R.G. (Randy) Goebel is currently professor of Computing Science in the Department of Computing Science at the University of Alberta, Associate Vice President (Research) and Associate Vice President (Academic), and founding principle investigator in the Alberta Machine Intelligence Institute (AMII).
He received the B.Sc. (Computer Science), M.Sc. (Computing Science), and Ph.D. (Computer Science) from the Universities of Regina, Alberta, and British Columbia, respectively.
Professor Goebel's theoretical work on abduction, hypothetical reasoning and belief revision is internationally well know, and his recent research is focused on the formalization of visualization and explainable artificial intelligence (XAI).
He has worked on optimization, algorithm complexity, systems biology, and natural language processing, including applications in legal reasoning and medical informatics.
Randy has previously held faculty appointments at the University of Waterloo, University of Tokyo, Multimedia University (Kuala Lumpur), Hokkaido University (Sapporo), visiting researcher engagements at National Institute of Informatics (Tokyo), DFKI (Germany), and NICTA (now Data61, Australia); is actively involved in collaborative research projects in Canada, Japan, China, and Germany.
GPS for Chemical Space - Digital Assistants to Support Molecule Design - Chem...ChemAxon
Boehringer Ingelheim's Nils Weskamp discusses eDesign: a computational platform for molecule design and optimization. This presentation explaing how to combine data, algorithms and user experience to impact compound design, and gives a glimpse into the agile and interdisciplinary teamwork as facilitated by Design Hub as a success factor for the development of digital tools.
Infection Research with Maxeler Dataflow ComputingLEGATO project
Presentation given by Tobias Becker (Maxeler) at the LEGaTO Final Event: Low-Energy Heterogeneous Computing Workshop on 4 September 2020
This event was collocated with FPL 2020
Selection of Articles Using Data Analytics for Behavioral Dissertation Resear...PhD Assistance
Outcomes in health-related issues including psychological, educational, Behavioral, environmental, and social are intended to sustain positive change by digital interferences. These changes may be delivered using any digital device like a phone or computer, and make them gainful for the provider. Complex and large-scale datasets that contain usage data can be yielded by testing a digital intervention. This data provides invaluable detail about how the users interact with these interventions and notify their knowledge of engagement, if they are analyzed properly. This paper recommends an innovative framework for the process of analyzing usage associated with a digital intervention .
PhD Assistance is an Academic The Best Dissertation Writing Service & Consulting Support Company established in 2001. specialiWeze in providing PhD Assignments, PhD Dissertation Writing Help , Statistical Analyses, and Programming Services to students in the USA, UK, Canada, UAE, Australia, New Zealand, Singapore and many more.
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Data science concept by Raj Krishna PaulSubir Paul
Get clear concept about What is Data Science . Why it is the emerging area of research and jobs. How to go about it.
Developed by Rajkrishna Paul, B S Engg ( USA), Technical Lead ,Verizon Data Services
GPS for Chemical Space - Digital Assistants to Support Molecule Design - Chem...ChemAxon
Boehringer Ingelheim's Nils Weskamp discusses eDesign: a computational platform for molecule design and optimization. This presentation explaing how to combine data, algorithms and user experience to impact compound design, and gives a glimpse into the agile and interdisciplinary teamwork as facilitated by Design Hub as a success factor for the development of digital tools.
Infection Research with Maxeler Dataflow ComputingLEGATO project
Presentation given by Tobias Becker (Maxeler) at the LEGaTO Final Event: Low-Energy Heterogeneous Computing Workshop on 4 September 2020
This event was collocated with FPL 2020
Selection of Articles Using Data Analytics for Behavioral Dissertation Resear...PhD Assistance
Outcomes in health-related issues including psychological, educational, Behavioral, environmental, and social are intended to sustain positive change by digital interferences. These changes may be delivered using any digital device like a phone or computer, and make them gainful for the provider. Complex and large-scale datasets that contain usage data can be yielded by testing a digital intervention. This data provides invaluable detail about how the users interact with these interventions and notify their knowledge of engagement, if they are analyzed properly. This paper recommends an innovative framework for the process of analyzing usage associated with a digital intervention .
PhD Assistance is an Academic The Best Dissertation Writing Service & Consulting Support Company established in 2001. specialiWeze in providing PhD Assignments, PhD Dissertation Writing Help , Statistical Analyses, and Programming Services to students in the USA, UK, Canada, UAE, Australia, New Zealand, Singapore and many more.
Website Visit: https://bit.ly/3dANXUD
Contact Us:
UK NO: +44-1143520021
India No: +91-8754446690
Email: info@phdassistance.com
Data science concept by Raj Krishna PaulSubir Paul
Get clear concept about What is Data Science . Why it is the emerging area of research and jobs. How to go about it.
Developed by Rajkrishna Paul, B S Engg ( USA), Technical Lead ,Verizon Data Services
Maximize Your Understanding of Operational Realities in Manufacturing with Pr...Bigfinite
Maximize Your Understanding of Operational Realities in Manufacturing with Predictive Insights using Big Data, Artificial Intelligence, and Pharma 4.0
by Toni Manzano, PhD, Co-founder and CSO, Bigfinite
PDA Annual Meeting 2020
Big data and macroeconomic nowcasting from data access to modellingDario Buono
Parallel advances in IT and in the social use of Internet-related applications, provide the general public with access to a vast amount of information. The associated Big Data are potentially very useful for a variety of applications, ranging from marketing to tapering fiscal evasion.
From the point of view of official statistics, the main question is whether and to what extent Big Data are a field worth investing to expand, check and improve the data production process and which types of partnerships will have to be formed for this purpose. Nowcasting of macroeconomic indicators represents a well-identified field where Big Data has the potential to play a decisive role in the future.
In this paper we present the results and main recommendations from the Eurostat-funded project “Big Data and macroeconomic nowcasting”, implemented by GOPA Consultants, which benefits from the cooperation and work of the Eurostat task force on Big Data and a few external academic experts.
The science of statistics deals with the collection, analysis, interpretation, and presentation of data. We see and use data in our everyday lives. The measure of whether the results of research were due to chance. The more statistical significance assigned to an observation, the less likely the observation occurred by chance.
A short Introduction to the Influence of Big Data in today's world and how it's helping the organization and industry to be familiar with their clients and partners.
Big Data Day LA 2016 Keynote - Tom Horan/ Claremont Graduate UniversityData Con LA
Big Data Day LA 2016 Keynote - Tom Horan, Dean of the Drucker-Ito School of Management & Director of the Center for Information Systems and Technology at Claremont Graduate University (CGU)
7 excellent reasons why statistics are important statsworkStats Statswork
Statistics are used to analyze what's happening within the world around us. In this data-driven world, all activities of ours are monitored by someone else every time. Statistics help us to convert whatever occurs in the past can be used in predicting the future. Statswork Is A Premier Statistics Consulting Company That Spearheaded Online Statistics Consultancy Service With Clientele Ranging From Educational Institutions, Academics, Corporations And Ngos. We Provide End-To-End Service And Assistance For Your Statistical Research And Analytical Needs From Data Collection, Data Mining, Data Analysis To Research Framework And Research Methodology.
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Plagiarism Free | Unlimited Support | Prompt Turnaround Times | Subject Matter Expertise | Experienced Bio-statisticians & Statisticians | Statistics Across Methodologies | Wide Range Of Tools & Technologies Supports | Tutoring Services | 24/7 Email Support | Recommended by Universities
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UnitedKingdom: +44-1143520021
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This presentation discussed the availability of big data and its opportunities to use innovative analytics and technologies. It was shown how big data can be visualized in different government contexts. The focus was summarized on two challanges: regulatory impact assessment, as well as on information processing support on rulemaking. The application of a novel big data analytics framework - Mixed-Initiative Social Media Analytics (MISMA) - will address these two rulemaking challenges.
Attend The Data Science Course in Bangalore From ExcelR. Practical Data Science Course in Bangalore Sessions With Assured Placement Support From Experienced Faculty. ExcelR Offers The Data Science Course in Bangalore.
Data for Impact - Horizon 2020 project pioneering big data approaches for improved assessment of the societal impact in the health, demographic change and well-being societal challenge at national and EU levels. Data4Impact aspires to develop a set of new indicators for assessing research and innovation performance based on a hands-on and data-driven approach.
Here is the presentation from the Data4Impact workshop, which took place on 24th of September 2018.
Introduction to Research methodology: Orientation for Doctoral Program Course...niloysarkar
Despite this critical importance of research, the research and innovation investment in India is, at the current time, only 0.69% of GDP as compared to 2.8% in the United States of America, 4.3% in Israel and 4.2% in South Korea. (Source: NEP2020, GoI)
Data Science and Big Data Analytics are everywhere. They are buzzwords that everyone is talking about. Garnet even released Hype Cycle for Data Science in July this year. And yet, many people are still confused as to what data science and big data analytics are and why they will become the new black!
This slide focuses on the core concepts and clarify the mis-understanding of those myths.
Maximize Your Understanding of Operational Realities in Manufacturing with Pr...Bigfinite
Maximize Your Understanding of Operational Realities in Manufacturing with Predictive Insights using Big Data, Artificial Intelligence, and Pharma 4.0
by Toni Manzano, PhD, Co-founder and CSO, Bigfinite
PDA Annual Meeting 2020
Big data and macroeconomic nowcasting from data access to modellingDario Buono
Parallel advances in IT and in the social use of Internet-related applications, provide the general public with access to a vast amount of information. The associated Big Data are potentially very useful for a variety of applications, ranging from marketing to tapering fiscal evasion.
From the point of view of official statistics, the main question is whether and to what extent Big Data are a field worth investing to expand, check and improve the data production process and which types of partnerships will have to be formed for this purpose. Nowcasting of macroeconomic indicators represents a well-identified field where Big Data has the potential to play a decisive role in the future.
In this paper we present the results and main recommendations from the Eurostat-funded project “Big Data and macroeconomic nowcasting”, implemented by GOPA Consultants, which benefits from the cooperation and work of the Eurostat task force on Big Data and a few external academic experts.
The science of statistics deals with the collection, analysis, interpretation, and presentation of data. We see and use data in our everyday lives. The measure of whether the results of research were due to chance. The more statistical significance assigned to an observation, the less likely the observation occurred by chance.
A short Introduction to the Influence of Big Data in today's world and how it's helping the organization and industry to be familiar with their clients and partners.
Big Data Day LA 2016 Keynote - Tom Horan/ Claremont Graduate UniversityData Con LA
Big Data Day LA 2016 Keynote - Tom Horan, Dean of the Drucker-Ito School of Management & Director of the Center for Information Systems and Technology at Claremont Graduate University (CGU)
7 excellent reasons why statistics are important statsworkStats Statswork
Statistics are used to analyze what's happening within the world around us. In this data-driven world, all activities of ours are monitored by someone else every time. Statistics help us to convert whatever occurs in the past can be used in predicting the future. Statswork Is A Premier Statistics Consulting Company That Spearheaded Online Statistics Consultancy Service With Clientele Ranging From Educational Institutions, Academics, Corporations And Ngos. We Provide End-To-End Service And Assistance For Your Statistical Research And Analytical Needs From Data Collection, Data Mining, Data Analysis To Research Framework And Research Methodology.
Why Statswork?
Plagiarism Free | Unlimited Support | Prompt Turnaround Times | Subject Matter Expertise | Experienced Bio-statisticians & Statisticians | Statistics Across Methodologies | Wide Range Of Tools & Technologies Supports | Tutoring Services | 24/7 Email Support | Recommended by Universities
Contact Us:
Website: www.statswork.com/
Email: info@statswork.com
UnitedKingdom: +44-1143520021
India: +91-4448137070
WhatsApp: +91-8754446690
This presentation discussed the availability of big data and its opportunities to use innovative analytics and technologies. It was shown how big data can be visualized in different government contexts. The focus was summarized on two challanges: regulatory impact assessment, as well as on information processing support on rulemaking. The application of a novel big data analytics framework - Mixed-Initiative Social Media Analytics (MISMA) - will address these two rulemaking challenges.
Attend The Data Science Course in Bangalore From ExcelR. Practical Data Science Course in Bangalore Sessions With Assured Placement Support From Experienced Faculty. ExcelR Offers The Data Science Course in Bangalore.
Data for Impact - Horizon 2020 project pioneering big data approaches for improved assessment of the societal impact in the health, demographic change and well-being societal challenge at national and EU levels. Data4Impact aspires to develop a set of new indicators for assessing research and innovation performance based on a hands-on and data-driven approach.
Here is the presentation from the Data4Impact workshop, which took place on 24th of September 2018.
Introduction to Research methodology: Orientation for Doctoral Program Course...niloysarkar
Despite this critical importance of research, the research and innovation investment in India is, at the current time, only 0.69% of GDP as compared to 2.8% in the United States of America, 4.3% in Israel and 4.2% in South Korea. (Source: NEP2020, GoI)
Data Science and Big Data Analytics are everywhere. They are buzzwords that everyone is talking about. Garnet even released Hype Cycle for Data Science in July this year. And yet, many people are still confused as to what data science and big data analytics are and why they will become the new black!
This slide focuses on the core concepts and clarify the mis-understanding of those myths.
Bridge the Gap Between Data and Decisions: Master Data Science Course using Machine Learning
Empower yourself with the in-demand skills of data science and machine learning through our dynamic Applied Hybrid Training program!
This innovative data science course seamlessly blends classroom instruction with online learning, providing a well-rounded foundation for your data science journey. Learn to unlock the power of data and leverage machine learning algorithms to solve real-world challenges.
Uncover the Magic Behind the Data:
Machine Learning Fundamentals: Demystify the concepts of machine learning algorithms and explore their practical applications across various industries.
Python Programming Prowess: Gain hands-on experience with Python, the language of choice for data science. Learn how to leverage its libraries and tools to implement machine learning models effectively.
Data Wrangling Expertise: Master techniques for handling and manipulating datasets from diverse fields. Understand how to prepare data for optimal use with machine learning algorithms.
Actionable Insights from Algorithms: Discover how to interpret machine learning outputs and translate them into actionable insights that drive real-world results.
Data Communication Mastery: Learn to communicate your data science findings with clarity and impact, effectively presenting the results of your machine learning models.
By the end of this Data Science Course using Machine Learning, you will have enough knowledge and hands-on expertise in Python to use and apply them in the real world around you. Also, you will be able to get prepared for certifications of Data Camp and Cognitive AI.
Information fusion and algorithm training framework objective in ICT4Life H2020 Project. Presented in IEEEHealthcom'16 within Project Alfred workshop in Munich (14-17 September 2016).
How AstraZeneca is Applying AI, Imaging & Data Analytics (AI-Driven Drug Deve...Nick Brown
Keynote AI Presentation given at AI-Driven Drug Development Summit Europe on 26th April 2023 in London. Overview around how AstraZeneca has been developing AI in the past 5+ years. Predominantly focused on R&D and how we are developing digital solutions & AI for right safety and right dose. AI examples include machine learning for safety assessment, augmenting digital pathology for image quantification & segmentation, understanding more about our drugs through advanced imaging modalities and first steps in applying AI for right dose - immunogenicity, adverse events and tolerability.
Abstract:
Big Data concern large-volume, complex, growing data sets with multiple, autonomous sources. With the fast development of networking, data storage, and the data collection capacity, Big Data are now rapidly expanding in all science and engineering domains, including physical, biological and biomedical sciences. This paper presents a HACE theorem that characterizes the features of the Big Data revolution, and proposes a Big Data processing model, from the data mining perspective. This data-driven model involves demand-driven aggregation of information sources, mining and analysis, user interest modeling, and security and privacy considerations. We analyze the challenging issues in the data-driven model and also in the Big Data revolution.
Supporting a Collaborative R&D Organization with a Dynamic Big Data SolutionSaama
Nikhil Gopinath presents regarding big data solutions at the Big Data and Analytics for Healthcare and Life Sciences Summit on October 18, 2017 in San Francisco, CA.
First presented in CPHl Istanbul 2016. It introduces the future developments on CTMS and EDC systems for clinical trials and their effects on the research industry. Shows how technology can revolutionize the clinical research in areas like risk based monitoring, key risk indicators, machine learning and remote SDV.
Economics & Statistics Insights in Data Science by DataPerts TechnologiesRavindra Panwar
DATA is an inevitable part of our life today. These tiny pieces of information from which we derive valuable insights
have their genesis in the domain of ECONOMICS and STATISTICS.
BIMCV, Banco de Imagen Medica de la Comunidad Valenciana. María de la IglesiaMaria de la Iglesia
Según Hal Varian (experto en microeconomía y economía de la información y, desde el año 2002, Chief Economist de Google) “En los próximos años, el trabajo más atractivo será el de los estadísticos: La capacidad de recoger datos, comprenderlos, procesarlos, extraer su valor, visualizarlos, comunicarlos serán todas habilidades importantes en las próximas décadas. Ahora disponemos de datos gratuitos y omnipresentes. Lo que aún falta es la capacidad de comprender estos datos“.
Similar to Randy Goebel for the KIEF 2018. FROM DATA TO ECONOMIC VALUE (20)
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Randy Goebel for the KIEF 2018. FROM DATA TO ECONOMIC VALUE
1. Randy Goebel, Professor of Computing Science at the University of Alberta
From Data to Economic Value
2. Like many potentially impactful technologies, the positive economic impact of Artificial Intelligence
(AI) is challenged by both strategic and practical misunderstandings. Line of sight from science to
value is required to help achieve positive impact.
Speaker: Randy Goebel,
Alberta Machine Intelligence Institute, Edmonton, Canada
Volkswagen Data Lab, Munich, Germany
From Data to Economic Value
3. Federal AI Strategy Development
https://medium.com/politics-ai/an-overview-of-national-ai-strategies-2a70ec6edfd
6. Data Science
Workflow
Define Objectives
• Confirm
access to
appropriate
data
• Define clear
domain specific
KPIs
Data Capture &
Curation
• Acquire data from
original sources
(e.g. sensors or
legacy systems)
• Ensure possibility
for continuous
capture, correction,
and adjustment
Data Analysis
• Perform data
analysis to explore
data value
potential
E.g,. time series
cycles, principle
component
analysis, data
labelling/annotatio
n requirements
Data Model Generation
• experiment with
alternative model
generation
techniques
E.g., logistic
regression, support
vector machines
(SVM), deep
learning,
Reinforcement
Learning,
condition-action
rules, etc.
• Create
Interactive
Dashboard for
Domain Experts
• Design
Evaluation
Experiments to
Measure
performance
against KPIs
Data Model Interaction
Interaction, Feedback, and Adjustment as required
Key success requirements:
1. access to data
2. data domain expertise, including how to measure
potential value for related business processes, and
3. data scientists committed to work with the data
domain experts to achieve improvements in domain
expert defined key performance indicators.
7. Where does
data science
apply?
• Personal and public (health) data
• Repertoire of changing intervention
choices
• Feedback loop for intervention outcomes.
Precision Health
Precision Law
Precision Education
Precision Democracy
11. Image-based
glioma biopsy
• Input:
• - ?? labeled cases
• Method:
• compute S-transform frequency
spectrum for each pixel, the average over
all directions to get 1D spectra for each
tumor;
• build multi-frequency classifier based
on these labeled cases
• in these measurement results, BLUE 30
co-deleted 1p/19q, GREEN 24 intact
1p/19q
• Results:
• - 95-96% accurate
12. Image-based
glioma biopsy
• Input:
• - 55 labeled cases
• Method:
• compute S-transform frequency spectrum
for each pixel, the average over all directions
to get 1D spectra for each tumor;
• build multi-frequency classifier based on
these labeled cases
• in these measurement results, BLUE 30 co-
deleted 1p/19q, GREEN 24 intact 1p/19q
• Results:
• - 95-96% accurate
13. Summary
Keeping abreast of AI Science to quickly develop
and apply AI technologies
• Strengthen connections between science and
industry
• Keep attention on social impact of AI and
emerging societal values
Economic Value of AI – like anything, what’s the
ROI?
• Based on identifying and extracting models
which support business models and economic
KPIs
Impact obtains from connecting good research
and good business expertise
• Access to (good) data
• Access/collaboration with domain experts
• Collaboration/commitment of data scientists