Intensified polishing using single-pass tangential flow filtration (SPTFF) wi...Frédéric Sengler
The bioprocessing industry is interested in Next Generation Processes with higher flexibility, lower costs, and higher product quality. Single-pass tangential flow filtration (SPTFF) can be used to intensify manufacturing processes to meet these goals. Here, SPTFF preconcentration is used to intensify the anion exchange (AEX) polishing step in monoclonal antibody (mAb) processing for improved impurity removal and column productivity. This intensified polishing approach can be linked with upstream steps for a more continuous process which eliminates tankage and hold time, and enables the use of smaller polishing columns to improve productquality at higher throughputs.
Intensified mAb polishing: linking single-pass tangential flow filtration wit...Frédéric Sengler
Process intensification is an approach to improve operational
throughput by running a manufacturing process or unit operation
differently. In mAb purification, intensified processing can remove
bottlenecks created by high bioreactor titers, increase manufacturing
flexibility for multi-product facilities, and reduce cost of goods while
increasing the focus on product quality.
This work focuses on intensifying the anion exchange (AEX) mAb
polishing step. AEX polishing is commonly used to provide clearance
of host cell protein (HCP) and virus impurities.
The mAb polishing
step can be intensified by pre-concentrating the AEX feed
material using Single-Pass Tangential Flow Filtration (SPTFF).
Single-Pass Tangential Flow Filtration (SPTFF) Theory and PracticeMilliporeSigma
This data-driven presentation explores the theoretical and practical implications of single-pass tangential flow filtration in bioprocessing and will address the following:
• What is single-pass TFF and how does it work?
• How does SPTFF improve process economics?
• How can single-use technology be utilized for speed and safety?
To learn more about this topic or collaborate with our technical experts, schedule an in-person or remote visit at our M Lab™ Collaboration Centers: www.emdmillipore.com/mlab
Single-Pass Tangential Flow Filtration (SPTFF) Theory and PracticeMerck Life Sciences
This data-driven presentation explores the theoretical and practical implications of single-pass tangential flow filtration in bioprocessing and will address the following:
• What is single-pass TFF and how does it work?
• How does SPTFF improve process economics?
• How can single-use technology be utilized for speed and safety?
To learn more about this topic or collaborate with our technical experts, schedule an in-person or remote visit at our M Lab™ Collaboration Centers: www.merckmillipore.com/mlab
Intensified polishing using single-pass tangential flow filtration (SPTFF) wi...Frédéric Sengler
The bioprocessing industry is interested in Next Generation Processes with higher flexibility, lower costs, and higher product quality. Single-pass tangential flow filtration (SPTFF) can be used to intensify manufacturing processes to meet these goals. Here, SPTFF preconcentration is used to intensify the anion exchange (AEX) polishing step in monoclonal antibody (mAb) processing for improved impurity removal and column productivity. This intensified polishing approach can be linked with upstream steps for a more continuous process which eliminates tankage and hold time, and enables the use of smaller polishing columns to improve productquality at higher throughputs.
Intensified mAb polishing: linking single-pass tangential flow filtration wit...Frédéric Sengler
Process intensification is an approach to improve operational
throughput by running a manufacturing process or unit operation
differently. In mAb purification, intensified processing can remove
bottlenecks created by high bioreactor titers, increase manufacturing
flexibility for multi-product facilities, and reduce cost of goods while
increasing the focus on product quality.
This work focuses on intensifying the anion exchange (AEX) mAb
polishing step. AEX polishing is commonly used to provide clearance
of host cell protein (HCP) and virus impurities.
The mAb polishing
step can be intensified by pre-concentrating the AEX feed
material using Single-Pass Tangential Flow Filtration (SPTFF).
Single-Pass Tangential Flow Filtration (SPTFF) Theory and PracticeMilliporeSigma
This data-driven presentation explores the theoretical and practical implications of single-pass tangential flow filtration in bioprocessing and will address the following:
• What is single-pass TFF and how does it work?
• How does SPTFF improve process economics?
• How can single-use technology be utilized for speed and safety?
To learn more about this topic or collaborate with our technical experts, schedule an in-person or remote visit at our M Lab™ Collaboration Centers: www.emdmillipore.com/mlab
Single-Pass Tangential Flow Filtration (SPTFF) Theory and PracticeMerck Life Sciences
This data-driven presentation explores the theoretical and practical implications of single-pass tangential flow filtration in bioprocessing and will address the following:
• What is single-pass TFF and how does it work?
• How does SPTFF improve process economics?
• How can single-use technology be utilized for speed and safety?
To learn more about this topic or collaborate with our technical experts, schedule an in-person or remote visit at our M Lab™ Collaboration Centers: www.merckmillipore.com/mlab
Process Development for Continuous Flow-Through Polishing Purification for mA...Merck Life Sciences
View the interactive recording here: https://bit.ly/2JYehee
Abstract:
Over the last several years, the biopharmaceutical industry has had a significant focus on connected and continuous processing to improve both process economics and plant utilization. As opposed to the traditional polishing trains comprised of bind-elute chromatography operations, an all flow-through polishing train easily enables connected and continuous processing while simultaneously improving process economics, flexibility, and productivity. Leveraging commercially available and novel prototype chemistries and devices, we investigated how a properly designed flow-through polishing train can be used to meet the stringent demands expected for mAb polishing purification. A streamlined methodology will be described to investigate the performance of individual units as well as synergies between technologies. For both individual technologies and connected processes, results will be discussed on their ability to meet purity and yield targets robustly. Finally, we will show how leveraging the integrated combination of unit operations can result in improved performance over the standard batch, segregated processing paradigm.
In this webinar, you will learn:
• New process design for continuous flow-through polishing and its operational robustness
• Economic benefits (43% savings in COGs) of implementing a robust flow-through polishing toolbox
Process Development for Continuous Flow-Through Polishing Purification for mA...MilliporeSigma
View the interactive recording : https://bit.ly/2JYehee
Abstract:
Over the last several years, the biopharmaceutical industry has had a significant focus on connected and continuous processing to improve both process economics and plant utilization. As opposed to the traditional polishing trains comprised of bind-elute chromatography operations, an all flow-through polishing train easily enables connected and continuous processing while simultaneously improving process economics, flexibility, and productivity. Leveraging commercially available and novel prototype chemistries and devices, we investigated how a properly designed flow-through polishing train can be used to meet the stringent demands expected for mAb polishing purification. A streamlined methodology will be described to investigate the performance of individual units as well as synergies between technologies. For both individual technologies and connected processes, results will be discussed on their ability to meet purity and yield targets robustly. Finally, we will show how leveraging the integrated combination of unit operations can result in improved performance over the standard batch, segregated processing paradigm.
In this webinar, you will learn:
• New process design for continuous flow-through polishing and its operational robustness
• Economic benefits (43% savings in COGs) of implementing a robust flow-through polishing toolbox
An overview of a wastewater treatment process aimed at recovering commodity products from industrial effluent without the addition of chemical coagulants.
Dissolve air flotation technology to treat highly polluted wastewaterIndia Water Portal
Air flotation technology has proved to be an efficient method to treat heavily polluted wastewater from tanneries, slaughterhouses and chemical industries
Nett Technologies Inc. - The Ninth Annual Southeast Diesel Collaborative Partners Meeting Presentation
In this presentation, Nett Technologies discusses the following topics:
- Verified Retrofit Technologies
- Nett Technologies
- Engine Emission Testing Capabilities
- EPA and ARB verified products
- Selective Catalytic Reduction System discussion
- Active DPF and SCR System discussions
- Passive DPF and SCR System discussions
- Diesel Oxidation Catalyst System discussions
- 3-Way Catalyst System discussions
- Passive Diesel Particulate System discussions
- Active Diesel Particulate System discussions
Handling High Titer Processes and Strategies for DSP Facility Fit | KBI Biop...KBI Biopharma
Handling High Titer Processes and Strategies for DSP Facility Fit. Originally presented at BioProcess International 2018 by Christopher Miller, Senior Scientist, Downstream Process Development, KBI Biopharma.
Process Development for Continuous Flow-Through Polishing Purification for mA...Merck Life Sciences
View the interactive recording here: https://bit.ly/2JYehee
Abstract:
Over the last several years, the biopharmaceutical industry has had a significant focus on connected and continuous processing to improve both process economics and plant utilization. As opposed to the traditional polishing trains comprised of bind-elute chromatography operations, an all flow-through polishing train easily enables connected and continuous processing while simultaneously improving process economics, flexibility, and productivity. Leveraging commercially available and novel prototype chemistries and devices, we investigated how a properly designed flow-through polishing train can be used to meet the stringent demands expected for mAb polishing purification. A streamlined methodology will be described to investigate the performance of individual units as well as synergies between technologies. For both individual technologies and connected processes, results will be discussed on their ability to meet purity and yield targets robustly. Finally, we will show how leveraging the integrated combination of unit operations can result in improved performance over the standard batch, segregated processing paradigm.
In this webinar, you will learn:
• New process design for continuous flow-through polishing and its operational robustness
• Economic benefits (43% savings in COGs) of implementing a robust flow-through polishing toolbox
Process Development for Continuous Flow-Through Polishing Purification for mA...MilliporeSigma
View the interactive recording : https://bit.ly/2JYehee
Abstract:
Over the last several years, the biopharmaceutical industry has had a significant focus on connected and continuous processing to improve both process economics and plant utilization. As opposed to the traditional polishing trains comprised of bind-elute chromatography operations, an all flow-through polishing train easily enables connected and continuous processing while simultaneously improving process economics, flexibility, and productivity. Leveraging commercially available and novel prototype chemistries and devices, we investigated how a properly designed flow-through polishing train can be used to meet the stringent demands expected for mAb polishing purification. A streamlined methodology will be described to investigate the performance of individual units as well as synergies between technologies. For both individual technologies and connected processes, results will be discussed on their ability to meet purity and yield targets robustly. Finally, we will show how leveraging the integrated combination of unit operations can result in improved performance over the standard batch, segregated processing paradigm.
In this webinar, you will learn:
• New process design for continuous flow-through polishing and its operational robustness
• Economic benefits (43% savings in COGs) of implementing a robust flow-through polishing toolbox
An overview of a wastewater treatment process aimed at recovering commodity products from industrial effluent without the addition of chemical coagulants.
Dissolve air flotation technology to treat highly polluted wastewaterIndia Water Portal
Air flotation technology has proved to be an efficient method to treat heavily polluted wastewater from tanneries, slaughterhouses and chemical industries
Nett Technologies Inc. - The Ninth Annual Southeast Diesel Collaborative Partners Meeting Presentation
In this presentation, Nett Technologies discusses the following topics:
- Verified Retrofit Technologies
- Nett Technologies
- Engine Emission Testing Capabilities
- EPA and ARB verified products
- Selective Catalytic Reduction System discussion
- Active DPF and SCR System discussions
- Passive DPF and SCR System discussions
- Diesel Oxidation Catalyst System discussions
- 3-Way Catalyst System discussions
- Passive Diesel Particulate System discussions
- Active Diesel Particulate System discussions
Handling High Titer Processes and Strategies for DSP Facility Fit | KBI Biop...KBI Biopharma
Handling High Titer Processes and Strategies for DSP Facility Fit. Originally presented at BioProcess International 2018 by Christopher Miller, Senior Scientist, Downstream Process Development, KBI Biopharma.
Smart TV Buyer Insights Survey 2024 by 91mobiles.pdf91mobiles
91mobiles recently conducted a Smart TV Buyer Insights Survey in which we asked over 3,000 respondents about the TV they own, aspects they look at on a new TV, and their TV buying preferences.
Pushing the limits of ePRTC: 100ns holdover for 100 daysAdtran
At WSTS 2024, Alon Stern explored the topic of parametric holdover and explained how recent research findings can be implemented in real-world PNT networks to achieve 100 nanoseconds of accuracy for up to 100 days.
Transcript: Selling digital books in 2024: Insights from industry leaders - T...BookNet Canada
The publishing industry has been selling digital audiobooks and ebooks for over a decade and has found its groove. What’s changed? What has stayed the same? Where do we go from here? Join a group of leading sales peers from across the industry for a conversation about the lessons learned since the popularization of digital books, best practices, digital book supply chain management, and more.
Link to video recording: https://bnctechforum.ca/sessions/selling-digital-books-in-2024-insights-from-industry-leaders/
Presented by BookNet Canada on May 28, 2024, with support from the Department of Canadian Heritage.
DevOps and Testing slides at DASA ConnectKari Kakkonen
My and Rik Marselis slides at 30.5.2024 DASA Connect conference. We discuss about what is testing, then what is agile testing and finally what is Testing in DevOps. Finally we had lovely workshop with the participants trying to find out different ways to think about quality and testing in different parts of the DevOps infinity loop.
The Metaverse and AI: how can decision-makers harness the Metaverse for their...Jen Stirrup
The Metaverse is popularized in science fiction, and now it is becoming closer to being a part of our daily lives through the use of social media and shopping companies. How can businesses survive in a world where Artificial Intelligence is becoming the present as well as the future of technology, and how does the Metaverse fit into business strategy when futurist ideas are developing into reality at accelerated rates? How do we do this when our data isn't up to scratch? How can we move towards success with our data so we are set up for the Metaverse when it arrives?
How can you help your company evolve, adapt, and succeed using Artificial Intelligence and the Metaverse to stay ahead of the competition? What are the potential issues, complications, and benefits that these technologies could bring to us and our organizations? In this session, Jen Stirrup will explain how to start thinking about these technologies as an organisation.
Why You Should Replace Windows 11 with Nitrux Linux 3.5.0 for enhanced perfor...SOFTTECHHUB
The choice of an operating system plays a pivotal role in shaping our computing experience. For decades, Microsoft's Windows has dominated the market, offering a familiar and widely adopted platform for personal and professional use. However, as technological advancements continue to push the boundaries of innovation, alternative operating systems have emerged, challenging the status quo and offering users a fresh perspective on computing.
One such alternative that has garnered significant attention and acclaim is Nitrux Linux 3.5.0, a sleek, powerful, and user-friendly Linux distribution that promises to redefine the way we interact with our devices. With its focus on performance, security, and customization, Nitrux Linux presents a compelling case for those seeking to break free from the constraints of proprietary software and embrace the freedom and flexibility of open-source computing.
In his public lecture, Christian Timmerer provides insights into the fascinating history of video streaming, starting from its humble beginnings before YouTube to the groundbreaking technologies that now dominate platforms like Netflix and ORF ON. Timmerer also presents provocative contributions of his own that have significantly influenced the industry. He concludes by looking at future challenges and invites the audience to join in a discussion.
Essentials of Automations: The Art of Triggers and Actions in FMESafe Software
In this second installment of our Essentials of Automations webinar series, we’ll explore the landscape of triggers and actions, guiding you through the nuances of authoring and adapting workspaces for seamless automations. Gain an understanding of the full spectrum of triggers and actions available in FME, empowering you to enhance your workspaces for efficient automation.
We’ll kick things off by showcasing the most commonly used event-based triggers, introducing you to various automation workflows like manual triggers, schedules, directory watchers, and more. Plus, see how these elements play out in real scenarios.
Whether you’re tweaking your current setup or building from the ground up, this session will arm you with the tools and insights needed to transform your FME usage into a powerhouse of productivity. Join us to discover effective strategies that simplify complex processes, enhancing your productivity and transforming your data management practices with FME. Let’s turn complexity into clarity and make your workspaces work wonders!
GraphRAG is All You need? LLM & Knowledge GraphGuy Korland
Guy Korland, CEO and Co-founder of FalkorDB, will review two articles on the integration of language models with knowledge graphs.
1. Unifying Large Language Models and Knowledge Graphs: A Roadmap.
https://arxiv.org/abs/2306.08302
2. Microsoft Research's GraphRAG paper and a review paper on various uses of knowledge graphs:
https://www.microsoft.com/en-us/research/blog/graphrag-unlocking-llm-discovery-on-narrative-private-data/
Observability Concepts EVERY Developer Should Know -- DeveloperWeek Europe.pdfPaige Cruz
Monitoring and observability aren’t traditionally found in software curriculums and many of us cobble this knowledge together from whatever vendor or ecosystem we were first introduced to and whatever is a part of your current company’s observability stack.
While the dev and ops silo continues to crumble….many organizations still relegate monitoring & observability as the purview of ops, infra and SRE teams. This is a mistake - achieving a highly observable system requires collaboration up and down the stack.
I, a former op, would like to extend an invitation to all application developers to join the observability party will share these foundational concepts to build on:
LF Energy Webinar: Electrical Grid Modelling and Simulation Through PowSyBl -...DanBrown980551
Do you want to learn how to model and simulate an electrical network from scratch in under an hour?
Then welcome to this PowSyBl workshop, hosted by Rte, the French Transmission System Operator (TSO)!
During the webinar, you will discover the PowSyBl ecosystem as well as handle and study an electrical network through an interactive Python notebook.
PowSyBl is an open source project hosted by LF Energy, which offers a comprehensive set of features for electrical grid modelling and simulation. Among other advanced features, PowSyBl provides:
- A fully editable and extendable library for grid component modelling;
- Visualization tools to display your network;
- Grid simulation tools, such as power flows, security analyses (with or without remedial actions) and sensitivity analyses;
The framework is mostly written in Java, with a Python binding so that Python developers can access PowSyBl functionalities as well.
What you will learn during the webinar:
- For beginners: discover PowSyBl's functionalities through a quick general presentation and the notebook, without needing any expert coding skills;
- For advanced developers: master the skills to efficiently apply PowSyBl functionalities to your real-world scenarios.
SAP Sapphire 2024 - ASUG301 building better apps with SAP Fiori.pdfPeter Spielvogel
Building better applications for business users with SAP Fiori.
• What is SAP Fiori and why it matters to you
• How a better user experience drives measurable business benefits
• How to get started with SAP Fiori today
• How SAP Fiori elements accelerates application development
• How SAP Build Code includes SAP Fiori tools and other generative artificial intelligence capabilities
• How SAP Fiori paves the way for using AI in SAP apps
Alt. GDG Cloud Southlake #33: Boule & Rebala: Effective AppSec in SDLC using ...James Anderson
Effective Application Security in Software Delivery lifecycle using Deployment Firewall and DBOM
The modern software delivery process (or the CI/CD process) includes many tools, distributed teams, open-source code, and cloud platforms. Constant focus on speed to release software to market, along with the traditional slow and manual security checks has caused gaps in continuous security as an important piece in the software supply chain. Today organizations feel more susceptible to external and internal cyber threats due to the vast attack surface in their applications supply chain and the lack of end-to-end governance and risk management.
The software team must secure its software delivery process to avoid vulnerability and security breaches. This needs to be achieved with existing tool chains and without extensive rework of the delivery processes. This talk will present strategies and techniques for providing visibility into the true risk of the existing vulnerabilities, preventing the introduction of security issues in the software, resolving vulnerabilities in production environments quickly, and capturing the deployment bill of materials (DBOM).
Speakers:
Bob Boule
Robert Boule is a technology enthusiast with PASSION for technology and making things work along with a knack for helping others understand how things work. He comes with around 20 years of solution engineering experience in application security, software continuous delivery, and SaaS platforms. He is known for his dynamic presentations in CI/CD and application security integrated in software delivery lifecycle.
Gopinath Rebala
Gopinath Rebala is the CTO of OpsMx, where he has overall responsibility for the machine learning and data processing architectures for Secure Software Delivery. Gopi also has a strong connection with our customers, leading design and architecture for strategic implementations. Gopi is a frequent speaker and well-known leader in continuous delivery and integrating security into software delivery.
Alt. GDG Cloud Southlake #33: Boule & Rebala: Effective AppSec in SDLC using ...
Lọc khí Saafcarb%20mc%20gpf 1-114
1. SAAFCarb™
MC Media
• Non-toxic
• Landfill disposable
The SAAFCarb MC media is recommended for emergency
removal of chlorine. Scrubber capacities range from 150
pounds to one ton and greater.
SAAFCarb MC media consists of manufactured, generally
spherical, porous pellets measuring 1/8" in diameter. Pellets
are formed from a combination of powdered activated carbon,
alumina and other binders, suitably impregnated to enhance
the capacity for removal of chlorine. Impregnants shall be
applied during pellet formation, such that the impregnant is
uniformly distributed throughout the pellet volume.
Removal Capacity
SAAFCarb MC media meets the following contaminant removal
capacity by weight:
• Chlorine gas (CI2): 10% minimum
For instance, 100 pounds (45.36 kg) of SAAFCarb MC media
will remove a minimum of 10 pounds (4.53 kg) of chlorine gas.
Chemisorptive Process
The SAAFCarb MC media chemisorptive process removes the impure
gases by adsorption, adsorption, and chemical reaction. In the
process, the gas is trapped within the pellet where oxidation changes
the gases into harmless solids, thereby eliminating the possibility of
desorption. SAAFCarb MC media's engineering allows the process to
be instantaneous, irreversible and chemically safe.
Better Air is Our Business®