Signalling mechanism and drug receptors

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Signaling Mechanism. The signaling mechanism is chemical in nature (i.e., paracrine) and incorporates specialized sensing functions of intestinal mast cells for antigens in concert with the capacity of the ENS for intelligent interpretation of antigen-evoked mast cell signals.

Signalling mechanism and drug receptors

Signalling mechanism and drug receptors

Signalling mechanism and drug receptors

Signalling mechanism and drug receptors

Signalling mechanism and drug receptors

Signalling mechanism and drug receptors

Signalling mechanism and drug receptors

Signalling mechanism and drug receptors

Signalling mechanism and drug receptors

Signalling mechanism and drug receptors

Signalling mechanism and drug receptors

Signalling mechanism and drug receptors

Signalling mechanism and drug receptors

Signalling mechanism and drug receptors

Signalling mechanism and drug receptors

Signalling mechanism and drug receptors

Signalling mechanism and drug receptors

Signalling mechanism and drug receptors

Signalling mechanism and drug receptors

Signalling mechanism and drug receptors

Signalling mechanism and drug receptors

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organic chemistry, amines (/əˈmiːn, ˈæmiːn/,[1][2] UK also /ˈeɪmiːn/)[3] are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia, wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group[4] (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines). Important amines include amino acids, biogenic amines, trimethylamine, and aniline; see Category:Amines for a list of amines. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).[5] The substituent -NH2 is called an amino group.[6] Compounds with a nitrogen atom attached to a carbonyl group, thus having the structure R–CO–NR′R″, are called amides and have different chemical properties from amines.

Amines and types properties

Amines and types properties

Amines and types properties

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An aldehyde /ˈældɪhaɪd/ is a compound containing a functional group with the structure −CHO, consisting of a carbonyl center (a carbon double-bonded to oxygen) with the carbon atom also bonded to hydrogen and to an R group,[1] which is any generic alkyl or side chain. The group—without R—is the aldehyde group, also known as the formyl group. Aldehydes are common in organic chemistry, and many fragrances are or contain aldehydes.

Aldehyde ketone and their types and properties

Aldehyde ketone and their types and properties

Aldehyde ketone and their types and properties

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The action of drugs on the human body is called pharmacodynamics, and what the body does with the drug is called pharmacokinetics. The drugs that enter the human tend to stimulate certain receptors, ion channels, act on enzymes or transporter proteins. As a result, they cause the human body to react in a specific way. There are 2 different types of drugs: Agonists - they stimulate and activate the receptors Antagonists - they stop the agonists from stimulating the receptors Once the receptors are activated, they either trigger a particular response directly on the body, or they trigger the release of hormones and/or other endogenous drugs in the body to stimulate a particular response.

Signaling mechanism with drug actions

Signaling mechanism with drug actions

Signaling mechanism with drug actions

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resonance is a way of describing bonding in certain molecules or ions by the combination of several contributing structures (or forms,[1] also variously known as resonance structures or canonical structures) into a resonance hybrid (or hybrid structure) in valence bond theory. It has particular value for describing delocalized electrons within certain molecules or polyatomic ions where the bonding cannot be expressed by one single Lewis structure.

Resonance in organic molecules and their types

Resonance in organic molecules and their types

Resonance in organic molecules and their types

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Formulation consideration of drug

Formulation consideration of drug

Formulation consideration of drug

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The citric acid cycle (CAC) – also known as the TCA cycle (tricarboxylic acid cycle) or the Krebs cycle[1][2] – is a series of chemical reactions used by all aerobic organisms to release stored energy through the oxidation of acetyl-CoA derived from carbohydrates, fats, and proteins, into adenosine triphosphate (ATP) and carbon dioxide. In addition, the cycle provides precursors of certain amino acids, as well as the reducing agent NADH, that are used in numerous other reactions. Its central importance to many biochemical pathways suggests that it was one of the earliest established components of cellular metabolism and may have originated abiogenically.[3][4] Even though it is branded as a 'cycle', it is not necessary for metabolites to follow only one specific route; at least three segments of the citric acid cycle have been recognized.[5] The name of this metabolic pathway is derived from the citric acid (a type of tricarboxylic acid, often called citrate, as the ionized form predominates at biological pH[6]) that is consumed and then regenerated by this sequence of reactions to complete the cycle. The cycle consumes acetate (in the form of acetyl-CoA) and water, reduces NAD+ to NADH, and produces carbon dioxide as a waste byproduct. The NADH generated by the citric acid cycle is fed into the oxidative phosphorylation (electron transport) pathway. The net result of these two closely linked pathways is the oxidation of nutrients to produce usable chemical energy in the form of ATP. In eukaryotic cells, the citric acid cycle occurs in the matrix of the mitochondrion. In prokaryotic cells, such as bacteria, which lack mitochondria, the citric acid cycle reaction sequence is performed in the cytosol with the proton gradient for ATP production being across the cell's surface (plasma membrane) rather than the inner membrane of the mitochondrion. The overall yield of energy-containing compounds from the TCA cycle is three NADH, one FADH2, and one GTP.[7]

Significance of tca cycle

Significance of tca cycle

Significance of tca cycle

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Organic chemistry is a subdiscipline of chemistry that studies the structure, properties and reactions of organic compounds, which contain carbon in covalent bonding.[1] Study of structure determines their chemical composition and formula. Study of properties includes physical and chemical properties, and evaluation of chemical reactivity to understand their behavior. The study of organic reactions includes the chemical synthesis of natural products, drugs, and polymers, and study of individual organic molecules in the laboratory and via theoretical (in silico) study. The range of chemicals studied in organic chemistry includes hydrocarbons (compounds containing only carbon and hydrogen) as well as compounds based on carbon, but also containing other elements,[1][2][3] especially oxygen, nitrogen, sulfur, phosphorus (included in many biochemicals) and the halogens. Organometallic chemistry is the study of compounds containing carbon–metal bonds. In addition, contemporary research focuses on organic chemistry involving other organometallics including the lanthanides, but especially the transition metals zinc, copper, palladium, nickel, cobalt, titanium and chromium

Basic concepts of organic chmeistry

Basic concepts of organic chmeistry

Basic concepts of organic chmeistry

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Enzymes /ˈɛnzaɪmz/ are both proteins and biological catalysts (biocatalysts). Catalysts accelerate chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. Almost all metabolic processes in the cell need enzyme catalysis in order to occur at rates fast enough to sustain life.[1]:8.1 Metabolic pathways depend upon enzymes to catalyze individual steps. The study of enzymes is called enzymology and a new field of pseudoenzyme analysis has recently grown up, recognising that during evolution, some enzymes have lost the ability to carry out biological catalysis, which is often reflected in their amino acid sequences and unusual 'pseudocatalytic' properties.[2][3] Enzymes are known to catalyze more than 5,000 biochemical reaction types.[4] Other biocatalysts are catalytic RNA molecules, called ribozymes. Enzymes' specificity comes from their unique three-dimensional structures. Like all catalysts, enzymes increase the reaction rate by lowering its activation energy. Some enzymes can make their conversion of substrate to product occur many millions of times faster. An extreme example is orotidine 5'-phosphate decarboxylase, which allows a reaction that would otherwise take millions of years to occur in milliseconds.[5][6] Chemically, enzymes are like any catalyst and are not consumed in chemical reactions, nor do they alter the equilibrium of a reaction. Enzymes differ from most other catalysts by being much more specific. Enzyme activity can be affected by other molecules: inhibitors are molecules that decrease enzyme activity, and activators are molecules that increase activity. Many therapeutic drugs and poisons are enzyme inhibitors. An enzyme's activity decreases markedly outside its optimal temperature and pH, and many enzymes are (permanently) denatured when exposed to excessive heat, losing their structure and catalytic properties. Some enzymes are used commercially, for example, in the synthesis of antibiotics. Some household products use enzymes to speed up chemical reactions: enzymes in biological washing powders break down protein, starch or fat stains on clothes, and enzymes in meat tenderizer break down proteins into smaller molecules, making the meat easier to chew.

Enzymes and their types and properties

Enzymes and their types and properties

Enzymes and their types and properties

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In biology and biochemistry, a lipid is a biomolecule that is soluble in nonpolar solvents.[3] Non-polar solvents are typically hydrocarbons used to dissolve other naturally occurring hydrocarbon lipid molecules that do not (or do not easily) dissolve in water, including fatty acids, waxes, sterols, fat-soluble vitamins (such as vitamins A, D, E, and K), monoglycerides, diglycerides, triglycerides, and phospholipids. The functions of lipids include storing energy, signaling, and acting as structural components of cell membranes.[4][5] Lipids have applications in the cosmetic and food industries as well as in nanotechnology.[6] Scientists sometimes define lipids as hydrophobic or amphiphilic small molecules; the amphiphilic nature of some lipids allows them to form structures such as vesicles, multilamellar/unilamellar liposomes, or membranes in an aqueous environment. Biological lipids originate entirely or in part from two distinct types of biochemical subunits or "building-blocks": ketoacyl and isoprene groups.[4] Using this approach, lipids may be divided into eight categories: fatty acids, glycerolipids, glycerophospholipids, sphingolipids, saccharolipids, and polyketides (derived from condensation of ketoacyl subunits); and sterol lipids and prenol lipids (derived from condensation of isoprene subunits).[4] Although the term "lipid" is sometimes used as a synonym for fats, fats are a subgroup of lipids called triglycerides. Lipids also encompass molecules such as fatty acids and their derivatives (including tri-, di-, monoglycerides, and phospholipids), as well as other sterol-containing metabolites such as cholesterol.[7] Although humans and other mammals use various biosynthetic pathways both to break down and to synthesize lipids, some essential lipids can't be made this way and must be obtained from the diet.

Lipid and their types with propertes

Lipid and their types with propertes

Lipid and their types with propertes

রেজা তানজিল

In chemistry, alcohol is an organic compound that carries at least one hydroxyl functional group (−OH) bound to a saturated carbon atom.[2] The term alcohol originally referred to the primary alcohol ethanol (ethyl alcohol), which is used as a drug and is the main alcohol present in alcoholic beverages. An important class of alcohols, of which methanol and ethanol are the simplest members, includes all compounds for which the general formula is CnH2n+1OH. Simple monoalcohols that are the subject of this article include primary (RCH2OH), secondary (R2CHOH) and tertiary (R3COH) alcohols. The suffix -ol appears in the IUPAC chemical name of all substances where the hydroxyl group is the functional group with the highest priority. When a higher priority group is present in the compound, the prefix hydroxy- is used in its IUPAC name. The suffix -ol in non-IUPAC names (such as paracetamol or cholesterol) also typically indicates that the substance is an alcohol. However, many substances that contain hydroxyl functional groups (particularly sugars, such as glucose and sucrose) have names which include neither the suffix -ol, nor the prefix hydroxy-.

Alcohol phenol ether with types and properties

Alcohol phenol ether with types and properties

Alcohol phenol ether with types and properties

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Peptic ulcer disease (PUD) is a break in the inner lining of the stomach, the first part of the small intestine, or sometimes the lower esophagus.[1][7] An ulcer in the stomach is called a gastric ulcer, while one in the first part of the intestines is a duodenal ulcer.[1] The most common symptoms of a duodenal ulcer are waking at night with upper abdominal pain and upper abdominal pain that improves with eating.[1] With a gastric ulcer, the pain may worsen with eating.[8] The pain is often described as a burning or dull ache.[1] Other symptoms include belching, vomiting, weight loss, or poor appetite.[1] About a third of older people have no symptoms.[1] Complications may include bleeding, perforation, and blockage of the stomach.[2] Bleeding occurs in as many as 15% of cases.[2] Common causes include the bacteria Helicobacter pylori and non-steroidal anti-inflammatory drugs (NSAIDs).[1] Other, less common causes include tobacco smoking, stress due to serious illness, Behcet disease, Zollinger-Ellison syndrome, Crohn disease, and liver cirrhosis.[1][3] Older people are more sensitive to the ulcer-causing effects of NSAIDs.[1] The diagnosis is typically suspected due to the presenting symptoms with confirmation by either endoscopy or barium swallow.[1] H. pylori can be diagnosed by testing the blood for antibodies, a urea breath test, testing the stool for signs of the bacteria, or a biopsy of the stomach.[1] Other conditions that produce similar symptoms include stomach cancer, coronary heart disease, and inflammation of the stomach lining or gallbladder inflammation.[1] Diet does not play an important role in either causing or preventing ulcers.[9] Treatment includes stopping smoking, stopping use of NSAIDs, stopping alcohol, and taking medications to decrease stomach acid.[1] The medication used to decrease acid is usually either a proton pump inhibitor (PPI) or an H2 blocker, with four weeks of treatment initially recommended.[1] Ulcers due to H. pylori are treated with a combination of medications, such as amoxicillin, clarithromycin, and a PPI.[4] Antibiotic resistance is increasing and thus treatment may not always be effective.[4] Bleeding ulcers may be treated by endoscopy, with open surgery typically only used in cases in which it is not successful.[2] Peptic ulcers are present in around 4% of the population.[1] New ulcers were found in around 87.4 million people worldwide during 2015.[5] About 10% of people develop a peptic ulcer at some point in their life.[10] Peptic ulcers resulted in 267,500 deaths in 2015, down from 327,000 in 1990.[6][11] The first description of a perforated peptic ulcer was in 1670, in Princess Henrietta of England.[2] H. pylori was first identified as causing peptic ulcers by Barry Marshall and Robin Warren in the late 20th century,[4] a discovery for which they received the Nobel Prize in 2005

Drugs for peptic ulcer

Drugs for peptic ulcer

Drugs for peptic ulcer

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Nucleic acids are the biopolymers, or small biomolecules, essential to all known forms of life. The term nucleic acid is the overall name for DNA and RNA. They are composed of nucleotides, which are the monomers made of three components: a 5-carbon sugar, a phosphate group and a nitrogenous base. If the sugar is a compound ribose, the polymer is RNA (ribonucleic acid); if the sugar is derived from ribose as deoxyribose, the polymer is DNA (deoxyribonucleic acid). Nucleic acids are the most important of all biomolecules. These are found in abundance in all living things, where they function to create and encode and then store information of every living cell of every life-form organism on Earth. In turn, they function to transmit and express that information inside and outside the cell nucleus—to the interior operations of the cell and ultimately to the next generation of each living organism. The encoded information is contained and conveyed via the nucleic acid sequence, which provides the 'ladder-step' ordering of nucleotides within the molecules of RNA and DNA. Strings of nucleotides are bonded to form helical backbones—typically, one for RNA, two for DNA—and assembled into chains of base-pairs selected from the five primary, or canonical, nucleobases, which are: adenine, cytosine, guanine, thymine, and uracil. Thymine occurs only in DNA and uracil only in RNA. Using amino acids and the process known as protein synthesis,[1] the specific sequencing in DNA of these nucleobase-pairs enables storing and transmitting coded instructions as genes. In RNA, base-pair sequencing provides for manufacturing new proteins that determine the frames and parts and most chemical processes of all life forms.

Nucleic acid and its types with properties

Nucleic acid and its types with properties

Nucleic acid and its types with properties

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Bioenergetics is a field in biochemistry and cell biology that concerns energy flow through living systems.[1] This is an active area of biological research that includes the study of the transformation of energy in living organisms and the study of thousands of different cellular processes such as cellular respiration and the many other metabolic and enzymatic processes that lead to production and utilization of energy in forms such as adenosine triphosphate (ATP) molecules.[2][3] That is, the goal of bioenergetics is to describe how living organisms acquire and transform energy in order to perform biological work.[4] The study of metabolic pathways is thus essential to bioenergetics.

Bioenergetics and its types and properties

Bioenergetics and its types and properties

Bioenergetics and its types and properties

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A buffer solution (more precisely, pH buffer or hydrogen ion buffer) is an aqueous solution consisting of a mixture of a weak acid and its conjugate base, or vice versa. Its pH changes very little when a small amount of strong acid or base is added to it. Buffer solutions are used as a means of keeping pH at a nearly constant value in a wide variety of chemical applications. In nature, there are many systems that use buffering for pH regulation. For example, the bicarbonate buffering system is used to regulate the pH of blood.

Buffer capacity in detail reactions

Buffer capacity in detail reactions

Buffer capacity in detail reactions

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The pharmaceutical industry discovers, develops, produces, and markets drugs or pharmaceutical drugs for use as medications to be administered (or self-administered) to patients, with the aim to cure them, vaccinate them, or alleviate the symptoms.[1][2] Pharmaceutical companies may deal in generic or brand medications and medical devices. They are subject to a variety of laws and regulations that govern the patenting, testing, safety, efficacy and marketing of drugs.

paracetmol antacid iron syrup formations

paracetmol antacid iron syrup formations

paracetmol antacid iron syrup formations

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A liquid is a nearly incompressible fluid that conforms to the shape of its container but retains a (nearly) constant volume independent of pressure. As such, it is one of the four fundamental states of matter (the others being solid, gas, and plasma), and is the only state with a definite volume but no fixed shape. A liquid is made up of tiny vibrating particles of matter, such as atoms, held together by intermolecular bonds. Like a gas, a liquid is able to flow and take the shape of a container. Most liquids resist compression, although others can be compressed. Unlike a gas, a liquid does not disperse to fill every space of a container, and maintains a fairly constant density. A distinctive property of the liquid state is surface tension, leading to wetting phenomena. Water is, by far, the most common liquid on Earth. The density of a liquid is usually close to that of a solid, and much higher than in a gas. Therefore, liquid and solid are both termed condensed matter. On the other hand, as liquids and gases share the ability to flow, they are both called fluids. Although liquid water is abundant on Earth, this state of matter is actually the least common in the known universe, because liquids require a relatively narrow temperature/pressure range to exist. Most known matter in the universe is in gaseous form (with traces of detectable solid matter) as interstellar clouds or in plasma from within stars.

Liquid dosage form and their properties

Liquid dosage form and their properties

Liquid dosage form and their properties

রেজা তানজিল

Amino acids are organic compounds that contain amine (-NH2) and carboxyl (-COOH) functional groups, along with a side chain (R group) specific to each amino acid.[1][2] The key elements of an amino acid are carbon (C), hydrogen (H), oxygen (O), and nitrogen (N), although other elements are found in the side chains of certain amino acids. About 500 naturally occurring amino acids are known (though only 20 appear in the genetic code) and can be classified in many ways.[3] They can be classified according to the core structural functional groups' locations as alpha- (α-), beta- (β-), gamma- (γ-) or delta- (δ-) amino acids; other categories relate to polarity, pH level, and side chain group type (aliphatic, acyclic, aromatic, containing hydroxyl or sulfur, etc.). In the form of proteins, amino acid residues form the second-largest component (water is the largest) of human muscles and other tissues.[4] Beyond their role as residues in proteins, amino acids participate in a number of processes such as neurotransmitter transport and biosynthesis.

Amino acid and their types with properties

Amino acid and their types with properties

Amino acid and their types with properties

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Suppositories and their types and properties

Suppositories and their types and properties

Suppositories and their types and properties

রেজা তানজিল

The Geiger–Marsden experiments (also called the Rutherford gold foil experiment) were a landmark series of experiments by which scientists discovered that every atom has a nucleus where all of its positive charge and most of its mass is concentrated. They deduced this by measuring how an alpha particle beam is scattered when it strikes a thin metal foil. The experiments were performed between 1908 and 1913 by Hans Geiger and Ernest Marsden under the direction of Ernest Rutherford at the Physical Laboratories of the University of Manchester.

Alpha Particle scatterring experiment

Alpha Particle scatterring experiment

Alpha Particle scatterring experiment

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Quantum mechanics (QM; also known as quantum physics, quantum theory, the wave mechanical model, or matrix mechanics), including quantum field theory, is a fundamental theory in physics describing the properties of nature.[2] Classical physics, the description of physics that existed before the formulation of the theory of relativity and of quantum mechanics, describes many aspects of nature at ordinary (macroscopic) scale. Quantum mechanics explains the aspects of nature at ordinary (macroscopic) scales but extends this description to the small (atomic and subatomic) scales. Most theories in classical physics can be derived from quantum mechanics as an approximation valid at large (macroscopic) scale.[3] Quantum mechanics differs from classical physics in that energy, momentum, angular momentum, and other quantities of a bound system are restricted to discrete values (quantization), objects have characteristics of both particles and waves (wave-particle duality), and there are limits to how accurately the value of a physical quantity can be predicted prior to its measurement, given a complete set of initial conditions (the uncertainty principle).[note 1] Quantum mechanics arose gradually, from theories to explain observations which could not be reconciled with classical physics, such as Max Planck's solution in 1900 to the black-body radiation problem, and the correspondence between energy and frequency in Albert Einstein's 1905 paper which explained the photoelectric effect. Early quantum theory was profoundly re-conceived in the mid-1920s by Erwin Schrödinger, Werner Heisenberg, Max Born and others. The modern theory is formulated in various specially developed mathematical formalisms. In one of them, a mathematical function, the wave function, provides information about the probability amplitude of energy, momentum, and other physical properties of a particle.

Quantum theory and the electronic structure of atoms

Quantum theory and the electronic structure of atoms

Quantum theory and the electronic structure of atoms

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Amines and types properties

Amines and types properties

Amines and types properties

Aldehyde ketone and their types and properties

Aldehyde ketone and their types and properties

Aldehyde ketone and their types and properties

Signaling mechanism with drug actions

Signaling mechanism with drug actions

Signaling mechanism with drug actions

Resonance in organic molecules and their types

Resonance in organic molecules and their types

Resonance in organic molecules and their types

Formulation consideration of drug

Formulation consideration of drug

Formulation consideration of drug

Significance of tca cycle

Significance of tca cycle

Significance of tca cycle

Basic concepts of organic chmeistry

Basic concepts of organic chmeistry

Basic concepts of organic chmeistry

Enzymes and their types and properties

Enzymes and their types and properties

Enzymes and their types and properties

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Lipid and their types with propertes

Lipid and their types with propertes

Alcohol phenol ether with types and properties

Alcohol phenol ether with types and properties

Alcohol phenol ether with types and properties

Drugs for peptic ulcer

Drugs for peptic ulcer

Drugs for peptic ulcer

Nucleic acid and its types with properties

Nucleic acid and its types with properties

Nucleic acid and its types with properties

Bioenergetics and its types and properties

Bioenergetics and its types and properties

Bioenergetics and its types and properties

Buffer capacity in detail reactions

Buffer capacity in detail reactions

Buffer capacity in detail reactions

paracetmol antacid iron syrup formations

paracetmol antacid iron syrup formations

paracetmol antacid iron syrup formations

Liquid dosage form and their properties

Liquid dosage form and their properties

Liquid dosage form and their properties

Amino acid and their types with properties

Amino acid and their types with properties

Amino acid and their types with properties

Suppositories and their types and properties

Suppositories and their types and properties

Suppositories and their types and properties

Alpha Particle scatterring experiment

Alpha Particle scatterring experiment

Alpha Particle scatterring experiment

Quantum theory and the electronic structure of atoms

Quantum theory and the electronic structure of atoms

Quantum theory and the electronic structure of atoms

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Andreas Schleicher presents at the OECD webinar ‘Digital devices in schools: detrimental distraction or secret to success?’ on 27 May 2024. The presentation was based on findings from PISA 2022 results and the webinar helped launch the PISA in Focus ‘Managing screen time: How to protect and equip students against distraction’ https://www.oecd-ilibrary.org/education/managing-screen-time_7c225af4-en and the OECD Education Policy Perspective ‘Students, digital devices and success’ can be found here - https://oe.cd/il/5yV

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