This document compares four major GUI toolkits for Python: PyGTK, PyQt, Tkinter, and wxPython. It discusses their look and feel across platforms, capabilities for customization, and options for integrating web resources into desktop applications. The document provides details on the level of customization supported by each toolkit, from compromising customizations that affect familiarity, to pleasant customizations that improve usability, to runtime customizations. It notes that customizations are not always welcomed by users and their benefits should be considered. The document also examines each toolkit's abilities for rendering HTML and incorporating web technologies into applications.