Reply in a well-developed paragraph (300-350 words) to each Response , integrating an evidence-based resources. Respectfully agree and disagree with your peers’ responses and explain your reasoning by including your rationales in your explanation. Response 1 The purpose of this week’s discussion post is to describe two diagnoses and the medications used for their symptoms. This week I will be focusing on migraines and insomnia. Both conditions are neurological by nature and have negative effects on people’s lives. They interfere with activities of daily living as well as mental and physical health. Migraines are defined as either a classic migraine that has momentary focal symptoms-with aura or a common migraine that has specific symptoms- without aura (Woo & Robinson, 2020). Although the exact catalyst for migraines is not clear there are various theories that help to navigate the course of treatment. Some theories include heightened brain activity from genetics, intracranial vasodilation, and a sensitivity to trigeminovascular systems which causes alterations in structure and function (Woo & Robinson, 2020). Treatment course depends on if migraines are acute or chronic and if the patient has success with preventing or aborting symptoms. One drug class used for acute/abortive migraines are analgesics (Woo & Robinson, 2020). Aspirin and Naprosyn are often used as first line recommendations for acute migraines. It was found that the use of high dose aspirin (900-1,300mg) was successful in aborting, as well as preventing, the symptoms of an acute migraine attack without associated nausea (Alpert, 2020). Aspirin helps alleviate symptoms by interfering with prostaglandins and platelet activity as well as possibly effecting the serotonin activity (Woo & Robinson, 2020). Of course, high doses of aspirin have a long list of warning to teach the patient. Gastrointestinal bleeding, ulcers, and discomfort should be educated and reported. Aspirin is also contradicted in pregnancy, children, prior to surgeries, with any active bleeds or ulcers, and caution with hepatic dysfunction (Woo & Robinson, 2020). The patient should report any signs of bleeding, dizziness, hearing issues, or new pain. The use of aspirin should also be avoided if taking anticoagulants, antihypertensives, NSAIDs, and glucocorticoids (Woo & Robinson, 2020). Naprosyn or naproxen is the other analgesic that is used for the treatment of migraines. Naproxen is used for menstrual specific migraines as well and is contradicted in the last trimester of pregnancy (Woo & Robinson, 2020). Caution should be taken with naproxen with comorbidities such as kidney disease, ulcers, and gastritis. This medication has similar side effects and interactions as aspirin. Gastrointestinal bleeds being the most common. Medication interactions include antihypertensive, antithrombotic, antidepressants, and corticosteroids (Cooney et al., 2015). Being a COX inhibitor, naproxen works for migraines by dec.