Presentation: Developing Science-Informed Policy Responses to Curb Endocrine Disruption in Freshwater, Milo de Baat - The Netherlands

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Presentation: Developing Science-Informed Policy Responses to Curb Endocrine Disruption in Freshwater, Milo de Baat - KWR Water Research Institute, the Netherlands

Environment

18 October 2022, OECD Paris
Future perspectives
for effect-based EDC
monitoring
Market trends of new technologies
Milo de Baat, Ph.D.

2
Technology readiness of effect-based methods
Technology Readiness Levels (TRL) based on NASA model
Fasterholdt et al., 2018 BMC Health Services Research
• The technological development of EBMs is
at an advanced stage (Session 2)
• EBMs offer important advantages in the
monitoring of EDCs
• What is needed to achieve their
implementation in the management of
endocrine disruption in freshwater?

3
https://www.flickr.com/photos/nasahqphoto/5724817740/in/photostream
Are we ready
for launch?

4
• GWRC survey in 2020
• “Perception and barriers to
implementation of EBM”
• 63 respondents in 19 countries
Survey among water sector stakeholders
Main barriers to EBM implementation
According to you, would
EBM improve existing
water quality monitoring?

5
• EDC monitoring costs for EBM and
target chemicals are very similar
• Costs are a concern: Motivation to
apply the method best fit for managing
endocrine disruption in freshwater
• Are the methods complimentary, or
can EBM replace target chemical
analyses?
EBM and target chemical analyses

6
Quality standards
for single
chemicals
Bioassay(s)
Single chemical ED assessments
Water sample
Single chemical concentrations
ED potential of the total mixture
(OECD)
validation for
single chemicals,
but no official
guideline for
water samples
What is the aim of the assessment?
And which method best suits that aim?
“To curb endocrine
disruption in
freshwater”

7
EBM within Water Safety Planning:
• Scientific basis
• Resources and guides for laboratory analysts
and water safety planners
• Case studies
• Framework to support decision making
• Engagement with international experts
• Reports, factsheets, scientific papers
• http://www.globalwaterresearchcoalition.net/
Demonstration

8
The Dutch “Knowledge Impulse Water
Quality – Toxicology” project:
• Includes ED activity assessment based
on chemical analyses and EBM
• Website with digital tools, background
documents, factsheets, e-learning
• Based on the DPSIR model to facilitate
suitable Responses
Implementation
https://kiwk-tox.netlify.app/nl/

9
Implementation
• EBM approach for drinking water
and surface water
• Chemical water quality represented
in 5 classes (colours)
• Preliminary use by water authorities
and utilities
• Valuable insight into SWOT

10
Technology readiness of effect-based methods







?
?

11
• Standardisation & validation
• (International) guidelines
• Legislation
• Bioanalytical capacity (multiple
laboratories)
- Academia
- Contract labs
- Water utility/authority labs
Requirements

12
• Online platform/ stand-alone tools for
data analysis and interpretation
• Workshops
• Continued research
- Bioassay (battery) development
- Mixture risk calculation
- Sensors for real-time monitoring
Outlook

13
https://www.pinterest.com/pin/97320041918774957/
5…4…3…2…1
Let’s discuss!

KWR_Water
KWR
@KWR_Water
T +31 (0)30 60 69 511
E info@kwrwater.nl
I www.kwrwater.nl
Groningenhaven 7
3433 PE Nieuwegein
The Netherlands
Milou Dingemans
milou.dingemans@kwrwater.nl
Stefan Kools
stefan.kools@kwrwater.nl
Milo de Baat
milo.de.baat@kwrwater.nl
+31 6 21 70 44 02

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