The Renaissance began in late 14th century Italy as a rediscovery of classical Roman and Greek culture which inspired great developments in art, architecture, literature, science and more. This rebirth of interest in antiquity began to spread across Europe over subsequent centuries, aided by new technologies like the printing press. The Renaissance challenged medieval scholasticism and Catholic doctrine, helping to spark both Protestant Reformation and new modes of thought. It profoundly impacted all areas of culture through more naturalistic and human-centered developments in art, literature, music, science and politics.