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RECOMBINATION ERROR
Or
Double stranded DNA repair
Or
Non-homologous end joining repair
Presented by
Mr.Karthick J.
• It is also called double stranded DNA repair
because in this phenomenon repair of the two
broken ends of the DNA takes place and protect
the genome from further degradation .
•Double stranded breaks are generated by
exposure to ionizing radiation or chemical
mutagens or during recombination events .
• A multi-component protein complex directs a DNA
Ligase to the break.
• The complex contains a protein called Ku, having two
non – identical subunit binds to two broken ends of
the DNA
• The binding of Ku is accomplished by the DNA -PK
Protein kinase.
• It activates a third protein XRCC4, which interacts with
the mammalian DNA Ligase –IV directing this repair
to join the double strands broken ends.
• Like recombination, non-homologous ends are joined
by this process.
• Therefore, this type of repair process is also
called non- homologous end joining repair
process.
RECOMBINATION ERROR.pptx
RECOMBINATION ERROR.pptx
RECOMBINATION ERROR.pptx
RECOMBINATION ERROR.pptx

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RECOMBINATION ERROR.pptx

  • 1. RECOMBINATION ERROR Or Double stranded DNA repair Or Non-homologous end joining repair Presented by Mr.Karthick J.
  • 2. • It is also called double stranded DNA repair because in this phenomenon repair of the two broken ends of the DNA takes place and protect the genome from further degradation . •Double stranded breaks are generated by exposure to ionizing radiation or chemical mutagens or during recombination events .
  • 3. • A multi-component protein complex directs a DNA Ligase to the break. • The complex contains a protein called Ku, having two non – identical subunit binds to two broken ends of the DNA
  • 4. • The binding of Ku is accomplished by the DNA -PK Protein kinase. • It activates a third protein XRCC4, which interacts with the mammalian DNA Ligase –IV directing this repair to join the double strands broken ends. • Like recombination, non-homologous ends are joined by this process.
  • 5. • Therefore, this type of repair process is also called non- homologous end joining repair process.