Chronic skin disease Other name = Leukoderma White spots occur when the skin no longer forms melanin (pigment that determines the color of your skin, hair, and eyes) The white patches of irregular shapes begin to appear on your skin
White patches of skin Whitening or graying of the hair on your scalp, eyelashes, eyebrows or beard Loss of color in the tissues that line the inside of your mouth Loss or change in color of the inner layer of your eye
Chalk white color Convex margins 5mm to 5cm or more in diameter Round, oval, or elongated in shape AVRF
Focal pattern—the depigmentation is limited to one or only a few areas Segmental pattern—depigmented patches develop on only one side of the body Generalized pattern—(most common) depigmentation occurs symmetrically on both sides of the body Focal and segmental patterns do not spread. The generalized pattern is hard to predict and can randomly stop
Can appear at any age, usually first appears between the ages of 20 and 30 White patches may begin on your face above your eyes or on your neck, armpits, elbows, genitals, hands or knees 1-100 of the world population develops Affects both genders and all races equally
When no melanin is produced, the involved patch of skin becomes white When a white patch grows or spreads the cause may be Vitiligo Exact cause is unknown May be due to an immune disorder, heredity, or environmental causes like sunburn or emotional distress that trigger the condition
A family history of Premature graying of vitiligo the hair (before age 35) Look to see if there is a Stress or physical rash, sunburn, or other illness skin trauma that has occurred within 2 or 3 Also they may ask for months after an eye examination pigmentation was (inflammation of your discovered eye) and/or blood test (autoimmune disease)
Vitiligois difficult to treatEarly treatment options include: Exposure to intense ultraviolet light, such as narrow-band UVB therapy Medicines taken by mouth such as trimethylpsoralen (Trisoralen)Medicines: Corticosteroid creams Immunosuppressants such as pimecrolimus (Elidel) and tacrolimus (Protopic) Repigmenting agents such as methoxsalen ( Oxsoralen)
The use of steroid creams may be helpful in returning the color to the white patches Doctors often prescribe a mild topical corticosteroid cream for children under 10 years old and a stronger one for adults Cream must be applied to the white patches on the skin for at least 3 months before seeing any results Corticosteriod creams are the simplest and safest treatment for vitiligo, but are not as effective as psoralen photochemotherapy SIDE EFFECTS occur in areas where the skin is thin, such as on the face and armpits, or in the genital region › They can be minimized by using weaker formulations of steroid creams in these areas.
Most effective treatment available in the United States. PUVA therapy is to repigment the white patches time-consuming, and care must be taken to avoid side effects Psoralen is a drug that contains chemicals that react with ultraviolet light to cause darkening of the skin. Psoralen is injected orally or is applied to the skin Then skin is carefully timed exposure to sunlight or to ultraviolet A (UVA) light that comes from a special lamp. WWHT Dermatology
Used for children 2 years old and older who have small number white spots in a few areas Treatments are done under an artificial UVA light once or twice a week. Psoralen is applied to your depigmented patches about 30 minutes before exposing you to enough UVA light to turn the affected area pink. The doctor usually increases the dose of UVA light slowly over many weeks. Eventually, the pink areas fade and a more normal skin color appears. SIDE EFFECTS: › (1) severe sunburn and blistering › (2) too much repigmentation or darkening (hyperpigmentation) of the treated patches or the normal skin surrounding the vitiligo. For people with extensive vitiligo (affecting more than 20 percent of the body) or for people who do not respond to topical PUVA therapy Not recommended for children under 10 years of age because it increases the risk of damage to the eyes caused by conditions such as cataracts. You take a prescribed dose of psoralen by mouth about 2 hours before exposure to artificial UVA light or sunlight. Treatments are usually given 2 or 3 times a week, but never 2 days in a row. For patients who cannot go to a facility to receive PUVA therapy, the doctor may prescribe psoralen that can be used with natural sunlight exposure. SIDE EFFECTS include: Sunburn, nausea and vomiting, itching, abnormal hair growth, and hyperpigmentation. May also increase the risk of skin cancer,
Used for people with small patches of vitiligo The doctor removes sections of the normal, pigmented skin and places them on the depigmented areas Infections may occur at the donor or recipient sites The recipient and donor sites may develop scarring, a cobblestone appearance, or a spotty pigmentation, or may fail to cure the white spot area Takes time and is very costly Doctor creates blisters on your pigmented skin by using heat, suction, or freezing cold The tops of the blisters are then cut out and transplanted to a depigmented skin area SIDE EFFECTS: scarring and lack of repigmentation Less risk of scarring with this procedure than with other types of grafting.
Implanting pigment into the skin with a special surgical instrument Works best for the lip area, particularly in people with dark skin Difficult to match perfectly the color of the skin of the surrounding area The tattooed area will not change in color when exposed to sun, while the surrounding normal skin will. Tattooing tends to fade over time Also tattooing of the lips may lead to episodes of blister outbreaks caused by the herpes simplex virus Takes a sample of your normal pigmented skin and places it in a laboratory dish containing a special cell-culture solution to grow melanocytes. When the melanocytes in the culture solution have multiplied, the doctor transplants them to your depigmented skin patches Currently experimental and is impractical for the routine care of people with vitiligo Very expensive and its side effects are not known.
Blue Lizard Baby& Sunscreen Sensitive Sunscreen Helps protect the skin from sunburn and long- term damage Minimizes tanning, which makes the contrast between normal and depigmented skin less noticeable AVRF
Some vitiligo patients cover depigmented patches with stains, makeup, or self-tanning lotions. Dermablend, Lydia O’Leary, Clinique, Fashion Flair, Vitadye, and Chromelin offer makeup or dyes that you may find helpful for covering up depigmented patches Self tanning lotions have an advantage over makeup in that the color will last for several days and will not come off with washing. AVRF
SUPPORTorganizations 1)National Vitiligo Foundation 2)Vitiligo Support International 3)American Vitiligo Research Fou
Nation Library of Medicine (Medicine Plus) American Vitiligo Research Foundation National Institutes of Health, Department of Health and Hum : National Institute of Arthritis and Musculoskeletal and Skin Diseases Drugs.com (Treatments) youtube.com (Lee Thomas- Turning White 20/20 Interview) National Vitiligo Foundation (video gallery-Elizabeth Vargas Interview)
National Vitiligo Foundation American Vitiligo Research Foundation Inc. Visualdxhealth Revolution Health WWHT Dermatology Elidel National Vitiligo Foundation Vitiligo Support International
Kids coping with VitiligLee ThomasElizabeth Vargas Interv
Ingredient Main active substance Action Coconut oil is the only type of oil that one Coconut oil contains should use on one‘s essential saturated skin for it is absorbed and unsaturated fatty easily and keeps theCocos nucifera oil acids, High skin soft. Coconut oil concentration of contains Vitamin E Vitamin E and K, high Alpha Tocopherol. This concentration of Zinc kind of Vitamin is a .and Iron well-known potent antioxidant and is .beneficial to the skin
Ingredient Main active Action substancePsoralea corylifolia Psoralea corylifolia Psoralea corylifolia appears to have a purely local action with a specificextract contains flavons, effect on the arterioles of the subcapillary plexuses, which are isoflavons, dilated so that the plasma is furanocoumarins, increased in this area. The skin becomes red and the melanoblasts chalcones and )pigment-forming cells( are stimulated. In leukoderma, coumesterol group of melanoblasts do not function compounds which properly and their stimulation by the drug leads them to form and includes psoralen, exudate pigments, which gradually diffuse into the white leukodermic isopsoralen and patches.] Also, the phytochemically .bavichinin2 induced covalent binding of the drug to pyrimidine bases is responsible for its therapeutic effect. The photoconjunction involves thymine dimer adducts on the opposite strands of DNA. Psoralen has been found to intercalate into DNA, where they form mono- and di-adducts in the presence of long wavelength UV light and thus are used for the treatment of hypo-pigmented lesions of the skin, such as .leukoderma
Ingredient Main active substance Action Barberry includes such alkaloids as berbamine, berberine, oxyacanthine, resin and tannins, and Barberry root hasBerberis vulgaris root chelidonic acid. antioxidant andextract Barberry Root also cytoprotective constituents the B- .properties vitamin thiamine, vitamin C, lutein, zeaxanthin, the carotenoids beta- carotene, chromium, .zinc, and cobalt
Ingredient Main active substance Action Picrorhiza kurroa was found to be a potent immunostimulant of Picrorhiza kurroa root both cell-mediatedPicrorhiza kurroa root extract contains and humoral immunity.extract Kutkin, D-Mannitol and picrorhiza was Vanillic acid reported to stimulate cell mediated and humoral components of the immune system including stimulation of .phagocytosis
Ingredient Main active substance Action Powerful and broad spectrum anti-Melaleuca Alternifolia Terpineol ,Cineol, microbial agent )Anti-)TeaTree( Leaf Oil Pinene ,Terpinenes bacterial, anti-fungal and anti-mycotic agent(, and it has an immune system stimulant effect
Ingredient Main active substance Action Used by the Aboriginal people of Australia for the treatment of muscle and joint pain, contains a variety ofEmu oil Linolinic acis and fatty acids. Modern Oleic acid research into the properties of emu oil has found that this is the greatest skin emollient in the world, with deep skin penetration properties better than any other .natural oil
Ingredient Main active substance Action)Vitamin E )Tocopherol Alpha-tocopherol Powerful anti-oxidant agent
Natural pathway for PUVA therapy. Rich source of natural powerful anti- oxidants. Rich source of essential minerals and vitamins for vitiligo patients. Safe with minor side effects. Cost effective.
Great thanks for your listeningKena Roots for therapeutic cosmetics Dr. Hani Malkawi