Early physiotherapy, i.e., started during mechanical ventilation, is considered feasible and safe to improve patient performance and long-term quality of life ( kayambu et al., 2013), although this has not yet been proven in COVID-19. Among chest physiotherapy strategies during mechanical ventilation, mucus clearance and alveolar RMs are very commonly applied in clinical practice. Sputum production was reported in about 34 % of COVID-19 patients ( Guan et al., 2020), thus suggesting that, by promoting mucus clearance during mechanical ventilation, early physiotherapy interventions (such as subglottic secretion drainage, postural hygiene, and ventilator hyperinflation) may produce beneficial effects in this new critically ill population (Thomas et al., 2020).