing and maintaining:
         Portable tubing welders
         Quality function when used in a wide range of specialties
         Durability and longevity

13                                              Product availability varies by country.
Believing in the potential of blood to do even
more f patients th it d
      for ti t than does t d    today


          This belief unites our organization, inspires our innovation
          and strengthens our collaboration with customers to
          ultimately b
           lti t l benefit th patients we all serve.
                          fit the ti t        ll




14
“You create technology that allows life.” Laura Fraser
 “Each day is such a gift to me.” Christy Cassidy




 Sisters Christy and Laura are now free of non-Hodgkin's Lymphoma

15

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About Us Terumo BCT

  • 1. ABOUT TERUMO BCT CORPORATE PRESENTATION 2012
  • 2. Terumo BCT is the world leader in blood component technologies. We believe in the potential of blood to do even more for patients than it does today. This belief unites our organization, inspires our innovation and strengthens our collaboration with customers. ll b ti ith t Terumo BCT Unlocking the Potential of Blood 2
  • 3. Unlocking the Potential of Blood Our focus, working with one of the world’s most vital resources to ensure the lifesaving gift of blood is available to p g patients g globally y Our future together, to think new and differently, to strive for higher levels of performance to ensure our products performance, and services enable customers to reap new benefits and outcomes Our scientific insight, engineering abilities and manufacturing in collaboration with customers to innovate technologies and discover new ways t use current technologies t i to t t h l i to increase productivity, efficiency and d ti it ffi i d patient care
  • 4. Looking at Terumo BCT at a glance Parent company: Terumo Corporation Division: Blood Management Business Chairman: David Perez Revenues: In excess of $875M in FY2011 President and CEO: David Perez Associates: More than 2,500 globally Classification: Medical Device Manufacturer Industry: Blood Banking, Transfusion Medicine, Cell Therapies and Cell Processing Customer segments: Blood Centers Hospitals and Therapeutic Apheresis Centers, Centers, and Biotech and Cell Processing Global headquarters: Lakewood, Colorado, United States Regional headquarters: Brussels, Buenos Aires, Hong Kong, Tokyo Major manufacturing facilities: China, India, Japan, Northern Ireland, United States 4
  • 5. Working to satisfy customer needs wherever customers are l t located t d Terumo BCT does business in more than 120 countries ▲ Terumo BCT has manufacturing locations in 5 countries This map is a symbolic representation s ap s sy bo c ep ese a o 5
  • 6. Listening to our customers inspires our commitment to innovation and our quest to deliver higher levels of quality, safety and efficiency COBE® SSpectra t Trima Apheresis System Collection Atreus® Spectra Optia® System IMUFLEX® In-Line Whole Blood Apheresis TACSI® Processing System System WB Filter System Est. 2012 T-ACE II T-RAC II Mirasol® System Manager Reveos Automated TERUFLEX® HEMOQUICK T-ACE TSCD® II Blood Blood Bag System Processing Invented System Vista® Atreus® Mirasol LRS® Est. 2012 Information System Platelet technology System Manager TACSI in PAS 1969 2012 Atreus Components Protocol Double Mirasol® Cadence Data Trima IMUGARD Platelet Pathogen Collection Automated Products Reduction System System Quantum® Red Cells Cell COBE® TERUSYS Trima Accel® OrbiSac Elutra® Cell (Plasma and Platelets) Expansion 2991 Cell System Automated System Separation System Processor Blood Collection System System T-SEAL II 6 Product availability varies by country.
  • 7. Providing a comprehensive product portfolio to meet the needs of our customers o r c stomers Blood Bl d Hospitals and H it l d Biotech d Bi t h and Centers Therapeutic Apheresis Cell Processing Centers Striving to make even safer, Helping our customers bring Supporting researchers in higher-quality transfusions even more treatment options to developing cell therapies that available to more patients patients may fundamentally improve globally health care 7
  • 8. Focusing on adding value at every step in Blood Centers Blood C t Bl d Center operations ti Donor Management: Matching each donor to better collection options Collections: Enhancing efficiency and flexibility for in-center and mobile blood drives Processing: Improving lab efficiency, blood component g p g y p quality and process control through automation Pathogen Reduction: Working toward safer blood for p patients, with safe and simple p , p procedures for operators p 8 Product availability varies by country.
  • 9. Offering the most comprehensive Blood Centers product range f Bl d C t d t for Blood Centers Donor Management DonorMAX DonorMAX Program │Trima for Prediction g │ of Donation (T-POD)│Productivity Tools Trima Accel System Collections Trima Accel System │ Cadence Data Collection System │ O t R i │Vi t Information S t │ Outcome Review│Vista I f ti System│ Trima Accel Reporter│TOMEs Data Management Software│ T-RAC II System │IMUFLEX In-Line Filter System│ TERUFLEX/ TERUFLEX Blood Bag System│Atreus Whole Blood Processing System IMUFLEX Disposables │ Blood Collection Accessories │Solutions Processing Atreus System │TACSI System│OrbiSac System │T-ACE II+ Blood Component Expressor │T-SEAL II and Teruseal Tube Sealers│ TSCD II, TSCD and SCD II B Sterile Tube Welders│ Reveos System (Est. 2012) Atreus System Manager│Cadence Data Collection System TACSI System Pathogen Reduction Mirasol System │Mirasol Manager Mirasol System 9 Product availability varies by country.
  • 10. Helping Blood Centers diversify Blood Centers and grow in new di d i directions ti Offering therapeutic apheresis:  Expands treatment options for patients  Includes plasmapheresis, cytapheresis and red blood cell exchange  Is possible in freestanding clinics, dedicated centers or in conjunction with l t i j ti ith local h l hospitals it l Expanding into cell therapy:  Has the potential to fundamentally change the way many diseases are treated  Includes cell collections, secondary processing and expansion  Enables scalable production of cell therapies Product availability varies by country. 10
  • 11. Terumo BCT is the only company leveraging unique technology technology, innovation and core competencies in therapeutic apheresis, cell collections and cell processing Hospitals and Therapeutic Apheresis Centers Biotech and Cell Processing Improving the lives of patients with powerful Providing devices that wash, separate, and flexible platforms to treat multiple disease concentrate and culture cells for research, states industry and clinical use as well as dependable use, tools for supporting sterile lab applications Sterile Connection Devices Elutra El t Quantum COBE 2991 Spectra Optia System COBE Spectra System System System Cell Processor 11 Product availability varies by country.
  • 12. Biotech and Supporting the cell processing value Cell Processing chain f from end to end Cell Cell Cell Cell Washing and Cell g Storage collection isolation analysis expansion concentration analysis and distribution Activity: Cells C ll are Cells are C ll Cell C ll population l ti Cells C ll are Cells are C ll Cell C ll population l ti Cells C ll are stored t d collected from separated and is analyzed expanded washed or is analyzed prior to patient bone marrow, sorted and (cultured) concentrated and administration cord blood, characterized and/or prior to storage characterized tissue or modified or p p peripheral administration blood Products: COBE Spectra p COBE 2991 cell Quantum COBE 2991 cell TSCD II system processor system processor (cell expansion) Spectra Optia Elutra system Elutra system system (elutriation) TSCD II (elutriation) TSCD II 12 Product availability varies by country.
  • 13. Enabling scalable production of Biotech and Cell Processing cell th ll therapies i Traditional methods of cell expansion may be cost prohibitive to scale, and require:  A skilled labor force  Expensive equipment and facilities  Complex requirements and manual processes, which may compromise commercial viability Our automated cell expansion provides scalability, which:  Is relevant for pre-clinical research through large-scale manufacturing  Minimizes the need to revalidate or revisit manufacturing methods later  Potentially P t ti ll accelerates ti l t time t market to k t  Complements well-established, closed secondary processing technologies We d li W deliver well-established solutions for related cell processes, such as: ll t bli h d l ti f l t d ll h  Washing  Concentration  Enrichment  Depletion Our fast, strong, sterile welds are critical to establishing and maintaining:  Portable tubing welders  Quality function when used in a wide range of specialties  Durability and longevity 13 Product availability varies by country.
  • 14. Believing in the potential of blood to do even more f patients th it d for ti t than does t d today This belief unites our organization, inspires our innovation and strengthens our collaboration with customers to ultimately b lti t l benefit th patients we all serve. fit the ti t ll 14
  • 15. “You create technology that allows life.” Laura Fraser “Each day is such a gift to me.” Christy Cassidy Sisters Christy and Laura are now free of non-Hodgkin's Lymphoma 15