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SHS.202 Lec-06
Dr. Savera Jabeen
Cerebellum
Location
Located in posterior cranial fossa below
occipital lobe.
It is connected to brainstem by 3 peduncles:
a.Superior cerebellar peduncle – Midbrain.
b.Middle cerebellar peduncle – Pons.
c.Inferior cerebellar peduncle – Medulla
oblongata.
Lobes
It consists of 3 lobes:
a.Anterior lobe.
b.Posterior lobe.
c.Flocculonodular lobe.
Structure
It consists of 2 cerebellar hemispheres connected by
median vermis.
Each cerebellar hemisphere is further divided into an
intermediate zone and a lateral zone.
a. Central zone (Vermis) – Influences the movements of
long axis of the body (neck, shoulders, thorax,
abdomen, hips).
b. Intermediate zone – Influences distal muscles of upper
and lower limbs especially hands & feet.
c. Lateral zone – Planning of movements and correction of
movement errors.
Functional Areas of Cerebellum
On the basis of incoming and outgoing
connections with specific areas of nervous
system, cerebellum is divided into 3 areas:
a.Vestibulocerebellum – Flocculonodular
lobe.
b.Spinocerebellum – Vermis, intermediate
zone.
c.Cerebrocerebellum – Lateral zone.
Layers of Cerebellar Cortex
a.Molecular layer – Outermost.
b.Purkinje cell layer.
c.Granular layer – Innermost.
Deep Cerebellar Nuclei
Located deep to the layers of cerebellar cortex,
there are 4 masses of gray matter called deep
cerebellar nuclei. They include:
a.Dentate.
b.Emboliform.
c.Globose.
d.Fastigial.
Axons of these deep cerebellar nuclei form the
cerebellar output.
Input to Cerebellar Cortex
Climbing Fibers – From inferior olivary nucleus of
medulla oblongata.
Mossy Fibers:
a.From cerebral cortex.
b.From spinal cord – Anterior & posterior
spinocerebellar pathways.
c.From vestibular system.
d.From nucleus cuneatus of medulla oblongata.
e.From red nucleus of midbrain.
Output of Cerebellar Cortex
a.Dentothalamic Pathway - Dentate nucleus →
Thalamus → Cerebral cortex.
b.Globose-Emboliform-Rubral Pathway – Globose
& emboliform nuclei → Thalamus → Cerebral
cortex → Basal ganglia → Red nucleus of
midbrain.
c.Fastigial-Vestibular Pathway – Fastigial nucleus
→ Lateral vestibular nucleus.
d.Fastigial-Reticular Pathway – Fastigial nucleus →
Reticular formation.
Functions of Cerebellum
Vestibulocerebellum:
a.Control of equilibrium and postural
movements.
b.Maintenance of balance when body
is rapidly moving or changing
directions.
Functions of Cerebellum
Spinocerebellum:
a.Coordination of movements of agonist and
antagonist muscles of distal limbs during voluntary
purposeful movements.
b.Damping of the movements to prevent
overshooting.
c.Coordination of rapid alternating movements
(ballistic movements) such as saccadic
movements of the eyes during reading.
Functions of Cerebellum
Cerebrocerebellum:
a.Planning of sequential movements.
b.Timing of movements.
Basal Ganglia/Basal
Nuclei
Introduction
They include:
a.Corpus striatum
i. Caudate.
ii. Putamen.
iii.Globus pallidus.
b.Amygdala.
c.Claustrum.
Connections of Basal Ganglia
Basal ganglia are connected via complex circuitry to:
a.Motor cortex.
b.Somatosensory cortex.
c.Ventrolateral (VL) & ventral anterior (VA) nuclei of
Thalamus.
d.Subthalamus.
e.Substantia nigra (midbrain).
f. Red nucleus (midbrain).
g.Reticular formation.
Function
a.Control complex patterns of motor activity
e.g., writing of alphabets.
b.Cognitive control of motor activities.
c.Timing of movements.
d.Scaling the intensity of movements.
Motor Cortex
Primary Motor Area
Located in frontal lobe.
Responsible for execution of movements.
Different muscle groups of the body are
represented in different areas of primary motor
area forming a map called motor homunculus.
More than half of entire primary cortex is
concerned with controlling muscles of hands
and speech.
Premotor Area
Located in frontal lobe.
Responsible for generating a plan of
movement which is then transferred to
primary motor cortex for execution.
Supplementary Motor Area
Located in frontal lobe.
Exact function is not understood.
Lesion of this area does not cause any
paralysis.
Pyramidal Tracts
Motor signals are transmitted from motor
cortex to lower motor neurons by means
of:
a. Corticospinal tract → LMNs in anterior
horn of spinal cord.
b. Corticobulbar (cortcionuclear) tract →
LMNs in motor nuclei of cranial nerves
within brainstem.
Questions?
Thank You

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SHS.202 Lec-06 CNS.pdf

  • 3. Location Located in posterior cranial fossa below occipital lobe. It is connected to brainstem by 3 peduncles: a.Superior cerebellar peduncle – Midbrain. b.Middle cerebellar peduncle – Pons. c.Inferior cerebellar peduncle – Medulla oblongata.
  • 4. Lobes It consists of 3 lobes: a.Anterior lobe. b.Posterior lobe. c.Flocculonodular lobe.
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  • 6. Structure It consists of 2 cerebellar hemispheres connected by median vermis. Each cerebellar hemisphere is further divided into an intermediate zone and a lateral zone. a. Central zone (Vermis) – Influences the movements of long axis of the body (neck, shoulders, thorax, abdomen, hips). b. Intermediate zone – Influences distal muscles of upper and lower limbs especially hands & feet. c. Lateral zone – Planning of movements and correction of movement errors.
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  • 8. Functional Areas of Cerebellum On the basis of incoming and outgoing connections with specific areas of nervous system, cerebellum is divided into 3 areas: a.Vestibulocerebellum – Flocculonodular lobe. b.Spinocerebellum – Vermis, intermediate zone. c.Cerebrocerebellum – Lateral zone.
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  • 10. Layers of Cerebellar Cortex a.Molecular layer – Outermost. b.Purkinje cell layer. c.Granular layer – Innermost.
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  • 12. Deep Cerebellar Nuclei Located deep to the layers of cerebellar cortex, there are 4 masses of gray matter called deep cerebellar nuclei. They include: a.Dentate. b.Emboliform. c.Globose. d.Fastigial. Axons of these deep cerebellar nuclei form the cerebellar output.
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  • 14. Input to Cerebellar Cortex Climbing Fibers – From inferior olivary nucleus of medulla oblongata. Mossy Fibers: a.From cerebral cortex. b.From spinal cord – Anterior & posterior spinocerebellar pathways. c.From vestibular system. d.From nucleus cuneatus of medulla oblongata. e.From red nucleus of midbrain.
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  • 16. Output of Cerebellar Cortex a.Dentothalamic Pathway - Dentate nucleus → Thalamus → Cerebral cortex. b.Globose-Emboliform-Rubral Pathway – Globose & emboliform nuclei → Thalamus → Cerebral cortex → Basal ganglia → Red nucleus of midbrain. c.Fastigial-Vestibular Pathway – Fastigial nucleus → Lateral vestibular nucleus. d.Fastigial-Reticular Pathway – Fastigial nucleus → Reticular formation.
  • 17. Functions of Cerebellum Vestibulocerebellum: a.Control of equilibrium and postural movements. b.Maintenance of balance when body is rapidly moving or changing directions.
  • 18. Functions of Cerebellum Spinocerebellum: a.Coordination of movements of agonist and antagonist muscles of distal limbs during voluntary purposeful movements. b.Damping of the movements to prevent overshooting. c.Coordination of rapid alternating movements (ballistic movements) such as saccadic movements of the eyes during reading.
  • 19. Functions of Cerebellum Cerebrocerebellum: a.Planning of sequential movements. b.Timing of movements.
  • 21. Introduction They include: a.Corpus striatum i. Caudate. ii. Putamen. iii.Globus pallidus. b.Amygdala. c.Claustrum.
  • 22.
  • 23. Connections of Basal Ganglia Basal ganglia are connected via complex circuitry to: a.Motor cortex. b.Somatosensory cortex. c.Ventrolateral (VL) & ventral anterior (VA) nuclei of Thalamus. d.Subthalamus. e.Substantia nigra (midbrain). f. Red nucleus (midbrain). g.Reticular formation.
  • 24.
  • 25. Function a.Control complex patterns of motor activity e.g., writing of alphabets. b.Cognitive control of motor activities. c.Timing of movements. d.Scaling the intensity of movements.
  • 27. Primary Motor Area Located in frontal lobe. Responsible for execution of movements. Different muscle groups of the body are represented in different areas of primary motor area forming a map called motor homunculus. More than half of entire primary cortex is concerned with controlling muscles of hands and speech.
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  • 29. Premotor Area Located in frontal lobe. Responsible for generating a plan of movement which is then transferred to primary motor cortex for execution.
  • 30. Supplementary Motor Area Located in frontal lobe. Exact function is not understood. Lesion of this area does not cause any paralysis.
  • 31. Pyramidal Tracts Motor signals are transmitted from motor cortex to lower motor neurons by means of: a. Corticospinal tract → LMNs in anterior horn of spinal cord. b. Corticobulbar (cortcionuclear) tract → LMNs in motor nuclei of cranial nerves within brainstem.
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  • 33.