The document presents an adaptive variable power sliding mode observer-based model predictive control (avpsmo-mpc) method aimed at improving trajectory tracking of a mecanum-wheeled mobile robot (MWMR) under external disturbances and model uncertainties. The method effectively transforms the tracking problem into a constrained quadratic programming issue and enhances the robot's stability by incorporating a feedforward compensation controller. Comparative simulations demonstrate the method's robustness and efficacy in maintaining precise tracking control amid various conditions.