Sirion Portfolio
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Sirion Biotech offers a range of viral vectors, ready-to-use cells, and cell services for research and clinical applications including adenovirus and AAV vectors for gene knockdown and overexpression, immortalized primary cell lines, targeted genome modification, and cellular assay systems with modulated pathways. Their portfolio also includes vaccine development using adenovirus serotype vectors.
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Next-generation sequencing has enabled clinicians and researchers alike to identify novel genetic variants associated with rare Mendelian Diseases across the human genome. To help enable researchers and clinicians understand the role of CNVs in human health and disease, Golden Helix has a fully integrated CNV annotations to provide clinicians and researchers with more effective methods to identify pathogenic CNVs for heritable diseases. In this webcast, we will present our comprehensive clinical workflows that integrates the annotating and reporting of high-quality CNV alongside their existing NGS variants.
EMBL grants exclusive license for synthetic baculoviral genomes to Geneva Bio...
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Richard Cormier has over 15 years of experience in biotechnology manufacturing with a focus on purification techniques. He holds an Associate's degree in Biotechnology from Middlesex Community College with a 3.96 GPA. His experience includes cell culture skills, lab skills like SDS-PAGE and HPLC, and purification work using chromatography columns and filtration processes at Sanofi Genzyme and previously at Wyeth Biotech/Pfizer. At his current role at Sanofi Genzyme, he serves as a Purification Senior Technician and is responsible for training others, assisting with audits and documentation, and helping to start up a new production division.
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The most common and standard technique (2-4 months for one specific antigen)
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https://www.creative-biolabs.com/sdab/construction-of-immune-single-domain-antibody-library.htm
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This document summarizes a presentation on the production and purification of virus-like particle (VLP) based vaccines. It discusses using hepatitis C VLPs as a model system produced using an insect cell/baculovirus expression platform. Key points covered include:
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Technovax Presentation @ Influenza Congress USA 2012
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This document summarizes a presentation on the production and purification of virus-like particle (VLP) based vaccines. It discusses using hepatitis C VLPs as a model system produced using an insect cell/baculovirus expression platform. Key points covered include:
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- Hepatitis C VLPs containing E1 and E2 glycoproteins were successfully produced using Sf9 insect cells in a Mobius 3L disposable bioreactor, with comparable results to a glass bioreactor.
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Virus like-particles-based-vaccine-development-services
Virus-like Particles (VLPs) Based Vaccine, an approach that fights viruses with its own weapon, is one of the most exciting emerging vaccine technologies for generating effective and long-lasting protection. https://www.creative-biolabs.com/vaccine/virus-like-particles-based-vaccines.htm
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The GRE has two types of essays: the issue essay and argument essay. For the issue essay, test takers are given a debatable topic and must choose a side to support using personal thoughts, views, experiences, and examples. Essays should use logical examples and explanations to convince the reader while maintaining correct grammar, structure, and focus on the main topic without digressing. The issue essay evaluates not just critical thinking, but also writing and expression skills through assessing grammar usage, sentence structure, and ability to convey ideas.
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The document summarizes the design of a ceiling lamp called "LiF" for a 45-year-old housewife named Andrea. Key details include:
- LiF uses translucent textures and LED technology to spread light throughout a home in an elegant yet affordable design.
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Virus like-particles-based-vaccine-development-services
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CD Bioparticles provides one-stop customization services for gene therapy including nucleic acid synthesis, modifications, encapsulation in delivery systems like nanoparticles and viral vectors, and characterization of physical and biological properties. Their services include design and synthesis of nucleic acids, incorporation of modifications, development of polymer nanoparticles, liposomes, lipid nanoparticles, exosome and viral vectors for delivery, and characterization of size, structure, encapsulation, expression and animal studies. They aim to offer reliable delivery systems and a full suite of services to support academic and industrial customers in gene therapy and vaccine development research and applications.
Gene Therapy Delivery Platforms
CD Bioparticles provides one-stop customization services for gene therapy including nucleic acid synthesis, modifications, encapsulation in delivery systems like nanoparticles and viral vectors, and characterization of physical and biological properties. Their services include design and synthesis of nucleic acids, incorporation of modifications, development of polymer nanoparticles, liposomes, lipid nanoparticles, exosome and viral vectors for delivery, and characterization of size, structure, encapsulation, expression and animal studies. They aim to offer reliable delivery systems and a full suite of services to support academic and industrial customers in gene therapy research and development.
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Releasing Your AAV Therapy with Confidence: Regulatory Considerations and Key...
Watch the presentation of this webinar here: https://bit.ly/3icKkbZ
Ensuring the safety and quality of your AAV vector is of the utmost importance. Join this webinar for a high-level overview of the regulatory requirements for AAV testing throughout the manufacturing process, as well as a more detailed look at rcAAV and infectious titer assays.
Adeno-associated virus (AAV) vectors possess a number of advantages for use in human therapy including: high titer preparations, low immunogenicity, capacity to infect a wide range of cell types, and replication deficiency. Even with these advantages, there are biosafety concerns to consider when using AAV vectors.
This webinar will discuss key regulatory considerations across the manufacturing process, from the helper/packaging plasmids through to lot release testing. We will highlight critical assays that are required and delve into specifics on replication competent AAV testing and infectious titer determination by TCID50.
In this webinar, you will learn:
• Critical biosafety considerations for AAV vectors based on the latest regulatory guidance
• How replication competent AAV testing fits into your bulk and final release testing package
• The benefits of routine and platform assays over custom assay development
Presented by:
Steven McDade, Senior Technical Specialist, Field Technology Management
Alfonso Lavorgna, Ph.D., Operations Manager, Virology Services
Releasing Your AAV Therapy with Confidence: Regulatory Considerations and Key...
Watch the presentation of this webinar here: https://bit.ly/3icKkbZ
Ensuring the safety and quality of your AAV vector is of the utmost importance. Join this webinar for a high-level overview of the regulatory requirements for AAV testing throughout the manufacturing process, as well as a more detailed look at rcAAV and infectious titer assays.
Adeno-associated virus (AAV) vectors possess a number of advantages for use in human therapy including: high titer preparations, low immunogenicity, capacity to infect a wide range of cell types, and replication deficiency. Even with these advantages, there are biosafety concerns to consider when using AAV vectors.
This webinar will discuss key regulatory considerations across the manufacturing process, from the helper/packaging plasmids through to lot release testing. We will highlight critical assays that are required and delve into specifics on replication competent AAV testing and infectious titer determination by TCID50.
In this webinar, you will learn:
• Critical biosafety considerations for AAV vectors based on the latest regulatory guidance
• How replication competent AAV testing fits into your bulk and final release testing package
• The benefits of routine and platform assays over custom assay development
Presented by:
Steven McDade, Senior Technical Specialist, Field Technology Management
Alfonso Lavorgna, Ph.D., Operations Manager, Virology Services
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Sirion Portfolio
- 1. Product and Service Portfolio Adenovirus, Cell Pools or clonal cells for -Knock Down and Vectors Ready-to-Use Cells -Virus construction , Overexpression using purification, enhancement AV, AAV or LV technology ‘TransMAX’, ‘LentiMAX’ -Custom vector preparations Cell Immortailzation AV miRNA expression systems Immortalized primary Cells - Virus vectors for target validation Industrial - ImHUVEC and Clinical Viral vectors for basic research and Applications Production cell line optimization Drug development Systems Biology-based rational screening Mission® cells (Sigma Aldrich-SirionBiotech) Immortalization of primary human cells New! Cell products for screening Vaccine development option - Targeted genome modification (BAC technology) - hCMV vaccine candidate - Cellular assay systems with specifically modulated - Adenovirus serotype vectors pathways For further information please send an Email to: frost@sirion-biotech.de or call us under: +49 89 700 961 99 16