Presentation on publishing scientific research and how to write high-impact scientific papers by Dr. John Uhlrich as the Editor-in-Chief of Energy Technology and Dr. Esther Levy, the Editor-in-Chief of Advanced Materials Technologies, both published by Wiley-VCH. Slide were presented on 28 June 2019 at the Singapore University of Technology and Design (SUTD).
Publishing Scientific Research & How to Write High-Impact Research Papersjjuhlrich
Presentation on publishing scientific research and how to write high-impact scientific papers by Dr. John Uhlrich as the Editor-in-Chief of Energy Technology published by Wiley-VCH, given on 25 October 2018 at the University of Pittsburgh, USA.
Publishing Scientific Research & How to Write High-Impact Research Papersjjuhlrich
Presentation on publishing scientific research and how to write high-impact scientific papers by Dr. John Uhlrich as the Editor-in-Chief of Energy Technology published by Wiley-VCH, given on 25 October 2018 at the National Energy Technology Laboratory, USA.
Publishing Scientific Research & How to Write High-Impact Research Papers jjuhlrich
Presentation on publishing scientific research and how to write high-impact scientific papers by Dr. John Uhlrich as the Editor-in-Chief of Energy Technology, published by Wiley-VCH. Slides were presented on 07 December 2021 virtually for the Institute of Materials Research and Engineering (IMRE) at A*Star, Singapore.
Publishing Scientific Research & How to Write High-Impact Research Papersjjuhlrich
Presentation on publishing scientific research and how to write high-impact scientific papers by Dr. John Uhlrich as the Editor-in-Chief of Energy Technology published by Wiley-VCH, given on 02 November 2018 at the Wilton E. Scott Institute for Energy Innovation at Carnegie Mellon University, USA.
Publishing Scientific Research & How to Write High-Impact Research Papersjjuhlrich
Presentation on publishing scientific research and how to write high-impact scientific papers by Dr. John Uhlrich as the Editor-in-Chief of Energy Technology published by Wiley-VCH, given on 03 October 2018 at the EPFL campus in Sion.
Publishing Scientific Research and How to Write High-Impact Research Papersjjuhlrich
Presentation on how to publish high-impact scientific papers by John Uhlrich, Editor-in-Chief of the journal Energy Technology, published by Wiley-VCH.
Wiley-VCH Mathero Summer School Presentation-John Uhlrichjjuhlrich
Tips on the publication process and how to write successful scientific papers, given for PhD students in the physical sciences at the Mathero Summer School.
Freudenberg, Germany
26 August 2015
Publishing Scientific Research & How to Write High-Impact Research Papersjjuhlrich
Presentation on publishing scientific research and how to write high-impact scientific papers by Dr. John Uhlrich as the Editor-in-Chief of Energy Technology published by Wiley-VCH, given on 25 October 2018 at the University of Pittsburgh, USA.
Publishing Scientific Research & How to Write High-Impact Research Papersjjuhlrich
Presentation on publishing scientific research and how to write high-impact scientific papers by Dr. John Uhlrich as the Editor-in-Chief of Energy Technology published by Wiley-VCH, given on 25 October 2018 at the National Energy Technology Laboratory, USA.
Publishing Scientific Research & How to Write High-Impact Research Papers jjuhlrich
Presentation on publishing scientific research and how to write high-impact scientific papers by Dr. John Uhlrich as the Editor-in-Chief of Energy Technology, published by Wiley-VCH. Slides were presented on 07 December 2021 virtually for the Institute of Materials Research and Engineering (IMRE) at A*Star, Singapore.
Publishing Scientific Research & How to Write High-Impact Research Papersjjuhlrich
Presentation on publishing scientific research and how to write high-impact scientific papers by Dr. John Uhlrich as the Editor-in-Chief of Energy Technology published by Wiley-VCH, given on 02 November 2018 at the Wilton E. Scott Institute for Energy Innovation at Carnegie Mellon University, USA.
Publishing Scientific Research & How to Write High-Impact Research Papersjjuhlrich
Presentation on publishing scientific research and how to write high-impact scientific papers by Dr. John Uhlrich as the Editor-in-Chief of Energy Technology published by Wiley-VCH, given on 03 October 2018 at the EPFL campus in Sion.
Publishing Scientific Research and How to Write High-Impact Research Papersjjuhlrich
Presentation on how to publish high-impact scientific papers by John Uhlrich, Editor-in-Chief of the journal Energy Technology, published by Wiley-VCH.
Wiley-VCH Mathero Summer School Presentation-John Uhlrichjjuhlrich
Tips on the publication process and how to write successful scientific papers, given for PhD students in the physical sciences at the Mathero Summer School.
Freudenberg, Germany
26 August 2015
Research Skills Session 10: Improve a Research Paper QualityNader Ale Ebrahim
In this workshop, Dr. Nader introduces some tools for improving a research paper quality from his Research Tools Mind Map. The Research Tools enable researchers to follow the correct path in research and to ultimately produce high-quality research outputs with more accuracy and efficiency. Besides introducing some tools, he emphasize on ten techniques such as: Collaborate with excellent researchers, Choose a good research team, Focus on quality instead of quantity, Use recent and relevant references, Avoid obvious errors, Don’t forget story telling style, Write clearly, concisely and smartly, Read your paper several times, Target the top journals, and Follow patterns of well-written papers in your field, for improving a research paper quality.
How to Increase the Visibility and Impact of your ResearchNader Ale Ebrahim
Why would a researcher or a research department want to increase the visibility of their research? It can be as simple as wanting to improve their university ranking or academic impact by gaining more views and citations for their research articles. However, others may wish to increase their visibility to attract more opportunities for collaboration or even to highlight their research impact on a larger society. It would be a disappointment if people who are interested in your work cannot fully access your research. Researchers have spent plenty of time and effort on writing their research for publication. Dissemination and improving an article's impact is an essential phase of the publication life cycle. However, most of the researchers stop their work after publication and do not give any thought about the importance of their research visibility and impact. In this webinar, you will find some tools that help you to achieve your goal to increase the visibility and impact of your research.
A new research impact measuring system by nader ale ebrahimNader Ale Ebrahim
For years, scientists have been trying to measure the quality of scholarly work by the number of times an article is cited in other articles or the impact factor of the journal which published an article. However, citation is a lagging indicator and journal impact factor may be misleading since a Journal's citation count is usually caused by a small number of articles in that journal.
With the rise of the web as the archiving and emerging interaction platform, there is a need for new ways to measure articles and books impact. Altmetrics attempts to use the online activity to measure impact, buzz, word of mouth for scientific information and it includes new ways to measure usage at the citation level. In this workshop, I will explain about application of altmetrics tools such as: Altmetric.com, Impactstory.org, Plumanalytics.com, and PLoS metrics.
Tactics on Research and Advanced Optimization Techniques in Engineering Appl...Ajay Kumar
• Identification of research problem
• Literature review
• Specifying the purpose of research
• Determine specific research questions
• Specification of a conceptual framework, usually a set of hypotheses
• Choice of a methodology (for data collection)
• Data collection
• Verify data
• Analyzing and interpreting the data
• Reporting and evaluating research
• Communicating the research findings and, possibly, recommendations
S.SENTHIL MURUGAN, Assistant Professor
Department of Mechanical Engineering
Mepco Schlenk Engineering College (Autonomous), Sivakasi
Developing and PublishingAcademic ProductsSanjay Goel
These lecture slides were used in two lectures delivered on 25th June 2014 at a 3 day workshop organised under the TEQIP (Technical Education Quality Improvement Programme ) scheme by Equate India for the faculty participants from few NITs, Aligarh Muslim University, and Sardar Patel College of Engineering.
This presentation was provided by Lauren Kane of Morressier during the NFAIS Forethought Strategic Summit "Transforming Systems Through Transformed Content." The event was held June 16-17, 2021.
Bibliometrics can be defined as the statistical analysis of publications. Bibliometrics has focused on the quantitative analysis of citations and citation counts which is complex. It is so complex and specialized that personal knowledge and experience are insufficient for understanding trends and then making decisions. We need tools for analysis of bibliometrics information to recognize the research trends and evaluate scientific/institution/country’s research productivity. This presentation will provide procedure to write a Bibliometrics paper.
Finding research papers (resources) within a specific research area can be done based on many aspects, such as keywords set, subject area, journal name, author profile, and dominant institution or country. The most important aspect, is the selected keywords set. Researchers are usually spending a long time on the net to find their interesting papers and keeping them. Reference management software offer an easy way of finding relevant literature, collecting references, organizing them in a database, and insert citations works in a manuscript with proper citation style. The workshop concentrates on how to find and keep the right papers for your research interest.
Why is Test Driven Development so hard to implement in an analytics platform?Phil Watt
Test Driven Development (TDD) is a common pattern in software engineering that helps reduce cycle time, improve code quality and reduce production defects. Within data engineering and analytics projects, TDD is held up as best practice in development and maintenance lifecycle phases. Anecdotally, many organisations do not see the promised benefits of TDD in an analytics context, prompting the question:
Why is it so hard to effectively implement Test Driven Development in an analytics platform?
This talk outlines Phil's research so far in his master's thesis on the topic of test automation in data and analytics projects. He presents seven key challenges revealed in academic studies, and the next steps in the research process.
Getting research into action: issues, challenges, solutions by Dr Sarah MortonHazel Hall
Sarah Morton has worked across research, policy and practice for most of her career, and will draw on examples from different settings encountered over this time in her presentation. She is keen to interrogate our learning about effective evidence use from the last 20 years, and review how this can be supported from research and practice perspectives. She will present a vision for the effective use of evidence of all kinds to plan, develop and improve policy, practice, and services. As part of this she will explain some of the ways that she is currently developing tools and support for effective evidence use.
What Do Editors Do All Day? From Science to Publishing.jjuhlrich
Presentation by John Uhlrich, the Editor-in-Chief of the journal Energy Technology at Wiley-VCH publishing, at the International Max Planck Research School (IMPRS) at Ringberg Castle on February 22, 2018 as a snapshot of what editors do and a few current challenges in the publishing industry.
Research Skills Session 10: Improve a Research Paper QualityNader Ale Ebrahim
In this workshop, Dr. Nader introduces some tools for improving a research paper quality from his Research Tools Mind Map. The Research Tools enable researchers to follow the correct path in research and to ultimately produce high-quality research outputs with more accuracy and efficiency. Besides introducing some tools, he emphasize on ten techniques such as: Collaborate with excellent researchers, Choose a good research team, Focus on quality instead of quantity, Use recent and relevant references, Avoid obvious errors, Don’t forget story telling style, Write clearly, concisely and smartly, Read your paper several times, Target the top journals, and Follow patterns of well-written papers in your field, for improving a research paper quality.
How to Increase the Visibility and Impact of your ResearchNader Ale Ebrahim
Why would a researcher or a research department want to increase the visibility of their research? It can be as simple as wanting to improve their university ranking or academic impact by gaining more views and citations for their research articles. However, others may wish to increase their visibility to attract more opportunities for collaboration or even to highlight their research impact on a larger society. It would be a disappointment if people who are interested in your work cannot fully access your research. Researchers have spent plenty of time and effort on writing their research for publication. Dissemination and improving an article's impact is an essential phase of the publication life cycle. However, most of the researchers stop their work after publication and do not give any thought about the importance of their research visibility and impact. In this webinar, you will find some tools that help you to achieve your goal to increase the visibility and impact of your research.
A new research impact measuring system by nader ale ebrahimNader Ale Ebrahim
For years, scientists have been trying to measure the quality of scholarly work by the number of times an article is cited in other articles or the impact factor of the journal which published an article. However, citation is a lagging indicator and journal impact factor may be misleading since a Journal's citation count is usually caused by a small number of articles in that journal.
With the rise of the web as the archiving and emerging interaction platform, there is a need for new ways to measure articles and books impact. Altmetrics attempts to use the online activity to measure impact, buzz, word of mouth for scientific information and it includes new ways to measure usage at the citation level. In this workshop, I will explain about application of altmetrics tools such as: Altmetric.com, Impactstory.org, Plumanalytics.com, and PLoS metrics.
Tactics on Research and Advanced Optimization Techniques in Engineering Appl...Ajay Kumar
• Identification of research problem
• Literature review
• Specifying the purpose of research
• Determine specific research questions
• Specification of a conceptual framework, usually a set of hypotheses
• Choice of a methodology (for data collection)
• Data collection
• Verify data
• Analyzing and interpreting the data
• Reporting and evaluating research
• Communicating the research findings and, possibly, recommendations
S.SENTHIL MURUGAN, Assistant Professor
Department of Mechanical Engineering
Mepco Schlenk Engineering College (Autonomous), Sivakasi
Developing and PublishingAcademic ProductsSanjay Goel
These lecture slides were used in two lectures delivered on 25th June 2014 at a 3 day workshop organised under the TEQIP (Technical Education Quality Improvement Programme ) scheme by Equate India for the faculty participants from few NITs, Aligarh Muslim University, and Sardar Patel College of Engineering.
This presentation was provided by Lauren Kane of Morressier during the NFAIS Forethought Strategic Summit "Transforming Systems Through Transformed Content." The event was held June 16-17, 2021.
Bibliometrics can be defined as the statistical analysis of publications. Bibliometrics has focused on the quantitative analysis of citations and citation counts which is complex. It is so complex and specialized that personal knowledge and experience are insufficient for understanding trends and then making decisions. We need tools for analysis of bibliometrics information to recognize the research trends and evaluate scientific/institution/country’s research productivity. This presentation will provide procedure to write a Bibliometrics paper.
Finding research papers (resources) within a specific research area can be done based on many aspects, such as keywords set, subject area, journal name, author profile, and dominant institution or country. The most important aspect, is the selected keywords set. Researchers are usually spending a long time on the net to find their interesting papers and keeping them. Reference management software offer an easy way of finding relevant literature, collecting references, organizing them in a database, and insert citations works in a manuscript with proper citation style. The workshop concentrates on how to find and keep the right papers for your research interest.
Why is Test Driven Development so hard to implement in an analytics platform?Phil Watt
Test Driven Development (TDD) is a common pattern in software engineering that helps reduce cycle time, improve code quality and reduce production defects. Within data engineering and analytics projects, TDD is held up as best practice in development and maintenance lifecycle phases. Anecdotally, many organisations do not see the promised benefits of TDD in an analytics context, prompting the question:
Why is it so hard to effectively implement Test Driven Development in an analytics platform?
This talk outlines Phil's research so far in his master's thesis on the topic of test automation in data and analytics projects. He presents seven key challenges revealed in academic studies, and the next steps in the research process.
Getting research into action: issues, challenges, solutions by Dr Sarah MortonHazel Hall
Sarah Morton has worked across research, policy and practice for most of her career, and will draw on examples from different settings encountered over this time in her presentation. She is keen to interrogate our learning about effective evidence use from the last 20 years, and review how this can be supported from research and practice perspectives. She will present a vision for the effective use of evidence of all kinds to plan, develop and improve policy, practice, and services. As part of this she will explain some of the ways that she is currently developing tools and support for effective evidence use.
What Do Editors Do All Day? From Science to Publishing.jjuhlrich
Presentation by John Uhlrich, the Editor-in-Chief of the journal Energy Technology at Wiley-VCH publishing, at the International Max Planck Research School (IMPRS) at Ringberg Castle on February 22, 2018 as a snapshot of what editors do and a few current challenges in the publishing industry.
Publishing Scientific Research and How to Write High-Impact Research Papersjjuhlrich
Presentation given by John Uhlrich, as the Editor-in-Chief of Energy Technology at Wiley-VCH, at Lawrence Berkeley National Laboratory on November 18, 2016.
Publishing Scientific Research and How to Write High-Impact Research Papersjjuhlrich
Invited presentation by John Uhlrich as Editor-in-Chief of the scientific journal Energy Technology published by Wiley-VCH, given at King Abdullah University of Science and Technology on 29 January 2017.
Publishing Scientific Research & How to Write High-Impact Research Papersjjuhlrich
Presentation on publishing scientific research and how to write high-impact scientific papers by Dr. John Uhlrich as the Editor-in-Chief of Energy Technology, published by Wiley-VCH. Slides were presented on 04 July 2019 at the Karlsruhe Institute of Technology (KIT) energy center.
Publishing Scientific Research & How to Write High-Impact Research Papersjjuhlrich
Presentation on publishing scientific research and how to write high-impact scientific papers by Dr. John Uhlrich as the Editor-in-Chief of Energy Technology, published by Wiley-VCH. Slides were presented on 25 November 2019 at the Techical University of Darmstadt.
Publishing Scientific Research & How to Write High-Impact Research Papersjjuhlrich
Presentation on publishing scientific research and how to write high-impact scientific papers by Dr. John Uhlrich as the Editor-in-Chief of Energy Technology, published by Wiley-VCH. Slides were presented on 29 July 2019 at the Helmholtz Institute Ulm (HIU).
Publishing Scientific Research & How to Write High-Impact Research Papersjjuhlrich
Presentation given by John Uhlrich, editor of the journal Energy Technology at Wiley-VCH, on a visit to Friedrich-Schiller-University Jena, 5th of October 2016.
Publishing Scientific Research and How to Write High-Impact Research Papersjjuhlrich
Presentation given on 16 June 2017 by John Uhlrich, as Editor-in-Chief of the journal Energy Technology published by Wiley-VCH, on how to write high-impact research papers from the editorial perspective.
Publishing Scientific Research and How to Write High-Impact Research Papersjjuhlrich
Presentation on publishing scientific research and how to write high-impact scientific papers by Dr. John Uhlrich as the Editor-in-Chief of Energy Technology, published by Wiley-VCH. Slides were presented on 27 October 2020 virtually for the SFB/TRR 270 Meeting of PhD students from the Technical University Darmstadt and University of Duisburg-Essen.
Publishing Scientific Research & How to Write High-Impact Research Papersjjuhlrich
Presentation on publishing scientific research and how to write high-impact scientific papers by Dr. John Uhlrich as the Editor-in-Chief of Energy Technology, published by Wiley-VCH. Slides were presented on 07 February 2020 at Justus-Liebig-Universität Gießen.
Publishing Scientific Research & How to Write High-Impact Research Papersjjuhlrich
Presentation on publishing scientific research and how to write high-impact scientific papers by Dr. John Uhlrich as the Editor-in-Chief of Energy Technology, published by Wiley-VCH. Slides were presented on 17 February 2020 at the Technical University of Braunschweig.
Workshop objectives
This virtual workshop will provide information to the participants that will enhance the quality of their research publications by informing them of the peer- review process, the publication process, the structure of a research paper and by improving their scientific writing style.
Participants
This will be a participatory workshop. It is aimed at authors who wish to improve the quality of their research papers. Participants will have a manuscript in preparation or a research project ready to be written up. They will work on their draft manuscripts during the workshop to incorporate their learning from the workshop into practice. Participants will also bring 1 manuscript each from 2 of their top pick journals they want to submit to and the instructions to authors from the same.
These are the slides on the Introduction to quantitative research course presented to the MBE (Master of Bioethics) students at Prince Sattam bin Abdulaziz University. It is focused on bioethics and in particular writing research rather than doing research. Please note that the sources of the slides are added as a link at the bottom of the slide itself.
A 2-day workshop on how to publish your research. It includes a full and detailed explanation of the publication process and many technical details needed by the health researcher to publish his/her research.
It was delivered to the staff of the Northern Area Armed Forces Hospital in Hafr Albaten City, Saudi Arabia (13-14 Nov. 2019)
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
15. Biography of an Editor
Education
1990-1993 Otago University (New Zealand) BSc (Hons) in chemistry
1993-1996 Cambridge University (UK) PhD in supramolecular chemistry
Publishing Experience
1997-1998, 1999-2006 Wiley-VCH (Germany)
Assistant Editor Associate Editor Deputy Editor Editor-in-Chief
– Advanced Materials, Advanced Functional Materials, Small
2007-2010 Wiley Australia (Australia)
Senior Commissioning Editor for APAC (books, journals, societies)
2011-now Wiley Australia (Australia)
Consulting Editor
– Advanced Materials, Small, Advanced Intelligent Systems
Editor-in-Chief
– Advanced Materials Technologies
Dr. Esther Levy
Editor-in-Chief
16. Materials science research focusing on device
design, engineering, fabrication & technology
Applications in:
Launched in April 2016
• Energy
• Healthcare
• Electronics
• Optics
• Microfluidics
• Sensors
• Food safety
• Environmental
technologies
• And more!
First Full Impact Factor:
5.395
www.advmattechnol.com
Advanced Materials Technologies
Editor-in-Chief: Esther Levy
Editors: Jovia Jiang, Valentina Lombardo, Jolke Perelaer,
Marco Squillaci
Co-chairs of the International Editorial Advisory Board:
• John Rogers, Northwestern, USA
• Andrew DeMello, ETH Zurich, Switzerland
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