NanoSynergy Worldwide has developed a proprietary nanotechnology processing platform called NanoSynergy that can molecularly disperse nutrient aggregates without altering chemical bonds. This allows for smaller particle sizes that have greater absorption and efficacy. Their patented technology has been proven to dramatically improve various nutraceutical and pharmaceutical compounds. It can enhance existing products by creating stable nano-sized formulations. This provides a competitive edge through superior performance at lower dosages. NanoSynergy licenses its technology to strategic partners to develop innovative health and wellness products across multiple markets.

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Strategic Technology
Overview
Russell Van de Casteele,
Inventor
“Setting the Standard in Nanotechnology”

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“All forms of technology, including
information technology and biotechnology,
will become passé with the advent of
nanoscience. It is a precursor to the next
wave of pervasive technology.”
Robert Curl Jr.
Nobel Laureate

3. NanoSynergy Worldwide has been acknowledged for its’ technology
through:
 The Smithsonian Institute
 The Hubert Humphrey Institute of Public Affairs
 The Woodrow Wilson Institute of Nanotechnology
 The National Nanotechnology Initiative (NNI)
 Food and Drug Administration (FDA)
 New York Times, LA Times, Palm Beach Post, Nutraceutical World,
Nutritional Outlook, Drug Store News, Bloomberg Businessweek,
Nanotechnology Now, and many other publications & journals globally.
NanoSynergy Worldwide has been featured in:
 Hugh Downs National Medical Report
 28 minute infomercial
 Home Shopping Group 60 second commercial
 Genimation Marketing Report

5.  Hubert Humphrey Institute of Public Affairs analysed all
212 claims of nano in the NY Times article ...
 Only 13 products in all categories ... out of 212 products
named were rated as “nano”
 Spray For Life's Vitamin B-12 was the only health product
that actually was rated as “nano”

6. One meter is @ 39 inches – so a nanometer
is one-billionth of a meter.
A sheet of paper is 100,000 nm thick.
The width of a human hair is @ 80,000 nm.
A nm is to 1 inch as 1 inch is to 400 miles.
A person who is 6-feet tall is 1,830,000,000 nm tall.
The letter “I” printed here is @ 1 million nm wide.

7. Recommended Dietary Allowance (RDA) the amounts of selected nutrients considered adequate
to meet the nutrient needs of healthy people. These recommendations are set on the basis of studies
taken from healthy people involving the various states of nutrient depletion.
Electron Micrograph
NanoSynergy conducted Particle Size Studies on 100’s of Market Leaders
- Tablets, Capsules, Sprays, Liquids, Gel Capsules, Beverages
- Vitamins, Herbal Extracts, Minerals, Nutrients, “Nano”
Too Hard
Too Large

8. Conclusion: Numerous commonly prescribed medications in their undissolved,
undigested state are visible on plain x-ray films, as are mineral supplements, which
have high radiodensities. At times, the appearance of these medications and
supplements may be confused with organic pathologic conditions.
MAYO CLINIC PROC. 1998;73:516-519

9. Biophysical Digestion
How Does the Body Mechanically Breakdown Particles? Chewing
Digestive enzymes only breakdown biopolymers, not aggregates.
NanoSynergy ® uses biophysics to digest aggregates into
molecular dispersions, solutions, and emulsions that are
optimized for cellular absorption and biological activity.
Biomechanics of Teeth
NanoSynergy ® uses biophysics to digest aggregates into
molecular dispersions, solutions, and emulsions that are
optimized for cellular absorption and biological activity.

10. Nano Micron
Dehydration and Compaction
NanoSynergy® Hydration and Molecular Dispersion
<1nm

11. A comparison of shear rates of a Microfluidizer versus other technologies

12. NanoSynergy®

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NanoSynergy® developed
technology to accelerate
fluids faster than the
speed of sound to 1500
ft/sec for 3-5 nanoseconds
to create extreme shear and
impact forces necessary for
molecular dispersion
without excessive heat or
breaking chemical bonds.

14. Niacinamide Liquid Emulsion Study
Particle Size 15.1 microns
Before processing
100x each dash is 10 µm
Particle Size 0.087 microns
87 nanometers (175x smaller)
After processing
100x each dash is 10 µm
NanoSynergy®
Trade Secrets

15. NanoSynergy®
Restoring Nature

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Approved Processing Patent:
A Method of Delivery of a Biological
Active Agent For
Humans And Animals
(U.S. Patent#6,861,066 March 1, 2005)
International Patents Filed:
NanoSyzed™ B-12 Composition for treatment of Pernicious Anemia
(Patent Pending#20060280761)
Enhanced Artemisinin-Based Combination Therapy For Treating
Parasitic Mediated Disease For Malaria
(Patent Pending#20140256761)
For Dengue Fever (Patent Pending#20140256762)

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“The combination of applied Nanotechnology with any
compound, molecule, mixture or fluid so as to result in an end
product of smaller particle size to yield greater efficiency, efficacy,
activity or penetration without altering its atomic,
molecular or chemical structure.”
~1000x
~1000x

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 Proven to be Cost-Effective
 Fast and efficient flow rates
 Meets all standards for sanitary and sterile
manufacturing requirements
 Utilizes cold processing technology platform
 Breaks apart aggregates, but does not break covalent
chemical bonds
 Customizes particle size of various compounds at the Nano
and Micro scale levels

19. NanoSynergy® Sprays
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NanoSynergy® sprays are water based with natural stabilizers to maximize
cellular bioavailability. In contrast, dry nanoparticles aggregate during
hydration.
New Products – Vitamin C+ Zinc, Spray For Life Sports™ - Energy, Alert-Focus,
Breakfast For The Brain - Neurological Health.
Spray for Life®

20. NANO
CHARGED
Boost energy, metabolism, mood, and strength along with supporting proper
nervous system functioning. Also improves concentration, mental clarity, and
cognitive function while strengthening our immune system. A new product to
our Spray For Life® Family.
B 5000

21. 2nm
human hair dust mite
mosquito
bacteria
virus
cell receptor
human cell
insulin
DNA
<1nm

24. Spray for Life ®
Nano-B12 (0.8nM)
Text
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450 times larger
2,700 times larger 80,000 times larger
Competitor A
Competitor B Competitor C

27. “Nano” Competitors 100 to 100,000 times Larger than NanoSynergy® Products
<1nm

29. Nano-Diffuse “patent pending” by Iovate Health Sciences and MuscleTech

30. Particle Size = 5 to 100 Microns
5,000 to 100,000 times larger than Spray For Life Nano B-12
Mislabeled Product – Not possible to be 2,003mg/ml
<1nm

31. 200nM
Filter
Only Spray for Life® B-12 was small enough to pass through the 200nM filter.

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0
50
100
150
200
250
Spray For Life® (NanoSyzed™ B-12 spray)
vs. non-processed B-12 tablet
percent change above baseline
Tablet
Spray

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Abnormalities of size and shape of the red blood cells in a patient
with pernicious anemia induced by vitamin B-12 deficiency.
NanoSyzed™ Spray For Life® B-12 Booster
Results within 30 days of treatment using

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“In my 30 years of evaluating manual red blood
cells, I've never seen such rapid and positive change
in my patients, not only in test results, but
symptoms. Normally using a typical sublingual
tablet or injection of vitamin B-12, it would take
much longer to correct.”
Ellie Cullen, RN
Your Future Health, Tampa, FL

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37. Nature's Answer
Sedimentation Comparisons
What Would You Buy if You Knew What was Inside?
Spray
For Life®
Comp A Comp B Comp C

39. Utilizing a Malvern Spraytec device,
each micron sized droplet contains
thousands of nanoparticles. The
micron size NanoMist® droplets will
not be transported to the lungs

40. Spray For Life® vs Leading
100 mg of Ubiquinone COQ10
Baseline before Competitor - 1.35 ug/mL
After Competitor -1.46 ug/mL, a difference of .11
Baseline before SFL - 1.01 ug/mL
After SFL - 3.02 ug/mL, a difference of 2.01
Conclusion: Spray For Life® was found to be over 18 times better absorbed than the Leading
Competitor while starting with a much lower baseline. If you would take the regular Spray
For Life® COQ10 25mg, the absorption rate would be over 4.5 times better absorbed than
the Leading Competitor’s 100 mg CoQ10.

41. Before BFB
After BFB
0
2
4
6
8
10
12
14
16
18
Level
of
Depression
Average Depression Scores, Before & After BFB
Depression Before & After BFB
Twenty-nine subjects from ages 19-77 were tested. Treatment was at least two weeks
demonstrating 100% overall improvement, only two were slightly improved. These
results are quite noteworthy in that no antidepressant medications have as high an
efficacy (93%) in treating depression.
Figure 1. Average Depression Scores Before and After BFB Treatment
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4
6
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10
12
0 5 10 15 20 25 30
Depression
Score
AFTER
BFB
Depression Score BEFORE BFB
Individual Depression Scores
Before & After BFB
Figure 2. Individual Depression Scores Before and After BFB Treatment Values
Most subjects showed a very high level of change in their depression scores, reporting
either no or minimal depression after using BFB. All subjects reported fewer or less
severe anxiety attacks in the 2+ weeks following use of BFB. 85% reporting no
anxiety attacks whatsoever after starting to use BFB. Meanwhile, regarding subjects’
responses to stressors in their lives, all but one subject in the current sample – i.e., 97%
of subjects – reported a decrease in their perceived level of stress.

42. Sedimentation Comparisons
What Would You Buy if You Knew What was Inside?
SFL Comp A Comp B Comp C
Spray for Life® Vitamin D3 blows away the competition!
Leading store brand Vitamin D3 tablets as shown above are completely insoluble
in simulated gastric fluid. One spray of our Spray for Life® Nano Vitamin D3 is
equal to one tablet (1000IU), if it completely dissolved.
SFL Vit D3 Comp A Comp B
Note areas of
insolubility/creaming

43. “I highly recommend Spray For Life products to my patients as a
superior delivery system and as an effective treatment for specific
related problems.”
Lise M. Lambert. MD, Holy Cross Hospital, FL.
“I use Spray For Life in my clinical practice. I have long been a
proponent of boosting Vitamin D-3 above 70 in patients and disregard
the suboptimal "reference range" of 40-70 as within range. The difficult
part is getting patients into the optimal range, even with weekly
100,000iu intramuscular injections. This nano Spray For Life has really
impressed me and changed the way I address patients with a Vitamin D-
3 deficiency. The first few times I did follow-up lab work on serum D-3
levels I thought it was a lab reporting error by how quickly the levels
increased. After several patients demonstrated the same increase I
knew it could only be the product.”
Dr. Ryan Brady, Miami

44. An independent evaluation utilizing the Malvern NanoSight equipment
at the University of Minnesota has confirmed that the Spray For Life D-3
product resulted in particles within the solution that were mostly 95
nm, with very few at 185nm.

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Cells
+ B-Amyloid
+ M-Vit E (0.6 mg/ml) or
N-Vit E (0.005 mg/ml)
Cells
+ B-Amyloid
Control
Untreated Cells
Arbitrary
units
for
Generation
of
ROS
Vitamin E - Enhanced Anti-oxidant activity NanoSyzed™ vs Microemulsion
NanoSyzed™ Vitamin E is 100 times more active than
Microemulsion Encapsulated Vitamin E in reducing levels of
reactive oxygen species (ROS) in cell culture.
43 nm

46. Nano ID:Q20025-1
AthenticNano™ Certificate
Spray For Life® B-12 Booster
This day 1st of January 2021
Russell Van de Casteele - Inventor
It is hereby certified that the listed sample submitted for testing has
exceeded the established Nano-Standard guidelines and qualifies to
be accurately labeled as an authentic NanoSyzed ™ product.
This product has met the stringent testing criteria for an Authentic
NanoSuspension defined as particles within the medium consisting
of 200 nanometers or less.
Samples taken from this commercial product lot were evaluated for
size and volume distribution using a minimum of three ISO13320-1
testing methodologies.
Russell Van de Casteele

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Features for Manufacturers
 Enhances existing products & formulations by creating stable NanoSyzed™
solutions, emulsions, dispersions
 Reduce amount of raw materials and increase the absorption of nutrients into
the body by stable biophysical “digestion” of agglomerates
 Competitive marketing edge with efficient integration with existing processing
to create superior, stable, and patentable products
Benefits for Consumer
 No water or large tablets (40% of Americans experience difficulty)
 Exceptional product performance – faster acting (e.g. B12 Spray vs Shot)
 Prevent wasting of money on useless aggregated products

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Market Opportunities for Premier Products
Nutraceuticals
Sports Nutrition
Personal Care
Branded Functional Ingredients
Functional Beverages
Pet Nutrition
Over the Counter (OTC)
Pharmaceutical
Biologicals
Veterinary Medicine
Agriculture

49. Nano Liquid Compatible Delivery Methods
Sprays and Droppers (oral, eye, nasal)
Liquid and Gel Caps
Functional Beverages and Foods
Dissolving Mouth Strips
Transdermal Patches
Creams, Toothpaste, Mouthwash
Gummy and Confections
Hydroponics

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NanoSynergy® Worldwide, Inc. is a life science
pioneer that develops and markets science-based
formulations that utilize our proprietary trade
secrets and patented nano-processing platform.
Through strategic partnerships we license technology
to create effective and patentable health and
wellness products for diverse therapeutic areas.

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R&D Begins
Product
Concepts
Feasibility
Study
Product
Development Production
Marketing and Revenue
From Idea to Revenue in 3 to 9 months

52. 25 cents $3/day

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Our particle size analysis of 100’s of leading nutraceutical products shows that
nearly the entire industry could benefit from the patented technology
developed by NanoSynergy Worldwide, Inc.
The lead technology platform, NanoSynergy®, is already proven as a
commercially viable system that works effectively for a variety of water soluble
and insoluble nutraceutical and pharmaceutical compounds.
Our patented technology can be incorporated into common dosage forms for
substantial improvements in product performance.
NanoSynergy® has the potential to dramatically improve the marketability
of a vast range of products that have issues with solubility, stability,
bioavailability, and efficacy.

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Toll Free: 877-NSW-NANO (676-6266)
Fax: 888-248-3960
Websites: Contact:
www.nanosynergyww.com NanoSynergy Worldwide
www.sprayforlife.com info@nanosynergyww.com
www.sprayforlife.org donations@sprayforlife.org