This document discusses several protozoan and parasitic worm diseases. It describes the life cycles and immune responses to Plasmodium, the causative agent of malaria, transmitted by Anopheles mosquitoes. It also summarizes Trypanosoma, which causes African sleeping sickness transmitted by tsetse flies, and evades the immune system by continually changing its surface proteins. Finally, it provides details on the life cycle and immune response to Schistosoma worms, which cause schistosomiasis transmitted by freshwater snails.