This document discusses parameters for permitting risky medical treatments when life is in question. It explores how long "chayei sha'ah" or imminent death is considered, how much risk is acceptable, and how to define success. Regarding risk, an operation is only permitted if chances of life and death are equal, not if death is most likely. Success is defined as regular life without the illness, or a situation requiring lifestyle changes but allowing many years of life.
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Despite remarkable advancement of modern medicine in last century, people are still not satisfied with current health care.
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neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
5. CRITERIA FOR RISKY TREATMENTS
Patient will surely die
Complete cure is possible
Most physicians agree
Rabbinic authority agrees
– Rabbi Ya’akov Reischer
6. DEFINING THE PARAMETERS
1 2 3
How long is How much risk is How do we define
chayei sha’ah? acceptable? success?
8. HOW LONG IS CHAYEI SHA’AH?
Despite the fact that the boundary
marking the transition from chayei sha’ah
to long term life expectancy is not clearly
delineated, it is logical to assume that as
long as we know that the illness is
already terminal, regardless of how much
time will pass until death arrives, it is
considered chayei sha’ah.
Rabbi Avraham Yitschak Hakohen Kook
(1865-1935), Mishpat Kohen 144:3
10. HOW LONG IS CHAYEI SHA’AH?
“It does not state clearly the
definition of chayei sha’ah. It is
clear that a life expectancy of one to
two years is not considered chayei
sha’ah, because if so, what is chayei
olam?
Ultimately everyone is mortal, and
what difference is there between one
year or two years, or 100 years, since
no one can live forever? Are we to
categorize all life as chayei sha’ah?
11. HOW LONG IS CHAYEI SHA’AH?
Nor does it appear correct to
say that chayei sha’ah only
refers to a situation in
which the person will die
from the specific illness
[that he is seeking a cure
from] and not from other
ailments; for what
difference should it make
what illness will cause his
death? . . .
12. HOW LONG IS CHAYEI SHA’AH?
[Rather it would appear that] just
as a tereifah is defined as an ill
person who will not live more
than twelve months, so
too, anyone whose illness will not
let him live for more than twelve
months is considered to be in the
category of chayei sha’ah.
However, if the illness will cause
death after twelve months, this is
not chayei sha’ah but chayei olam.
Rabbi Shlomo Kluger (1783-1869), cited
by Darchei Teshuvah, Yoreh De’ah 195:6
13. HOW LONG IS CHAYEI SHA’AH?
tereifah
ravaged / mauled
may die within a year
14. HOW MUCH RISK IS ACCEPTABLE?
However, this [permission to
operate] is only if the chances
of life and death as a result of
the surgery are equal, but not
if, in the majority of cases, the
patient will die as a result of
the operation.
Rabbi Eliezer Waldenberg (1915-2006),
Tsits Eliezer, vol. 10, 25:5
15. HOW MUCH RISK IS ACCEPTABLE?
In a situation when we have
otherwise given up hope, we
disregard chayei sha’ah, even
for a remote possibility that
the patient will be healed.
Rabbi Chaim Ozer Grodzinski (1863-
1940), Achiezer, Yoreh De’ah 16:6
16. HOW DO WE DEFINE SUCCESS?
Regular life is life without the illness that in
the natural course of events, will allow one to
live like any normal person.
Obviously this includes situations where the
patient is expected to be totally healed. . . but
it even includes the more common
situation, in which the patient is weak after
surgery and needs to attend carefully to many
things, such as a proper diet, avoiding
excessive exertion, and often, taking various
medicines in order to avoid a relapse.
17. HOW DO WE DEFINE SUCCESS?
This too, is considered like
the life of a normal
person, since there are many
weak people who need to be
careful about these
matters, and it is possible for
them to live for many
years, just as long as healthy
people, and sometimes even
longer . . .
18. HOW DO WE DEFINE SUCCESS?
If, however, the surgery will only help in that the
patient will be able to continue in his ill state for a
long period of time instead of a short one, and
there is also the possibility that the surgery could
cause immediate death, then, since, even if the
surgery were to be successful, the patient would be
prone to die from this illness at any time, even
though the surgery would create the possibility for
him to go on in this dangerous state for a long
time, it is likely, in my humble opinion, that one
should not permit the surgery.
Rabbi Moses Feinstein (1895-1986),
Igrot Moshe, Yoreh De’ah 2:36
19. APPLYING THIS TO TOM?
Wife’s
Smoke? opinion?
Experts
Drink? concur?
Risks of
Terminal? surgery
Lifestyle
changes?