The document proposes a new approach to metropolitan business planning that is grounded in economics and develops comprehensive and actionable strategies. It involves identifying regional assets and opportunities, developing customized strategies, implementing concrete actions, and building institutional capacity. The goal is to take an integrated, cross-sectoral approach to enhancing regional concentrations, deploying human capital, developing innovation infrastructure, increasing efficiency, and creating effective public institutions to promote sustainable and inclusive prosperity. Key elements include developing a regional investment prospectus, coordinating federal programs through cross-agency teams, and establishing pooled and flexible funding to support regional goals.