ResMed is a global leader in sleep and respiratory medicine focused on developing innovative products and technologies to diagnose, treat, and monitor sleep disorders like sleep apnea as well as respiratory conditions. The company is organized into several business units focused on key strategic initiatives like the link between sleep apnea and cardiovascular disease. ResMed acquired other companies to expand into new areas like ventilation and monitoring technologies and has partnerships to distribute its products more broadly.
Challenges in the management of chronic goutJames Wei 魏正宗
1. The document discusses the challenges in managing chronic gout, including lack of patient awareness and compliance, unmet medical needs of drugs' efficacy and safety in special populations, and doctors' poor adherence to treatment guidelines.
2. It outlines the pathogenesis and progression of hyperuricemia in chronic kidney disease and cardiovascular disease.
3. Newer drugs like febuxostat are presented as promising alternatives to conventional urate-lowering therapies like allopurinol and benzbromarone, which have limitations including difficulty achieving target serum urate levels, potential fatal adverse effects, and reduced efficacy in patients with renal impairment.
1) Thyroid eye disease (TED) is an autoimmune disorder associated with Graves' disease. It can affect the eye muscles, fatty tissue, and optic nerve.
2) Treatment depends on the severity and activity of TED. Mild and inactive cases may only require monitoring. Moderate to severe or active cases are treated with intravenous steroids, radiation therapy, or surgery.
3) Sight-threatening TED requires immediate treatment such as steroids or orbital decompression to reduce pressure on the optic nerve. Rehabilitative surgery can help with functional issues from TED.
The document discusses diabetic peripheral neuropathy (DPN), including its prevalence, impact, signs and symptoms, and strategies for management. DPN is nerve damage caused by diabetes that affects around 50-90% of patients. It can lead to foot ulcers and amputations, as well as other complications. DPN produces both positive symptoms like pain and negative symptoms like numbness. Disease modifying strategies aim to slow progression while symptomatic strategies target pain and other sensations. Diagnostic tests are needed to detect and monitor DPN.
ACTEP2014: Therapeutic hypothermia for ACTEP 2014taem
This document discusses therapeutic hypothermia after cardiac arrest and suggests starting it in the emergency department. It defines therapeutic hypothermia and reviews studies showing improved neurological outcomes when mild hypothermia is induced after cardiac arrest. The benefits of therapeutic hypothermia are explained. Methods for inducing hypothermia in the emergency department are presented, including cold intravenous fluids and surface cooling techniques. The document recommends inducing therapeutic hypothermia for comatose cardiac arrest patients with initial rhythms of ventricular fibrillation or pulseless ventricular tachycardia.
This document presents the 2018 consensus statement of the Section of Regional Anaesthesia and Pain Therapy of the Polish Society of Anaesthesiology and Intensive Therapy on postoperative pain management. It provides guidelines and recommendations based on a review of the latest scientific evidence published since 2014. The guidelines cover appropriate use of opioids and other drugs for postoperative pain relief, and emphasize the importance of multimodal analgesia and the need to individualize treatment to the patient and surgery. Pethidine is not recommended due to concerns about its efficacy and safety profile compared to other opioids.
Fosphenytoin is a prodrug that is metabolized to phenytoin, which works to decrease seizures by blocking sodium channels. It is given parenterally when rapid onset is required to treat seizures or status epilepticus. Fosphenytoin avoids complications of parenteral phenytoin such as poor solubility and tissue irritation. Metabolism occurs primarily in the liver, so patient factors like liver function and other medications affecting protein binding or hepatic metabolism must be considered. Close monitoring is needed due to potential adverse effects like hypotension, rash, and interactions. Interprofessional collaboration optimizes safety when using fosphenytoin in complex patients.
Study of Sensory Nerve Conduction Abnormalities in Hypothyroid PatientsAI Publications
This study evaluated sensory nerve conduction in 50 hypothyroid patients and 50 healthy controls between 18-60 years old. Nerve conduction studies of the median, ulnar, and sural nerves were performed to assess latency, amplitude, and conduction velocity. The median nerve was found to be the most commonly affected nerve in hypothyroid patients, with 56% showing abnormalities. The study found significant decreases in conduction velocity and increases in latency of the median and sural nerves in hypothyroid patients compared to controls. This suggests hypothyroidism can cause demyelinating peripheral neuropathy, especially affecting the median nerve. Estimating nerve conduction values may help diagnose neuropathy in hypothyroidism.
Painful diabetic peripheral neuropathy: diagnosis and managementSudhir Kumar
Diabetes mellitus is a common illness and the prevalence has been increasing all over the world, especially in Asia and India. Diabetes leads to several complications, affecting kidneys, nerves, eyes, brain and heart. The involvement of nerves due to diabetes is called diabetic neuropathy, which can be painful and disabling. The current presentation looks at the symptoms and diagnosis of painful diabetic neuropathy and also the treatment options.
Challenges in the management of chronic goutJames Wei 魏正宗
1. The document discusses the challenges in managing chronic gout, including lack of patient awareness and compliance, unmet medical needs of drugs' efficacy and safety in special populations, and doctors' poor adherence to treatment guidelines.
2. It outlines the pathogenesis and progression of hyperuricemia in chronic kidney disease and cardiovascular disease.
3. Newer drugs like febuxostat are presented as promising alternatives to conventional urate-lowering therapies like allopurinol and benzbromarone, which have limitations including difficulty achieving target serum urate levels, potential fatal adverse effects, and reduced efficacy in patients with renal impairment.
1) Thyroid eye disease (TED) is an autoimmune disorder associated with Graves' disease. It can affect the eye muscles, fatty tissue, and optic nerve.
2) Treatment depends on the severity and activity of TED. Mild and inactive cases may only require monitoring. Moderate to severe or active cases are treated with intravenous steroids, radiation therapy, or surgery.
3) Sight-threatening TED requires immediate treatment such as steroids or orbital decompression to reduce pressure on the optic nerve. Rehabilitative surgery can help with functional issues from TED.
The document discusses diabetic peripheral neuropathy (DPN), including its prevalence, impact, signs and symptoms, and strategies for management. DPN is nerve damage caused by diabetes that affects around 50-90% of patients. It can lead to foot ulcers and amputations, as well as other complications. DPN produces both positive symptoms like pain and negative symptoms like numbness. Disease modifying strategies aim to slow progression while symptomatic strategies target pain and other sensations. Diagnostic tests are needed to detect and monitor DPN.
ACTEP2014: Therapeutic hypothermia for ACTEP 2014taem
This document discusses therapeutic hypothermia after cardiac arrest and suggests starting it in the emergency department. It defines therapeutic hypothermia and reviews studies showing improved neurological outcomes when mild hypothermia is induced after cardiac arrest. The benefits of therapeutic hypothermia are explained. Methods for inducing hypothermia in the emergency department are presented, including cold intravenous fluids and surface cooling techniques. The document recommends inducing therapeutic hypothermia for comatose cardiac arrest patients with initial rhythms of ventricular fibrillation or pulseless ventricular tachycardia.
This document presents the 2018 consensus statement of the Section of Regional Anaesthesia and Pain Therapy of the Polish Society of Anaesthesiology and Intensive Therapy on postoperative pain management. It provides guidelines and recommendations based on a review of the latest scientific evidence published since 2014. The guidelines cover appropriate use of opioids and other drugs for postoperative pain relief, and emphasize the importance of multimodal analgesia and the need to individualize treatment to the patient and surgery. Pethidine is not recommended due to concerns about its efficacy and safety profile compared to other opioids.
Fosphenytoin is a prodrug that is metabolized to phenytoin, which works to decrease seizures by blocking sodium channels. It is given parenterally when rapid onset is required to treat seizures or status epilepticus. Fosphenytoin avoids complications of parenteral phenytoin such as poor solubility and tissue irritation. Metabolism occurs primarily in the liver, so patient factors like liver function and other medications affecting protein binding or hepatic metabolism must be considered. Close monitoring is needed due to potential adverse effects like hypotension, rash, and interactions. Interprofessional collaboration optimizes safety when using fosphenytoin in complex patients.
Study of Sensory Nerve Conduction Abnormalities in Hypothyroid PatientsAI Publications
This study evaluated sensory nerve conduction in 50 hypothyroid patients and 50 healthy controls between 18-60 years old. Nerve conduction studies of the median, ulnar, and sural nerves were performed to assess latency, amplitude, and conduction velocity. The median nerve was found to be the most commonly affected nerve in hypothyroid patients, with 56% showing abnormalities. The study found significant decreases in conduction velocity and increases in latency of the median and sural nerves in hypothyroid patients compared to controls. This suggests hypothyroidism can cause demyelinating peripheral neuropathy, especially affecting the median nerve. Estimating nerve conduction values may help diagnose neuropathy in hypothyroidism.
Painful diabetic peripheral neuropathy: diagnosis and managementSudhir Kumar
Diabetes mellitus is a common illness and the prevalence has been increasing all over the world, especially in Asia and India. Diabetes leads to several complications, affecting kidneys, nerves, eyes, brain and heart. The involvement of nerves due to diabetes is called diabetic neuropathy, which can be painful and disabling. The current presentation looks at the symptoms and diagnosis of painful diabetic neuropathy and also the treatment options.
This document provides an analysis of ResMed, a leading manufacturer of medical equipment for sleep disorders. It begins with an executive summary and overview of the company. It then conducts an external environment analysis, using Porter's Five Forces to examine opportunities and threats in the industry. Finally, it performs an internal analysis of ResMed's value chain and distinctive resources and capabilities. The document analyzes factors influencing ResMed's competitive position in the sleep device industry.
The document describes the process of creating a magazine focused on indie rock music. Key elements incorporated from research include a band index on the contents page adapted from Q Magazine. Advertisements were included related to the genre, such as for Noah and the Whale. An interview with a fictional indie rock artist was created to attract readers. Technologies like Photoshop and PowerPoint were used to design and layout the magazine pages.
Simon Perkins analyzed ResMed's logistics spending and found they could save money by consolidating their three suppliers into one. Negotiating with the new sole supplier, he achieved significant tariff reductions and cost savings for ResMed. This freed up the Operations Manager's time to focus on other responsibilities and allowed ResMed to fulfill more orders. Perkins also worked with ResMed and the supplier to implement a new distribution system allowing customers to pick up orders from local convenience stores, improving the customer experience. As a result of the savings and process improvements, ResMed expressed that Expense Reduction Analysts not only achieved cost savings but enhanced customer relationships.
ResMed is a leading manufacturer of medical devices for sleep-disordered breathing with over 2,500 employees globally. They operate in over 68 countries and have strong financial performance with annual sales over $1 billion. Their main products are masks, accessories, and CPAP machines which treat sleep apnea through continuous positive airway pressure. ResMed aims to increase awareness of sleep apnea, deliver innovative new products, and maximize their global operations to further grow their business.
ResMed is an Australian company that leads the world in developing and marketing products for diagnosing and treating sleep-disordered breathing. It has experienced consistent growth over 10 years, with over $750 million in revenue across major operations in Australia, the US, and Europe. ResMed recently opened a new campus facility in Sydney housing over 800 staff across manufacturing, offices, research labs, and more. Dexion Office provided complex storage solutions for the new campus, installing over 4.5km of lateral filing and storage systems to meet ResMed's various departmental needs.
Treating Agitation and De to an Alphabet Soup of Potential Optionshospira2010
1) The MINDS trial compared haloperidol to placebo for treatment of delirium in mechanically ventilated ICU patients and found no difference in the number of delirium/coma-free days between the two groups.
2) Haloperidol treatment did not reduce the duration of delirium or coma compared to placebo.
3) There was no evidence from this randomized controlled trial that haloperidol is effective for treating delirium in critically ill patients.
A review of epilepsy in the elderly, the etiopathogenesis, clinical challenges, diagnosis, use of antiseizure drugs and outcomes. Also the various special considerations in managing elderly patients with epilepsy.
Epilepsy is a common neurological disorder in the elderly population. Incidence and prevalence of both seizures and epilepsy are highest in those over age 75. The most common causes of epilepsy in the elderly are cerebrovascular disease, brain tumors, and dementia. Seizures may present differently in elderly patients, often appearing as subtle changes in mental status rather than overt convulsions. Treatment involves identifying and managing the underlying cause, with antiseizure drugs chosen based on safety and tolerability over efficacy due to increased risk of interactions and side effects. Careful dosing and monitoring is needed due to age-related changes in pharmacokinetics and pharmacodynamics.
This document discusses considerations for anaesthetists regarding patients with epilepsy. It notes that anaesthetists should be concerned about potential drug interactions, predisposition to seizures during surgery, and certain anaesthetic drugs having epileptogenic properties. It then covers classifications of seizures, diagnostic investigations like EEG and MRI, medical and surgical management options, the pharmacophysiology of epilepsy treatment, preferred anti-epileptic drugs, status epilepticus, and surgical options. It concludes with specific considerations for various anaesthetic drugs and muscle relaxants regarding their propensity to cause seizures.
This document provides an overview of rapid sequence intubation (RSI) drugs and techniques. It discusses the "7 P's" approach to RSI, with a focus on pretreatment to reduce reflex sympathetic responses and potential increases in intracranial pressure. A number of induction agents (midazolam, thiopental, propofol, ketamine, etomidate) and paralytics (succinylcholine, rocuronium) are reviewed, noting their hemodynamic and other effects. The risks and benefits of different options are considered depending on the patient's condition, such as risk of adrenal suppression with etomidate in sepsis. Overall it emphasizes selecting drugs carefully based on individual patient
Neuroreceptor Modulation Will Deliver Many Different Flavorshospira2010
The document discusses neuroreceptor modulation and delirium. It begins by defining delirium and its various subtypes. It then discusses the pathophysiology of delirium, including several hypotheses such as neurotransmitter imbalance, oxygen deprivation, and inflammation. Specifically, it explores how decreased acetylcholine and excess dopamine may contribute to delirium symptoms. The document also notes pharmacologic risk factors for delirium and potential mechanisms involving various neurotransmitter systems.
Haloperidol is the “Go To” Drug for Delirium: But are Atypicals a Better Option?hospira2010
1) A randomized controlled trial compared haloperidol to placebo for treatment of delirium in critically ill patients. It found no significant differences between groups in days alive without delirium or coma, duration of delirium, or other outcomes.
2) Another randomized controlled trial compared quetiapine to placebo for treatment of delirium. It found that patients receiving quetiapine had significantly faster resolution of delirium compared to placebo.
3) While haloperidol is commonly used to treat delirium, evidence from randomized trials does not clearly support its use over alternatives like atypical antipsychotics.
This document discusses obstructive sleep apnea (OSA) from an ophthalmologic perspective. It defines OSA and describes its prevalence. It outlines the ophthalmologist's role in identifying OSA and discusses various ocular associations with OSA including floppy eyelid syndrome, glaucoma, non-arteritic ischemic optic neuropathy, papilledema, and keratoconus. It then describes a proposed study at Dasman Institute to examine the prevalence of optic neuropathies in patients with moderate-severe OSA and determine if treatment affects these conditions.
The document describes a case of delirium in an 81-year-old man. He presented with fever, confusion, and urinary retention and was diagnosed with a urinary tract infection. His risk factors for delirium included older age, hypertension, smoking, and acute infection. Non-pharmacological management includes ensuring nutrition, safety precautions, and early rehabilitation. Atypical antipsychotics in low doses may help control symptoms, though the prognosis depends on resolving the underlying medical issues. Preventing delirium requires a multidisciplinary approach and addressing reversible risk factors.
Лікувальна гіпотермія новонароджених із гіпоксично-ішемічною енцефалопатієюMCH-org-ua
1) Therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy has been shown to reduce mortality and morbidity when initiated before 6 hours of life.
2) Studies have found hypothermia reduces brain injury as seen on MRI and lowers rates of cerebral palsy, cognitive impairment, and death when compared to normothermia.
3) While mid-term outcomes up to age 7 show benefits of hypothermia, long-term follow up is still needed to fully understand impacts on neurocognitive, behavioral, and social development into childhood. Combining hypothermia with neuroprotective drugs is a promising area for further research.
Therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathyMCH-org-ua
International conference «Actual approaches to the extremely preterm babies: International experience and Ukrainian realities» (Kyiv, Ukraine, March 5-6, 2013)
The document summarizes key concepts related to common symptoms experienced by cancer patients, including dyspnea, cancer-related fatigue, and pain. It defines each symptom, discusses prevalence, potential causes, and approaches to management. For each symptom, it provides details on pharmacological and non-pharmacological treatment options. The document is intended to educate healthcare providers on assessing and managing these important symptoms experienced by cancer patients.
This document discusses novel strategies for treating anemia, including erythropoietin mimetic peptides and hypoxia-inducible factor stabilizers. It provides a history of erythropoietin discovery and treatment of anemia in chronic kidney disease patients. Two clinical trials of the erythropoietin mimetic peginesatide showed it was effective at maintaining hemoglobin levels but also found an increased risk of cardiovascular events. Other experimental erythropoietin therapies mentioned include CNTO 528-530 peptides and modified erythropoietin-albumin fusion proteins. HIF stabilizers are also discussed as a potential future anemia treatment by upregulating endogenous erythropoietin production.
This document summarizes key points about pain management in dementia and new developments in opioid use. It discusses the high prevalence of pain in older adults and undertreatment of pain in dementia patients. Cognitive impairment makes pain assessment challenging, requiring evaluation of behaviors, medical history and empirical trials. General factors like reduced liver and kidney function in older adults affect drug absorption and elimination. The document reviews guidelines for opioid use in dementia, emphasizing hydromorphone, oxycodone, fentanyl and methadone. It also discusses new opioids like tapentadol and tramadol, as well as transdermal patches and modified release formulations.
This document provides an analysis of ResMed, a leading manufacturer of medical equipment for sleep disorders. It begins with an executive summary and overview of the company. It then conducts an external environment analysis, using Porter's Five Forces to examine opportunities and threats in the industry. Finally, it performs an internal analysis of ResMed's value chain and distinctive resources and capabilities. The document analyzes factors influencing ResMed's competitive position in the sleep device industry.
The document describes the process of creating a magazine focused on indie rock music. Key elements incorporated from research include a band index on the contents page adapted from Q Magazine. Advertisements were included related to the genre, such as for Noah and the Whale. An interview with a fictional indie rock artist was created to attract readers. Technologies like Photoshop and PowerPoint were used to design and layout the magazine pages.
Simon Perkins analyzed ResMed's logistics spending and found they could save money by consolidating their three suppliers into one. Negotiating with the new sole supplier, he achieved significant tariff reductions and cost savings for ResMed. This freed up the Operations Manager's time to focus on other responsibilities and allowed ResMed to fulfill more orders. Perkins also worked with ResMed and the supplier to implement a new distribution system allowing customers to pick up orders from local convenience stores, improving the customer experience. As a result of the savings and process improvements, ResMed expressed that Expense Reduction Analysts not only achieved cost savings but enhanced customer relationships.
ResMed is a leading manufacturer of medical devices for sleep-disordered breathing with over 2,500 employees globally. They operate in over 68 countries and have strong financial performance with annual sales over $1 billion. Their main products are masks, accessories, and CPAP machines which treat sleep apnea through continuous positive airway pressure. ResMed aims to increase awareness of sleep apnea, deliver innovative new products, and maximize their global operations to further grow their business.
ResMed is an Australian company that leads the world in developing and marketing products for diagnosing and treating sleep-disordered breathing. It has experienced consistent growth over 10 years, with over $750 million in revenue across major operations in Australia, the US, and Europe. ResMed recently opened a new campus facility in Sydney housing over 800 staff across manufacturing, offices, research labs, and more. Dexion Office provided complex storage solutions for the new campus, installing over 4.5km of lateral filing and storage systems to meet ResMed's various departmental needs.
Treating Agitation and De to an Alphabet Soup of Potential Optionshospira2010
1) The MINDS trial compared haloperidol to placebo for treatment of delirium in mechanically ventilated ICU patients and found no difference in the number of delirium/coma-free days between the two groups.
2) Haloperidol treatment did not reduce the duration of delirium or coma compared to placebo.
3) There was no evidence from this randomized controlled trial that haloperidol is effective for treating delirium in critically ill patients.
A review of epilepsy in the elderly, the etiopathogenesis, clinical challenges, diagnosis, use of antiseizure drugs and outcomes. Also the various special considerations in managing elderly patients with epilepsy.
Epilepsy is a common neurological disorder in the elderly population. Incidence and prevalence of both seizures and epilepsy are highest in those over age 75. The most common causes of epilepsy in the elderly are cerebrovascular disease, brain tumors, and dementia. Seizures may present differently in elderly patients, often appearing as subtle changes in mental status rather than overt convulsions. Treatment involves identifying and managing the underlying cause, with antiseizure drugs chosen based on safety and tolerability over efficacy due to increased risk of interactions and side effects. Careful dosing and monitoring is needed due to age-related changes in pharmacokinetics and pharmacodynamics.
This document discusses considerations for anaesthetists regarding patients with epilepsy. It notes that anaesthetists should be concerned about potential drug interactions, predisposition to seizures during surgery, and certain anaesthetic drugs having epileptogenic properties. It then covers classifications of seizures, diagnostic investigations like EEG and MRI, medical and surgical management options, the pharmacophysiology of epilepsy treatment, preferred anti-epileptic drugs, status epilepticus, and surgical options. It concludes with specific considerations for various anaesthetic drugs and muscle relaxants regarding their propensity to cause seizures.
This document provides an overview of rapid sequence intubation (RSI) drugs and techniques. It discusses the "7 P's" approach to RSI, with a focus on pretreatment to reduce reflex sympathetic responses and potential increases in intracranial pressure. A number of induction agents (midazolam, thiopental, propofol, ketamine, etomidate) and paralytics (succinylcholine, rocuronium) are reviewed, noting their hemodynamic and other effects. The risks and benefits of different options are considered depending on the patient's condition, such as risk of adrenal suppression with etomidate in sepsis. Overall it emphasizes selecting drugs carefully based on individual patient
Neuroreceptor Modulation Will Deliver Many Different Flavorshospira2010
The document discusses neuroreceptor modulation and delirium. It begins by defining delirium and its various subtypes. It then discusses the pathophysiology of delirium, including several hypotheses such as neurotransmitter imbalance, oxygen deprivation, and inflammation. Specifically, it explores how decreased acetylcholine and excess dopamine may contribute to delirium symptoms. The document also notes pharmacologic risk factors for delirium and potential mechanisms involving various neurotransmitter systems.
Haloperidol is the “Go To” Drug for Delirium: But are Atypicals a Better Option?hospira2010
1) A randomized controlled trial compared haloperidol to placebo for treatment of delirium in critically ill patients. It found no significant differences between groups in days alive without delirium or coma, duration of delirium, or other outcomes.
2) Another randomized controlled trial compared quetiapine to placebo for treatment of delirium. It found that patients receiving quetiapine had significantly faster resolution of delirium compared to placebo.
3) While haloperidol is commonly used to treat delirium, evidence from randomized trials does not clearly support its use over alternatives like atypical antipsychotics.
This document discusses obstructive sleep apnea (OSA) from an ophthalmologic perspective. It defines OSA and describes its prevalence. It outlines the ophthalmologist's role in identifying OSA and discusses various ocular associations with OSA including floppy eyelid syndrome, glaucoma, non-arteritic ischemic optic neuropathy, papilledema, and keratoconus. It then describes a proposed study at Dasman Institute to examine the prevalence of optic neuropathies in patients with moderate-severe OSA and determine if treatment affects these conditions.
The document describes a case of delirium in an 81-year-old man. He presented with fever, confusion, and urinary retention and was diagnosed with a urinary tract infection. His risk factors for delirium included older age, hypertension, smoking, and acute infection. Non-pharmacological management includes ensuring nutrition, safety precautions, and early rehabilitation. Atypical antipsychotics in low doses may help control symptoms, though the prognosis depends on resolving the underlying medical issues. Preventing delirium requires a multidisciplinary approach and addressing reversible risk factors.
Лікувальна гіпотермія новонароджених із гіпоксично-ішемічною енцефалопатієюMCH-org-ua
1) Therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy has been shown to reduce mortality and morbidity when initiated before 6 hours of life.
2) Studies have found hypothermia reduces brain injury as seen on MRI and lowers rates of cerebral palsy, cognitive impairment, and death when compared to normothermia.
3) While mid-term outcomes up to age 7 show benefits of hypothermia, long-term follow up is still needed to fully understand impacts on neurocognitive, behavioral, and social development into childhood. Combining hypothermia with neuroprotective drugs is a promising area for further research.
Therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathyMCH-org-ua
International conference «Actual approaches to the extremely preterm babies: International experience and Ukrainian realities» (Kyiv, Ukraine, March 5-6, 2013)
The document summarizes key concepts related to common symptoms experienced by cancer patients, including dyspnea, cancer-related fatigue, and pain. It defines each symptom, discusses prevalence, potential causes, and approaches to management. For each symptom, it provides details on pharmacological and non-pharmacological treatment options. The document is intended to educate healthcare providers on assessing and managing these important symptoms experienced by cancer patients.
This document discusses novel strategies for treating anemia, including erythropoietin mimetic peptides and hypoxia-inducible factor stabilizers. It provides a history of erythropoietin discovery and treatment of anemia in chronic kidney disease patients. Two clinical trials of the erythropoietin mimetic peginesatide showed it was effective at maintaining hemoglobin levels but also found an increased risk of cardiovascular events. Other experimental erythropoietin therapies mentioned include CNTO 528-530 peptides and modified erythropoietin-albumin fusion proteins. HIF stabilizers are also discussed as a potential future anemia treatment by upregulating endogenous erythropoietin production.
This document summarizes key points about pain management in dementia and new developments in opioid use. It discusses the high prevalence of pain in older adults and undertreatment of pain in dementia patients. Cognitive impairment makes pain assessment challenging, requiring evaluation of behaviors, medical history and empirical trials. General factors like reduced liver and kidney function in older adults affect drug absorption and elimination. The document reviews guidelines for opioid use in dementia, emphasizing hydromorphone, oxycodone, fentanyl and methadone. It also discusses new opioids like tapentadol and tramadol, as well as transdermal patches and modified release formulations.
This document reviews acute respiratory distress syndrome (ARDS), fat embolism, and thromboembolic disease in orthopaedic trauma patients. It discusses the history, diagnosis, classification, epidemiology, pathophysiology, and treatment of ARDS, fat embolism, and venous thromboembolism (VTE). For ARDS, it outlines the Berlin Definition criteria and risk factors. It describes the two main theories for the pathophysiology of fat embolism. The document also reviews prevention and treatment strategies for fat embolism and VTE in orthopaedic trauma patients.
1) Pulmonary arterial hypertension (PAH) occurs in approximately 5% of adults with congenital heart disease (CHD) and accounts for 40-50% of PAH in children.
2) PAH is associated with increased mortality and morbidity in patients with CHD, with a 10-fold increase in mortality for those with Eisenmenger syndrome.
3) Targeted therapies have shown benefits for treating PAH in patients with CHD, though survival remains poor compared to other forms of PAH. Earlier diagnosis and treatment may help improve outcomes.
1) The document discusses guidelines developed by Dr. Papadakos for sedation of critically ill patients, including the first use guidelines for propofol in neurosurgery patients and development of protocols for sedation in critically ill patients.
2) It describes goals of sedation in the ICU as well as characteristics of an ideal sedation agent. Common sedative drugs used in the ICU like benzodiazepines, propofol, and dexmedetomidine are discussed along with their mechanisms of action, pharmacodynamics, clinical effects, and limitations.
3) Sedation scales used to assess level of sedation like the Ramsay and SAS scales are also summarized.
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Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Does Over-Masturbation Contribute to Chronic Prostatitis.pptxwalterHu5
In some case, your chronic prostatitis may be related to over-masturbation. Generally, natural medicine Diuretic and Anti-inflammatory Pill can help mee get a cure.
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Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
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share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system