(2015, June). Poster presented at the 4th convention of the Association for Research in Personality, St. Louis, MO. Religious and spiritual struggles arise in various forms and circumstances. The newly developed Religious and Spiritual Struggles (RSS) scale reveals a coherent, multidimensional structure in these domain-specific problems that applies to religious and nonreligious people alike. Thus new questions emerge. Do religious people struggle less with religion, or more? Struggles and stress seem likely to coincide, but might stress give rise to fewer religious struggles among religious people? We tested this moderation hypothesis in a large sample of American undergraduates, who completed the RSS and measures of stressful life events, religious belief salience, and religious participation. A hierarchical regression of factor scores based on a structural equation model of polychoric correlations found support for the hypothesis. Religion and stress related positively to all subscales of the RSS and their overall mean, but a small, negative interaction also manifested, which suggested a weakening relationship between struggles and stress as religiousness increases.