This document provides an overview of sedatives, hypnotics, and anxiolytics. It discusses the differences between sedatives and hypnotics, outlines common drug classes used including benzodiazepines, barbiturates, and newer agents. It describes the mechanisms of action of benzodiazepines at GABA receptors and how they facilitate GABA. Common uses, adverse effects, and important safety considerations are summarized for various drug classes.
complete and detail study of the topic of sedative and hypnotics under the guidance of faculty member. the ppt is made for the benefit of all the peoples
This document discusses sedative-hypnotic drugs. It notes that this drug classification is based on clinical uses of sedation and encouraging sleep rather than chemical structure. Common sedative-hypnotic drugs include benzodiazepines, barbiturates, and newer nonbenzodiazepine hypnotics like zolpidem, zaleplon, and eszopiclone. These drugs work by enhancing the effects of the inhibitory neurotransmitter GABA at GABA receptors in the brain. Their clinical uses include treatment of anxiety, insomnia, and as sedatives for medical and surgical procedures.
The document discusses sedatives and hypnotics. It defines sedatives as drugs that decrease activity and excitement and produce calmness and drowsiness. Hypnotics are sedatives that higher doses that produce deep sleep. The document then covers the classification of various sedatives and hypnotics like benzodiazepines, barbiturates, alpha-2 adrenergic agonists, chloral derivatives, and paraldehydes. For each class, it discusses their mechanism of action, examples, pharmacological effects, pharmacokinetics, clinical uses and dosages.
This document discusses sedative-hypnotic drugs. It defines sedatives as drugs that decrease central nervous system activity and anxiety without causing sleep, while hypnotics produce sleep. Sedative-hypnotics include both types of drugs. Key differences are outlined between sedatives and hypnotics in terms of their effects and doses needed. The mechanisms of action of barbiturates and benzodiazepines are described as facilitating the effects of the inhibitory neurotransmitter GABA. Various therapeutic uses are provided for barbiturates, benzodiazepines, and other sedative-hypnotic drugs.
This document discusses sedative-hypnotic drugs. It defines sedatives as drugs that decrease excitement and cause drowsiness without sleep, while hypnotics induce and maintain sleep. Different stages of sleep are described, along with the effects of sedative-hypnotics on sleep architecture. Benzodiazepines and barbiturates are provided as examples of sedative-hypnotic drugs and their mechanisms of action, effects, uses, and adverse effects are summarized. Non-benzodiazepine hypnotics such as zolpidem and zopiclone are also mentioned.
This document provides an overview of sedatives and hypnotics. It discusses the stages of normal sleep and classifies sedatives and hypnotics. Benzodiazepines and barbiturates are the main classes described. Benzodiazepines have short, intermediate, and long-acting types while barbiturates have ultra-short, short, and long-acting types. The document covers the pharmacokinetics, therapeutic uses, adverse effects, and mechanisms of action of these drug classes and compares their advantages. Treatment for barbiturate poisoning is also summarized.
This document discusses anxiolytic and hypnotic drugs. It describes how these drugs work by modulating neurotransmitters like GABA and glutamate. Common classes of anxiolytic drugs are benzodiazepines and 5-HT1A agonists which enhance the effects of the inhibitory neurotransmitter GABA. Benzodiazepines bind to GABA receptors to open chloride channels more frequently. Barbiturates also potentiate GABA but prolong the opening of chloride channels. These drugs are used to treat anxiety disorders and insomnia by their sedative, anxiolytic, and muscle relaxing effects. Common side effects include drowsiness but benzodiazepines have a lower risk of dependence than barbiturates
This document defines sedative and hypnotic drugs and describes their mechanisms of action and effects. It discusses different classes of sedative-hypnotics including benzodiazepines, barbiturates, and newer non-benzodiazepine hypnotics. Benzodiazepines potentiate GABA's effects by binding to GABA-A receptors. They are generally safe but can cause drowsiness, impaired coordination, and interaction risks with other CNS depressants. Barbiturates directly activate GABA receptors and carry greater overdose and dependence risks than benzodiazepines. Newer non-benzodiazepine hypnotics like zolpidem selectively target
complete and detail study of the topic of sedative and hypnotics under the guidance of faculty member. the ppt is made for the benefit of all the peoples
This document discusses sedative-hypnotic drugs. It notes that this drug classification is based on clinical uses of sedation and encouraging sleep rather than chemical structure. Common sedative-hypnotic drugs include benzodiazepines, barbiturates, and newer nonbenzodiazepine hypnotics like zolpidem, zaleplon, and eszopiclone. These drugs work by enhancing the effects of the inhibitory neurotransmitter GABA at GABA receptors in the brain. Their clinical uses include treatment of anxiety, insomnia, and as sedatives for medical and surgical procedures.
The document discusses sedatives and hypnotics. It defines sedatives as drugs that decrease activity and excitement and produce calmness and drowsiness. Hypnotics are sedatives that higher doses that produce deep sleep. The document then covers the classification of various sedatives and hypnotics like benzodiazepines, barbiturates, alpha-2 adrenergic agonists, chloral derivatives, and paraldehydes. For each class, it discusses their mechanism of action, examples, pharmacological effects, pharmacokinetics, clinical uses and dosages.
This document discusses sedative-hypnotic drugs. It defines sedatives as drugs that decrease central nervous system activity and anxiety without causing sleep, while hypnotics produce sleep. Sedative-hypnotics include both types of drugs. Key differences are outlined between sedatives and hypnotics in terms of their effects and doses needed. The mechanisms of action of barbiturates and benzodiazepines are described as facilitating the effects of the inhibitory neurotransmitter GABA. Various therapeutic uses are provided for barbiturates, benzodiazepines, and other sedative-hypnotic drugs.
This document discusses sedative-hypnotic drugs. It defines sedatives as drugs that decrease excitement and cause drowsiness without sleep, while hypnotics induce and maintain sleep. Different stages of sleep are described, along with the effects of sedative-hypnotics on sleep architecture. Benzodiazepines and barbiturates are provided as examples of sedative-hypnotic drugs and their mechanisms of action, effects, uses, and adverse effects are summarized. Non-benzodiazepine hypnotics such as zolpidem and zopiclone are also mentioned.
This document provides an overview of sedatives and hypnotics. It discusses the stages of normal sleep and classifies sedatives and hypnotics. Benzodiazepines and barbiturates are the main classes described. Benzodiazepines have short, intermediate, and long-acting types while barbiturates have ultra-short, short, and long-acting types. The document covers the pharmacokinetics, therapeutic uses, adverse effects, and mechanisms of action of these drug classes and compares their advantages. Treatment for barbiturate poisoning is also summarized.
This document discusses anxiolytic and hypnotic drugs. It describes how these drugs work by modulating neurotransmitters like GABA and glutamate. Common classes of anxiolytic drugs are benzodiazepines and 5-HT1A agonists which enhance the effects of the inhibitory neurotransmitter GABA. Benzodiazepines bind to GABA receptors to open chloride channels more frequently. Barbiturates also potentiate GABA but prolong the opening of chloride channels. These drugs are used to treat anxiety disorders and insomnia by their sedative, anxiolytic, and muscle relaxing effects. Common side effects include drowsiness but benzodiazepines have a lower risk of dependence than barbiturates
This document defines sedative and hypnotic drugs and describes their mechanisms of action and effects. It discusses different classes of sedative-hypnotics including benzodiazepines, barbiturates, and newer non-benzodiazepine hypnotics. Benzodiazepines potentiate GABA's effects by binding to GABA-A receptors. They are generally safe but can cause drowsiness, impaired coordination, and interaction risks with other CNS depressants. Barbiturates directly activate GABA receptors and carry greater overdose and dependence risks than benzodiazepines. Newer non-benzodiazepine hypnotics like zolpidem selectively target
This document discusses sedatives and hypnotics. It defines sedatives as drugs that reduce excitement and produce calming effects without inducing sleep, while hypnotics produce sleep resembling natural sleep. Both act through GABA receptors in the brain. Common classes discussed are benzodiazepines, which potentiate GABA receptors, and barbiturates, which directly activate chloride channels. Specific drugs are described along with their mechanisms, effects, uses, and toxicity risks. Sleep cycles and how different drug classes impact sleep stages are also outlined.
This document is a lecture on sedative-hypnotic and anxiolytic drugs given by Dr. Marc Imhotep Cray. The learning objectives cover the GABAA receptor structure and drug binding sites, pharmacokinetics of benzodiazepines, similarities and differences among benzodiazepines and between benzodiazepines and barbiturates, factors in drug selection, and abuse potential of sedative-hypnotics. The lecture discusses mechanisms of action, side effects, clinical uses including treatment of anxiety and insomnia, and specifics of benzodiazepines, barbiturates, and other agents.
This document provides an overview of sedative and hypnotic drugs. It begins with definitions of sedatives, hypnotics, and anxiolytics. It then discusses the history of sedative drugs from antiquity through modern times. It covers the classification, mechanisms of action, pharmacokinetics, therapeutic uses and adverse effects of major classes of sedative-hypnotics including barbiturates and benzodiazepines.
Sedatives and hypnotics are drugs that calm or induce sleep. Common classes include benzodiazepines (BZDs), barbiturates, and non-BZD hypnotics. BZDs are widely used and bind to GABA receptors to facilitate the effects of GABA, producing sedation, hypnosis, or anesthesia in a dose-dependent manner. They have a high safety profile but can cause dependence. Barbiturates also act at GABA receptors but have a lower safety margin and greater risk of overdose. Newer non-BZD drugs like zolpidem, zaleplon, and zopiclone have fewer side effects and lower abuse potential than B
This document discusses various sedative-hypnotic drugs that act on the central nervous system. It begins by distinguishing drugs that produce sedation from those that induce sleep. It then describes normal sleep cycles and the stages of sleep. The rest of the document details different classes of sedative-hypnotic drugs including benzodiazepines, barbiturates, antihistamines, and others. It provides information on their mechanisms of action, pharmacological effects, clinical uses, and important considerations regarding administration and withdrawal.
This document discusses several classes of sedative-hypnotic drugs, including benzodiazepines, barbiturates, newer hypnotics like zolpidem and eszopiclone, ramelteon, and buspirone. It covers their mechanisms of action, pharmacokinetics including absorption, distribution, metabolism and excretion, factors affecting these processes, and side effect profiles. The metabolism and elimination of these drugs varies significantly based on properties like lipid solubility and specific cytochrome P450 isoenzyme involvement.
This document discusses sedative and hypnotic drugs. It begins by defining sedation and differentiating sedatives and hypnotics. It then classifies common sedative and hypnotic drugs such as benzodiazepines, barbiturates, and atypical drugs. The document reviews the sleep cycle and mechanisms of action of different drug classes. It provides details on pharmacology, uses, and side effects of individual sedative and hypnotic drugs including benzodiazepines, barbiturates, z-drugs, buspirone, and newer drugs.
Sedative, Hypnotic and Anxiolytic Drugs are used to treat anxiety, insomnia and induce sleep. They work by potentiating the action of the inhibitory neurotransmitter GABA in the brain. Benzodiazepines and barbiturates are common classes of these drugs. Benzodiazepines increase the frequency of chloride channel opening, while barbiturates increase the duration. Both classes are used as sedatives, hypnotics and to relieve anxiety. They can cause dependence and tolerance with long term use. Newer non-benzodiazepine drugs like Zolpidem and Zaleplon have fewer side effects.
This document summarizes information on sedative and hypnotic drugs. It discusses the mechanisms and effects of benzodiazepines, barbiturates, and other drugs such as zolpidem, zaleplon, zopiclone, melatonin, and buspirone. It provides details on the pharmacokinetics, therapeutic uses, and side effects of these classes of drugs. The document also covers topics like tolerance, dependence and withdrawal symptoms, overdose treatment, and newer non-benzodiazepine hypnotics.
This document discusses sedatives and hypnotics. It defines them as chemical substances that reduce tension, anxiety and induce calm or sleep. Most drugs have sedative effects at low doses and hypnotic (sleep inducing) effects at higher doses. Barbiturates are one class that act by potentiating GABA receptors in the brain. They have fallen out of favor due to risk of dependence and overdose. Benzodiazepines emerged as safer alternatives that also target GABA receptors. Other classes discussed include non-benzodiazepines, barbiturates, alcohols, and various other substances.
The document discusses sedative-hypnotic drugs and their uses. It describes the phases of sleep including non-REM sleep and REM sleep. Some key points are:
- Benzodiazepines are commonly used as hypnotics for insomnia and as anxiolytics for acute anxiety. Short acting BDZs are preferred to avoid daytime sedation.
- BDZs potentiate the effects of GABA by binding to sites adjacent to the GABA receptor. This increases chloride ion conductance and membrane hyperpolarization.
- While effective, long-term BDZ use can cause tolerance, dependence, and cognitive impairment so they should only be used short-term for severe anxiety and insomnia.
The document summarizes information about sedative-hypnotics presented in a lecture. It discusses the properties of individual benzodiazepines (BZDs) like diazepam, flurazepam, alprazolam, and midazolam. It also covers non-BZD hypnotics like zopiclone, zolpidem, and zaleplon that act on specific BZD receptor subunits. Melatonin and ramelteon, which act as melatonin receptor agonists, are also discussed. The concluding section notes that long-acting BZDs can cause next day sedation while flumazenil acts as a BZD antagonist to
This document discusses sedative, hypnotic, and anxiolytic drugs. It describes barbiturates and benzodiazepines, which are commonly used as sedative-hypnotics. Barbiturates act by potentiating the inhibitory neurotransmitter GABA, while benzodiazepines facilitate GABA effects by binding to GABAA receptors. The document outlines the mechanisms, effects on sleep, and adverse effects of these drug classes. It also discusses newer nonbenzodiazepine hypnotics and the benzodiazepine antagonist flumazenil.
This document discusses different classes of sedative and hypnotic drugs, including their mechanisms of action, pharmacokinetics and therapeutic uses. It covers barbiturates, benzodiazepines, zolpidem, and buspirone. Barbiturates and benzodiazepines enhance the effects of the inhibitory neurotransmitter GABA, whereas zolpidem selectively binds to GABA receptors. These drugs have varying onset and duration of action and are used to treat conditions like anxiety, insomnia and seizures. Adverse effects include respiratory depression, dependence and withdrawal symptoms.
This document discusses sedative/hypnotics and anxiolytics. It begins by explaining how these drugs work in the nervous system, producing sedation, hypnosis, and effects ranging from confusion to coma and death depending on dose. It then focuses on benzodiazepines and barbiturates, the two major classes of these drugs. Both act by enhancing GABAergic transmission but differ in their mechanisms and properties. Benzodiazepines are generally safer with less respiratory depression but can cause dependence, while barbiturates have greater toxicity and abuse potential. The document emphasizes using these drugs only short-term to avoid adverse effects.
This document discusses anxiolytics and hypnotics such as benzodiazepines and barbiturates. It describes how these drugs work by enhancing the effects of the neurotransmitter GABA at GABA receptors in the brain, resulting in sedation, anxiety reduction, and sleep induction. Both classes of drugs are controlled substances due to their potential for dependence and withdrawal symptoms. While benzodiazepines are still commonly used, barbiturates have been largely replaced due to greater safety and tolerability of benzodiazepines.
Sedative-hypnotic drugs reduce anxiety and induce sleep by depressing activity in the central nervous system. The main classes are benzodiazepines, barbiturates, and newer non-benzodiazepine agents. Benzodiazepines have largely replaced barbiturates due to their wider therapeutic index, lower risk of interactions and dependence, and the availability of antagonists. Both benzodiazepines and barbiturates work by enhancing the effects of the inhibitory neurotransmitter GABA.
This document provides an overview of sedative hypnotics, including their terminology, pharmacology, historical perspectives, and case studies. It discusses how opioids, bromides, and barbiturates were historically used as sedatives before the development of benzodiazepines in the 1950s. Benzodiazepines like diazepam, lorazepam and alprazolam became widely prescribed to treat anxiety and insomnia in the 1960s-1980s. The document outlines the pharmacokinetics of various sedative hypnotics and risks of abuse, dependence and overdose. It also presents a case study of a man who developed hand ischemia after injecting crushed zolpidem
The document discusses drugs acting on the central nervous system (CNS). It begins by introducing the basic anatomy and function of the CNS. It then describes the excitatory and inhibitory pathways in the CNS and lists several important neurotransmitters like glutamate, GABA, acetylcholine, dopamine, norepinephrine, and serotonin. The document categorizes drugs acting on the CNS as sedative-hypnotics, antiepileptics, antiparkinsonians, antidepressants, and antipsychotics. It provides detailed descriptions of barbiturates, benzodiazepines, and newer sedative-hypnotics. It also discusses the pharmacology and treatment of Parkinson's disease with a focus on
This document discusses sedative-hypnotic drugs, including barbiturates and benzodiazepines. It describes their mechanisms of action, which involve facilitating the effects of the neurotransmitter GABA at GABA-A receptors in the brain. Specific drugs are categorized and their indications, pharmacokinetics, adverse effects and interactions are outlined. Newer non-benzodiazepine hypnotics such as zolpidem and zopiclone that also target GABA receptors are also discussed.
This document discusses sedatives and hypnotics. It defines sedatives as drugs that reduce excitement and produce calming effects without inducing sleep, while hypnotics produce sleep resembling natural sleep. Both act through GABA receptors in the brain. Common classes discussed are benzodiazepines, which potentiate GABA receptors, and barbiturates, which directly activate chloride channels. Specific drugs are described along with their mechanisms, effects, uses, and toxicity risks. Sleep cycles and how different drug classes impact sleep stages are also outlined.
This document is a lecture on sedative-hypnotic and anxiolytic drugs given by Dr. Marc Imhotep Cray. The learning objectives cover the GABAA receptor structure and drug binding sites, pharmacokinetics of benzodiazepines, similarities and differences among benzodiazepines and between benzodiazepines and barbiturates, factors in drug selection, and abuse potential of sedative-hypnotics. The lecture discusses mechanisms of action, side effects, clinical uses including treatment of anxiety and insomnia, and specifics of benzodiazepines, barbiturates, and other agents.
This document provides an overview of sedative and hypnotic drugs. It begins with definitions of sedatives, hypnotics, and anxiolytics. It then discusses the history of sedative drugs from antiquity through modern times. It covers the classification, mechanisms of action, pharmacokinetics, therapeutic uses and adverse effects of major classes of sedative-hypnotics including barbiturates and benzodiazepines.
Sedatives and hypnotics are drugs that calm or induce sleep. Common classes include benzodiazepines (BZDs), barbiturates, and non-BZD hypnotics. BZDs are widely used and bind to GABA receptors to facilitate the effects of GABA, producing sedation, hypnosis, or anesthesia in a dose-dependent manner. They have a high safety profile but can cause dependence. Barbiturates also act at GABA receptors but have a lower safety margin and greater risk of overdose. Newer non-BZD drugs like zolpidem, zaleplon, and zopiclone have fewer side effects and lower abuse potential than B
This document discusses various sedative-hypnotic drugs that act on the central nervous system. It begins by distinguishing drugs that produce sedation from those that induce sleep. It then describes normal sleep cycles and the stages of sleep. The rest of the document details different classes of sedative-hypnotic drugs including benzodiazepines, barbiturates, antihistamines, and others. It provides information on their mechanisms of action, pharmacological effects, clinical uses, and important considerations regarding administration and withdrawal.
This document discusses several classes of sedative-hypnotic drugs, including benzodiazepines, barbiturates, newer hypnotics like zolpidem and eszopiclone, ramelteon, and buspirone. It covers their mechanisms of action, pharmacokinetics including absorption, distribution, metabolism and excretion, factors affecting these processes, and side effect profiles. The metabolism and elimination of these drugs varies significantly based on properties like lipid solubility and specific cytochrome P450 isoenzyme involvement.
This document discusses sedative and hypnotic drugs. It begins by defining sedation and differentiating sedatives and hypnotics. It then classifies common sedative and hypnotic drugs such as benzodiazepines, barbiturates, and atypical drugs. The document reviews the sleep cycle and mechanisms of action of different drug classes. It provides details on pharmacology, uses, and side effects of individual sedative and hypnotic drugs including benzodiazepines, barbiturates, z-drugs, buspirone, and newer drugs.
Sedative, Hypnotic and Anxiolytic Drugs are used to treat anxiety, insomnia and induce sleep. They work by potentiating the action of the inhibitory neurotransmitter GABA in the brain. Benzodiazepines and barbiturates are common classes of these drugs. Benzodiazepines increase the frequency of chloride channel opening, while barbiturates increase the duration. Both classes are used as sedatives, hypnotics and to relieve anxiety. They can cause dependence and tolerance with long term use. Newer non-benzodiazepine drugs like Zolpidem and Zaleplon have fewer side effects.
This document summarizes information on sedative and hypnotic drugs. It discusses the mechanisms and effects of benzodiazepines, barbiturates, and other drugs such as zolpidem, zaleplon, zopiclone, melatonin, and buspirone. It provides details on the pharmacokinetics, therapeutic uses, and side effects of these classes of drugs. The document also covers topics like tolerance, dependence and withdrawal symptoms, overdose treatment, and newer non-benzodiazepine hypnotics.
This document discusses sedatives and hypnotics. It defines them as chemical substances that reduce tension, anxiety and induce calm or sleep. Most drugs have sedative effects at low doses and hypnotic (sleep inducing) effects at higher doses. Barbiturates are one class that act by potentiating GABA receptors in the brain. They have fallen out of favor due to risk of dependence and overdose. Benzodiazepines emerged as safer alternatives that also target GABA receptors. Other classes discussed include non-benzodiazepines, barbiturates, alcohols, and various other substances.
The document discusses sedative-hypnotic drugs and their uses. It describes the phases of sleep including non-REM sleep and REM sleep. Some key points are:
- Benzodiazepines are commonly used as hypnotics for insomnia and as anxiolytics for acute anxiety. Short acting BDZs are preferred to avoid daytime sedation.
- BDZs potentiate the effects of GABA by binding to sites adjacent to the GABA receptor. This increases chloride ion conductance and membrane hyperpolarization.
- While effective, long-term BDZ use can cause tolerance, dependence, and cognitive impairment so they should only be used short-term for severe anxiety and insomnia.
The document summarizes information about sedative-hypnotics presented in a lecture. It discusses the properties of individual benzodiazepines (BZDs) like diazepam, flurazepam, alprazolam, and midazolam. It also covers non-BZD hypnotics like zopiclone, zolpidem, and zaleplon that act on specific BZD receptor subunits. Melatonin and ramelteon, which act as melatonin receptor agonists, are also discussed. The concluding section notes that long-acting BZDs can cause next day sedation while flumazenil acts as a BZD antagonist to
This document discusses sedative, hypnotic, and anxiolytic drugs. It describes barbiturates and benzodiazepines, which are commonly used as sedative-hypnotics. Barbiturates act by potentiating the inhibitory neurotransmitter GABA, while benzodiazepines facilitate GABA effects by binding to GABAA receptors. The document outlines the mechanisms, effects on sleep, and adverse effects of these drug classes. It also discusses newer nonbenzodiazepine hypnotics and the benzodiazepine antagonist flumazenil.
This document discusses different classes of sedative and hypnotic drugs, including their mechanisms of action, pharmacokinetics and therapeutic uses. It covers barbiturates, benzodiazepines, zolpidem, and buspirone. Barbiturates and benzodiazepines enhance the effects of the inhibitory neurotransmitter GABA, whereas zolpidem selectively binds to GABA receptors. These drugs have varying onset and duration of action and are used to treat conditions like anxiety, insomnia and seizures. Adverse effects include respiratory depression, dependence and withdrawal symptoms.
This document discusses sedative/hypnotics and anxiolytics. It begins by explaining how these drugs work in the nervous system, producing sedation, hypnosis, and effects ranging from confusion to coma and death depending on dose. It then focuses on benzodiazepines and barbiturates, the two major classes of these drugs. Both act by enhancing GABAergic transmission but differ in their mechanisms and properties. Benzodiazepines are generally safer with less respiratory depression but can cause dependence, while barbiturates have greater toxicity and abuse potential. The document emphasizes using these drugs only short-term to avoid adverse effects.
This document discusses anxiolytics and hypnotics such as benzodiazepines and barbiturates. It describes how these drugs work by enhancing the effects of the neurotransmitter GABA at GABA receptors in the brain, resulting in sedation, anxiety reduction, and sleep induction. Both classes of drugs are controlled substances due to their potential for dependence and withdrawal symptoms. While benzodiazepines are still commonly used, barbiturates have been largely replaced due to greater safety and tolerability of benzodiazepines.
Sedative-hypnotic drugs reduce anxiety and induce sleep by depressing activity in the central nervous system. The main classes are benzodiazepines, barbiturates, and newer non-benzodiazepine agents. Benzodiazepines have largely replaced barbiturates due to their wider therapeutic index, lower risk of interactions and dependence, and the availability of antagonists. Both benzodiazepines and barbiturates work by enhancing the effects of the inhibitory neurotransmitter GABA.
This document provides an overview of sedative hypnotics, including their terminology, pharmacology, historical perspectives, and case studies. It discusses how opioids, bromides, and barbiturates were historically used as sedatives before the development of benzodiazepines in the 1950s. Benzodiazepines like diazepam, lorazepam and alprazolam became widely prescribed to treat anxiety and insomnia in the 1960s-1980s. The document outlines the pharmacokinetics of various sedative hypnotics and risks of abuse, dependence and overdose. It also presents a case study of a man who developed hand ischemia after injecting crushed zolpidem
The document discusses drugs acting on the central nervous system (CNS). It begins by introducing the basic anatomy and function of the CNS. It then describes the excitatory and inhibitory pathways in the CNS and lists several important neurotransmitters like glutamate, GABA, acetylcholine, dopamine, norepinephrine, and serotonin. The document categorizes drugs acting on the CNS as sedative-hypnotics, antiepileptics, antiparkinsonians, antidepressants, and antipsychotics. It provides detailed descriptions of barbiturates, benzodiazepines, and newer sedative-hypnotics. It also discusses the pharmacology and treatment of Parkinson's disease with a focus on
This document discusses sedative-hypnotic drugs, including barbiturates and benzodiazepines. It describes their mechanisms of action, which involve facilitating the effects of the neurotransmitter GABA at GABA-A receptors in the brain. Specific drugs are categorized and their indications, pharmacokinetics, adverse effects and interactions are outlined. Newer non-benzodiazepine hypnotics such as zolpidem and zopiclone that also target GABA receptors are also discussed.
Sedatives calm patients without inducing sleep by decreasing responsiveness to stimulation. Hypnotics induce and maintain sleep. Barbiturates and benzodiazepines are common sedative-hypnotic drugs. Barbiturates act directly on GABA receptors to facilitate the opening of chloride channels. Benzodiazepines enhance the effects of GABA through binding to GABA receptors. Newer nonbenzodiazepine drugs like zolpidem and zaleplone also act through GABA pathways to produce sedation and hypnosis.
1. Benzodiazepines and barbiturates are commonly used anxiolytics and hypnotics that act by enhancing the effects of the inhibitory neurotransmitter GABA.
2. They are classified based on duration of action and include short, intermediate, and long acting agents. Newer non-benzodiazepine drugs like zolpidem and buspirone are also used.
3. They produce sedation, hypnosis, anxiolysis and can have adverse effects like respiratory depression if overdosed. Tolerance and dependence may also occur with long term use.
This document provides an overview of sedatives and hypnotics. It discusses the sleep cycle and classification of different drug groups including benzodiazepines, barbiturates, non-benzodiazepine hypnotics, and atypical anxiolytics. It covers the mechanisms of action, pharmacokinetics, therapeutic uses, and adverse effects of various sedative and hypnotic drugs. Recent advances mentioned include drugs that act as melatonin receptor agonists for treatment of insomnia.
This document discusses anti-anxiety drugs and their classification and mechanisms of action. It summarizes that anxiety is an unpleasant emotional state associated with uneasiness or fear, and anti-anxiety drugs aim to control anxiety symptoms without interfering with normal mental or physical functions. The main classes described are benzodiazepines, which facilitate inhibitory GABA transmission, azapirones like buspirone which act on serotonin receptors, and beta-blockers which reduce physical symptoms of anxiety. Side effects of benzodiazepines include sedation while buspirone causes minor side effects. Lithium is discussed as an antimanic drug that acts as a mood stabilizer in bipolar disorder by modifying ion fluxes and
This document defines sedatives and hypnotics, and classifies common drugs used as such. It describes the mechanisms, pharmacokinetics, uses and side effects of barbiturates, benzodiazepines, zolpidem, and zaleplon. Barbiturates act by facilitating GABA activity and directly activating chloride channels, while benzodiazepines facilitate GABA activity at receptor sites. Both are metabolized in the liver and have risks of tolerance, dependence and withdrawal. Benzodiazepines generally have fewer side effects and less abuse potential than barbiturates. Zolpidem and zaleplon are shorter acting hypnotics that also facilitate G
This document summarizes different classes of sedative hypnotics and antianxiety drugs. It discusses benzodiazepines, barbiturates, nonbenzodiazepine hypnotics, melatonin receptor agonists, and selective serotonin reuptake inhibitors. The main points covered are the mechanism of action, pharmacological effects, uses, and adverse effects of these drug classes. Specific examples are provided for different drugs within each class.
This document summarizes sedatives and hypnotics, including their mechanisms of action and classifications. It discusses that sedatives calm without inducing sleep while hypnotics induce and maintain sleep. The main classes covered are barbiturates and benzodiazepines. Barbiturates act by potentiating GABA receptors but are no longer commonly used due to side effects like tolerance and dependence. Benzodiazepines also act through GABA receptors with fewer side effects and are still frequently prescribed as hypnotics, anxiolytics, anticonvulsants, and muscle relaxants.
This document discusses sedatives and hypnotics, including their classification, mechanisms of action, pharmacokinetics, uses, and adverse effects. It covers barbiturates, benzodiazepines, and newer non-benzodiazepine hypnotics. Barbiturates and benzodiazepines act as depressants in the central nervous system by enhancing GABA activity. They are used as hypnotics to induce and maintain sleep, but have risks of tolerance, dependence, and withdrawal symptoms with chronic use. Newer non-benzodiazepine hypnotics like zolpidem, zopiclone, and zaleplon selectively target GABA receptors to
This document provides information on antianxiety drugs. It discusses that anxiety is an unpleasant emotional state associated with unease from an unknown threat. Treatment is needed when anxiety is disproportionate or excessive. It then describes various classes of antianxiety drugs including benzodiazepines, azapirones, barbiturates, beta blockers, and antidepressants. The document focuses on benzodiazepines, explaining their mechanism of action by enhancing GABA through binding sites on GABA receptors. It discusses their therapeutic uses for anxiety disorders, seizures, muscle disorders and as amnesia for medical procedures. Potential adverse effects and drug interactions are also summarized.
This document discusses anxiety and its treatment. It defines anxiety as an unpleasant emotional state accompanied by nervous behavior. It notes that neurotransmitters like GABA, norepinephrine, and serotonin play a role in anxiety, and that certain brain regions like the amygdala and hippocampus are involved. It describes several theories for the neurochemical basis of anxiety. It then discusses different classes of anxiolytic drugs like benzodiazepines, azapirones, antihistamines, and beta blockers that treat anxiety by enhancing GABA transmission or blocking the sympathetic nervous system. Finally, it provides examples of individual anxiolytic drugs and notes some of their side effects and interactions.
The document discusses sedative/hypnotic and anxiolytic drugs. It describes their mechanisms of action, which primarily involve enhancing GABAergic transmission in the brain. Benzodiazepines and barbiturates act as agonists at GABA-A receptors. These drugs can relieve anxiety and induce sleep, but have side effects like sedation, respiratory depression, and dependence with long-term use. Newer non-benzodiazepine drugs like zolpidem are also discussed.
Sedative-hypnotic drugs act on the central nervous system to produce a calming effect. Barbiturates were commonly used but have been largely replaced by benzodiazepines due to their safer profile. Both classes of drugs act by enhancing the effects of the inhibitory neurotransmitter GABA at GABA receptors in the brain. This causes sedation, hypnosis, anxiety relief and other effects depending on the specific drug and dose. While effective for treating conditions like anxiety, these drugs can also cause side effects like dependence and withdrawal symptoms with prolonged use.
Sedatives and hypnotics drugs ppt by kashikant yadavKashikant Yadav
Sedatives and hypnotics are central nervous system depressants that are used to induce sleep or reduce anxiety. Barbiturates were previously commonly used but have largely been replaced by benzodiazepines due to lower risks of dependence and overdose. Both classes of drugs work by enhancing the effects of the inhibitory neurotransmitter GABA. Sedatives primarily reduce anxiety and excitement while hypnotics are used to induce sleep. Common side effects include drowsiness, dizziness, and impaired coordination. Tolerance can develop with repeated use of both barbiturates and benzodiazepines.
This document summarizes different classes of sedative-hypnotic drugs, including benzodiazepines, barbiturates, non-benzodiazepine hypnotics (Z-drugs), melatonin agonists, and orexin antagonists. It describes their mechanisms of action, indications, pharmacokinetics, adverse effects, and contraindications. Sedative-hypnotics work by enhancing the effects of the inhibitory neurotransmitter GABA or by antagonizing orexin receptors to reduce arousal. Common side effects include drowsiness, respiratory depression, and withdrawal symptoms upon discontinuation. Long-term use carries risks of tolerance and dependence that limit the use of certain agents like
Sedatives relieve anxiety with minimal central nervous system depression, while hypnotics produce drowsiness and facilitate sleep onset with more pronounced CNS depression. Benzodiazepines are classified based on their duration of action as short, intermediate, or long acting. They produce pharmacological effects like sedation, amnesia, hypnosis, and muscle relaxation by potentiating the action of GABA at GABA-A receptors. Adverse effects include CNS depression, withdrawal symptoms on discontinuation, and teratogenicity during pregnancy. Barbiturates also act by enhancing GABAergic transmission but can cause respiratory depression at high doses. Novel non-benzodiazepine hypnotics like z
This document discusses sedative, hypnotic, and anxiolytic drugs. It describes barbiturates and benzodiazepines. Barbiturates were popular hypnotics and sedatives until the 1960s but are no longer used due to risks of overdose, dependence, and withdrawal effects. Benzodiazepines replaced barbiturates as they have a higher therapeutic index and are less likely to cause respiratory depression even at high doses. The document outlines the mechanisms, effects on sleep, and pharmacological properties of barbiturates and benzodiazepines.
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These lecture slides, by Dr Sidra Arshad, offer a simplified look into the mechanisms involved in the regulation of respiration:
Learning objectives:
1. Describe the organisation of respiratory center
2. Describe the nervous control of inspiration and respiratory rhythm
3. Describe the functions of the dorsal and respiratory groups of neurons
4. Describe the influences of the Pneumotaxic and Apneustic centers
5. Explain the role of Hering-Breur inflation reflex in regulation of inspiration
6. Explain the role of central chemoreceptors in regulation of respiration
7. Explain the role of peripheral chemoreceptors in regulation of respiration
8. Explain the regulation of respiration during exercise
9. Integrate the respiratory regulatory mechanisms
10. Describe the Cheyne-Stokes breathing
Study Resources:
1. Chapter 42, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 36, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 13, Human Physiology by Lauralee Sherwood, 9th edition
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4. Naturally recurring,periodic state of depression of consciousness,relatively
inhibited sensory activity and inhibition of voluntary muscles.There is decreased
ability to react to stimuli but person is arousable.
Non-rapid eye movement(NREM) sleep: 70%-75%
Stage 1,2 (Thinking when awakened)
Stage 3,4:slow wave sleep, SWS(restoration )
Stage4-low metabolic rate & GH secretion highest,NIGHT TERRORS
Rapid eye movement(REM) sleep-about 20-25%-
dreams, tachycardia,relaxation of voluntary muscles,(dreaming when
awakened),consolidation of learning,NIGHT MARES
Normal sleep
4
9. SEDATIVE
Drugs that have an inhibitory effect on the CNS to the degree that they
reduce:
– Nervousness
– Excitability
– Irritability without causing sleep
(McKenry et al., 2003)
An effective sedative agent should reduce anxiety and exert a calming
effect with little or no effect on motor or mental functions.
(Katzung et al., ed 11)
9
10. HYPNOTICS
• Calm or soothe the CNS to the point that they
cause sleep
• A hypnotic drug should produce drowsiness and encourage
the onset and maintenance of a state of sleep that as far as
possible resembles the natural sleep state.
• A sedative can become a hypnotic if it is given in large enough
doses dose dependent
(Katzung; Goodman & Gilman)
10
11. Anxiolytic & Hypnotic drugs
• Anxiety (adaptive response)
– Intense ,excessive and persistent worry and fear about
everyday situations. When bcm all consuming and interfere
with daily living.
– Among other fear responses include defensive behaviors,
autonomic reflexes, arousal and alertness, corticoid
secretion and negative emotions
20. Site of action
BZD-depresses-
LIMBIC SYSTEM > RAS
(thoughts & mental functions) wakefulness
***ANXIOLYTIC WITH LESS Sedative effect
Muscle relaxation-
medullary action-(-) polysynaptic reflexes in spinal cord
22. Site and Structure of Action
• Site of action is the GABAA receptor Cl channel complex
• GABA acts on –
GABA A – Post synaptic-linked to Cl ion channels
GABA B –GPCRs-decreased cAMP-pre & post synaptic inhibition –by inhibiting
Ca channels &increasing K conductance
• Structure of GABAA receptor
– Comprised of 5 subunits
• 2 α subunits (to which GABA binds)
• 2 β subunits (to which barbiturates bind)
• 1 γ subunit (to which benzodiazepines bind)
22
28. 2.INSOMNIA-
Transient insomnia short term ins. Long term ins
-<7 d 1-3 wks >3 wks
-Jet lag,shift,journey bereavement,occupational underlying disease
-Triazolam, Temazepam temazepam,flurazepam flurazepam,nitrazepam
29. 3.PREANAESTHETIC MEDICATION& INDUCTION OF
ANAESTHESIA-
Lorazepam, midazolam, diazepam
4.SMR-diazepam
Spasticity of central* origin
5.ANTICONVULSANTS-
Diazepam,clonazepam
Status epilepticus,myoclonic/petimal seizures,tetanic spasm
35. NON BENZODIAZEPINE HYNOTICS/Z HYPNOTICS
• Zopiclone,zaleplon,zolpidem,eszopiclone
• Chemically different from benzodiazepines
• Act on specific BZD receptors located on α subunit-agonist at
modulatory site of GABAA rec.-facilitate the actions of GABA
• BZ1-brain&cerebellum- antianxiety,sedative ,hypnotic
• BZ2-cortex,hippocampus,spinal cord- muscle
relaxation,anticonvulsant,amnesia
• Flumazenil is competitive antagonist
• Hypnotic amnesic but weak anti anxiety, anticonvulsant &
muscle relaxant-short term use
• Low abuse ,REM alteration/residual sedation/rebound
insomnia
Sleep is subdivided into:
rapid eye movement (REM) sleep, which is characterized by high-frequency electroencephalogram (EEG) recordings and muscle atonia
non-REM (slow-wave) sleep, characterized by low frequency EEG recordings and body rest
Graded dose-dependent depression of central nervous system function is a characteristic of most sedative-hypnotics.
However, individual drugs differ in the relationship between the dose and the degree of central nervous system depression.
The linear slope for drug A (most non benzodiazepine drugs) is typical of many of the older sedative-hypnotics, including the barbiturates and alcohols. With such drugs, an increase in dose higher than that needed for hypnosis may lead to a state of general anesthesia. At still higher doses, these sedative-hypnotics may depress respiratory and vasomotor centers in the medulla, leading to coma and death.
Deviations from a linear dose-response relationship, as shown for drug B, require proportionately greater dosage increments to achieve central nervous system depression more profound than hypnosis. This appears to be the case for benzodiazepines and for certain newer hypnotics that have a similar mechanism of action.
Sedative-hypnotic drugs. In: Basic and clinical pharmacology, 8th edition. Katzung BG. USA: The McGraw Hill Companies, Inc, 2001:364–381.
Benzodiazepines (BDZs) bind to the gamma sub-unit of the GABA-A receptor. Their binding causes an allosteric (structural) modification of the receptor that results in an increase in GABA A receptor activity. BDZs do not substitute for GABA, which bind at the alpha sub-unit, but increase the frequency of channel opening events which leads to an increase in chloride ion conductance and inhibition of the action potential
A model of the GABAA receptor-chloride ion channel macromolecular complex.
The complex consists of five or more membrane-spanning subunits. GABA appears to interact with alpha or beta subunits triggering chloride channel opening with resultant membrane hyperpolarization.
Binding of BZs to gamma subunits facilitates the process of channel opening
The speed of Absorption and the extent of plasma binding are in equilibrium with liposolubility .
More than 90 % bind → absorbed quickly, such as diazapam , etc.
Liver metabolism : metabolised to a range of active substances by liver drug enzyme , t1 / 2 longer than the mother nuclide .
Demethyldiazapam is metabolised to a wide range of active metabolins, t1/2 20-100 hr.