Reversing diabetes

Consultant Obstetrician & Gynaecologist
M.B.B.S. (Madras), F.R.C.O.G (London)
Board Certified Anti-Aging Physician
ABAARM & IHS
By Datuk Dr. SelvamRengasamy
President, SAHAMM
(Society for Advancement of Hormones
and Healthy Aging Medicine, Malaysia)
SAHAMM ROADSHOW MALACCA , 15thJune 2013

Society for Advancement of Hormones and Healthy Aging Medicine, Malaysia (SAHAMM)
website : www.sahamm.org
email : sahamm020212sec@gmail.com
Tel : 03-62030190 / 016-3078074Fax : 603-62049223
Datuk Dr. Selvam Rengasamy 3

DatukDr. SelvamRengasamy
SPEAKERS
DatukDr. Selvam
Dr. KarelHromek
Prof. Mel Sydney Smith
Dr. Robyn Cosford
CPD Points: 10
4

Datuk Dr. Selvam Rengasamy
Topics:
Introduction to Nutritional Medicine
Nutritional Bio Chemistry
Diabesity
Cancer Causes & Nutritional Support
Children’s Health in the 21stCentury
Pediatric Allergy
InjectableNutrients
The Sensitive Patients
Skin Prick Testing with Practical Demonstrations
5

The SUPERIOR doctor prevents sickness;
The doctor attends to
impending sickness;
The INFERIORdoctor treats actual
sickness.
Chinese Proverb
6

High Blood Glucose
Insulin Excess / Insulin Resistance
Insulin Deficiency
But Treatment Is The Same !!!
DIABETES

INSULIN RESISTANCE
INSULIN RESISTANCE = PRE DIABETES
2.5% Increase In Type 1 Diabetes Annually
9

INCEDENCE OF
HYPERINSULINEMIA
10
TEST
INSULIN
FASTING SUGAR
%
TOTAL TESTED
700
700
47
LEVELS> 11 uU/ml
331
247
35
2007 -2009

INCEDENCE OF
HYPERINSULINEMIA
11
Test
Yr2010
Yr2011
Yr 2012
TOTAL TESTED
468
533
496
LEVELS> 11 uU/ml
223
231
202

12
0
100
200
300
400
500
600
Yr 2010
Yr 2011
Yr 2012
TOTAL TESTED
LEVELS > 11 uU/ml HYPERINSULINEMIA &
PRE - DIABETES
No Of
Patients

02040608010012014016018010-2021-3031-4041-5051-6061-70Gt <5.2Gt >5.2Is <11Is >11
GLUCOSE & INSULIN STUDY
* 2 Years Data
Age Group
Gl<5.2
Gl>5.2
In <11
In >11
10-20
11
8
9
10
21-30
172
25
117
80
31-40
152
80
127
105
41-50
78
67
66
79
51-60
36
45
39
42
61-70
4
22
11
15
Gl ≤5.2
In < 11
Gl 5.2
In > 11
13


Control Blood Sugar

Reduce Glycation-HbA1c

Reduce Oxidative StressControlling Blood Sugar only Does Not Reduce / Prevent Complications
DIABETES

Excess Sugar
Excess HbA1c
Rust In Your Body
Systemic
Once Formed -Permanent & Cannot Be Reversed
Cannot Metabolized Or Eliminated( Until Death Of RBC’S )
HbA1c

INSULIN & HISTORY
1980’s -Insulin Resistance Recognized
AND DIABETES STILL REMAINS IRREVERSIBLE !!!
18

Aging Increases Gluconeogenesis
-3 Times More GluconeogenesisIn The Liver
HYPERGLYCEMIA
INSULIN DOES NOT DECREASE GLUCONEOGENESIS
19

Insulin Is Not The Best Option For Type 2 Diabetes with Insulin Resistance
20
(HYPERINSULINEMIA)

INSULIN

Storage Hormone -Fat

Anabolic Hormone -Muscle

Hypoglycemic

Potassium, Magnesium & Amino Acids into CellsPOTENT INFLAMMATORY HORMONE IN EXCESS !!!
21

Society for Advancement of Hormones and Healthy Aging Medicine, Malaysia (SAHAMM)
website : www.sahamm.orgemail : sahammsec@gmail.com Tel : 03 -62030190 / 016 -3078074Fax : 603 -62061627
HYPERINSULINEMIA
=

Insulin Resistance

Metabolic Syndrome

Syndrome X

Cardio-metabolic Syndrome

CHAOS . . .more terms to come!!!

HYPERINSULINEMIA
A Severe Imbalance Of The Endocrine System -Destroy Our Ability To Metabolize Food
Balanced / Healthy Diet
Replacing The Missing Essential Elements ofNutrition -mostly MINERALS
Correcting Hormone Deficiencies
Exercise
Eliminating Toxins In Food Supply
24

HYPERINSULINEMIA
High Insulin = Chronic Silent Inflammation
CHRONIC
DEGENERATIVE DISEASES

HYPERINSULINEMIA
CAN REMAIN ASYMTOMATIC FOR YEARS
NEED TO SCREEN AND TREAT THIS CONDITION
26


Weight Gain

Sugar Cravings

Intense Hunger

Weakness , Fatique

Need For Frequent Meals

Poor Concentration , Memory Loss

Emotional Instability -Anxiety Or
Panic Attacks
SYMPTOMS
= HYPOGLYCEMIA 27

HYPERINSULINEMIA
FASTING INSULIN
> 11 uU/ ml
HEALTHY LEVELS
5 -7 uU/ ml
28

HYPERINSULINEMIA

Fasting Glucose 3.5 -4.8 mmol/ L

BMI 25 or more

TGL > 1.68 mmol/ L ( 150mg )

HDL < 1.53 (40mg) for men / > 1.93 (50mg ) for women

BP > 130 / 85 mm / Hg

Waist Circumference > 40 in (men) & > 35 (women)
29

INSULIN
INSULIN IN EXCESS IS A DEATH HORMONE
Damages Vascular Endothelium
Promotes Atherosclerosis
Promotes Weight Gain
Promotes Cancer“A SILENT KILLER”
30

Premature Aging
Insulin Resistance
Diabetes Mellitus
Metabolic Syndrome
Hypertension -Angiotensin
Clotting -PAI Complex
HYPERINSULINEMIA
31

HYPERINSULINEMIA
Chronic Degenerative Diseases
Heart Failure, Stroke, Kidney Failure, Impotence, Neuropathy, Retinopathy And A Host Of Other Diseases
Likely To Be Implicated, Very Closely
in ADHD & ADD 32

HYPERINSULINEMIA
Hypertension
Central Obesity
Decreased HDL
Increased TGL
33

HyperinsulinemiaThe
Delta-desaturaseEnzyme
Conversion Of Omega 6 Fatty Acid
To ArachidonicAcid And PGE2
Chronic Silent Inflammation
HEART CONNECTION
34

HEART CONNECTION
“GOOD” Eicosanoids(EPA / DHA)
Decrease Insulin
Inhibited
By EPA
Effects Of Insulin On EFA Production
Activated
By Insulin
Delta 5 Desaturase
Omega 6 Fatty Acids
ArachidonicAcid
“Bad” Eicosanoids
Increase Insulin
Production
35

THROMBOXANE A2
HEART CONNECTION
ARACHIDONIC ACID(Inhibited By Eating Less Insulin-stimulating Carbohydrates, Meat And By Consuming More Cold-water Fish, Fish Oil And Sesame Lignans)
COX –1
(Inhibited By
Low-dose Aspirin)
COX –2
(Inhibited B y Celebrex, Curcumin, ResveratrolAnd Green Tea)
5 -LIPOXYGENASE
(Inhibited By Zyflo, Curcumin And 5-LOXIN)
PROSTAGLANDIN E2
LEUKOTRIENE B4
5 -HETE
Abnormal Platelet Aggregation
Inflammation, Atherosclerosis and Joint Destruction
Interferes With Cancer Cell Death (Apoptosis)
36

Datuk Dr. Selvam
Rengasamy
Hyperinsulinemia Leads To Visceral Fat
Inflammatory Cytokines ( TNF α,
PAI Complex, Adiponectin e.t.c )
&
Free Radicals
Interaction With TNF αReceptors
More Insulin Resistance
OBESITY / INFLAMMATION CONNECTION
37

Decreased IGF-1 Premature Aging
Homocysteine
Leads To Mood And BehaviourDisturbances -Depression, Anxiety, Panic Attacks, ADHD e.t.c
HYPERINSULINEMIA
38

HYPERINSULINEMIA
Increased Uric AcidLevels -Gouty Arthritis
AcanthosisNigricans
Haemochromatosis
39

HYPERINSULINEMIA
ISCHEMIC EVENTS
AN INCREASED SUSCEPTIBILITY TO INFECTIONS (Dental) & INFLAMMATION
INLAMMATION RECOGNISED BY IMMUNE SYSTEM
PATCHES UP THE DAMAGE WITH MACROPHAGES , PLATELETES , FIBRIN , Lip(a), CALCIUM E.T.C.
ATHEROMA
40

More Inflammation
Leaky Gut Syndrome
CANDIDA CONNECTION
1. Intestinal CandidalOvergrowth
2. Increased AGE Products
Host Of Problems Like
Multiple And Changing Food Allergies
Unexplained Illnesses
Fibromyalgia e.t.c.
41

IMMUNE CONNECTION
HyperinsulinemiaSuppresses Immune System
ACTIVATES ONCOGENES
42

INSULIN & CANCER
MetforminAlone –Reduced Cancers
Insulin Alone -80% Higher Risk of Cancer or CVD orDeath from any cause
Insulin + Metformin–31% Higher Risk of the above
Increases IGF-1 Receptors
Cell Proliferation
Increased Cancers esp. GIT & Pancreas
Ref: CardicUniversity 2000-2010 / 84622 PatientsClinEndocrinolMetab. 2013 Jan 31
43

Temporary Glucose Intolerance in Pregnancy -7 Fold Increase in PancreaticCancer Ref: SellaT, ChodickG, BarchanaM , et.al . Cancer Causes Control . 2011 Nov;22 (11:1513- 20)
Gestational Diabetes
& Cancer

INSULIN & DHEA
DHEA
Anti -Diabetic
Anti -Obesity
Anti -Atherogenic
Boost Immune System
Lowers Cancer Risk
Appetite Suppressant
Neuro-Hormone
HYPERINSULINEMIA = LOW DHEA
Ref: NestlerJ.E, Beer N.A, JukubowiczD.J. J ClinEndocrinolMetab, 1994 Mar; 78(3):549 -554 NestlerJ.E, CloreJ.N, BlackardW.G FASEB J, 1992, Sept; 6(12): 3073-75
45

INSULIN & MAGNESIUM
Insulin Is Necessary For Mg Entry Into The CellsHYPERINSULINEMIA = INCREASE URINARY LOSSLOW SERUM MAGNESIUM

Hypertension / CVD

Cardiac Arrhythmias

Migraine, Cramps & etc.

Low Thyroid Function

PMSMore Than 300 Enzymatic Reactions Affected
Ref: Drug the Bull 1995; 33:25-7 Chen MD, Chew WH J Trace Elem Med Biol2001;14:228-31
46

Reduces Blood Pressure
Regulates Heart Rhythm
Improves Nerve Conduction
Reduces Tissue Edema

PMS CONNECTION
Increased Blood Glucose
=
Increase Insulin, Cortisol,
Adrenaline And PRL
48
Estrogen Dominance
Block Progesterone Activity

PCO CONNECTION
Increased Insulin
=
Decreased Conversion Of AndrostenedioneTo Estrogen
Androgen Dominance
49

CORTISOL -INSULIN CONNECTION
Increased Cortisol
Increased Blood Glucose
Increased
Insulin
Chronic
Inflammation
50

HbA1c
The Rust In Your Body
Complex Molecule of Glucose and Protein
Once Formed, Is Permanent & Irreversible
Once Formed , Cannot Be Metabolized & Excreted
Once Formed , Remains In The BodyUntil Death of RBC’s
HbA1C IS INFLAMMATORY
Affects All Cells Optimum Level : < 5% 51

ETIOLOGY
AGEING
Physical Activity
Excess Caloric Intake
Obesity
Insulin Resistance
Vitamin Deficiency ( Vitamins B & D )
Cellular Mineral Deficiencye.g. Chromium, Magnesium, ZincManganese, Vanadium
52

Toxic Overload
Genetics
HYPER INSULINEMIA
RARE CAUSES
Insulinoma
Excess βCells In ThePancreas
53

WHEAT AND DIABETES
GLUTEN
Raises Glucose Level Higher Than Sucrose ( Table Sugar )
Acidic
Inflammatory
Triggers Autoimmune Reaction -Pancreatic Damage
Increases Visceral Fat Inflammation
Insulin Resistance
Diabetes
54

SUGAR
Inflammatory
Suppresses Immune System
Suppresses Hormones
Acidic
55

Artificial Sweeteners & Iron ( Lean Meat) increase Insulin Resistance
HYPER INSULINEMIA
56
Ref: CorkeyBE. BantingLecture 2011. Diabetes . 2012 Jan; 61 (1):4-13

Poor Muscle Mass
Central Obesity
Insulin Resistance
Decrease Physical Performance
Effects On Other Hormones
WATCH XENO –ESTROGENS !!!
HORMONES
57

Testosterone & Diabetes
Mollerfrom 1950 –1984 treated
> 10000 men & women with Testosterone injections to treat D. M, Gangrene & Heart Disease
Ref: Oh JY, Barrett-Connor E et al. Diabetes Care 25:55-60

Decreases Fat Mass
Increases Muscle Mass
Improves OGTT Values
Improves Fasting and Postprandial Blood Sugar
Improves HbA1c
Reduces Diabetic Related Complications & Mortality
Increases Haemoglobin–Beneficial For Dialysis Patients
59
Ref:
Ding EL. Sex Differences of Exogenous Sex hormones and Risk of type II Diabetes.
Journal of the American Medical Association 2006; 295:1288-1299
Hayward RA, ManingWG, Kaplan SH, Wagner EH, Greenfield S. Starting insulin therapy in patients with type 2 diabetes: effectiveness, complications and resource utilization. JAMA. 1997; 278:663-69
GascanAM, BelvisJJ, et al. Nandrolonedecanoateis a good alternative for the treatment of anemia in elderly male patients on hemodialysis. Geriatric Nephrology & Urology. 1999; 9(2):67-72

Testosterone Improves Insulin Sensitivity
Testosterone Increases -Glucose To Glycogen-Glycogen To Glucose↓ Prevents Hypoglycemia
Ref: GasconAA. NandroloneDecanoateis a good Alternative for the treatment of Anaemiain elderly male patients on Hemodialysis. Geriatric Nephrology and Urology. 1999; 9(2):67-72TeruelJL, et al. Androgen versus erythropoietin for the treatment of anaemiain HemodialyzedPatients: A prospective study. Journal American Society of Nephrology. 1996; 7(1):140-4


Average Increase in Muscle Mass -1.2 kg

Average Decrease in Fat Mass -1.5 kgExercise Induced Fat Loss Is Accelerated with Testosterone TherapyRef : BhasinS , StorerTW, Berman N, et al J. of Clin. Endocrinol. and Metabol82: 407-13KupelinnV, Page ST, AramijoAB, et al J. of Clin, Endocrinol, and Metabol91:843-50Wang C, SwerdCoffRS, IranmaneshA, et al J. of Clin. Endocrinoland Metabol85 (8):2839-53
6 MONTHS of TESTOSTERONE

TESTOSTERONE REFERENCES
KapoorD, Goodwin E, et al. Testosterone Replacement Therapy Improves Insulin Resistance, GlycemicControl, Visceral Adiposity & Hypercholesterolemia in HypogonadalMen with Type 2 Diabetes. European Journal of Endocrinology. 2006; 154(6):899-906
American Diabetes Association. Type 2 Diabetes in Children and Adolescents. Diabetes Care. 2000; 3:381-389
Cohen PG. Diabetes mellitus is associated with subnormal levels of free testosterone in men. British Journal of Urology. 2006; 97(3):652-3
Small M, et al. Metabolic Effects of Stanzololin type II Diabetes Mellitus. Hormones Metabolic Research. 1986; 18:647-8

DHEA & DIABETES
“Disease Predicting Hormone ”
Main Actions:
Increases Liver Glucose Oxidation
Reduces Gluconeogenesis( Glycogen to Glucose )
Promotes Fat Loss
Improves Insulin Sensitivity
Balance the effect of Cortisolon Fat Storage
Ref: Lardy H, StratinanF, Elsevier N.Y, 1988;337-42
NestlerJE, Clone JN, BlackardWG J Steroid BiochernMol Vol. 1991;40(6):599-605
NestlerJE, Mc ClanahanMA BallieresChin EndocrinolMetab, 1992 Oct: 6(4):829-47

DHEA & DIABETES

Increases Metabolism ( via Thyroid Function )

Reduces Complications of D.M & Islet Cell Exhaustion

Reduces Appetite

Inhibits Fat Synthesis and Storage
Ref: Cleary MP, Shepherd P, JenitsB, J Nutr. 1984;114:1242-51Coleman DL, LaiterEH, ApplerweigN. Endocrinol1984;115:239-43Kurtz BR, Givens JR et al. Chin EndocrinolMetab(64),1262-67
64

DHEA & REVERSING DIABETES
Low DHEA & Testosterone → High Insulin Levels
DHEA & Free Testosterone have Reverse
correlation with Blood Glucose
DHEA & Free Testosterone improve Insulin
Sensitivity in Aging & Obese Patients
Reduces complications of D.M espAtherosclerosis
65
Ref: Heffner JE, MilainM, AinJ. Respir. Cell Mol (2)1990:257-61
Buffington CK, Givens JR, KitbachiAE Chin. Res (36), 1988:41
Barrett –Corner E, KhawT N. Eng. J. Med. (315), 1986;1519-1524

66
Decreases Obesity
Increases Physical Performance
Reduces Insulin Resistance
Effects On Other Hormones

Increases Metabolism
Reduces Fat Mass
Improves Immune Function
THYROID
67

In Most Cases It Is Curable Permanently, Quickly, Economically And Often Easily And By :
Natural Means: Little Or No Designer Drugs Are Needed
A Cure Will Effect Financially The Orthodox Medical
Community, The Drug Business And The Food Processing Industries
“ In A Time Of Universal Deceit,
Telling The Truth Is A Revolutionary Act”
George Orwell
TREATMENT
68

Inhibit Amylase
Improve Insulin Sensitivity
Reduce Insulin Resistance
Inhibit Glucose -6 -Phosphatase
Increase LeptinLevels
Reduce Leptinresistance
Correct Hormone Deficiencies
Correct Mineral Deficiencies
69
TREATMENT

TREATMENT
DIET & Exercise
Maintain Healthy Weight
70

TREATMENT
-ChlorogenicAcid (Coffee Bean Extract) -White Kidney Bean Extract-Cinnamon-Brown Sea Weed-Fenugreek etc.
Fiber 71

CHROMIUM
Improves Carbohydrate Metabolism
Reduce Blood Sugar
Increases Insulin Receptors
Reduces Appetite (In Higher Doses)
Anti-oxidantDose : 500 -1000 mg / dayRef:AlthuisMD,JordonNEetal.AmJClinNutr76(1)(2002:148-55) AmatoPMoralesAJ,YenSS.JGerontolABiolSciMedSci55(5)(2000:M260-3) BahijriSM.SaudiMedJ21(1)(2000:45-50) BagchiB,StohsSJ,etal.Toxicology180(1)(2002:5-22)
72

ZINC
Constituent of > 300 Metalloenzymes
Improves Carbohydrate Metabolism
Improves Insulin Sensitivity &Pancreatic Function
Useful in Diabetic Leg Ulcers
Anti-oxidant -Improves Immune Function
Useful in Both Type I & II Diabetes
Diabetes Increases Urinary Loss of ZincDose : 25 -50 mg / dayRef:DiSilvestroRA.JNutr130.55Suppl(2000:1509-115) IllouzRetal.BiochemBiophysResCommun295.1(2002:102-6) NiewoehnerCBetal.AMJMed81.1(1986:63-8) HaegerKLannerE.Vasa3.1(1974:77-81) 73

MAGNESIUM
Involved in > 300 Enzymatic Reactions
Improves Glucose Metabolism
Reduces Diabetic Complications e.g. CCF, IHD, Hypertension, ArrhythmiasRef: Paulissoet al. AM J ClinNutr55.6 (1992: 1161-7) Rodriguez -Moran M , Guerrero Romero F. Diabetes Care 26.4(2003:1147-52) Rodriguez -Moran M , Guerrero Romero F. ActaDiabetol39.4(2002:209-13) FrishmanWH, Grattan JG, MamtaniR. Current ProbCardiol30.8(2005:383-459) Rasmussen HS et al. Arch Intern Med 148.2(1988:329-32)
74

ADDITIONAL MINERALS
FOR BETTER GLYCEMIC CONTROL
VANADIUM
MANGANEESE

TAURINE -THE WONDER AMINO ACID
Prevents & Treats Obesity
Reduces Blood Sugar
Prevents Type II Diabetes
Prevents & May Reverse Complication of Diabetes -esp. Cardiovascular + Neuropathy, Retinopathy & Nephropathy
Ref: Zhang M, Bi LF Fang, JH, et al. Amino Acids. 2004 June ;26(3):267-71Tsuboyama–KasaokaN, ShozawaC, et al . Endocrinol. 2006 July;141(7):3276-84FranconiFloizzoA, et al. CurrOpinClinNutrMetabCare. 2006 Jan; 9(1):32-6Kim KS , OhdaH, Kim Jy, et al. Exp Mol Med. 2012 Nov 30;44(11):665-73TippiaPS, ThliverisJ, et al. Exp Clean Cardiol. 2011 Fall;16(3):e 17-22Lee F, AbatanOI. NeurobiolDis. 2006 June ;22(3):669-76Yu X, XuZ, Mi M, et al. NeurochemRes. 2008 Mar; 33(3):500-7

NIACIN (VIT. B3)
Improves Insulin Secretion
Enhances Insulin Sensitivity
Good Results In Early Onset IDDM
Effective In The Prevention of IDDM In Children with Islet Cell AntibodiesDose : 2.5 mg / kg / dayRef:32000populationbasedstudyinNZBingleyPJ,etal.Diabetologia36,675-676,1993ElliotRb,PilcherCC.DiabetesResClinPract14,S85,1991MandrupPaulsenTetal.DiabetesMetabolRev9,295-309,1993
77

Avoid Hydrogenated Oils / Saturated Fats
Omega3 Fatty Acids
Vitamin D₃
REDUCING COMPLICATIONS
78

Natural ANTI INFLAMMATORYAgents: -Curcumin-Quercetin-Bromelain-Boswellia-Ginger
79

Natural ANTI-GLYCATION
Agents:
-Benfothiamine
-Methylcobalamin
-Carnosine
-Alpha LipoicAcid
80

ANTI OXIDANTS -Vit, C, E, D & A-CoQ10-Bio-Flavanoids-Carotenoids
81

HORMONES
Testosterone
DHEA
Thyroid Hormones
Growth Hormones 82

METFORMIN
39 % Reduction In M.I
36 % Reduction In Death From Any Cause
62 % Reduction In Pancreatic Cancer
Kills Cancer Stem Cells NO INCREASE IN LACTIC ACIDOSISRef: Hirsch HA, LliopoulosD, StruhlK. Proc NatlAcadSciUSA. 2013 Jan 15:110(3):972-7
83

Decrease Gluconegenesis(Insulin Has No Such Action)
Increase Insulin Sensitivity
Decrease Sr. Insulin Levels
Decrease TGL
Decrease HbA1c
Activates AMPK -Insulin Signaling -Metabolism Of Glucose And FatsBoth ChlorogenicAcid And CurcuminHas The Same Beneficial Effects
METFORMIN
84

METFORMIN
•
DECREASE GLUCONEOGENESIS
•
INCREASE INSULIN SENSITIVITY
•
DECREASE SERUM INSULIN LEVELS
•
ACTIVATES AMPK -INSULIN SIGNALING -METABOLISM OF GLUCOSE & FATS
•
DECREASE TGL
•
DECREASE HbA1c
METFORMIN -SIDE EFFFECTS
B12 Deficiencies -Increase Homocysteine-B12 & Folic Acid
Decrease Total & Free Testosterone? Sulphonylureas -Increase Weight Gain-Increase CVD
85

REFERENCES
Jung JW, Park SB, Lee SJ, SeoMS -PLoS1. 2011; 6 (11:e), 28068
Hardy TM, TollefsbolTO -Epigenomics. 2011 Aug; 3(4): 503-18
BachmeierBE, MohrenzIV -Carcinogenesis. 2008 Apr ; 29 (4): 779-89
SoerjomataramI, de VriesE, PukkalaE –IntJ Cancer 2007 Mar 15;
120 (6: 1336-43)
Proceedings of Am. Coll. Of Endocrin. Insulin Resis. Aug 25-26, 2002
Endocr. Pract, 2003 Sep-Oct; 9 Suppl2:22-112
Howard, G., etal. Circulation, 1996 May 15;93(10):1809-17
Duvnjak, L. and Duvnjak, M.J PhysiolPharmacol, 2009 Dec,:60 Suppl7:19-24
86

REFERENCES
Endemann, D.H. and Schiffrin, E.L. J MamSoc Nephrol, 2004 Aug; 15(8):1983-92Hemkens, L.G., etal. Diabetologia, 2009 Sep; 52(9):1732-44Samy, N., etal. DisMarkers, 2009:26(4):163-70deKort, S., etal. Leaky Gut ObesRev, 2011 Jun;12(6):449-58Schrijvers, E.M., et al. Neurology, 2010 Nov 30;75(22):1982-7McGeer, E.G. and McGeer, P.L. J AlzheimersDis. 2010;19(1):355-61Matsuzaky, T., et al. Neurology, 2010 Aug 31;75(9):764-70de la Monte, S.M. and Wands, J.R. J Diabetes SciTechnol, 2008 Nov;2(6): 1101-13
87

TREATMENT

Calorie Restriction Prolongs Life –60%

SIRT –1 Gene Activation

Delays Neuro-degeneration
You’re only as good as your last meal !!!
Ref: Tsai LH. J of NeurosienceMay 22, 2013
88

HIGH FRUCTOSE CORN SYRUP
Promotes Obesity More Readily Than Regular Sugar
Increases Appetite (Central Action)
More Addictive Than Cocaine
D.M
C.S.I
This Sugar Cannot Be Used By Muscles For Energy Production
Shunt To Liver -Non Alcoholic
Fatty Liver 89

1800
10
20
30
60
50
70
40
1900
90
80
20
10
40
30
60
50
80
70
10
2000
90
RISE IN SUGAR CONSUMPTION 1800 -2008
Sugar Consumption in pounds per person per year
World WarI
1815
1895
1914
1939
1955
1970
World
War
II
Years
90

OUR CHILDREN
Do We Need To Screen Their Fasting Insulin Levels ?

MILK TOXIN!!!!! Bovine Albumin Peptide
-
βCell AntibodiesRef: Gerstein HC. Diabetes Care 17, 13-19, 1994 92

HYPERINSULINEMIC DIET

C
F
P
Longevity Diet
94

HOMO VITRUVIAN
-DaVinci
HOMOFATRUVIAN
95

HYPERINSULINEMIA
1. have sugar / carbohydrate cravings
2. Eating Carbohydrates gives me temporary boost / energy and mood.
I later crash.
3. I get irritable, tired, anxious and get headaches intermittently but
feel better after meals
4. I feel shaky 2 to 3 hours after a meal
5. I have a family history of Diabetes, Hypoglycemia
6. I have difficulty in loosing weight
7. I feel weak, tired and irritable if I miss a meal
8. I feel sleepy, dull and feel “drugged” after eating a meal full of pasta,
bread, potatoes, rice, desert but feel better after a protein meal
9. I get palpitation after eating sweets
10.I get panic attacks in the afternoon If I skip breakfast
YesNo
QUESTIONAIRE
96

11.
My memory is poor
12.
I get night sweats
13.
I am tired most of the time
14.
My waist –to –Hip ratio is > 0.8
15.
I have polycystic ovaries
16.
I have irregular menses / infertility
17.
I have facial hair (for women only)
18.
I have Heart disease
19.
I have Diabetes Mellitus
20.
I have recurrent fungal infections (vaginal candidiasis, jock itch) If your score is > 7, you are likely to have Hyperinsulinemia / Insulin Resistance
QUESTIONAIRE
YesNo
97

THANK YOU…. For learning Medicine that HEALS and beHEALERS

HYPERINSULINEMIA ON YOUR BRAIN, YOUR BODY AND YOUR HEALTH
Thrombosis
Sti. Growth of Cancer Cells
Inflammation & Oxi. Stress
Homocystine By B6 & Folate
-Affects Methylation Cycle (Broken Brain)
Infertility & Hirsutism

Reversing diabetes

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