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Corresponding Author: Muniba Razzaq, Email: muneebach05@gmail.com
RESEARCH ARTICLE
www.ijms.co.in
Innovative Journal of Medical Sciences, 2018; 2(4):50-52
Sensibility of People about the Effects, Signs, and Treatment of Melioidosis
1
Muhammad Imran Qadir, Muniba Razzaq*
1*
Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan, Pakistan
Received on: 25/07/2018, Revised on: 01/09/2018, Accepted on: 10/10/2018
ABSTRACT
Concrete of the present toil is to check the sensibility of peoples about the effects, signs and treatment of
melioidosis. Melioidosis is an infective disorder which is produced by gram negative bacterium,
Burkholderiapseudomallei. About 75 subjects answered the questionnaire from which it is determined
that melioidosis is not much fatal as its cure is available.
Key words: melioidosis, its severity, causes and treatment
INTRODUCTION
Melioidosis is an infective disorder which is
produced by bacterium, Burkholderia
pseudomallei. It is gram negative. It spread
through soil and water. It mostly spread in
indigenoueas. It appears in serious and inveterate
forms. Indication and premonition include pain in
chest, bones, or joints, cough, skin infections, lung
nodules and pneumonia. acute melioidosis was
retainable for 9days (range 1-21 days).The long
era between presumed vulnerability and clinical
delivery is 62 years. Signs include cough or
pleuritic chest pain revelatory of pneumonia.
Chronic melioidosis is a one in which symptoms
remain for more than 2 months It indications
were chronic skin poison chronic lung nodules,
and pneumonia.
MATERIAL AND METHODS
Different questions were asked from peoples to
check the sensibility of melioidosis, its causes,
symptoms and treatment .The questions which
were asked are as follows-
Table 1: Questions to judge awareness about aetiology of
Melioidosis
Questions Yes No
Melioidosis is an infection of virus 0 78
Melioidosis is an infection of Bacteria 67 8
Melioidosis is an infection of Fungi 6 71
Melioidosis is a Genetic disease 2 74
Melioidosis is a Metabolic infection 4 71
Have you ever suffered from Melioidosis 0 77
Have your family member ever suffered from
Melioidosis
4 72
Have your relative ever suffered from Melioidosis 4 72
Have your neighbour ever suffered from Melioidosis 3 73
Have your friend ever suffered from Melioidosis 7 69
Melioidosis is transmitted by contiguity or through
blood transaction
22 54
Melioidosis is transmitted from parents to next era 11 65
Melioidosis may be treated by medicines 64 12
Melioidosis may be treated by surgery 7 69
No need of treatment 12 63
RESULTS AND DISCUSSIONS
The result of this project is that it is rather not
fatal nor much common as its treatment is
available. The detail about this project is given in
tables. Total 78 subjects were present in this
elaboration effort which was males and females. I
had asked 15 different questions relative to
bacterial disease melioidosis. First of all I had
asked that melioidosis was a viral disorder, out of
78 subjects no one harmonized with this question.
Then I had asked 2nd question that melioidosis
was a bacterial disorder, out of 78 subjects 67
subjects conceded with this question while 11
subjects were not coincided with this question.
Then I had asked 3rd question that melioidosis
was a fungal disorder, out of 78 subjects 7 were
agreed while 71 subjects were not agreed. Then I
had asked 4th question that melioidosis was a
genetic disorder, out of 78 subjects 4 were not
agreed with question while 74 were not agreed
with this question. Then I had asked 5th question
that melioidosis was a metabolic disorder, out of
78 subjects 7 subjects were harmonized with this
question while 71 subjects were not harmonized.
Then I had asked 6th question that you one even
suffered from melioidosis, out of 78 subjects no
one had suffered from this disorder. Then I had
asked 7th question that your family member
suffered from melioidosis, out of 78 subjects 6
ISSN: 2581-4346
Razzaq Muniba et al ./ Sensibility of People about the Effects, Signs, and Treatment of Melioidosis
© 2017, IJMS. All Rights Reserved 51
subjects had melioidosis in their family while 72
subjects had not this disorder in their family. Then
I had asked 8th
question that your relatives had
this bacterial disorder, out of 78 subjects 6 had
assumed in their relatives while 72 had not
assumed. Then I had asked 9th
question that your
neighbors had this disorder, out of 78 subjects 5
had assumed this disorder in their neighbor while
73 subjects had nit assumed. Then I had asked
10thquestion that your friends had melioidosis,
out of 78 subjects 7 had assumed this disorder in
their friends while 71 had not assumed. Then I
had asked 11th
question that melioidosis
transmitted by contact or blood transfusion, out of
78 subjects 22 assumed that melioidosis
transmitted by contact or blood transfusion while
56 were not assumed. Then I had asked 12th
question that melioidosis transmitted from parents
to off spring, out of 78 subjects 13 were agreed
while 65 were not agreed. Then I had asked 13th
question that melioidosis treated by medicines, out
of 78 subjects 66 were harmonized while 12 were
not harmonized. Then I had asked 14th
question
that melioidosis treated by surgery, out of 78
subjects 9 were conceded while 69 were not
coincided. Then I had asked last question that
melioidosis had no need of treatment, out of 78
subjects 15 were harmonized while 63 were not
harmonized.
Figure sensibility about etiology of
MELIOIDOSIS
Khupulsup reported that in hyper endemic areas
such as Thailand, rapid diagnosis of melioidosis
depends upon both bacteriological culture and
serological methods. However, interpretation of
indirect hem agglutination (IHA) for melioidosis
which is the only test available is seriously
hampered by increased IHA titers present in one-
third to one-half of the population. In order to get
the best results from the available tests, IHA and
indirect fluorescent antibody for IgM (IFA-IgM)
were evaluated in controls and patients in
Thailand. Thai people which greatly limits its use
for serodiagnosis of melioidosis. In sharp contrast,
serodiagnosis by IFA-IgM was more successful.
Positive IFA-IgM among healthy Thais did exist
indicating that serologic tests for melioidosis at
best are only supplementary to bacteriological
culture and clinical awareness.[11]
Dance reported
that there is remarkably little known about the
incidence of melioidosis outside a few countries
(Thailand, Australia, Singapore and Malaysia).
Presumably it is widespread in tropical south east
Asia. Elsewhere there are tantalising glimpses of
the tip of what may be a large iceberg. Since a
specific diagnosis of melioidosis requires
awareness on the part of clinicians, and the
existence of a laboratory capable of isolating and
identifying Burkholderia pseudomallei, a luxury
not available in most rural tropical areas, the size
of this iceberg is likely to remain unknown for the
foreseeable future. There is mounting evidence
that the disease is endemic in the Indian sub-
continent and the Caribbean, and there have been
unsubstantiated reports of recent cases in South
Africa and the Middle East. With increasing
worldwide travel of both humans and other
animals, the potential exists for melioidosis to
spread to new and fertile pastures. [12]
CONCLUSION
The outcome of this project is that melioidosis is a
bacterial disease. Melioidosis is an infective
disorder which is produced by gram negative
bacterium, Burkholderiapseudomallei. It is not
severe as its treatment is available.
REFERENCES
1. Stanton AT, Fletcher W. Melioidosis, a
Disease of Rodents communicable to Man.
Lancet. 1925.
2. Cheng AC, Currie BJ. Melioidosis:
epidemiology, pathophysiology, and
management. Clinical microbiology
reviews. 2005 Apr 1;18(2):383-416.
3. 3.Qadir MI, Javid A (2018) Awareness
about Crohn’s Disease in biotechnology
students. GloAdv Res J Med Medical Sci,
7(3): 062-064.
4. 4.Qadir MI, Saleem A (2018) Awareness
about ischemic heart disease in university
biotechnology students. GloAdv Res J
Med Medical Sci, 7(3): 059-061.
0 20 40 60 80
1. Viral disease
3. Fungal disease
5. Metabolic disease
6. You
8. Your relative
10. Your friend
11. Contacts or…
Melioidosis may…
14. Surgery
No
Yes
IJMS,
Oct-Dec,
2018,
Vol.
2,
Issue
4
Razzaq Muniba et al ./ Sensibility of People about the Effects, Signs, and Treatment of Melioidosis
© 2017, IJMS. All Rights Reserved 52
5. 5.Qadir MI, Ishfaq S (2018) Awareness
about hypertension in biology students. Int
J Mod Pharma Res, 7(2): 08-10.
6. 6.Qadir MI, Mehwish (2018) Awareness
about psoriasis disease. Int J Mod Pharma
Res, 7(2): 17-18.
7. 7.Qadir MI, Shahzad R (2018) Awareness
about obesity in postgraduate students of
biotechnology. Int J Mod Pharma Res,
7(2): 14-16.
8. 8.Qadir MI, Rizvi M (2018) Awareness
about thalassemia in post graduate
students. MOJ Lymphology&Phlebology,
2(1): 14-16.
9. 9.Qadir MI, Ghalia BA (2018) Awareness
survey about colorectal cancer in students
of M. Phil Biotechnology at
BahauddinZakariya University, Multan,
Pakistan. Nov Appro in Can Study, 1(3):
NACS.000514.2018.
10. 10.Qadir MI, Saba G (2018) Awareness
about intestinal cancer in university
student. Nov Appro in Can Study, 1(3):
NACS.000515.2018.
11. 11.Khupulsup K, Petchclai B. Application
of indirect hemagglutination test and
indirect fluorescent antibody test for IgM
antibody for diagnosis of melioidosis in
Thailand. The American journal of tropical
medicine and hygiene. 1986 Mar
1;35(2):366-9.
12. 12.Dance DA. Melioidosis as an emerging
global problem. Acta tropica. 2000 Feb
5;74(2-3):115-9.
IJMS,
Oct-Dec,
2018,
Vol.
2,
Issue
4

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Sensibility of People about the Effects, Signs, and Treatment of Melioidosis

  • 1. Corresponding Author: Muniba Razzaq, Email: muneebach05@gmail.com RESEARCH ARTICLE www.ijms.co.in Innovative Journal of Medical Sciences, 2018; 2(4):50-52 Sensibility of People about the Effects, Signs, and Treatment of Melioidosis 1 Muhammad Imran Qadir, Muniba Razzaq* 1* Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan, Pakistan Received on: 25/07/2018, Revised on: 01/09/2018, Accepted on: 10/10/2018 ABSTRACT Concrete of the present toil is to check the sensibility of peoples about the effects, signs and treatment of melioidosis. Melioidosis is an infective disorder which is produced by gram negative bacterium, Burkholderiapseudomallei. About 75 subjects answered the questionnaire from which it is determined that melioidosis is not much fatal as its cure is available. Key words: melioidosis, its severity, causes and treatment INTRODUCTION Melioidosis is an infective disorder which is produced by bacterium, Burkholderia pseudomallei. It is gram negative. It spread through soil and water. It mostly spread in indigenoueas. It appears in serious and inveterate forms. Indication and premonition include pain in chest, bones, or joints, cough, skin infections, lung nodules and pneumonia. acute melioidosis was retainable for 9days (range 1-21 days).The long era between presumed vulnerability and clinical delivery is 62 years. Signs include cough or pleuritic chest pain revelatory of pneumonia. Chronic melioidosis is a one in which symptoms remain for more than 2 months It indications were chronic skin poison chronic lung nodules, and pneumonia. MATERIAL AND METHODS Different questions were asked from peoples to check the sensibility of melioidosis, its causes, symptoms and treatment .The questions which were asked are as follows- Table 1: Questions to judge awareness about aetiology of Melioidosis Questions Yes No Melioidosis is an infection of virus 0 78 Melioidosis is an infection of Bacteria 67 8 Melioidosis is an infection of Fungi 6 71 Melioidosis is a Genetic disease 2 74 Melioidosis is a Metabolic infection 4 71 Have you ever suffered from Melioidosis 0 77 Have your family member ever suffered from Melioidosis 4 72 Have your relative ever suffered from Melioidosis 4 72 Have your neighbour ever suffered from Melioidosis 3 73 Have your friend ever suffered from Melioidosis 7 69 Melioidosis is transmitted by contiguity or through blood transaction 22 54 Melioidosis is transmitted from parents to next era 11 65 Melioidosis may be treated by medicines 64 12 Melioidosis may be treated by surgery 7 69 No need of treatment 12 63 RESULTS AND DISCUSSIONS The result of this project is that it is rather not fatal nor much common as its treatment is available. The detail about this project is given in tables. Total 78 subjects were present in this elaboration effort which was males and females. I had asked 15 different questions relative to bacterial disease melioidosis. First of all I had asked that melioidosis was a viral disorder, out of 78 subjects no one harmonized with this question. Then I had asked 2nd question that melioidosis was a bacterial disorder, out of 78 subjects 67 subjects conceded with this question while 11 subjects were not coincided with this question. Then I had asked 3rd question that melioidosis was a fungal disorder, out of 78 subjects 7 were agreed while 71 subjects were not agreed. Then I had asked 4th question that melioidosis was a genetic disorder, out of 78 subjects 4 were not agreed with question while 74 were not agreed with this question. Then I had asked 5th question that melioidosis was a metabolic disorder, out of 78 subjects 7 subjects were harmonized with this question while 71 subjects were not harmonized. Then I had asked 6th question that you one even suffered from melioidosis, out of 78 subjects no one had suffered from this disorder. Then I had asked 7th question that your family member suffered from melioidosis, out of 78 subjects 6 ISSN: 2581-4346
  • 2. Razzaq Muniba et al ./ Sensibility of People about the Effects, Signs, and Treatment of Melioidosis © 2017, IJMS. All Rights Reserved 51 subjects had melioidosis in their family while 72 subjects had not this disorder in their family. Then I had asked 8th question that your relatives had this bacterial disorder, out of 78 subjects 6 had assumed in their relatives while 72 had not assumed. Then I had asked 9th question that your neighbors had this disorder, out of 78 subjects 5 had assumed this disorder in their neighbor while 73 subjects had nit assumed. Then I had asked 10thquestion that your friends had melioidosis, out of 78 subjects 7 had assumed this disorder in their friends while 71 had not assumed. Then I had asked 11th question that melioidosis transmitted by contact or blood transfusion, out of 78 subjects 22 assumed that melioidosis transmitted by contact or blood transfusion while 56 were not assumed. Then I had asked 12th question that melioidosis transmitted from parents to off spring, out of 78 subjects 13 were agreed while 65 were not agreed. Then I had asked 13th question that melioidosis treated by medicines, out of 78 subjects 66 were harmonized while 12 were not harmonized. Then I had asked 14th question that melioidosis treated by surgery, out of 78 subjects 9 were conceded while 69 were not coincided. Then I had asked last question that melioidosis had no need of treatment, out of 78 subjects 15 were harmonized while 63 were not harmonized. Figure sensibility about etiology of MELIOIDOSIS Khupulsup reported that in hyper endemic areas such as Thailand, rapid diagnosis of melioidosis depends upon both bacteriological culture and serological methods. However, interpretation of indirect hem agglutination (IHA) for melioidosis which is the only test available is seriously hampered by increased IHA titers present in one- third to one-half of the population. In order to get the best results from the available tests, IHA and indirect fluorescent antibody for IgM (IFA-IgM) were evaluated in controls and patients in Thailand. Thai people which greatly limits its use for serodiagnosis of melioidosis. In sharp contrast, serodiagnosis by IFA-IgM was more successful. Positive IFA-IgM among healthy Thais did exist indicating that serologic tests for melioidosis at best are only supplementary to bacteriological culture and clinical awareness.[11] Dance reported that there is remarkably little known about the incidence of melioidosis outside a few countries (Thailand, Australia, Singapore and Malaysia). Presumably it is widespread in tropical south east Asia. Elsewhere there are tantalising glimpses of the tip of what may be a large iceberg. Since a specific diagnosis of melioidosis requires awareness on the part of clinicians, and the existence of a laboratory capable of isolating and identifying Burkholderia pseudomallei, a luxury not available in most rural tropical areas, the size of this iceberg is likely to remain unknown for the foreseeable future. There is mounting evidence that the disease is endemic in the Indian sub- continent and the Caribbean, and there have been unsubstantiated reports of recent cases in South Africa and the Middle East. With increasing worldwide travel of both humans and other animals, the potential exists for melioidosis to spread to new and fertile pastures. [12] CONCLUSION The outcome of this project is that melioidosis is a bacterial disease. Melioidosis is an infective disorder which is produced by gram negative bacterium, Burkholderiapseudomallei. It is not severe as its treatment is available. REFERENCES 1. Stanton AT, Fletcher W. Melioidosis, a Disease of Rodents communicable to Man. Lancet. 1925. 2. Cheng AC, Currie BJ. Melioidosis: epidemiology, pathophysiology, and management. Clinical microbiology reviews. 2005 Apr 1;18(2):383-416. 3. 3.Qadir MI, Javid A (2018) Awareness about Crohn’s Disease in biotechnology students. GloAdv Res J Med Medical Sci, 7(3): 062-064. 4. 4.Qadir MI, Saleem A (2018) Awareness about ischemic heart disease in university biotechnology students. GloAdv Res J Med Medical Sci, 7(3): 059-061. 0 20 40 60 80 1. Viral disease 3. Fungal disease 5. Metabolic disease 6. You 8. Your relative 10. Your friend 11. Contacts or… Melioidosis may… 14. Surgery No Yes IJMS, Oct-Dec, 2018, Vol. 2, Issue 4
  • 3. Razzaq Muniba et al ./ Sensibility of People about the Effects, Signs, and Treatment of Melioidosis © 2017, IJMS. All Rights Reserved 52 5. 5.Qadir MI, Ishfaq S (2018) Awareness about hypertension in biology students. Int J Mod Pharma Res, 7(2): 08-10. 6. 6.Qadir MI, Mehwish (2018) Awareness about psoriasis disease. Int J Mod Pharma Res, 7(2): 17-18. 7. 7.Qadir MI, Shahzad R (2018) Awareness about obesity in postgraduate students of biotechnology. Int J Mod Pharma Res, 7(2): 14-16. 8. 8.Qadir MI, Rizvi M (2018) Awareness about thalassemia in post graduate students. MOJ Lymphology&Phlebology, 2(1): 14-16. 9. 9.Qadir MI, Ghalia BA (2018) Awareness survey about colorectal cancer in students of M. Phil Biotechnology at BahauddinZakariya University, Multan, Pakistan. Nov Appro in Can Study, 1(3): NACS.000514.2018. 10. 10.Qadir MI, Saba G (2018) Awareness about intestinal cancer in university student. Nov Appro in Can Study, 1(3): NACS.000515.2018. 11. 11.Khupulsup K, Petchclai B. Application of indirect hemagglutination test and indirect fluorescent antibody test for IgM antibody for diagnosis of melioidosis in Thailand. The American journal of tropical medicine and hygiene. 1986 Mar 1;35(2):366-9. 12. 12.Dance DA. Melioidosis as an emerging global problem. Acta tropica. 2000 Feb 5;74(2-3):115-9. IJMS, Oct-Dec, 2018, Vol. 2, Issue 4