This document analyzes the relationship between regional industry clusters and entrepreneurship. It hypothesizes that strong clusters positively impact entrepreneurship by lowering business startup costs, enhancing innovation opportunities, and providing access to inputs and markets. The study uses Census Bureau and cluster mapping data to examine how cluster strength relates to the growth of new businesses and employment in startups, while controlling for convergence effects. Preliminary results suggest clusters facilitate higher growth in entrepreneurial activity and medium-term survival of startups. The presence of clusters may also influence where existing multi-location firms open new establishments.