The document describes a method for identifying alternative polyadenylation (APA) outliers in RNA sequencing and whole genome sequencing data from the GTEx project. RNA sequencing data from over 17,000 samples across 49 tissues were analyzed. APA outliers were identified as individuals with extreme APA usage scores, either in a single tissue or across multiple tissues. The results can be queried and visualized using scatter plots, and data on outliers and watershed model predictions can be downloaded.