This document discusses retinopathy of prematurity (ROP), including:
- ROP is a vasoproliferative disease of the retina that occurs in premature infants.
- It describes the classification system for ROP developed by the International Classification of ROP (ICROP) including the location, severity staging from 1-5, plus disease indicator, and aggressive posterior ROP.
- The classification aims to indicate how far the disease has progressed and its severity based on location within the retina and presence of extraretinal neovascularization. More posterior and extensive disease indicates a worse prognosis.
El documento describe los criterios de tratamiento y opciones terapéuticas para la retinopatía de la prematuridad (ROP), incluyendo láser, crioterapia, fármacos antiangiogénicos como bevacizumab y ranibizumab. También discute estudios clínicos en curso que evalúan el uso de anti-VEGF como tratamiento primario o adjunto al láser en casos graves de ROP.
El documento discute la retinopatía de la prematuridad (ROP) como un indicador de la calidad del cuidado neonatal. Explica que la ROP grave se puede prevenir mediante el uso apropiado de oxígeno y recursos como mezcladores de aire-oxígeno, humidificadores y oxímetros. También presenta datos sobre tasas de ROP y tratamientos en diferentes hospitales, mostrando que mejorar los recursos y procesos de oxigenoterapia puede reducir la incidencia de ROP grave.
Este documento proporciona una lista de nombres y números de teléfono de personas. La lista incluye el número de registro, nombre y teléfono de más de 200 personas. Proporciona información básica de contacto de individuos.
This document provides an overview and tour of the Latter-dayVillage website which offers various membership levels providing resources for Primary, Relief Society, Seminary, Sunday School, and Young Women with benefits including lesson plans, activities, and archives of content for each area for a low monthly fee; it also describes the website's history and origins in merging two prior sites along with an online store and customer support options.
This document summarizes a talk on electronic resources for research. It begins by outlining the objectives of discussing what research is, resources used in research, and electronic resources specifically. Electronic resources include digitized books, journals, databases, and tools that can be accessed online. They provide benefits like easy access from anywhere, full-text searchability, and cost effectiveness. However, they also pose dangers like questions of authenticity and plagiarism. Different types of electronic resources are then detailed, including online public access catalogs, digital journal archives, academic networking sites, search engines, and Scholarpedia - an open-access peer-reviewed online encyclopedia.
The document is the syllabus for an ITGS (Information Technology in a Global Society) course taught by Yvonne Mafunga at the Aga Khan School in Dar es Salaam. It provides definitions for key ITGS terms like information technology, social impact, and ethical considerations. It also outlines the course introduction and content, assessment methods, learner profile focusing on IB learner attributes, and policies around attendance and academic honesty. The syllabus aims to develop students' understanding of the impact of information technology on individuals and society through critical investigation and analysis of related social and ethical issues.
This document outlines the scheme of work for an Information Technology in a Global Society (ITGS) course over two academic terms. It includes the following:
- Six main topic areas to be covered including information systems, social/ethical impacts of IT, hardware/networks, databases/spreadsheets, word processing/presentations, and integrated systems.
- Specific learning objectives, subtopics, activities, resources and assessments for each topic.
- A focus on understanding technological concepts as well as evaluating the social and ethical issues of various IT applications.
- Real-life examples are to be used to demonstrate the impacts and applications of IT in various areas such as business, education, health, arts and
National Literature in a Multilingual Nation. Sujit chandak pre ph d presenta...Sujit Chandak
It was a presentation of a research topic as part of the Pre-Phd course work assessment @ University of Mumbai. The topic was to be entirely different from one's proposed research work. Made this PPT which was handy while speaking...
El documento describe los criterios de tratamiento y opciones terapéuticas para la retinopatía de la prematuridad (ROP), incluyendo láser, crioterapia, fármacos antiangiogénicos como bevacizumab y ranibizumab. También discute estudios clínicos en curso que evalúan el uso de anti-VEGF como tratamiento primario o adjunto al láser en casos graves de ROP.
El documento discute la retinopatía de la prematuridad (ROP) como un indicador de la calidad del cuidado neonatal. Explica que la ROP grave se puede prevenir mediante el uso apropiado de oxígeno y recursos como mezcladores de aire-oxígeno, humidificadores y oxímetros. También presenta datos sobre tasas de ROP y tratamientos en diferentes hospitales, mostrando que mejorar los recursos y procesos de oxigenoterapia puede reducir la incidencia de ROP grave.
Este documento proporciona una lista de nombres y números de teléfono de personas. La lista incluye el número de registro, nombre y teléfono de más de 200 personas. Proporciona información básica de contacto de individuos.
This document provides an overview and tour of the Latter-dayVillage website which offers various membership levels providing resources for Primary, Relief Society, Seminary, Sunday School, and Young Women with benefits including lesson plans, activities, and archives of content for each area for a low monthly fee; it also describes the website's history and origins in merging two prior sites along with an online store and customer support options.
This document summarizes a talk on electronic resources for research. It begins by outlining the objectives of discussing what research is, resources used in research, and electronic resources specifically. Electronic resources include digitized books, journals, databases, and tools that can be accessed online. They provide benefits like easy access from anywhere, full-text searchability, and cost effectiveness. However, they also pose dangers like questions of authenticity and plagiarism. Different types of electronic resources are then detailed, including online public access catalogs, digital journal archives, academic networking sites, search engines, and Scholarpedia - an open-access peer-reviewed online encyclopedia.
The document is the syllabus for an ITGS (Information Technology in a Global Society) course taught by Yvonne Mafunga at the Aga Khan School in Dar es Salaam. It provides definitions for key ITGS terms like information technology, social impact, and ethical considerations. It also outlines the course introduction and content, assessment methods, learner profile focusing on IB learner attributes, and policies around attendance and academic honesty. The syllabus aims to develop students' understanding of the impact of information technology on individuals and society through critical investigation and analysis of related social and ethical issues.
This document outlines the scheme of work for an Information Technology in a Global Society (ITGS) course over two academic terms. It includes the following:
- Six main topic areas to be covered including information systems, social/ethical impacts of IT, hardware/networks, databases/spreadsheets, word processing/presentations, and integrated systems.
- Specific learning objectives, subtopics, activities, resources and assessments for each topic.
- A focus on understanding technological concepts as well as evaluating the social and ethical issues of various IT applications.
- Real-life examples are to be used to demonstrate the impacts and applications of IT in various areas such as business, education, health, arts and
National Literature in a Multilingual Nation. Sujit chandak pre ph d presenta...Sujit Chandak
It was a presentation of a research topic as part of the Pre-Phd course work assessment @ University of Mumbai. The topic was to be entirely different from one's proposed research work. Made this PPT which was handy while speaking...
Staff study talk/ on search engine & internet in 2008Sujit Chandak
This document provides an overview of internet and web searching. It begins by outlining the objectives of better understanding how to use the internet for teaching and how search engines function. It then defines the internet as a vast global network that connects independent networks through a common internet protocol. It also visualizes the internet. The document discusses how the internet can be used for teaching by providing online resources, information, and collaboration. It defines an internet search and explains how search engines like Google function by using spiders to index pages and return relevant results. Finally, it provides tips for different types of searches like books, definitions, music, groups, blogs, and social networks.
The document outlines an upcoming training on object-oriented design principles and patterns. The training will last 3 hours and cover understanding design principles, patterns, and applying basic patterns. The agenda includes introducing design principles and patterns, as well as a question and answer section. The document provides details on the topics to be covered, including principles of object-oriented design, package architecture, design patterns, and key design concepts.
La retinopatía del prematuro es una enfermedad ocular que afecta a bebés prematuros y puede causar ceguera. Se produce por una interrupción en la vascularización de la retina debido a fluctuaciones en los niveles de oxígeno. Los factores de riesgo incluyen un bajo peso al nacer y exposición excesiva a oxígeno. Se diagnostica mediante examen oftalmológico y se clasifica en 5 estadios según su gravedad. El tratamiento incluye ablación láser de la retina no vascular
This document discusses examples of formwork designs and calculations by Munarus Suluch. It includes diagrams and calculations for formwork for floors, beams, and columns. For beams, it describes calculating the weight carried by the formwork, the moment, controlling for stress and deflection. The same process is described for column formwork calculations.
Gaurav Kumar Singh is an MBA marketing professional with over 4 years of experience in account management, technical sales, and marketing for IT hardware and networking solutions. He is currently a Solution Consultant at Ivalue Infosolution Pvt Ltd in Delhi, where he has contributed to over 100% growth in security and data protection products. He holds an MBA in Marketing and Finance and has experience in key account management, business development, proposal development, and channel management.
Este documento presenta un índice de contenidos para un atlas de urgencias en oftalmología dividido en dos volúmenes. El índice incluye secciones sobre tumores oculares, manifestaciones oftalmológicas de enfermedades sistémicas como el SIDA, la hipertensión arterial y la diabetes, y lista los capítulos y autores de cada volumen.
Este documento describe varias patologías de la retina. Incluye padecimientos congénitos como el albinismo y las fibras nerviosas mielinizadas. También cubre retinopatías vasculares como la serosa central, la de Coats y la del prematuro. Finalmente, analiza retinopatías asociadas a patologías sistémicas como la hipertensiva y la diabética.
Architecture Patterns - Open DiscussionNguyen Tung
This document provides an overview of software architecture fundamentals and patterns, with a focus on architectures for scalable systems. It discusses key quality attributes for architecture like performance, reliability, and scalability. Common patterns for scalable systems are described, including load balancing, map-reduce, and caching. The document also provides a detailed look at architectures used at Facebook, including the architectures for Facebook's website, chat service, and handling of big data. Key aspects of each system are summarized, including the technologies and design principles used.
This document provides an overview of software as a service (SaaS) architecture. It discusses SaaS characteristics and challenges, outlines common SaaS architecture stacks, and describes key considerations for architecting multi-tenant SaaS applications including hosting, application structure, data storage, and security services. Examples of SaaS reference architectures and conceptual models are also presented.
The document discusses microservice architecture, including concepts, benefits, principles, and challenges. Microservices are an architectural style that structures an application as a collection of small, independent services that communicate with each other, often using RESTful API's. The approach aims to overcome limitations of monolithic architectures like scalability and allow for independent deployments. The key principles include organizing services around business domains, automating processes, and designing services to be independently deployable.
VEGF is a growth factor that promotes abnormal blood vessel growth in the retina and causes vision loss. Anti-VEGF drugs like ranibizumab (Lucentis), bevacizumab (Avastin), and pegaptanib (Macugen) work by blocking VEGF and stopping this blood vessel growth. Ranibizumab was designed specifically for eye injections and has a short half-life, while bevacizumab was designed for cancer but is also used "off-label" in the eye. Clinical trials found that both drugs are effective in treating wet AMD, diabetic retinopathy, and other retinal diseases, but ranibizumab may have a slightly lower risk of rare side effects due to its shorter exposure in
Este documento resume los resultados de cuatro talleres sobre retinopatía de la prematuridad realizados en Venezuela entre 2006 y 2011. En estos talleres se discutieron temas como los estados con mayor riesgo de ceguera por ROP, el número de niños ciegos y las escuelas para ciegos en el país. Además, se informó que el número de estados con programas de detección y tratamiento de ROP aumentó de 8 en 2005 a 17 en 2011. Los talleres tuvieron la participación de expertos internacionales de países como Perú, Inglater
Este documento describe la retinopatía del prematuro (ROP), una enfermedad vasoproliferativa de la retina que afecta a los bebés prematuros. Explica los factores de riesgo de ROP como la oxigenoterapia excesiva, la hiperglicemia, y los bajos niveles de IGF-1. También propone intervenciones como controlar los niveles de oxígeno, prevenir la hiperglicemia, y usar suplementos de aminoácidos y omega-3 para aumentar los niveles de IGF-1 y
Este documento describe las recomendaciones para el control oftalmológico de pacientes con retinopatía del prematuro (ROP). Se recomienda realizar controles cada 3 meses hasta el año de edad, luego cada 6 meses hasta los 4 años y anualmente hasta los 18 años. Los controles incluyen examen de fondo de ojo, agudeza visual, refracción y otros tests. El objetivo es detectar y tratar cualquier complicación ocular asociada a la ROP como estrabismo, ambliopía o defectos de refracción.
Este documento describe diferentes estrategias y herramientas para la evaluación y tratamiento de problemas de visión en niños de diferentes edades. Se detallan programas de intervención, instrumentos de medición y adaptaciones para niños de 0-3 años, 3-6 años y mayores de 6 años. Incluye información sobre estimulación visual, incorporación de ayudas ópticas y no ópticas, y adaptación de instrumentos como lupas y amplificadores. El objetivo es orientar a padres y profesionales sobre cómo abordar problemas de visión en cada etapa del desarrol
ROP como causa de ceguera en LA y en el mundoEdwin Martinez
La Retinopatía de la Prematuridad (ROP) es una causa importante de ceguera en niños prematuros en Latinoamérica y en el mundo. En Latinoamérica, el 50% de los niños ciegos por ROP se encuentran en esta región. Factores como el aumento de nacimientos prematuros, la mejora en el cuidado neonatal pero la falta de programas adecuados de detección y tratamiento de la ROP contribuyen a una "tercera epidemia" de ceguera por ROP en países de ingresos medios como los de Latino
Este documento describe los cuidados de enfermería para prevenir y tratar la retinopatía del prematuro (ROP) en neonatos. Reconoce la importancia de mantener niveles adecuados de oxígeno para evitar daño a la retina, así como realizar exámenes oftalmológicos y aplicar tratamiento con láser cuando sea necesario. También enfatiza la educación del personal de enfermería para brindar los mejores cuidados posibles a los recién nacidos en riesgo de desarrollar ROP.
Staff study talk/ on search engine & internet in 2008Sujit Chandak
This document provides an overview of internet and web searching. It begins by outlining the objectives of better understanding how to use the internet for teaching and how search engines function. It then defines the internet as a vast global network that connects independent networks through a common internet protocol. It also visualizes the internet. The document discusses how the internet can be used for teaching by providing online resources, information, and collaboration. It defines an internet search and explains how search engines like Google function by using spiders to index pages and return relevant results. Finally, it provides tips for different types of searches like books, definitions, music, groups, blogs, and social networks.
The document outlines an upcoming training on object-oriented design principles and patterns. The training will last 3 hours and cover understanding design principles, patterns, and applying basic patterns. The agenda includes introducing design principles and patterns, as well as a question and answer section. The document provides details on the topics to be covered, including principles of object-oriented design, package architecture, design patterns, and key design concepts.
La retinopatía del prematuro es una enfermedad ocular que afecta a bebés prematuros y puede causar ceguera. Se produce por una interrupción en la vascularización de la retina debido a fluctuaciones en los niveles de oxígeno. Los factores de riesgo incluyen un bajo peso al nacer y exposición excesiva a oxígeno. Se diagnostica mediante examen oftalmológico y se clasifica en 5 estadios según su gravedad. El tratamiento incluye ablación láser de la retina no vascular
This document discusses examples of formwork designs and calculations by Munarus Suluch. It includes diagrams and calculations for formwork for floors, beams, and columns. For beams, it describes calculating the weight carried by the formwork, the moment, controlling for stress and deflection. The same process is described for column formwork calculations.
Gaurav Kumar Singh is an MBA marketing professional with over 4 years of experience in account management, technical sales, and marketing for IT hardware and networking solutions. He is currently a Solution Consultant at Ivalue Infosolution Pvt Ltd in Delhi, where he has contributed to over 100% growth in security and data protection products. He holds an MBA in Marketing and Finance and has experience in key account management, business development, proposal development, and channel management.
Este documento presenta un índice de contenidos para un atlas de urgencias en oftalmología dividido en dos volúmenes. El índice incluye secciones sobre tumores oculares, manifestaciones oftalmológicas de enfermedades sistémicas como el SIDA, la hipertensión arterial y la diabetes, y lista los capítulos y autores de cada volumen.
Este documento describe varias patologías de la retina. Incluye padecimientos congénitos como el albinismo y las fibras nerviosas mielinizadas. También cubre retinopatías vasculares como la serosa central, la de Coats y la del prematuro. Finalmente, analiza retinopatías asociadas a patologías sistémicas como la hipertensiva y la diabética.
Architecture Patterns - Open DiscussionNguyen Tung
This document provides an overview of software architecture fundamentals and patterns, with a focus on architectures for scalable systems. It discusses key quality attributes for architecture like performance, reliability, and scalability. Common patterns for scalable systems are described, including load balancing, map-reduce, and caching. The document also provides a detailed look at architectures used at Facebook, including the architectures for Facebook's website, chat service, and handling of big data. Key aspects of each system are summarized, including the technologies and design principles used.
This document provides an overview of software as a service (SaaS) architecture. It discusses SaaS characteristics and challenges, outlines common SaaS architecture stacks, and describes key considerations for architecting multi-tenant SaaS applications including hosting, application structure, data storage, and security services. Examples of SaaS reference architectures and conceptual models are also presented.
The document discusses microservice architecture, including concepts, benefits, principles, and challenges. Microservices are an architectural style that structures an application as a collection of small, independent services that communicate with each other, often using RESTful API's. The approach aims to overcome limitations of monolithic architectures like scalability and allow for independent deployments. The key principles include organizing services around business domains, automating processes, and designing services to be independently deployable.
VEGF is a growth factor that promotes abnormal blood vessel growth in the retina and causes vision loss. Anti-VEGF drugs like ranibizumab (Lucentis), bevacizumab (Avastin), and pegaptanib (Macugen) work by blocking VEGF and stopping this blood vessel growth. Ranibizumab was designed specifically for eye injections and has a short half-life, while bevacizumab was designed for cancer but is also used "off-label" in the eye. Clinical trials found that both drugs are effective in treating wet AMD, diabetic retinopathy, and other retinal diseases, but ranibizumab may have a slightly lower risk of rare side effects due to its shorter exposure in
Este documento resume los resultados de cuatro talleres sobre retinopatía de la prematuridad realizados en Venezuela entre 2006 y 2011. En estos talleres se discutieron temas como los estados con mayor riesgo de ceguera por ROP, el número de niños ciegos y las escuelas para ciegos en el país. Además, se informó que el número de estados con programas de detección y tratamiento de ROP aumentó de 8 en 2005 a 17 en 2011. Los talleres tuvieron la participación de expertos internacionales de países como Perú, Inglater
Este documento describe la retinopatía del prematuro (ROP), una enfermedad vasoproliferativa de la retina que afecta a los bebés prematuros. Explica los factores de riesgo de ROP como la oxigenoterapia excesiva, la hiperglicemia, y los bajos niveles de IGF-1. También propone intervenciones como controlar los niveles de oxígeno, prevenir la hiperglicemia, y usar suplementos de aminoácidos y omega-3 para aumentar los niveles de IGF-1 y
Este documento describe las recomendaciones para el control oftalmológico de pacientes con retinopatía del prematuro (ROP). Se recomienda realizar controles cada 3 meses hasta el año de edad, luego cada 6 meses hasta los 4 años y anualmente hasta los 18 años. Los controles incluyen examen de fondo de ojo, agudeza visual, refracción y otros tests. El objetivo es detectar y tratar cualquier complicación ocular asociada a la ROP como estrabismo, ambliopía o defectos de refracción.
Este documento describe diferentes estrategias y herramientas para la evaluación y tratamiento de problemas de visión en niños de diferentes edades. Se detallan programas de intervención, instrumentos de medición y adaptaciones para niños de 0-3 años, 3-6 años y mayores de 6 años. Incluye información sobre estimulación visual, incorporación de ayudas ópticas y no ópticas, y adaptación de instrumentos como lupas y amplificadores. El objetivo es orientar a padres y profesionales sobre cómo abordar problemas de visión en cada etapa del desarrol
ROP como causa de ceguera en LA y en el mundoEdwin Martinez
La Retinopatía de la Prematuridad (ROP) es una causa importante de ceguera en niños prematuros en Latinoamérica y en el mundo. En Latinoamérica, el 50% de los niños ciegos por ROP se encuentran en esta región. Factores como el aumento de nacimientos prematuros, la mejora en el cuidado neonatal pero la falta de programas adecuados de detección y tratamiento de la ROP contribuyen a una "tercera epidemia" de ceguera por ROP en países de ingresos medios como los de Latino
Este documento describe los cuidados de enfermería para prevenir y tratar la retinopatía del prematuro (ROP) en neonatos. Reconoce la importancia de mantener niveles adecuados de oxígeno para evitar daño a la retina, así como realizar exámenes oftalmológicos y aplicar tratamiento con láser cuando sea necesario. También enfatiza la educación del personal de enfermería para brindar los mejores cuidados posibles a los recién nacidos en riesgo de desarrollar ROP.
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptxHolistified Wellness
We’re talking about Vedic Meditation, a form of meditation that has been around for at least 5,000 years. Back then, the people who lived in the Indus Valley, now known as India and Pakistan, practised meditation as a fundamental part of daily life. This knowledge that has given us yoga and Ayurveda, was known as Veda, hence the name Vedic. And though there are some written records, the practice has been passed down verbally from generation to generation.
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Does Over-Masturbation Contribute to Chronic Prostatitis.pptxwalterHu5
In some case, your chronic prostatitis may be related to over-masturbation. Generally, natural medicine Diuretic and Anti-inflammatory Pill can help mee get a cure.
9. Clasificación Internacional de la
Retinopatía del Prematuro
Dr. Pedro R Mattar Neri
Medico Oftalmólogo
Saturday, July 23, 2011
10. Es una enfermedad vasoproliferativa de la retina de etiología
multifactorial que ocurre en el niño prematuro
Saturday, July 23, 2011
11. Universo de la ROP
VASCULARIZACION MADURA
L
RMA
NO
ON
CI
RI
ZA 90%
85-
U LA N
SC IO
VA ES
GR
RE
PRO
G RE
RETRASO SIO
DR N
16 semana ROP ACTIVA
SEMANAS
Pathogenesis of retinopathy of prematurity L E.H. Smitth Growth Hormone & IGF Research
14 (2004) S140–S144
Antivascularendothelial growthfactor for retinopathy of prematurity H.A. Mintz-Hittnera et al.
CurrentOpinioninPediatrics2009, 21:182–187
Saturday, July 23, 2011
12. Universo de la ROP
VASCULARIZACION MADURA
L
RMA
NO
ON
CI
RI
ZA 90%
85-
U LA N
SC IO
VA VASCULOGENESESIS ES
GR
RE
FASE I (UTERO HIPOXIA
FISIOLOGICA)
22 - 30 S
PRO
G RE
RETRASO SIO
DR N
16 semana ROP ACTIVA
SEMANAS
Pathogenesis of retinopathy of prematurity L E.H. Smitth Growth Hormone & IGF Research
14 (2004) S140–S144
Antivascularendothelial growthfactor for retinopathy of prematurity H.A. Mintz-Hittnera et al.
CurrentOpinioninPediatrics2009, 21:182–187
Saturday, July 23, 2011
13. Universo de la ROP
OX IN O
ER M T
IA O
IP ER EN
VASCULARIZACION MADURA
)
L
MA
(H ET IMI
R
NO
ON
CI
PR AC
RI
ZA 90%
85-
LA
N
U N
SC IO
VA VASCULOGENESESIS ES
GR
RE
FASE I (UTERO HIPOXIA
FISIOLOGICA)
22 - 30 S
PRO
G RE
RETRASO SIO
DR N
16 semana ROP ACTIVA
SEMANAS
Pathogenesis of retinopathy of prematurity L E.H. Smitth Growth Hormone & IGF Research
14 (2004) S140–S144
Antivascularendothelial growthfactor for retinopathy of prematurity H.A. Mintz-Hittnera et al.
CurrentOpinioninPediatrics2009, 21:182–187
Saturday, July 23, 2011
14. Universo de la ROP
OX IN O
ER M T
IA O
IP ER EN
VASCULARIZACION MADURA
)
L
MA
(H ET IMI
R
NO
ON
CI
PR AC
RI
ZA 90%
85-
LA
N
U N
SC IO
VA VASCULOGENESESIS ES
GR
RE
FASE I (UTERO HIPOXIA
FISIOLOGICA) ANGIOGENESIS
22 - 30 S (NEOV. PATOLOGICA)
PRO
RETRASO FASE II (HIPOXIA)
GR
ESI
O
31 - 45DR N
S
16 semana ROP ACTIVA
SEMANAS
Pathogenesis of retinopathy of prematurity L E.H. Smitth Growth Hormone & IGF Research
14 (2004) S140–S144
Antivascularendothelial growthfactor for retinopathy of prematurity H.A. Mintz-Hittnera et al.
CurrentOpinioninPediatrics2009, 21:182–187
Saturday, July 23, 2011
15. Retinopatía del Prematuro
“ROP es una enfermedad de las Unidades de
Neonatologia y hay que buscarlas en ellas”
J.C. Serrano
Saturday, July 23, 2011
16. Retinopatía del Prematuro
“ROP es una enfermedad de las Unidades de
Neonatologia y hay que buscarlas en ellas”
J.C. Serrano
Saturday, July 23, 2011
18. The International Classification of Retinopathy
of Prematurity (ICROP) 1981-1984
• 1981 Ross Laboratories ROP symp.
• 23 Oftalmologos
• 11 Paises
• Calgary, Alberta, Canada - Sept 1982
• Bethesda, Maryland - Sept 1983
• Arch Ophthalmol 1984;102:1130-1134
• San Francisco, California – 1985 – Further Classification of RD
• Arch Ophthalmol 1987;105:906-912
Saturday, July 23, 2011
19. ICROP- Revisited
Canada - Anna Ells, MD (Co-chair)
United Kingdom - Alistair Fielder, MD
United States -Antonio Capone, Jr., MD
John Flynn, MD
William Good, MD,
Jonathan Holmes, MD
Arch McNamara, MD
Earl Palmer, MD
Graham Quinn, MD, MSCE
(Co-chair)
Michael Shapiro, MD
Michael Trese, MD
David Wallace, MD
Australia - Glen Gole, MD
Sweden - Gerd Holmstrom, MD, PhD ICROP. Arch Ophthalmol.102: 1984
Latin America - Ximena Katz, MD ICROP.R; Arch Ophthalmol.123: 2005
Saturday, July 23, 2011
20. Principio Básico del ICROP-R
“Mientras mas posterior es la
enfermedad, mas retina esta
afectada, mas seria es la
enfermedad”
ICROP.R; Arch Ophthalmol.123: 2005
Saturday, July 23, 2011
21. CLASIFICACION ROP
Localización: Zonas
Extensión: Horas (Reloj)
Severidad:
Estadios 1-5
Aggressive Posterior ROP (AP-ROP)
Plus (+) disease/Pre-plus
ICROP. Arch Ophthalmol.102: 1984
ICROP.R; Arch Ophthalmol.123: 2005
Saturday, July 23, 2011
22. Progresión ROP
Anna Ells M.D. cortesia Graham Quinn M.D.
Saturday, July 23, 2011
23. LOCALIZACION
• Zona I (polo
posterior)
• Zona II (Ora
Serrata Nasal)
• Zona III (Ora
Serrata
Temporal)
ICROP
Saturday, July 23, 2011
24. Zona 1
Cortesía W. Tasman
Cortesía Dr. Gonzalez
Saturday, July 23, 2011
25. EXTENSION
EXTENSION
ICROP
Saturday, July 23, 2011
26. SEVERIDAD
• Inmadura - Sin ROP
• Estadio 1 – Linea Demarcación
• Estadio 2 – Pliegue
• Estadio 3 – Neovascularización Extraretinal desde el
área del pliegue
• Estadio 4 – Desprendimiento parcial de Retina
• Estadio 5 – Desprendimiento Total de Retina
Saturday, July 23, 2011
35. ESTADIO 5
(DR Total)
ICROP
Saturday, July 23, 2011
36. Aggressive Posterior
ROP
• Forma mas Severa, de progresion
rapida
• Retinopatia Virulenta
• Localizacion Posterior
• Agresiva enfermedad Plus
ICROP-R
Saturday, July 23, 2011
37. Indicadores de Severidad
PLUS (+)
•
Moderada tortuosidad y dilatación
Vasos Polo Posterior en presencia de
ROP
•
Vasos del Iris ingurgitados
•
Poca Dilatacion Pupilar
ICROP
Saturday, July 23, 2011
38. Cuanta Tortuosidad es Plus ?
Fotografia Standard
Define la minima dilatacion y tortuosisdad vascular para
Enf. Plus
ETROP, Pediatrics 2005 CRYO-ROP, Arch Ophth 1988
Saturday, July 23, 2011
39. ICROP, Arch Ophth
1984
Plus disease
CRYO-ROP, Arch Ophth 1988
ETROP, Pediatrics 2005
Saturday, July 23, 2011
40. Enfermedad Pre-Plus
Dilatacion insuficiente para Plus, que puede
progresar
ICROP-R
Saturday, July 23, 2011