Technology Insight Report                                 Anti- Aging Skin Care                                 Compositio...
OverviewIntroduction to Anti- Aging Skin CareAlthough the aging process encompasses a wear and deterioration on thevarious...
Ingredients & Compounds Commonly AssociatedWith Anti Aging Skin Care ProductsAs well as more conventional moisturizing ing...
Characteristics of Ingredients & Anti Aging SkinCare CompoundsRetinol – Skin care professionals consider this form of Vita...
Global Market For Anti Aging Skin Care ProductsAccording to a report by Global Industry Analysts published in a pressrelea...
Anti Aging Skin Care Compounds – Insights fromPatentsOverviewPatent filings around the compounds and compositions used for...
Categories of Skin Care CompositionsWe categorized Skin Care Compositions along the following lines:        Ingredient Cat...
Publication TrendWhat has been the IP publication trend for Anti- Aging related Skin Care ingredients and compounds?Patent...
Top AssigneesWho have been the top assignees or the key players within this industry?   1.  Proctor & Gamble Co           ...
Assignee - Key StatisticsHere we summarize key parameters of Top 15 Assignees such as filing trend, Avg. number of Forward...
How we did it?In order to compress all the information into a single report, we used the 360 ° series of reports available...
Inventor - Key StatisticsHere we summarize key parameters of Top 15 Inventors such as filing trend, average number of forw...
How we did it?In order to compress all the information into a single report, we used the 360 ° series of reports available...
Key inventor Groups: L’oreal                                    © 2010 Gridlogics. All Rights Reserved.                   ...
Key inventor Groups: Johnson & JohnsonHow we did it?Using the VizMAP tool, patents of top three assignees, namely, Procter...
Assignee Portfolios spread across different Ingredient CategoriesHere we have correlated key Ingredients used across anti-...
How we did it?We used the categories created and using the co-occurrence analyzer, we selected the categories and theassig...
Assignee Portfolios spread across various skin problems related to agingWhat are the key problem areas explored by top ass...
How we did it?We used the categories created and using the Co-occurrence Analyzer option, we selected the categories wewan...
What properties are used across different types of key ingredient categories?The matrix below shows the properties of diff...
How we did it?We manually created categories of key ingredients and properties. A two-level categorization was done in cas...
How do the key ingredients compare across various aging skin problems areas?The matrix below shows to what extent a partic...
How we did it?The clusters of categories of skin cream ingredients and skin aging problems that were created for the previ...
Assignee Landscape around Key Ingredients and popular skin aging problemsThe below chart shows the Assignee Landscape arou...
© 2010 Gridlogics. All Rights Reserved.       Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedb...
© 2010 Gridlogics. All Rights Reserved.       Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedb...
© 2010 Gridlogics. All Rights Reserved.       Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedb...
Many inferences around the Assignee focus area can be made from the above matrix. We can see thatAllergan Inc. focuses pri...
New Companies in the last 5 years having 3 or more recordsThe map below shows patents of new assignees in the last 5 years...
Appendix A: Key Assignee Normalization TablePROCTER & GAMBLE CO.PROCTER AND GAMBLE                                        ...
PFIZER INC.                                             UNILEVER PLCWILLIAMS KEVIN JON                                    ...
Appendix B: Search Strings Used for CategorizationCategorization: Ingredient Categories1. Chemical Peels                  ...
6. Boswellia Serrata                                             Boswellia Serrataaclm contains boswelli*                 ...
12. Sunscreen Ingredients                                        Sunscreen Ingredients aclm contains Enzacamene* or Parsol...
dimethico-diethylbenzalmalonate* or                      8 resultspolysilicone-15 or parsol slxaclm contains Ensulizole* o...
4. Anti inflammatory                                            Anti inflammatoryanti w/3 inflam*                         ...
SummaryPatent analysis shows research around anti aging skin care compoundsstart to take shape as early as the 1950’s but ...
Sources & References     http://en.wikipedia.org/wiki/Anti_Aging     http://www.myhealthnewsdaily.com/skin-care-anti-aging...
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Technology Insight Report Anti Aging Skin Care Compounds

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Technology Insight Report Anti Aging Skin Care Compounds

  1. 1. Technology Insight Report Anti- Aging Skin Care Compositions Finding solutions against aging or the signs of aging has been a quest for centuries according to history. However, the signs around us from advertisements on TV, the general media to the skin care shelves in retail stores all point to this demand for anti-aging skin care compounds being higher than ever before with ‘staying young’ on every consumers mind. What does patent data reveal about the quest for newer and better anti-aging skin care compounds? Is there really an increase in research around this? What are the key problems and solutions when it comes to aging skin? Who are leading the quest to provide consumers with the means to keep their appearances from falling victim to the aging process? We look into patent filings and data to uncover some insights.Disclaimer: This report should not be construed as business advice and the insights are not to be used as the basisfor investment or business decisions of any kind without your own research and validation. Gridlogics TechnologiesPvt. Ltd. disclaims all warranties whether express, implied or statutory, of reliability, accuracy or completeness ofresults, with regards to the information contained in this report. © 2010 Gridlogics. All Rights Reserved. Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd. Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com
  2. 2. OverviewIntroduction to Anti- Aging Skin CareAlthough the aging process encompasses a wear and deterioration on thevarious organ systems of the body, changes within the body and overallfitness levels, among the most visible signs on the exterior are signs ofaging on the skin. Wrinkles, lines, frown lines, blemishes and pigmentationchanges all point out to aging and the human need to prevent or slowdown these signs as far as possible has given rise to a multi-billion dollarmarket for products that can offer this. While the personal care and skincare industry on its own is a massive one, research and developmentactivity around anti-aging skin care compounds has played a large role indetermining which of the large players in this market can grab a largershare since the demand for anti-aging skincare products is growing rapidly.To understand the research around solutions for aging skin, we need totake a look at the problems associated with it.Problems Associated With Aging SkinAccording to Wikipedia as a source on the topic of anti-aging creams: Anti-aging creams are predominantly moisturiser based cosmeceutical skin careproducts marketed with the promise of making the consumer lookyounger by reducing visible wrinkles, expression lines, blemishes,pigmentation changes, discolourations and other environmentally(especially from the sun) related conditions of the skin. A comprehensivegrading scale for anti-aging of the skin has been validated and categorizesskin aging as: laxity (sagging), rhytids (wrinkles), and the various categoriesof photoaging, including erythema (redness), dyspigmentation (browndiscolorations), solar elastosis (yellowing), keratoses (abnormal growths),and poor textureSource: http://en.wikipedia.org/wiki/Anti-aging_cream © 2010 Gridlogics. All Rights Reserved. Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd. Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com
  3. 3. Ingredients & Compounds Commonly AssociatedWith Anti Aging Skin Care ProductsAs well as more conventional moisturizing ingredients, anti-aging creamsusually contain anti-aging ingredients such as: Retinol (for instance, in the form of retinyl palmitate). In various formulations it has been shown to reduce fine lines and pores. Epidermal Growth Factor, made of 53 amino acids to stimulate Retinol cell renewal and Collagen production in the skin and strengthen elasticity and structure. The discovery of Epidermal Growth Factor won Dr. Stanley Cohen a Nobel Prize in Physiology and Medicine in 1986. In various research Epidermal Growth Factor has been shown to reduce fine lines, wrinkles and sagging.[8]It also has healing (wounds and burns) and anti-inflammatory properties when applied to skin. Alpha hydroxy acids (AHAs) and beta hydroxy acids or other chemical peels. These help to dissolve the intracellular "glue" that holds the dead cells together on the skin. The use of Anti Oxidants this type of product on a daily basis gradually enhances the exfoliation of the epidermis. This exposes newer skin cells and can help improve appearance. AHAs may irritate some skin, causing redness and flaking. Peptides, such as Argireline (acetyl hexapeptide-3), Matryxil, and copper peptides. Coenzyme Q10 Anti-oxidants are substances that may protect cells from the damage caused by unstable molecules known as free radicals. Sunscreens. A high level of UVA protection is recommended as UVA radiation is associated with aging effects such as wrinkles.The effects of these ingredients depend on their concentration and mode Alpha Hydroxyl Acidsof application. Many skin care companies recommend using a treatmentprogram which may combine these ingredients. For example, AHAs canmake the skin more vulnerable to damage from the sun, so the increaseduse of sunscreens is often recommended. © 2010 Gridlogics. All Rights Reserved. Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd. Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com
  4. 4. Characteristics of Ingredients & Anti Aging SkinCare CompoundsRetinol – Skin care professionals consider this form of Vitamin A thegold standard of effective topical treatments. Also available asprescription strength Retin-A, retinol is an ingredient in myriad over-the-counter products. It ramps up cell turnover in the top layers of theskin, decreasing wrinkles and improving skin tone.Source: http://www.myhealthnewsdaily.com/skin-care-anti-aging-creams-100929-0464/Peptides – These chains of amino acids act as signaling molecules incells, telling them to heal, renew and slough away. One of the better-known peptides is argireline, also known as Matrixyl, which softenscrows feet by slowing the contraction of tiny muscles around theeyes. SunscreenSource: http://www.myhealthnewsdaily.com/skin-care-anti-aging-creams-100929-0464/Antioxidants – Fighting cell damage from free radicals, which areproduced when skin is exposed to sunlight and some chemicals,antioxidants can make skin firmer and more radiant, according toNeronha. Wear them, eat them and drink them, experts say. They areavailable in topical creams with extracts of ingredients such as greentea and pomegranate. Many foods, especially fresh produce andbeverages such as fruit juice and various varieties of tea, also containantioxidants. ExfoliantSource: http://www.myhealthnewsdaily.com/skin-care-anti-aging-creams-100929-0464/Alpha hydroxyl acids (AHAs) – These compounds, which includeglycolic, lactic, citric and mandelic acids, can help peel away the toplayers of the skin to erase fine lines. AHAs are available in both OTCand prescription strengths.Source: http://www.myhealthnewsdaily.com/skin-care-anti-aging-creams-100929-0464/Exfoliants – These help remove the uppermost layer of dead cells onthe skin in order to keep the skin clean and pores open. While thesecan be associated with mechanical means of scrubing the outer most Peptideslayer of skin, Chemical exfoliants include scrubs containing salicylicacid, glycolic acid, fruit enzymes, citric acid, or malic acid whichmay be applied in high concentrations by a medical professional, orin lower concentrations in over-the-counter productsSource: http://en.wikipedia.org/wiki/Exfoliation_(cosmetology) © 2010 Gridlogics. All Rights Reserved. Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd. Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com
  5. 5. Global Market For Anti Aging Skin Care ProductsAccording to a report by Global Industry Analysts published in a pressrelease by Worldhealth.net, the global market for anti-aging products(which includes pharmaceutical products for age related health issues,supplements and appearance based products which include skin care) willbe a estimated $291.9 billion by the year 2015.According to findings in thisreport, “The propensity to spend on skincare is not hugely impactedby a slowdown, rather consumer preferences during these periodstend to shift towards lower priced mass-market products.”Source:http://www.worldhealth.net/news/global_anti-aging_products_market_to_rea/Most research and reports point out to anti-aging skin care treatmentsbeing a major driving factor in the overall growth of the anti agingproducts market. Marketing studies by various sources point to anti-agingbeing a key motivator in the purchase of any skin care product clearlyshowing this is a very large and lucrative market for healthcare, personalcare and cosmetic businesses globally. IP related to new anti-aging skincare compounds can be extremely valuable. © 2010 Gridlogics. All Rights Reserved. Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd. Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com
  6. 6. Anti Aging Skin Care Compounds – Insights fromPatentsOverviewPatent filings around the compounds and compositions used for Anti AgingSkin Care hold great insights into the innovation, research anddevelopment within the space. With the help of Patent iNSIGHT Pro, wewill analyze the full Anti Aging Skin Care Compounds patent data to findanswers to the following: What does the IP publication trend for “Anti Aging Skin Care Compounds” look like and how has activity around filings evolved? Who are the top assignees in Anti aging compositions? How is Assignee Portfolio spread across different Ingredient Categories? How is Assignee Portfolio spread across various skin problems related to aging? What properties are used across different types of key ingredient categories? How do the key ingredients compare across various aging skin problems areas?These are just some of the insights that can be uncovered by lookingthrough related patents filed around this space over the previous years.The Search StrategyUsing the commercial patent database PatBase as our data source we usedthe following search query to create our patent set. ((TAC=((aging or ageing or "expression lines" or blemishes or “pigmentation change” or pigmentation-change* or UC- US Class “discolouration” or dis-colouration or “discoloration” or dis- TAC- Title Abstract Claim coloration” or laxity or sagging or rhytids or rhytid or wrinkle* or Class Description: photoaging or erythema or dyspigmentation or “solar elastosis” or keratoses or “poor texture” or “photo-aging” or “photo- US Class 424: DRUG, BIO-AFFECTING ageing”) and (soap or cleanser or moisturizer or moisturiser or AND BODY TREATING detergent or shampoo or cologne or oil or paste or cream or COMPOSITIONS ointment* or lotion* or gel* or balm or emollient))) and (UC=(424 or 514))) US Class 514: DRUG, BIO-AFFECTING AND BODY TREATING COMPOSITIONSThe query was directed to search with the assumption that all relatedpatents would be filed in US and the search was limited to US publications.The result was a patent set of 2561 records which would form the basis ofour research. © 2010 Gridlogics. All Rights Reserved. Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd. Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com
  7. 7. Categories of Skin Care CompositionsWe categorized Skin Care Compositions along the following lines: Ingredient Categories Properties of Skin Care Compositions Aging Skin ProblemsThe illustration below shows the different categories prepared and the number of records in each. Thecategorization involved defining a search strategy for each topic and then conducting the search usingthe Advanced Search capability in Patent iNSIGHT Pro. Details of search strings used for each categoryare given in Appendix B. © 2010 Gridlogics. All Rights Reserved. Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd. Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com
  8. 8. Publication TrendWhat has been the IP publication trend for Anti- Aging related Skin Care ingredients and compounds?Patents related to Skin Care Compositions can be traced back to before 1950 and the real surge in theactivity around this technology has happened in the last decade. Noticeably there was a very large spikein publications for 2006 and although the overall trend continues to show growth, the more recent yearsdon’t show the same level of filings as that year.How we did it?Once the patents were populated in Patent iNSIGHT Pro, the publication trend chart was generated on a singleclick using the dashboard tool. © 2010 Gridlogics. All Rights Reserved. Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd. Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com
  9. 9. Top AssigneesWho have been the top assignees or the key players within this industry? 1. Proctor & Gamble Co 11. Dermatrends Inc. 2. L’Oreal S.A. 12. Immunomedics Inc. 3. Johnson & Johnson 13. Cellgene Corp 4. Pfizer 14. Laughlin Products Inc. 5. Skye Pharma PLC 15. Cytori Therapeutics Inc. 6. Bioderm Research 16. Revalesio Corp 7. Galderma S.A. 17. Allergan Inc. 8. The Westaim Corp 18. Evonik Industries 9. The Regents of the University Of 19. Imperial Cancer Research California 20. Unilever PLC 10. Avon Products Inc.How we did it?Once the patents were populated in Patent iNSIGHT Pro, the assignee clean‐up tools were used to normalize thenames. Different cleanup tools were leveraged:• To locate assignees for unassigned records• To clean up records having multiple assignees• To locate the correct assignee names for US records using the US assignments database• To merge assignees that resulted from a merger or acquisition or name change.Please refer Appendix A for more details on Assignee merging.Once the Assignee names were cleaned up, the dashboard tool within Patent iNSIGHT Pro was used to find the top20 assignees within the given patent set. A visual graph was created based on the results of the top assignees withthe number of patents alongside each one.The full Assignee table is available here:http://www.patentinsightpro.com/techreports/1110/List%20of%20Assignees.xls © 2010 Gridlogics. All Rights Reserved. Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd. Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com
  10. 10. Assignee - Key StatisticsHere we summarize key parameters of Top 15 Assignees such as filing trend, Avg. number of Forward citations perrecord, Top inventors in each Assignee, Top Co-Assignees and Coverage of underlying patent families © 2010 Gridlogics. All Rights Reserved. Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd. Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com
  11. 11. How we did it?In order to compress all the information into a single report, we used the 360 ° series of reports available in thesoftware. From the Assignee 360° report options, we selected the different pieces of information we wanted toinclude in the singular display and then ran the report. The generated report was then exported to Excel using theoption provided for the same. © 2010 Gridlogics. All Rights Reserved. Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd. Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com
  12. 12. Inventor - Key StatisticsHere we summarize key parameters of Top 15 Inventors such as filing trend, average number of forwardcitations per record, key associated companies and top 5 co-inventors. © 2010 Gridlogics. All Rights Reserved. Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd. Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com
  13. 13. How we did it?In order to compress all the information into a single report, we used the 360 ° series of reports available in thesoftware. From the Inventor 360° report options, we selected the different pieces of information we wanted toinclude in the singular display and then ran the report. The generated report as then exported to Excel using theoption provided for the same.Detailed analysis of key inventor groups of top three assigneesThe generated maps below highlight the key inventor groups of top three assignees. These have beengenerated using VizMAP. The mapping technology employs computer algorithms to group and displaypatent documents based on either network relationships, contextual or co-citation relationships. Inmaps below the groups are created using network relationships and the records (blue dots) arepositioned on the map based on their relationship to the Assignee and to the inventors listed on thegraph.Key inventors present in the map, for instance, Blank Roy Lonnie in case of Procter & Gamble Co appearin the middle of the graph. Also groups of inventors who file together will appear clustered together.Finally, only those inventors with 2 or more records are shown in the map.Key inventor Groups: Procter & Gamble Co. © 2010 Gridlogics. All Rights Reserved. Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd. Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com
  14. 14. Key inventor Groups: L’oreal © 2010 Gridlogics. All Rights Reserved. Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd. Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com
  15. 15. Key inventor Groups: Johnson & JohnsonHow we did it?Using the VizMAP tool, patents of top three assignees, namely, Procter & Gamble Co., L’oreal S.A., and Johnson& Johnson were loaded on the map. These were then expanded by their respective inventor names. TheVizShade option was used to shade the inventors with potential overlapping patents between them. © 2010 Gridlogics. All Rights Reserved. Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd. Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com
  16. 16. Assignee Portfolios spread across different Ingredient CategoriesHere we have correlated key Ingredients used across anti-aging skin care compositions along with alisting of the key assignees in each category. The matrix highlights the focus areas within anti agingskin care ingredients being pursued by key companies.This comparison chart reveals which of the key players hold patents assigned for which of the mainingredients or compounds within the patent set. For example, Proctor & Gamble as well as L’Oreallead the assignees for patents in Sunscreen ingredients. It’s also visible that although L’Oreal has moreZinc Oxide related patents, P&G has more related to P-Aminobenzoic Acid. When it comes toinnovations around developing Botox, Allergan Inc. leads the way with 16 out of a total 425 patentsfor this category. © 2010 Gridlogics. All Rights Reserved. Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd. Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com
  17. 17. How we did it?We used the categories created and using the co-occurrence analyzer, we selected the categories and theassignees to be included and then ran the report. The generated report was then exported to Excel using theoption provided. © 2010 Gridlogics. All Rights Reserved. Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd. Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com
  18. 18. Assignee Portfolios spread across various skin problems related to agingWhat are the key problem areas explored by top assignees? For example most of The Westaim Corppatents are in the area of compounds related to Erythema Photo Aging in particular. Procter andGamble on the other hand has patents across the board but specifically more within research aroundRhytids and Laxity related problems. © 2010 Gridlogics. All Rights Reserved. Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd. Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com
  19. 19. How we did it?We used the categories created and using the Co-occurrence Analyzer option, we selected the categories wewanted to include in the singular display and then ran the report. The generated report was then exported toExcel using the option provided for the same. © 2010 Gridlogics. All Rights Reserved. Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd. Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com
  20. 20. What properties are used across different types of key ingredient categories?The matrix below shows the properties of different types of key ingredient categories. © 2010 Gridlogics. All Rights Reserved. Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd. Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com
  21. 21. How we did it?We manually created categories of key ingredients and properties. A two-level categorization was done in caseof Properties. Then using the co-occurrence matrix, a map was generated for properties vs. ingredients. © 2010 Gridlogics. All Rights Reserved. Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd. Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com
  22. 22. How do the key ingredients compare across various aging skin problems areas?The matrix below shows to what extent a particular problem area has been targeted by usingdifferent ingredients. For example, Beta Hydroxy Acids and Anti Oxidants appear to be importantingredients in the research around tackling skin laxity. Continued… © 2010 Gridlogics. All Rights Reserved. Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd. Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com
  23. 23. How we did it?The clusters of categories of skin cream ingredients and skin aging problems that were created for the previousanalysis were correlated using the co‐occurrence analyzer and then the resulting matrix for converted into achart and a heatmap was generated. © 2010 Gridlogics. All Rights Reserved. Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd. Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com
  24. 24. Assignee Landscape around Key Ingredients and popular skin aging problemsThe below chart shows the Assignee Landscape around the above matrix. © 2010 Gridlogics. All Rights Reserved. Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd. Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com
  25. 25. © 2010 Gridlogics. All Rights Reserved. Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com
  26. 26. © 2010 Gridlogics. All Rights Reserved. Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com
  27. 27. © 2010 Gridlogics. All Rights Reserved. Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com
  28. 28. Many inferences around the Assignee focus area can be made from the above matrix. We can see thatAllergan Inc. focuses primarily on Botox as Key ingredient in Rhytids.How we did it?The clusters of skin cream ingredients and skin cream problems that were created for the previous analysis werecorrelated using the co‐occurrence analyzer. The “Show Data” option in the Co-occurrence Analyzer was used toDrill out the companies from the resulted matrix and then the resulting matrix was converted into a chart. © 2010 Gridlogics. All Rights Reserved. Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd. Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com
  29. 29. New Companies in the last 5 years having 3 or more recordsThe map below shows patents of new assignees in the last 5 years having 3 or more records. The sizeof the patent node in dark blue color is dependent on the number of forward citing documents forthat record and the number against the node represents the exact number of forward citations.A new company with a promising new technology usually has a small but highly cited portfolio.How we did it?Using the Assignee Activity feature in VizMAP tool, we first set the filter definition for New Assignees to beequivalent to “All Patents Issued In/After 2005”. Clicking on New Assignees then generated the above map. Wethen restricted the map to those Assignees having 3 or more filings in the last 5 years. Each patent node for thenfurther enhanced by the number of forward citations it received. © 2010 Gridlogics. All Rights Reserved. Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd. Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com
  30. 30. Appendix A: Key Assignee Normalization TablePROCTER & GAMBLE CO.PROCTER AND GAMBLE JOHNSON & JOHNSONBISSETT DONALD LCLEAR ROSE M ALELES MARGARET A MARTIN KATHARINEROBINSON LARRY R COLE CURTIS A MITCHELL PHYLLISHEINRICH JAMES M LUKENBACH ELVIN R SOUTHALL MICHAELMIDHA SANJEEV NIEMIEC SUSAN TIERNEY NEENASMITH EDWARD D III SHAH SNEHAL KING DEANNA LSTRIFE ROBERT J BOBZIN STEVEN FERNANDEZSYFERT SCOTT W BODDUPALLI SEKHAR CANDELARIO A JRWAGNER JULIE A BROWN LESLEY KAMINSKI CLAUDIAWEI KARL S CHEN JIAN LUIZZI JOSEPHSMITH EDWARD DEWEY III DEL BALZO UGHETTA NATTER FLORENCEWAGNER JULIE ANN GILAT SYLVAIN BARKOVIC SYLVIAWEI KARL SHIQING MILLER GUY FERNANDEZ ALDO OMIDHA SANJEEV M SONG JIANGAO MARTENS NICOLASWELLA AG WANG BING SINGLETON LAURA CRICHARDSON VICKS INC ZHANG WEI LIN CONNIE BGILLETTE CO ZHANG YONG KANG SCARPA RICHARD C COLE CURTIS BERNSTEIN KEITH JLOREAL S.A. GANOPOLSKY IRINA NOORDUIN HENKOREAL LUKENBACH ELVIN SOUTHAM MARYBRETON LIONEL SKOVER GREGORY PAPPAS APOSTOLOSNONOTTE ISABELLE LIN CONNIE BAOZHEN SALEMO CATHERINE SCASTIEL ISABELLE SEIBERG MIRI BRUNING ELIZABETHFERRARIS CORINNE IOTSOVA VIOLETTA CAVENDER DRUIE EBERNERD FRANCOISE LIU JUE CHEN JANSSENMARTIN RICHARD CONNEY ALLAN H PHARMACEUTICA NVMAIGNAN JEAN HUANG MOU TUAN JOHNSON ANDMICHEL SERGE PAINE CHRISTINE JOHNSON CONSUMERCHEVALIER VERONIQUE SHAPIRO STANLEY S ALZA CORPCHRISTOPHIDES LORDI KALLIOPE DOLE VICTORIA ORTHO MCNEIL PHARMPOTIN ANTHONY NYSTRAND GLENN INCQUEST MELANIE SAH ARCHANA JOHNSON ANDULRICH MARIA BURROWS MARK JOHNSON PROD INCGENARD SYLVIE CRONIN JOHN JOHNSON ANDBOULLE CHRISTOPHE HULL RAYMOND J JR JOHNSON SADALKO MARIA NARSANA TUSHAR UNIV RUTGERSLEVEQUE JEAN LUC RYTEL JOHN FSIMONETTI LUCIE HULL RAYMOND JRGIRIER DUFOURNIER FRANCK MENKE JAMES CKHACHIKIAN HELENE HULL RAYMOND JLEMANN PATRICIA GUBEMICK DAVIDRICARD AUDREY STONE VIOLETTA IMOUGIN NATHALIE ZHAO RENBINDELACOUR MARIE LAURE GALILEORAY XAVIER PHARMACEUTICALS INCHADASCH ANKE BORDOLOI BINOY KBISSEY BEUGRAS LAURE LUKENBACH GLORIA JSENEE JEROME RUVOLO EDUARDOWILLEMIN CLAUDIE SOUTHALL MICHAEL DSOCI ET E L OR EAL S A KIZOULIS MENASSOCIETEL OREAL S A © 2010 Gridlogics. All Rights Reserved. Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd. Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com
  31. 31. PFIZER INC. UNILEVER PLCWILLIAMS KEVIN JON UNILEVER HOME AND PERSONAL CAREESPERION LUV DEV INC CONOPCO INC DBA UNILEVERUNIV BRITISH COLUMBIA LEVER BROTHERS LTDAMERICAN HOME PROD UNILEVER PATENT HOLDINGSINTELLIGENT MED SYST CHESEBROUGH PONDS USABASF AG CHESEBROUGH POND S USA CO A DIWARNER LAMBERT CO CHESEBROUGH POND S USA DIVISIOTALARIA THERAPEUTICS INCAMERICAN CYANAMID COPFIZERBAKER JANNIE LEAGROSU GEORGE THEODORECARON STEPHANEVENKATESAN ARANAPAKAM MUDUMBAISKYEPHARMA PLC ALLERGAN INC.HYAL PHARMA CORP ALLERGAN SALES INCHYAL PHARMACEUTICALS CORP ALLERGAN INCBIOGLAN AB HUNT TERRENCE JJAGOTEC AG © 2010 Gridlogics. All Rights Reserved. Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd. Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com
  32. 32. Appendix B: Search Strings Used for CategorizationCategorization: Ingredient Categories1. Chemical Peels Chemical Peelsaclm contains (α-hydroxy or alpha hydroxy) 70 resultsw/3 acid* or AHAaclm contains (Citric w/3 Acid) 83 results 83 resultsaclm contain (Glycolic or Dicarbonous or 16 resultshydroxyacetic) w/3 acid*aclm contains (lactic w/3 acid) 104 resultsaclm contains (malic w/3 acid) 44 resultsaclm contains (tartaric w/3 acid) 45 resultsaclm contains (Beta w/2 "hydroxy acid") or BHA 26 resultsaclm contains Salicylic acid or "2- 146 resultsHydroxybenzoic acid"Jessner* w/3 peel 2 results(Phenol or Croton) w/2 peel* 5 resultscroton w/5 oil 17 resultsaclm contains croton w/5 oil 1 resultphenol w/2 oil 1 resultaclm contains (Retino* w/3 acid) 84 resultsaclm contains (Trichloroacetic or 9 results"trichloroethanoic acid") or TCA2. Anti oxidants Anti-oxidantsaclm contains anti w/3 oxidant* 100 results3. Exfoliants Exfoliantsaclm contains exfoliant* 15 results4. Hyaluronic Acid Hyaluronic Acidaclm contains Hyaluronan or "hyaluronic acid" 112 resultsor hyalurona5. Botox Botoxaclm contains botox or botulinum toxin* 28 results © 2010 Gridlogics. All Rights Reserved. Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd. Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com
  33. 33. 6. Boswellia Serrata Boswellia Serrataaclm contains boswelli* 9 results7. Polylactic Acid Polylactic Acidaclm contain (Poly w/3 "lactic acid") or 50 resultspolylactide8. Coenzyme Q10 Coenzyme Q10aclm contains "coenzyme q10" or ubiquinone* 44 results or ubidecarenone* or "coenzyme q" or coq10or coq or q109. Niacinamide Niacinamideaclm contains Nicotinamide* or niacinamide* 54 resultsor "nicotinic acid amide" or 3-pyridinecarboxamide* or Vitamin PP10. Retinol Retinolaclm contains retinal or retinol or 98 resultsretinaldehyde* or retinyl palmitate* or vitaminpalmitate* or "retinol palmitate" or c36h60o211. Peptides Peptidesaclm contains peptide* 226 resultsacetyl hexapeptide-3 13 resultsaclm contains Argireline* or Acetyl 7 resultshexapeptide-3aclm contains "Acetyl hexapeptide-3" 7 resultsArgireline* or Acetyl hexapeptide-3 18 resultsaclm contains peptone* 2 resultsaclm contains Copper peptide* or GHK-Cu or 5 resultstri-peptide* © 2010 Gridlogics. All Rights Reserved. Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd. Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com
  34. 34. 12. Sunscreen Ingredients Sunscreen Ingredients aclm contains Enzacamene* or Parsol 5000 or 2 resultsEusolex 6300 or MBC or 4-Methylbenzylidenecamphor* or 4-MBCaclm contains Avobenzone* or "1-(4- 11 resultsmethoxyphenyl)-3-(4-tert-butylphenyl)propane-1 or 3-dione" or "Butylmethoxy dibenzoylmethane" or BMDBM orParsol 1789 or Eusolex 9020 or "t-butyldimethoxydibenzoylmethane"uvinul ds 49 or cas 3121-60-6 or “sodium 3 resultsdihydroxy dimethoxy disulfobenzophenone”Benzophenone-9 21 resultsaclm contains "2-Ethoxyethyl p- 5 resultsmethoxycinnamate" or Cinoxate*aclm contains Dioxybenzone* or 44 resultsbenzophenone- 8aclm contains ecamsule* or mexoryl sx or 1 result“terephthalylidene dicamphor sulfonic acid” aclm contains Homomethyl salicylate* or HMS 17 resultsor Homosalate* aclm contains "isopentenyl-4- 1 resultmethoxycinnamate" or "isoamyl p-methoxycinnamate"aclm contains Menthyl anthranilate* or 9 resultsMeradimate*aclm contains "drometrizole trisiloxane" 1 result“Bisdisulizole Disodium” or “Disodium 10 resultsphenyldibenzimidazole tetrasulfonate” orbisimidazylate* or DPDT aclm contains octocrylene* or "2-ethylhexyl-2- 16 resultscyano-3 3-diphenylacrylate"aclm contains "octyl methoxycinnamate" or 18 resultsOctinoxate* or EMC or OMC orEthylmethoxycinnamate* or Escalol 557 or "2-ethylhexyl-paramethoxycinnamate" or ParsolMCXaclm contains Octisalate* or "2-Ethylhexyl 18 resultssalicylate" or Escalol 587 or Octyl salicylate* aclm contains oxybenzone* or Benzophenone- 49 results3 or Eusolex 4360 or Escalol 567 or "2-hydroxy-4-methoxy-benzophenone"aclm contains padimate O or “2-ethylhexyl 4- 12 resultsdimethylaminobenzoate” or Escalol 507 oroctyldimethyl PABA or OD-PABA or σ-PABA aclm contains P-Aminobenzoic Acid* or 4- 30 resultsAminobenzoic acid* or "para-aminobenzoicacid" or PABA © 2010 Gridlogics. All Rights Reserved. Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd. Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com
  35. 35. dimethico-diethylbenzalmalonate* or 8 resultspolysilicone-15 or parsol slxaclm contains Ensulizole* or Eusolex 232 or 6 resultsPBSA or Parsol HS or “Phenylbenzimidazolesulfonic acid” or C13H10N2O3Saclm contains “2-Hydroxy-4- 42 resultsMethoxybenzophenone-5-sulfonic acid” or “3-benzoyl-4-hydroxy-6-methoxybenzenesulfonicacid” or Benzophenone-4 or Escalol 577 orSulisobenzone* or benzophenone-5aclm contains bisoctrizole or “methylene bis- 1 resultbenzotriazolyl tetramethylbutylphenol”aclm contains “Bis-ethylhexyloxyphenol 1 resultmethoxyphenol triazine” or Bemotrizinol orBEMT or anisotriazineaclm contains Titanium dioxide* or titanium(IV) 66 results oxide* or titania or TiO2 or titanium white* or"Pigment White 6" or CI 77891aclm contains trolamine salicylate* or 10 resultstriethanolamine salicylate*aclm contains iscotrizinol or "diethylhexyl 1 resultbutamido triazone" ordiethylhexylbutamidotriazone* or dbt oruvasorb hebaclm contains “Diethylamino hydroxybenzoyl 1 resulthexyl benzoate” or Uvinul A Plus or DHHB Ethylhexyl Triazone* or Ethylhexyltriazone* or 18 resultsUvinul T150aclm contains zinc oxide* or zno 69 resultsCategorization: Properties of Skin Care Compositions1. Hydrating Properties Hydrating Propertieshydrat* w/3 propert* 27 results2. Absorbable Absorbableabsorbab* 71 results3. Elasticity ElasticityElastic* 552 resultsflexibil* or flexibl* or elastic* or stretch* 1053 results © 2010 Gridlogics. All Rights Reserved. Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd. Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com
  36. 36. 4. Anti inflammatory Anti inflammatoryanti w/3 inflam* 1016 resultsnon w/2 inflam* 103 results5. Biodegradable BiodegradableBiodegrade* 370 results Categorization: Aging Skin Problems Aging Skin ProblemsBlemish* or "dark spot" 129 resultsBlotch* 112 resultslaxit* or sag* 415 resultslaxit* or sagging 175 resultsrhytid* or wrinkle* 863 resultsErythema 438 results"Solar elastosis" 13 results (actinic or solar) w/3 elastosis 18 resultsKeratose* 162 results"skin pigmentation" 59 resultsskin w/2 pigmentation 73 results © 2010 Gridlogics. All Rights Reserved. Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd. Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com
  37. 37. SummaryPatent analysis shows research around anti aging skin care compoundsstart to take shape as early as the 1950’s but the last decade hascertainly been the era when this space has taken off to levels far aboveany of the previous decades. The research and development around thisfield is clearly on the rise with no immediate signs of reducing as themarkets for anti aging skin care products also grow very rapidly. Severalof the large cosmetics, health and personal care global businesses haveIP portfolios within this market with P&G and L’Oreal topping the keyassignees of patents.In terms of focus areas, the 4 largest assignees of patents appear tocover all the problem areas related to aging skin while the remainingassignees have clearly defined problem areas within which they work tobuild their patents. Similarly we have seen the use of certain ingredientscommonly used within compounds to tackle a specific problem while fewingredients are used exclusively for one aging related skin problem.Overall, the research and development work related to finding solutionsto aging skin appears to be a highly active and growing one that can onlybe expected to increase in the near future.About Patent iNSIGHT ProPatent iNSIGHT Pro™ is a comprehensive patent analysis platform thatallows you to accelerate your time-to-decision from patent analysisactivities. Designed from inputs by experienced patent researchers,Patent iNSIGHT Pro easily blends into your existing Research workflow.Patent iNSIGHT Pro is used by leading legal services, Pharmaceutical &biotech, electronics companies and research organization across US,Europe, South America and India with more than 180 end users. PatentiNSIGHT Pro is developed and marketed by Gridlogics, a research drivenIT Company specializing in providing intellectual property analysis andvisualization solutions to aid R&D and corporate strategy.Gridlogics is headquartered in Pune, India and has a sales presence inDelhi, Mumbai and USA.For more information:Visit us at: www.patentinsightpro.comOr call us at: 1-408-786-5524Or mail us at:Have a comment on this report? Mail us atfeedback_tr@patentinsightpro.com © 2010 Gridlogics. All Rights Reserved. Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd. Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com
  38. 38. Sources & References http://en.wikipedia.org/wiki/Anti_Aging http://www.myhealthnewsdaily.com/skin-care-anti-aging- creams-100929-0464/ http://en.wikipedia.org/wiki/Exfoliation_(cosmetology) http://www.worldhealth.net/news/global_anti- aging_products_market_to_rea/ http://en.wikipedia.org/wiki/Skin_care © 2010 Gridlogics. All Rights Reserved. Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd. Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com

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