We guard the poor shores, Deep seas no one explores.
The research in India goes way back of BCE yet all we toil about now is the bigotry. One needs to reform to pay respect to the people who established the present era.
The beginnings of astronomy are related to the requirements of the ritual in early cultures. Ritual was a means of securing divine approval and support for terrestrial actions. To be effective, it had to be elaborate and well-timed, so that a careful distinction could be made between auspicious and inauspicious times.
(Note that mathematical problems such as obtaining the square root of two and approximate value of pi ( circumference of a circle divided by its diameter) were taken up in the context of preparation of fire altars and are discussed in the Shrautasutras.)
Since planetary motions provided a natural means of time keeping and were seen as couriers of divine signals. Skies were therefore regularly monitored. This was the beginning of astronomy as an intellectual discipline.
Ancient Indian astronomical tradition: Characteristics and accomplishmentsRajesh Kochhar
We begin by commenting on the nature and limitations of the primary source material on ancient Indian astronomy.We then highlight the accomplishments of Indian astro-mathematical tradition and its place in world history.
Amazing facts about astronomy in ancient India from a publication in 1790, published in the Transactions of the Royal Society of Edinburgh. The amazing fact is that astronomical calculations made more than 6000 years ago are in total agreement with the theory of gravity! It also shows how extremely sophisticated Indian mathematics was, and that most of the mathematics attributed to the Greeks actually originated in India, including the theorem attributed to Pythagoras! A must watch...
We as Indians have failed to understand the deep and real meaning of the holy Vedas and Hindu culture texts written by the great sages and our ancestors. Psychologically, if we look, any knowledge from our ancient times can be easily understood by adding some personal relevance around the subject to show it through storytelling, making it interesting and easy for the listener to remember. However, this concept given by our sages was not properly adopted by future generations, took only symbolic meaning without understanding it scientifically and due to lack of understanding of the original deep knowledge, a great blow was inflicted on the social, economic and spiritual spheres. Every knowledge, literature, concept written as some message is actually a deep scientific and technical concept, information about composition, medicine and surgery, advice on physical, mental and social health, nurturing and balancing of environment, life management and work management, political and economic considerations. The main objective was to create a socially, economically, spiritually healthy society so that the country and the world would progress at the same time with the theme “Vasudhaiva Kutumbakam”.
Advances in science and technology are the main reason for the growth of human civilization. India has been contributing in the field of science and technology since ancient times. Even today what we call “traditional knowledge” is actually based on scientific reasoning.
Veer Savarkar wanted, “Not only a particular caste, but everyone should raise the standard of living by developing modern technology using Vedic literature”.
Lokmanya Tilak had a very in-depth study of Vedic knowledge, a treatise can be written on his knowledge.
Hindu ancestors, sages put this great knowledge not only on paper but at that time with great skill and design many concepts were practically implemented on the ground. We can see various temples, metalwork, architectural beauty, mathematics, surgical methods….
Physics
The German physicist Werner Heisenberg once said … “About Indian philosophy, some of the ideas of quantum physics that seemed so crazy suddenly became more meaningful”.
The concepts of atoms, molecules and substances can be traced back to the Vedic age. Moreover, the concepts of astronomy, metaphysics and spirituality are described in the Rig Veda, the ancient Hindu scriptures of the Vedic period.
Why have Indians built thousands, so incredibly architecturally amazing temples around the world? Were they rich enough to spend money on this venture?
Yes, their eternal Sanatan Hindu culture gave them wisdom, intelligence, hard work, spirituality and most importantly progress in the field of research, the purpose behind which was to make humanity prosperous and peaceful.
The German philosopher Gottfried von Herder once said, “The origin of mankind can be traced back to India where the human mind got its first shape of wisdom and virtue.”These copper plates absoBS
Brief Presentation covering Introduction to Indian Knowledge System. This is based first two chapter of reference book, as per New Education Policy 2020 (NEP 2020)
The beginnings of astronomy are related to the requirements of the ritual in early cultures. Ritual was a means of securing divine approval and support for terrestrial actions. To be effective, it had to be elaborate and well-timed, so that a careful distinction could be made between auspicious and inauspicious times.
(Note that mathematical problems such as obtaining the square root of two and approximate value of pi ( circumference of a circle divided by its diameter) were taken up in the context of preparation of fire altars and are discussed in the Shrautasutras.)
Since planetary motions provided a natural means of time keeping and were seen as couriers of divine signals. Skies were therefore regularly monitored. This was the beginning of astronomy as an intellectual discipline.
Ancient Indian astronomical tradition: Characteristics and accomplishmentsRajesh Kochhar
We begin by commenting on the nature and limitations of the primary source material on ancient Indian astronomy.We then highlight the accomplishments of Indian astro-mathematical tradition and its place in world history.
Amazing facts about astronomy in ancient India from a publication in 1790, published in the Transactions of the Royal Society of Edinburgh. The amazing fact is that astronomical calculations made more than 6000 years ago are in total agreement with the theory of gravity! It also shows how extremely sophisticated Indian mathematics was, and that most of the mathematics attributed to the Greeks actually originated in India, including the theorem attributed to Pythagoras! A must watch...
We as Indians have failed to understand the deep and real meaning of the holy Vedas and Hindu culture texts written by the great sages and our ancestors. Psychologically, if we look, any knowledge from our ancient times can be easily understood by adding some personal relevance around the subject to show it through storytelling, making it interesting and easy for the listener to remember. However, this concept given by our sages was not properly adopted by future generations, took only symbolic meaning without understanding it scientifically and due to lack of understanding of the original deep knowledge, a great blow was inflicted on the social, economic and spiritual spheres. Every knowledge, literature, concept written as some message is actually a deep scientific and technical concept, information about composition, medicine and surgery, advice on physical, mental and social health, nurturing and balancing of environment, life management and work management, political and economic considerations. The main objective was to create a socially, economically, spiritually healthy society so that the country and the world would progress at the same time with the theme “Vasudhaiva Kutumbakam”.
Advances in science and technology are the main reason for the growth of human civilization. India has been contributing in the field of science and technology since ancient times. Even today what we call “traditional knowledge” is actually based on scientific reasoning.
Veer Savarkar wanted, “Not only a particular caste, but everyone should raise the standard of living by developing modern technology using Vedic literature”.
Lokmanya Tilak had a very in-depth study of Vedic knowledge, a treatise can be written on his knowledge.
Hindu ancestors, sages put this great knowledge not only on paper but at that time with great skill and design many concepts were practically implemented on the ground. We can see various temples, metalwork, architectural beauty, mathematics, surgical methods….
Physics
The German physicist Werner Heisenberg once said … “About Indian philosophy, some of the ideas of quantum physics that seemed so crazy suddenly became more meaningful”.
The concepts of atoms, molecules and substances can be traced back to the Vedic age. Moreover, the concepts of astronomy, metaphysics and spirituality are described in the Rig Veda, the ancient Hindu scriptures of the Vedic period.
Why have Indians built thousands, so incredibly architecturally amazing temples around the world? Were they rich enough to spend money on this venture?
Yes, their eternal Sanatan Hindu culture gave them wisdom, intelligence, hard work, spirituality and most importantly progress in the field of research, the purpose behind which was to make humanity prosperous and peaceful.
The German philosopher Gottfried von Herder once said, “The origin of mankind can be traced back to India where the human mind got its first shape of wisdom and virtue.”These copper plates absoBS
Brief Presentation covering Introduction to Indian Knowledge System. This is based first two chapter of reference book, as per New Education Policy 2020 (NEP 2020)
Samartha Bharat Parva is the celebration of Strength of India, observed from 25th December - the first day of Swami Vivekananda’s meditation on Rock in 1892 to 12th January – Swami Vivekananda’s birth anniversary.
http://www.vivekanandakendra.org
The pandemic has led to disruption of most ongoing educational efforts. It is feared that overtime many students are expected not to resume their education due to varied reasons (family, technological, personal etc.). Here are my two cents, striving to come up with a framework for organisations educating the marginalized section.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
2. INTRODUCTION
• A large number of researchers have started to discover references to the
latest scientific discoveries in the Vedic passage.
• The most recent twist tale being of the flying machine of Maharishi
Bharadwaj.
It took a team of researchers from IISC to put the rumors at rest.
• On the contrast though attempts have been made to patent gayatri mantra,
haldi and there is not a single patent by us on aloe vera¹ though it ‘s use has
been mentioned through out the Indian history.
• An attempt has been made to make the Vedas and meaning ²accessible to all.
• Ignorance could be bliss but believing a distorted history can be adverse.
¹“A study of patenting activity in aloe vera”- JIPR-
2002
² http://yg.cse.iitk.ac.in/Hinduism/
3. INDUS VALLEY CIVILIZATION
Mohenjo-daro’s
Ring stones
Standardized Harappan system of
weights- Dual binary decimal
progression(1,2,4,8,16,32,64,160,200.)
Kalibangan’s terracotta scale- unit
of 1.75cm³.
Arthashatra’s angul appears to be
10 lothal units.
³Analysed by Prof. R. Balasubramaniam, IITK
4. HISTORICAL ERA:
In the Sulabhsutras (6thBC)
complex geometry of fire
altars are mentioned.
Algebra did not exist.
It gives a geometric
expresssion for the
Pythagoras Theorem.
Other geometric expressions
are stated too. (√2,fractions..)
5. HISTORICAL ERA:
Pingala’s treatise
Chhandashastra gives verse
meter for verses ,identical to
binary notation.
Arabic Numerals and all
Indian numerals (except
Tamil) can be traced to
Brahmi script.
Evolution of numeral 4 by Georges Ifrah
Brahmgupta gave the
mathematical definition of
infinity.
Time scale, measurement was
way beyond.
6. Acharya Kanad
He was born around 600BC.
the founder of ” Vaisheshik Darshan “² - one of six
principal philosophies of India
A great philosopher who proposed the idea
of anu as the smallest indivisible particle.
² http://yg.cse.iitk.ac.in/Hinduism/
7. Acharya Charak (600BC)
He is crowned as the Father of
Medicine
His renowned work, the ”
Charak Samhita “, is considered as an
encyclopedia of Ayurveda ².
In the ” Charak Samhita ” he has
described the medicinal qualities and
functions of 100,000 herbal plants.
He has emphasized the influence of
diet and activity on mind and body
8. Acharya Sushrut (600 BC)
He details the first ever surgery procedures in ” Sushrut
Samhita ”.
He describes 125 types of surgical instruments and 300
types of operation.
He has also described use of anaesthesia and a number
of stitching methods.
9. Acharya Patanjali (200 BC)
He is considered as Father
of Yoga.
His 84 yogic postures
effectively enhance the
efficiency of the systems
and organs of the body.
As per him ultimate bliss lies
in Asthang yog :yam, niyam,
asan, pranayam, pratyahar,
dhyan, dharna and samadhi.
http://oer.nios.ac.in/wiki/index.php/Ashtang_Yog
10. Nagarjuna (931 AD)
He was a metallurgist and alchemist.
He authored ” Ras Ratnakar ,” “Rashrudaya” and “Rasendramangal”
which are renowned research in chemistry.
Extraction of metals such as silver, gold, tin and copper from their
ores and their purification were also mentioned in the treatise.
He also wrote “Arogyamanjari”, “Kakshaputatantra”,”Yogasara” and
“Yogasatak” on lines of Ayurvedic treatise.
His uttaratantra is a supplement to Sushutrasamhita, dealing with
preparation of medicinal drugs.
He was also appointed as Chancellor of the famous University of
Nalanda.
11. Aryabhatt (476-550 CE)
At the age of 23, he wrote a text on astronomy and an unparallel treatise
on mathematics called “Aryabhatiyam.”
The mathematical part of the Aryabhatiya covers arithmetic, algebra,
plane trigonometry, and spherical trigonometry, continued fractions,
quadratic equations, sums-of-power series, and a table of sines.
Arya-siddhanta, a lost work on astronomical computations, is known
through the writings of his contemporary, Varahamihira, and later
mathematicians and commentators, including Brahmagupta and Bhaskara
I.
Laplace (early 19th century) wrote testimonial for his great achievement.
12. CONCLUSIONS
• Our is an ancient and rich nation.
• The study of ancient knowledge is legitimate but discovering it after those
discoveries are made is not beneficial.
• Every year several manuscripts are destroyed, sold or just rot away. It always
takes a foreigner to tell us our tales.
• If we care least for our heritage than we deserve the least of it. And a false
sense of pride is of no good at all.
13. REFERENCES
• A study of patenting activity in aloe vera”-
http://nopr.niscair.res.in/bitstream/123456789/4929/1/JIPR%207(4)%203
30-341.pdf
• http://yg.cse.iitk.ac.in/Hinduism/
• http://oer.nios.ac.in/wiki/index.php/Ashtang_Yog
• http://www.iisc.ernet.in/prasthu/pages/PP_data/105.pdf
• The universal history of numbers-From prehistory to invention of
computer, George Ifrah (Penguin Books, 2005, 3 vols)
• Geometry in Ancient and Medieval India, T.A. Sarasvati Amma(Motilal
Banarasidas,1999)
• History of Technology in India, ed. A.K. Bag(Indian National Science
Academy 1997)
Editor's Notes
First 4 of ashtang yog can be practiced by all and last 4 only by rishis.