This document discusses adaptive maternal immune deviations as a potential ground for autism spectrum disorders (ASD) development in children. It proposes that one of the most likely mechanisms inducing ASD may be maternal immune imprinting, where maternal antibodies cross the placenta and epigenetically 'tune' the fetus's immune system. While this mechanism provides early infection resistance, it can also cause inborn pathologies like ASD in some cases. The document examines how different maternal autoantibody repertoires, influenced by microbes or environmental toxins, may impact fetal development and argues that immune changes are generally adaptive for the mother but potentially pathogenic for the fetus in some situations.
This document summarizes research on the potential link between infection with the parasite Toxoplasma gondii and different classifications of schizophrenia, specifically paranoid, disorganized, and catatonic schizophrenia. The research aims to address a gap in knowledge around whether T. gondii infection is correlated with specific schizophrenia subtypes rather than schizophrenia in general. The study analyzed serum samples from 500 schizophrenia patients and 500 controls in China to look for antibodies for T. gondii. Results found higher rates of latent T. gondii infection in women and those aged 20-29 with paranoid or catatonic schizophrenia compared to controls. This suggests T. gondii may be a risk factor for some schizophrenia subtypes. Further research is
Cluster analysis identified 4 clusters of childhood asthma in a study of 161 children with severe asthma. Cluster 1 had relatively normal lung function and less atopy. Cluster 2 had slightly lower lung function, more atopy, and increased symptoms and medication use. Cluster 3 had greater comorbidity, increased bronchial responsiveness, and lower lung function. Cluster 4 had the lowest lung function and greatest symptoms and medication use. The clusters did not correspond to current definitions of asthma severity. Larger longitudinal studies are needed to validate the clusters.
The document discusses various genetic studies of schizophrenia, including family, twin, and adoption studies. Family studies found an increased risk of schizophrenia in relatives of schizophrenic probands, suggesting a genetic basis. Twin studies estimated the heritability of schizophrenia to be around 80%, while adoption studies found an increased risk of schizophrenia in children adopted away from schizophrenic biological mothers. Overall, these various study designs provide strong evidence for a genetic contribution to schizophrenia.
Systemic lupus erythematosus (SLE) is an autoimmune disease and as we know immune
system is vast and complex and presents an enormous challenge to scientists working in this field as well as presents a challenge to anyone seeking to explain where pathogenesis research stands at the end of 2011
Maternal immunity plays an important role in pregnancy and a child's health. The document discusses how pregnancy can be viewed not as a conflict between mother and fetus, but as a mutually beneficial relationship where they function as a temporary superorganism. A healthy maternal immune system recognizes the fetus and supports development, while immune suppression can increase risks of miscarriage due to incomplete fetal recognition. The role of maternal immunity in pregnancy is complex and not fully understood.
This document summarizes research on the potential link between infection with the parasite Toxoplasma gondii and different classifications of schizophrenia, specifically paranoid, disorganized, and catatonic schizophrenia. The research aims to address a gap in knowledge around whether T. gondii infection is correlated with specific schizophrenia subtypes rather than schizophrenia in general. The study analyzed serum samples from 500 schizophrenia patients and 500 controls in China to look for antibodies for T. gondii. Results found higher rates of latent T. gondii infection in women and those aged 20-29 with paranoid or catatonic schizophrenia compared to controls. This suggests T. gondii may be a risk factor for some schizophrenia subtypes. Further research is
Cluster analysis identified 4 clusters of childhood asthma in a study of 161 children with severe asthma. Cluster 1 had relatively normal lung function and less atopy. Cluster 2 had slightly lower lung function, more atopy, and increased symptoms and medication use. Cluster 3 had greater comorbidity, increased bronchial responsiveness, and lower lung function. Cluster 4 had the lowest lung function and greatest symptoms and medication use. The clusters did not correspond to current definitions of asthma severity. Larger longitudinal studies are needed to validate the clusters.
The document discusses various genetic studies of schizophrenia, including family, twin, and adoption studies. Family studies found an increased risk of schizophrenia in relatives of schizophrenic probands, suggesting a genetic basis. Twin studies estimated the heritability of schizophrenia to be around 80%, while adoption studies found an increased risk of schizophrenia in children adopted away from schizophrenic biological mothers. Overall, these various study designs provide strong evidence for a genetic contribution to schizophrenia.
Systemic lupus erythematosus (SLE) is an autoimmune disease and as we know immune
system is vast and complex and presents an enormous challenge to scientists working in this field as well as presents a challenge to anyone seeking to explain where pathogenesis research stands at the end of 2011
Maternal immunity plays an important role in pregnancy and a child's health. The document discusses how pregnancy can be viewed not as a conflict between mother and fetus, but as a mutually beneficial relationship where they function as a temporary superorganism. A healthy maternal immune system recognizes the fetus and supports development, while immune suppression can increase risks of miscarriage due to incomplete fetal recognition. The role of maternal immunity in pregnancy is complex and not fully understood.
WRTG 3014 - Lydia Wallace - ASD Research ReviewLydia Wallace
The document analyzes potential causes of autism spectrum disorders (ASD) in Utah, specifically the Wasatch Front region which has one of the highest ASD diagnosis rates in the nation. It finds that ASD is caused by a complex combination of genetic and environmental factors. Genetic factors like single nucleotide polymorphisms and copy number variants increase risk when combined with environmental exposures during prenatal development, like air pollutants. Studies have identified ASD "hotspots" in densely populated areas along the Wasatch Front with higher pollution levels. Both the genetic characteristics of the local population from founders and current environmental exposures may contribute to elevated ASD rates in the region.
Prof. Dr. Vladimir Trajkovski-Etiology and pathogenesis of ASDVladimir Trajkovski
These are slides from webinar which Prof. Dr. Vladimir Trajkovski held for colleagues from India. The title of lecture is Etiology and pathogenesis of autism spectrum disorders. Webionar was on YouTube channel in live od 23.05.2018.
Autism Spectrum Disorder A case study of Mikey.pdfKathryn Patel
This case study describes an 8-year-old boy, Mikey, who was diagnosed with Autism Spectrum Disorder at age 4. Mikey is having behavioral issues during his morning routine that disrupt his entire day. An occupational therapy evaluation found that Mikey has sensory processing difficulties, engages in repetitive behaviors, and plays at the social developmental level of a 12-month old. The evaluation suggests occupational therapy to address Mikey's sensory needs and develop his social skills morning routine.
Identification of Biomarkers of Impaired sensory profile among autistic patientsHanan Qasem
This research article aims to identify biomarkers that can distinguish autistic patients from healthy controls and predict the severity of sensory impairment among autistic patients. The study analyzed two sets of biomarkers in plasma samples from autistic and control participants. Principal component analysis showed that six biomarkers significantly correlated with sensory profiles in autistic patients. Multiple regression identified a combination of three biomarkers as best predictors of sensory impairment severity. The identified biomarkers and analysis methods could accurately classify participants and sensory impairment levels, demonstrating their potential for autism diagnosis and assessment.
This document outlines a proposed research study examining whether dairy products and vitamin B12 are dietary inducers of autism spectrum disorder (ASD). The study would involve dividing 20 ASD participants ages 2-35 into four groups with varying diets and vitamin supplementation. Behaviors would be observed and questionnaires administered over 120 days to analyze the effects of the dietary manipulations. The research aims to test the hypothesis that ASD behaviors are influenced by levels of lactose, B vitamins, and sugar in the diet. Ethical considerations for conducting research with ASD participants are also discussed.
President of MSSA Prof. Dr. Vladimir Trajkovski prsented the his topic: "Association between cerebral palsy and autism spectrum disorders" at 8th interdisciplinary congress: "Cerebral palsy and other movement disorders" on 1-2 of November 2018 in Moscow, Russia.
This document discusses autism spectrum disorders and potential environmental and genetic factors that may contribute to autism. It covers topics such as:
- Autism is caused by genetic and environmental factors that influence early brain development.
- Potential environmental factors include advanced parental age, maternal illness during pregnancy, difficult births, and combinations of genetic and environmental risks.
- There is evidence that oxidative stress, issues with methylation pathways, and other biochemical abnormalities may play a role in autism.
- Various studies have found associations between autism and factors like mercury exposure, inflammation, disturbances in one-carbon metabolism, and polymorphisms in genes like MTHFR.
PECULIARITIES OF ANTIBIOTIC-ASSOCIATED DIARRHEA DEVELOPMENT IN CHILDREN WITH ...Alexander Smiyan
ABSTRACT Introduction: Acute respiratory infections (ARI) are the main cause of morbidity in most countries. The probability of complications and age determine antibiotics administration. Antibiotic associated diarrhea (AAD) is one of the side effects of antibiotics. The aim: The study of the prevalence rate of AAD and the characteristics of its development in children with ARI. Materials and methods: The study included 75 children aged from 1 to 12 y diagnosed with ARI, who were treated with age-specific doses of antibiotics. The influence of children's anamnesis, parents' health on the development of AAD was studied with odds ratio calculation (OR). Results: In general, AAD incidence was 52%. The highest frequency 59.3% was observed in children under 3 y. AAD most often developed in children treated with amoxicillin - 92%. The greatest dependence of AAD development was connected with breastfeeding less than 6 months - OR was 7.65, preterm birth - 2.9, functional GIT disorders in anamnesis - up to 3.14, allergy - 2.33. The risk of AAD development increased with the age of parents more than 35 y - 5.03, at the age of parents less than 18 and older than 35 y - 4.09, parents' allergies - 3.74 and parents smoking - 2.43. Conclusions: The most important factors of AAD development on antibiotics therapy in children with ARI are breastfeeding less than 6 months, functional GIT disorders and allergic conditions in anamnesis. Suboptimal age and parents' health (GIT disorders, allergic conditions and unhealthy habits) also increase the risk of AAD development. KEY WORDS: Antibiotic associated diarrhea, children
Autism is a neurodevelopmental disorder characterized by difficulties with social interaction and communication. It has a strong genetic component, with heritability estimates ranging from 40-80%. While hundreds of genes have been implicated, no single gene accounts for more than 1-3% of cases. Both rare and common genetic variants, as well as environmental factors, contribute to autism risk. The causes are highly heterogeneous and complex. Understanding the underlying genetics may help lead to improved diagnosis, treatment and prevention.
Study of Neonatal Outcome with Low Apgar Score in Term Neonatesiosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
An Analytical Study of Acute Flaccid Paralysis in a Tertiary Care Centreiosrjce
This study analyzed 32 cases of acute flaccid paralysis (AFP) admitted to a tertiary care center over one year. The results showed that Guillain-Barré syndrome (GBS) accounted for 14 cases, non-polio AFP for 13 cases, and transverse myelitis for 5 cases. Male patients outnumbered female patients. Respiratory failure was seen in 50% of GBS cases and was a significant complication. Bladder involvement was seen in all transverse myelitis cases. Most cases occurred during monsoon season between April and September.
There is no evidence of an association between schwannomatosis and multiple sclerosis based on a literature search. While some case reports have proposed a link between neurofibromatosis type 1 and multiple sclerosis, the evidence is limited. No previous cases of patients having both schwannomatosis and multiple sclerosis have been described.
A single etiology for autism or for any of the
disorders on the autistic spectrum has yet to be determined. In the past, suspected causes of these disorders included parentally induced autism, brain
injury/anomalies, constitutional vulnerability, and developmental aphasia, as well as deficits in the reticular activating system, and an unfortunate interplay between psychogenic and neurodevelopmental factors. Other suspected etiologies are structural cerebellar changes, genetics, viral infections, and immunological
abnormalities, with various teratogens, seizures and vaccines also being investigated. Until we know the multiple etiologies of those within the Autism
Spectrum; as researchers, health care providers, educators and optometrists, we must offer all within the autistic continuum the very best, most current and accessible care available based upon the latest known science.
A single etiology for autism or for any of the
disorders on the autistic spectrum has yet to be determined. In the past, suspected causes of these disorders included parentally induced autism, brain
injury/anomalies, constitutional vulnerability, and developmental aphasia, as well as deficits in the reticular activating system, and an unfortunate interplay between psychogenic and neurodevelopmental factors.Other suspected etiologies are structural cerebellar changes, genetics, viral infections, and immunological abnormalities, with various teratogens, seizures and
vaccines also being investigated. Until we know the multiple etiologies of those within the Autism Spectrum; as researchers, health care providers, educators and optometrists, we must offer all within
the autistic continuum the very best, most current and accessible care available based upon the latest known science.
This project was developed for a competitive intelligence company by mining data from the various information sources e.g. Company (News, Investor Section, SEC filings, Annual Reports, Presentations etc), Universities/Medical Schools/Organizations, Medical Affairs Companies, Non- Profit Medical Agency, Government Agencies, Drug Delivery Companies, Contract Manufacturing Organizations, Contract Research Organizations, Consultancies and Financial Institutions. The complete information available there complied into a single MS word document, listed in MS Excel and then by using MS publisher it was converted into the report which finally converted into PDF.
Maternal viral exposure during gestation is associated with schizophrenia-like characteristics in offspring. Studies have shown that exposing model organisms to viruses in utero leads offspring to display impaired neural development, brain abnormalities, and irregular activity in the serotogenic and reelin signaling systems. These characteristics mimic those seen in schizophrenia patients. Understanding how viral exposure disrupts development may help identify ways to mitigate schizophrenia risk.
AdVax is a company that is well positioned, developing a new suite of diagnostics, therapeutics, healthcare management tools, vaccines, and monoclonal antibodies in the emerging multi-billion dollar arena of oral-systemic biology. Newly discovered links between two unique oral bacterial pathogens and chronic debilitating systemic illnesses are the basis for AdVax’s groundbreaking solutions for multiple systemic diseases—including Alzheimer’s disease and cardiovascular diseases.
Systemic lupus erythematosus (SLE) predominantly affects young women, so pregnancy is a common occurrence; however, it requires comprehensive planning to ensure a safe pregnancy. SLE can increase the risks of disease flares during pregnancy, preterm birth, miscarriages, and hypertensive diseases of pregnancy. Recognition of SLE disease activity during pregnancy can be difficult due to overlapping physiological changes. Increased disease activity, high prednisone use, hypertension, and other risk factors can contribute to preterm birth and preeclampsia. The presence of antiphospholipid antibodies in SLE patients increases the risks of pregnancy loss, intrauterine growth retardation, and preterm births. Medications must be carefully managed during
This research proposal aims to study the effects of vaccination on neurological development in young children. It proposes a mixed methods case study comparing vaccinated children aged 6 months to 3 years to unvaccinated children on a range of sensory and motor skills tests. The main research question asks if unvaccinated children are healthier in growth and development compared to vaccinated children following the CDC vaccination schedule. If differences are found, it could provide insight into the debate around potential links between vaccination and autism. The study design, tests to be used, and data collection procedures over multiple sessions are outlined.
This review article summarizes the current understanding of the etiology and pharmacological treatment of autism spectrum disorder (ASD). It discusses that ASD is a complex neurodevelopmental disorder caused by both genetic and environmental factors. Several neurotransmitter systems, such as serotonin, dopamine, GABA, and glutamate, have been implicated in the pathogenesis of ASD based on evidence from genetic and preclinical studies. Currently, only two drugs (risperidone and aripiprazole) are approved for treating behavioral symptoms of ASD, but many new drug candidates targeting various neurotransmitter systems are under investigation. The review highlights ongoing research seeking to better understand ASD and develop improved pharmacological therapies for its core symptoms.
DECLARATION OF HELSINKI - History and principlesanaghabharat01
This SlideShare presentation provides a comprehensive overview of the Declaration of Helsinki, a foundational document outlining ethical guidelines for conducting medical research involving human subjects.
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
WRTG 3014 - Lydia Wallace - ASD Research ReviewLydia Wallace
The document analyzes potential causes of autism spectrum disorders (ASD) in Utah, specifically the Wasatch Front region which has one of the highest ASD diagnosis rates in the nation. It finds that ASD is caused by a complex combination of genetic and environmental factors. Genetic factors like single nucleotide polymorphisms and copy number variants increase risk when combined with environmental exposures during prenatal development, like air pollutants. Studies have identified ASD "hotspots" in densely populated areas along the Wasatch Front with higher pollution levels. Both the genetic characteristics of the local population from founders and current environmental exposures may contribute to elevated ASD rates in the region.
Prof. Dr. Vladimir Trajkovski-Etiology and pathogenesis of ASDVladimir Trajkovski
These are slides from webinar which Prof. Dr. Vladimir Trajkovski held for colleagues from India. The title of lecture is Etiology and pathogenesis of autism spectrum disorders. Webionar was on YouTube channel in live od 23.05.2018.
Autism Spectrum Disorder A case study of Mikey.pdfKathryn Patel
This case study describes an 8-year-old boy, Mikey, who was diagnosed with Autism Spectrum Disorder at age 4. Mikey is having behavioral issues during his morning routine that disrupt his entire day. An occupational therapy evaluation found that Mikey has sensory processing difficulties, engages in repetitive behaviors, and plays at the social developmental level of a 12-month old. The evaluation suggests occupational therapy to address Mikey's sensory needs and develop his social skills morning routine.
Identification of Biomarkers of Impaired sensory profile among autistic patientsHanan Qasem
This research article aims to identify biomarkers that can distinguish autistic patients from healthy controls and predict the severity of sensory impairment among autistic patients. The study analyzed two sets of biomarkers in plasma samples from autistic and control participants. Principal component analysis showed that six biomarkers significantly correlated with sensory profiles in autistic patients. Multiple regression identified a combination of three biomarkers as best predictors of sensory impairment severity. The identified biomarkers and analysis methods could accurately classify participants and sensory impairment levels, demonstrating their potential for autism diagnosis and assessment.
This document outlines a proposed research study examining whether dairy products and vitamin B12 are dietary inducers of autism spectrum disorder (ASD). The study would involve dividing 20 ASD participants ages 2-35 into four groups with varying diets and vitamin supplementation. Behaviors would be observed and questionnaires administered over 120 days to analyze the effects of the dietary manipulations. The research aims to test the hypothesis that ASD behaviors are influenced by levels of lactose, B vitamins, and sugar in the diet. Ethical considerations for conducting research with ASD participants are also discussed.
President of MSSA Prof. Dr. Vladimir Trajkovski prsented the his topic: "Association between cerebral palsy and autism spectrum disorders" at 8th interdisciplinary congress: "Cerebral palsy and other movement disorders" on 1-2 of November 2018 in Moscow, Russia.
This document discusses autism spectrum disorders and potential environmental and genetic factors that may contribute to autism. It covers topics such as:
- Autism is caused by genetic and environmental factors that influence early brain development.
- Potential environmental factors include advanced parental age, maternal illness during pregnancy, difficult births, and combinations of genetic and environmental risks.
- There is evidence that oxidative stress, issues with methylation pathways, and other biochemical abnormalities may play a role in autism.
- Various studies have found associations between autism and factors like mercury exposure, inflammation, disturbances in one-carbon metabolism, and polymorphisms in genes like MTHFR.
PECULIARITIES OF ANTIBIOTIC-ASSOCIATED DIARRHEA DEVELOPMENT IN CHILDREN WITH ...Alexander Smiyan
ABSTRACT Introduction: Acute respiratory infections (ARI) are the main cause of morbidity in most countries. The probability of complications and age determine antibiotics administration. Antibiotic associated diarrhea (AAD) is one of the side effects of antibiotics. The aim: The study of the prevalence rate of AAD and the characteristics of its development in children with ARI. Materials and methods: The study included 75 children aged from 1 to 12 y diagnosed with ARI, who were treated with age-specific doses of antibiotics. The influence of children's anamnesis, parents' health on the development of AAD was studied with odds ratio calculation (OR). Results: In general, AAD incidence was 52%. The highest frequency 59.3% was observed in children under 3 y. AAD most often developed in children treated with amoxicillin - 92%. The greatest dependence of AAD development was connected with breastfeeding less than 6 months - OR was 7.65, preterm birth - 2.9, functional GIT disorders in anamnesis - up to 3.14, allergy - 2.33. The risk of AAD development increased with the age of parents more than 35 y - 5.03, at the age of parents less than 18 and older than 35 y - 4.09, parents' allergies - 3.74 and parents smoking - 2.43. Conclusions: The most important factors of AAD development on antibiotics therapy in children with ARI are breastfeeding less than 6 months, functional GIT disorders and allergic conditions in anamnesis. Suboptimal age and parents' health (GIT disorders, allergic conditions and unhealthy habits) also increase the risk of AAD development. KEY WORDS: Antibiotic associated diarrhea, children
Autism is a neurodevelopmental disorder characterized by difficulties with social interaction and communication. It has a strong genetic component, with heritability estimates ranging from 40-80%. While hundreds of genes have been implicated, no single gene accounts for more than 1-3% of cases. Both rare and common genetic variants, as well as environmental factors, contribute to autism risk. The causes are highly heterogeneous and complex. Understanding the underlying genetics may help lead to improved diagnosis, treatment and prevention.
Study of Neonatal Outcome with Low Apgar Score in Term Neonatesiosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
An Analytical Study of Acute Flaccid Paralysis in a Tertiary Care Centreiosrjce
This study analyzed 32 cases of acute flaccid paralysis (AFP) admitted to a tertiary care center over one year. The results showed that Guillain-Barré syndrome (GBS) accounted for 14 cases, non-polio AFP for 13 cases, and transverse myelitis for 5 cases. Male patients outnumbered female patients. Respiratory failure was seen in 50% of GBS cases and was a significant complication. Bladder involvement was seen in all transverse myelitis cases. Most cases occurred during monsoon season between April and September.
There is no evidence of an association between schwannomatosis and multiple sclerosis based on a literature search. While some case reports have proposed a link between neurofibromatosis type 1 and multiple sclerosis, the evidence is limited. No previous cases of patients having both schwannomatosis and multiple sclerosis have been described.
A single etiology for autism or for any of the
disorders on the autistic spectrum has yet to be determined. In the past, suspected causes of these disorders included parentally induced autism, brain
injury/anomalies, constitutional vulnerability, and developmental aphasia, as well as deficits in the reticular activating system, and an unfortunate interplay between psychogenic and neurodevelopmental factors. Other suspected etiologies are structural cerebellar changes, genetics, viral infections, and immunological
abnormalities, with various teratogens, seizures and vaccines also being investigated. Until we know the multiple etiologies of those within the Autism
Spectrum; as researchers, health care providers, educators and optometrists, we must offer all within the autistic continuum the very best, most current and accessible care available based upon the latest known science.
A single etiology for autism or for any of the
disorders on the autistic spectrum has yet to be determined. In the past, suspected causes of these disorders included parentally induced autism, brain
injury/anomalies, constitutional vulnerability, and developmental aphasia, as well as deficits in the reticular activating system, and an unfortunate interplay between psychogenic and neurodevelopmental factors.Other suspected etiologies are structural cerebellar changes, genetics, viral infections, and immunological abnormalities, with various teratogens, seizures and
vaccines also being investigated. Until we know the multiple etiologies of those within the Autism Spectrum; as researchers, health care providers, educators and optometrists, we must offer all within
the autistic continuum the very best, most current and accessible care available based upon the latest known science.
This project was developed for a competitive intelligence company by mining data from the various information sources e.g. Company (News, Investor Section, SEC filings, Annual Reports, Presentations etc), Universities/Medical Schools/Organizations, Medical Affairs Companies, Non- Profit Medical Agency, Government Agencies, Drug Delivery Companies, Contract Manufacturing Organizations, Contract Research Organizations, Consultancies and Financial Institutions. The complete information available there complied into a single MS word document, listed in MS Excel and then by using MS publisher it was converted into the report which finally converted into PDF.
Maternal viral exposure during gestation is associated with schizophrenia-like characteristics in offspring. Studies have shown that exposing model organisms to viruses in utero leads offspring to display impaired neural development, brain abnormalities, and irregular activity in the serotogenic and reelin signaling systems. These characteristics mimic those seen in schizophrenia patients. Understanding how viral exposure disrupts development may help identify ways to mitigate schizophrenia risk.
AdVax is a company that is well positioned, developing a new suite of diagnostics, therapeutics, healthcare management tools, vaccines, and monoclonal antibodies in the emerging multi-billion dollar arena of oral-systemic biology. Newly discovered links between two unique oral bacterial pathogens and chronic debilitating systemic illnesses are the basis for AdVax’s groundbreaking solutions for multiple systemic diseases—including Alzheimer’s disease and cardiovascular diseases.
Systemic lupus erythematosus (SLE) predominantly affects young women, so pregnancy is a common occurrence; however, it requires comprehensive planning to ensure a safe pregnancy. SLE can increase the risks of disease flares during pregnancy, preterm birth, miscarriages, and hypertensive diseases of pregnancy. Recognition of SLE disease activity during pregnancy can be difficult due to overlapping physiological changes. Increased disease activity, high prednisone use, hypertension, and other risk factors can contribute to preterm birth and preeclampsia. The presence of antiphospholipid antibodies in SLE patients increases the risks of pregnancy loss, intrauterine growth retardation, and preterm births. Medications must be carefully managed during
This research proposal aims to study the effects of vaccination on neurological development in young children. It proposes a mixed methods case study comparing vaccinated children aged 6 months to 3 years to unvaccinated children on a range of sensory and motor skills tests. The main research question asks if unvaccinated children are healthier in growth and development compared to vaccinated children following the CDC vaccination schedule. If differences are found, it could provide insight into the debate around potential links between vaccination and autism. The study design, tests to be used, and data collection procedures over multiple sessions are outlined.
This review article summarizes the current understanding of the etiology and pharmacological treatment of autism spectrum disorder (ASD). It discusses that ASD is a complex neurodevelopmental disorder caused by both genetic and environmental factors. Several neurotransmitter systems, such as serotonin, dopamine, GABA, and glutamate, have been implicated in the pathogenesis of ASD based on evidence from genetic and preclinical studies. Currently, only two drugs (risperidone and aripiprazole) are approved for treating behavioral symptoms of ASD, but many new drug candidates targeting various neurotransmitter systems are under investigation. The review highlights ongoing research seeking to better understand ASD and develop improved pharmacological therapies for its core symptoms.
DECLARATION OF HELSINKI - History and principlesanaghabharat01
This SlideShare presentation provides a comprehensive overview of the Declaration of Helsinki, a foundational document outlining ethical guidelines for conducting medical research involving human subjects.
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
- Video recording of this lecture in English language: https://youtu.be/Pt1nA32sdHQ
- Video recording of this lecture in Arabic language: https://youtu.be/uFdc9F0rlP0
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Kosmoderma Academy, a leading institution in the field of dermatology and aesthetics, offers comprehensive courses in cosmetology and trichology. Our specialized courses on PRP (Hair), DR+Growth Factor, GFC, and Qr678 are designed to equip practitioners with advanced skills and knowledge to excel in hair restoration and growth treatments.
The skin is the largest organ and its health plays a vital role among the other sense organs. The skin concerns like acne breakout, psoriasis, or anything similar along the lines, finding a qualified and experienced dermatologist becomes paramount.
Mercurius is named after the roman god mercurius, the god of trade and science. The planet mercurius is named after the same god. Mercurius is sometimes called hydrargyrum, means ‘watery silver’. Its shine and colour are very similar to silver, but mercury is a fluid at room temperatures. The name quick silver is a translation of hydrargyrum, where the word quick describes its tendency to scatter away in all directions.
The droplets have a tendency to conglomerate to one big mass, but on being shaken they fall apart into countless little droplets again. It is used to ignite explosives, like mercury fulminate, the explosive character is one of its general themes.
share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system
These lecture slides, by Dr Sidra Arshad, offer a simplified look into the mechanisms involved in the regulation of respiration:
Learning objectives:
1. Describe the organisation of respiratory center
2. Describe the nervous control of inspiration and respiratory rhythm
3. Describe the functions of the dorsal and respiratory groups of neurons
4. Describe the influences of the Pneumotaxic and Apneustic centers
5. Explain the role of Hering-Breur inflation reflex in regulation of inspiration
6. Explain the role of central chemoreceptors in regulation of respiration
7. Explain the role of peripheral chemoreceptors in regulation of respiration
8. Explain the regulation of respiration during exercise
9. Integrate the respiratory regulatory mechanisms
10. Describe the Cheyne-Stokes breathing
Study Resources:
1. Chapter 42, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 36, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 13, Human Physiology by Lauralee Sherwood, 9th edition