A nasopharyngeal/oropharyngeal swab was collected from a 41-year-old female patient and tested for SARS-CoV-2 using real-time polymerase chain reaction (RT-PCR). The test result was negative, indicating that SARS-CoV-2 was not detected in the patient's specimen. A negative result does not rule out infection and should be interpreted along with the patient's clinical history and presentation. The report provides information on corona viruses, the test methodology, and guidance on interpreting negative and positive test results.