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UV RADIATION AND STRESS
FRACTURES IN FEMALE ATHLETES
Eliot Mar
THESIS
Female athletes in areas of low annual UV
radiation are at a higher risk than those athletes
in areas of high annual UV radiation for stress
fracture.
INTRODUCTION
 Vitamin D naturally produced
 Sunlight
 PTH and Calcium
 Women high risk
 Hypovitaminosis D
 20% ages 14-60 y/o
 Biological demands
 Biomechanical differences
 High physical intensity
 Military
 Sports (Rosenblom)
HYPOVITAMINOSIS D & STRESS FRACTURE
 Parathyroid
 Low Vitamin D
 Bone density loss
 Female Athlete Triad
 Dietary
supplementation
(Leidig-Bruckner et al)
MECHANISM: UV TO BONE DENSITY
IULIANO-BURNS ET AL
 Photolytic reaction
 7-dehydrocholesterol  cholecalciferol  25-
hydroxyvitamin D, (25(OH)D), or 1,25-
dihydroxyvitamin D, (1,25(OH)2D)
 VDR binding
 Absorption up
 Blood plasma calcium down
 Osteoclast suppressed
 Daily recommended amount
 75 nmol/L
OBSTACLES IN THE OPTIMIZATION OF BONE HEALTH OUTCOMES IN THE
FEMALE ATHLETE TRIAD
GAELE DUCHER ET AL.
ANTARCTIC UV EXPOSURE
IULIANO BURNS ET AL.
 UV radiation control
 Baseline vitamin D deficient
 Dietary supplementation
SKIN COMPLEXION AND UV ABSORPTION
SCOTT MONTAIN ET AL.
 Military and Collegiate Athletes
 White compared to black recruits
 More efficient use of vitamin D
VITAMIN D AND COLLEGIATE ATHLETES
TANYA M. HALLIDAY ET AL.
 Indoor and Outdoor
 PTH measured
 Outdoor = More UV
exposure
 Spring and fall > Winter
 Dietary supplementation
CONFOUNDING VARIABLES
 Gender predisposition
 Inconclusive supplementation results
 Geographic change
 Daily Recommended Dosages
 Overtraining
 Genetics
CONCLUSIONS
 Strong biochemical evidence
 Further quantitative studies
 Prehabilitation/Rehabilitation
REFERENCES
 Leidig-Bruckner, H. Roth, Bruckner T,
 Lorenz A, Raue F, Frank-Raue K. Osteoporos. Int. 22, 231–240.

 Barker, Tyler; Schneider, Erik D;
 Dixon, Brian M; Henriksen, Vanessa T; Weaver, Lindell K. Nutr. Rev. 68, 365–9.

 Wentz, Laurel; Liu, Pei-yang; Hay, Emily; Ilich, Jasminka Z 176, 420–431.

 Rosenblom, Christine. Nutrition Today. 48, 81-87

 Iuliano-Burns, S; Ayton, J; Hillam, S; Jones, G; King, K; Macleod, S; Seeman, E. Osterooros. Int. 23, 2461-7

 Montain, Scott J; McGraw, Susan M; Ely, Matthew R; Grier, Tyson L; Knapik, Joseph J. BMC Musculoskelet.
Disord. 14, 135.

 Borradale, David; Kimlin, Michael. Nutr. Res. Rev. 22, 118–36.

 Ducher, Gaele; Turner, Anne I; Kukuljan, Sonja; Pantano, Kathleen J; Carlson, Jennifer L; Williams, Nancy I;
Souza, Mary Jane De. 41, 587–608.

 Halliday, Tanya M; Peterson, Nikki J; Thomas, Joi J; Kleppinger, Kent; Hollis, Bruce W; Larson-Meyer, D Enette.
Med. Sci. Sports Exerc. 43, 335–43.

 McClung, James P; Karl, J Philip. Nutr. Rev. 68, 365–9.
QUESTIONS

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Senior Seminar

  • 1. UV RADIATION AND STRESS FRACTURES IN FEMALE ATHLETES Eliot Mar
  • 2. THESIS Female athletes in areas of low annual UV radiation are at a higher risk than those athletes in areas of high annual UV radiation for stress fracture.
  • 3. INTRODUCTION  Vitamin D naturally produced  Sunlight  PTH and Calcium  Women high risk  Hypovitaminosis D  20% ages 14-60 y/o  Biological demands  Biomechanical differences  High physical intensity  Military  Sports (Rosenblom)
  • 4. HYPOVITAMINOSIS D & STRESS FRACTURE  Parathyroid  Low Vitamin D  Bone density loss  Female Athlete Triad  Dietary supplementation (Leidig-Bruckner et al)
  • 5. MECHANISM: UV TO BONE DENSITY IULIANO-BURNS ET AL  Photolytic reaction  7-dehydrocholesterol  cholecalciferol  25- hydroxyvitamin D, (25(OH)D), or 1,25- dihydroxyvitamin D, (1,25(OH)2D)  VDR binding  Absorption up  Blood plasma calcium down  Osteoclast suppressed  Daily recommended amount  75 nmol/L
  • 6. OBSTACLES IN THE OPTIMIZATION OF BONE HEALTH OUTCOMES IN THE FEMALE ATHLETE TRIAD GAELE DUCHER ET AL.
  • 7. ANTARCTIC UV EXPOSURE IULIANO BURNS ET AL.  UV radiation control  Baseline vitamin D deficient  Dietary supplementation
  • 8. SKIN COMPLEXION AND UV ABSORPTION SCOTT MONTAIN ET AL.  Military and Collegiate Athletes  White compared to black recruits  More efficient use of vitamin D
  • 9. VITAMIN D AND COLLEGIATE ATHLETES TANYA M. HALLIDAY ET AL.  Indoor and Outdoor  PTH measured  Outdoor = More UV exposure  Spring and fall > Winter  Dietary supplementation
  • 10. CONFOUNDING VARIABLES  Gender predisposition  Inconclusive supplementation results  Geographic change  Daily Recommended Dosages  Overtraining  Genetics
  • 11. CONCLUSIONS  Strong biochemical evidence  Further quantitative studies  Prehabilitation/Rehabilitation
  • 12. REFERENCES  Leidig-Bruckner, H. Roth, Bruckner T,  Lorenz A, Raue F, Frank-Raue K. Osteoporos. Int. 22, 231–240.   Barker, Tyler; Schneider, Erik D;  Dixon, Brian M; Henriksen, Vanessa T; Weaver, Lindell K. Nutr. Rev. 68, 365–9.   Wentz, Laurel; Liu, Pei-yang; Hay, Emily; Ilich, Jasminka Z 176, 420–431.   Rosenblom, Christine. Nutrition Today. 48, 81-87   Iuliano-Burns, S; Ayton, J; Hillam, S; Jones, G; King, K; Macleod, S; Seeman, E. Osterooros. Int. 23, 2461-7   Montain, Scott J; McGraw, Susan M; Ely, Matthew R; Grier, Tyson L; Knapik, Joseph J. BMC Musculoskelet. Disord. 14, 135.   Borradale, David; Kimlin, Michael. Nutr. Res. Rev. 22, 118–36.   Ducher, Gaele; Turner, Anne I; Kukuljan, Sonja; Pantano, Kathleen J; Carlson, Jennifer L; Williams, Nancy I; Souza, Mary Jane De. 41, 587–608.   Halliday, Tanya M; Peterson, Nikki J; Thomas, Joi J; Kleppinger, Kent; Hollis, Bruce W; Larson-Meyer, D Enette. Med. Sci. Sports Exerc. 43, 335–43.   McClung, James P; Karl, J Philip. Nutr. Rev. 68, 365–9.

Editor's Notes

  1. Seattle University Women’s basketball team where Kristen O’Neill proposed idea and I thought it would be a good topic to discuss more
  2. Photolytic reaction. “recurring excessive strain caused by repetitive micro-trauma to bone at a rate greater than bone repair.” It is an “overuse injury,” where “the muscles of the affected area become fatigued,” and the impact or stress is then “transferred to the bone, resulting in a small crack…” Wentz, Laurel; Liu, Pei-yang; Hay, Emily; Ilich, Jasminka Z 176, 420–431.  
  3. Vitamin D deficiency is a major health issue for people in the United States. A study by Leidig-Bruckner et al. in 2011 suggested that as few as 20% of “ambulatory” (mobile) patients 14-60 years old had high enough vitamin D levels to prevent Vitamin D related bone diseases and bone injury. Leidig-Bruckner, H. Roth, Bruckner T, Lorenz A, Raue F, Frank-Raue K. Osteoporos. Int. 22, 231–240.  
  4. 25-hydroxyvitamin D, (25(OH)D), and 1,25-dihydroxyvitamin D, (1,25(OH)2D)). Iuliano-Burns, S; Ayton, J; Hillam, S; Jones, G; King, K; Macleod, S; Seeman, E. Osterooros. Int. 23, 2461-7  
  5. 6 It was also shown that “non-blacks were more likely than blacks to develop lower limb fractures…”6 UV radiation’s role in vitamin D production is diminished as available sunlight for absorption decreases. Black men and women experienced lower stress fracture rates than their white male and female counterparts. 10-5% of white vs. black females and 3-1.4% black to white recruits
  6. 9 Athletes in “wrestling, swimming, and basketball were considered outdoor athletes.”9 The results of the survey, were as follows: overall, 9.8% of the athletes in the fall were found to be vitamin D deficient. In the winter, 60.6 % of athletes were found to be vitamin D deficient. In the spring, 4% of athletes were found to be vitamin D deficient. When comparing outdoor to indoor athletes, 53.1% vs 31.9% of fall athletes, 31.9% to 10.2% of winter athletes, and 44.6% to 33.1% of spring athletes showed higher vitamin D blood plasma levels.ix The study found that limiting the availability and consumption of vitamin D rich foods, dietary supplementation of vitamin D made a negligible impact on the test group.
  7. With respect to gender, he found that 21% of females experienced stress fracturing compared to just 5% in men among the general military population.10 The study suggested that “up to 75% of the variation in peak bone mass” could be due to VDR variation and “up to 80% of the variability in [bone mass density] may be explained by genetic factors.”10