This document discusses the prenatal development of the cranial base. It begins with an introduction and overview of cranial base anatomy. It then describes the three major phases of skull base development: appearance of the mesenchymal anlage, chondrification, and ossification. Specific details are provided on the development of individual bones that make up the cranial base, including the ethmoid, sphenoid, and occipital bones. The document also discusses how variations in cranial base morphology can influence adjacent craniofacial structures and relationships.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Concepts of growth and development / orthodontic courses /certified fixed or...Indian dental academy
Welcome to Indian Dental Academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Theroies of growth /certified fixed orthodontic courses by Indian dental acad...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
Temporo Mandibular joint (TMJ) importance in orthodontic treatment /certifie...Indian dental academy
Welcome to Indian Dental Academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Growth assessment in Orthodontics.
By using the element of timing of maximum growth in conjunction with the knowledge of magnitude and direction, one can readily transform orthodontics to a profession of face forming as well as tooth positioning. Key to successful orthodontic treatment in growing
patients is the harnessing of growth and unless we know the exact status of growth both in magnitude as well as in direction, treatment planning would be futile.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all
aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Muscle physiology /certified fixed orthodontic courses by Indian dental academy Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
Construction bite /certified fixed orthodontic courses by Indian dental academy Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Concepts of growth and development / orthodontic courses /certified fixed or...Indian dental academy
Welcome to Indian Dental Academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Theroies of growth /certified fixed orthodontic courses by Indian dental acad...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
Temporo Mandibular joint (TMJ) importance in orthodontic treatment /certifie...Indian dental academy
Welcome to Indian Dental Academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Growth assessment in Orthodontics.
By using the element of timing of maximum growth in conjunction with the knowledge of magnitude and direction, one can readily transform orthodontics to a profession of face forming as well as tooth positioning. Key to successful orthodontic treatment in growing
patients is the harnessing of growth and unless we know the exact status of growth both in magnitude as well as in direction, treatment planning would be futile.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all
aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Muscle physiology /certified fixed orthodontic courses by Indian dental academy Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
Construction bite /certified fixed orthodontic courses by Indian dental academy Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
USMLE neuroanatomy neuroanatomy 019 CNS development .pdfAHMED ASHOUR
The development of the CNS is a fascinating process that occurs during embryonic development and continues into early childhood.
Disruptions or abnormalities during this process can lead to a wide range of neurological disorders and developmental disabilities.
Understanding the mechanisms underlying CNS development is critical for advancing our knowledge of brain development and for developing new therapies for neurological disorders.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
3. CONTENTS
• INTRODUCTION
• BASIC GROWTH PRINCIPLES
• GROWTH MOVEMENTS
• ANATOMY OF NEUROCRANIUM
• CRANIAL BASE ANATOMY
• PRENATAL DEVELOPMENT OF THE SKULL BASE
• TYPES OF OSSIFICATIONS
4. • SKULL BASE OSSIFICATION
• CRANIAL BASE INTERRELATIONS CRANIOFACIAL DEVELOPMENT AND
MALOCCLUSION
• INFLUENCE OF CRANIAL BASE MORPHOLOGY ON ADJACENT STRUCTURES
• CRANIAL BASE ABNORMALITIES
• CONCLUSION
• REFERENCES
5. INTRODUCTION
• An understanding of the growth of the
craniofacial complex has come to
assume great importance in orthodontic.
• The cranial base supports the brain and
provides adaptation between the
developing neurocranium and viscero
cranium during growth.
6. • Located on a junction point between the cranium, midface and glenoid fossa,
the cranial base plays a key role in craniofacial growth, helping to integrate
spatially and functionally, different patterns of growth in various
adjoining regions of the skull such as components of the brain, the nasal
cavity, the oral cavity, and the pharynx.
7. • Depending on the fact that the maxilla is connected with the anterior part of
the cranial base and the rotation of the mandible is influenced by the maxilla,
a relationship can be found between the cranial base variations and sagittal
malposition of the jaws.
8. Basic Growth Principles and its
relevance in Neurocranial Growth
• Cephalocaudal Growth
• Scammon’s growth curve
9. • The cranial base, which from a functional point of view may be regarded as
the border between brain and facial structure, is obliged,
therefore, to develop in conformity with the different growth patterns of the
brain ease and facial structure and, consequently,must follow two different
growth rates, one along its internal surface and another along its external
surface. “(Björk 1955)
11. Anatomy of the Neurocranium
• Fastest growing area of the craniofacial skeleton at birth
• The face and jaws are relatively underdeveloped .
• The neurocranium can be subdivided into the cartilaginous part, which form
base of the skull (or chondrocranium), and the membranous part, which form
cranial vault (or Calvarium).
(Sadler & Langman 2011; Jin et al. 2016)
12. Cranial Base Anatomy
• The cranial base or cranial floor’s function is to
support and protect the brain and spinal cord.
• It articulates with the vertebral column, the
mandible and the maxillary
regions and forms a buffer area between the
brain, face and pharyngeal
region as these areas grow at different rates.
• The Bones that constitutes the Cranial base is
the Occipital bone, Sphenoid bone, Temporal
bone, Ethmoid bone and Frontal bone.
13. • The internal surface of the cranial base is divided into anterior,
middle and posterior cranial fossae due to the depressions caused by the lobes
and intracranial contents.
• The midsagittal section is divided into anterior and posterior sections.
• The Anterior cranial base being from Sella to nasion and posterior cranial base
being from Sella to basion.
14.
15. Prenatal Development of the
Skull Base
The development of the skull base and calvaria goes through 3 major phases:
I. The appearance of a mesenchymal anlage (the ectomeningeal capsule)
II.Chondrification of this anlage by the development of multiple discreet
cartilages that eventually fuse together. This happens only in bones that
undergo Endochondral Ossification
III.Ossification of this cartilage, or intramembraneously, from more than 100
ossification centres.
16. • There are 2 types of ossification:
• Endochondral ossification
• Mesenchyme or intramembranous ossification.
17.
18.
19. • During this process, the brain will become surrounded by the
developing skull base as it meets the evolving calvaria. During foetal life, the
bones of the calvaria are separated by attenuated connective tissue membrane
that form the neonatal fibrous sutures and frontanelles.
20. i‐ Mesenchymal Anlagen
• Development of the skull initiates in the fourth embryonic week, as the
mesenchyme that surrounds the developing brain forms a capsule.
• Mesenchymal tissue is derived from neural crest and occipital sclerotomes.
21. • The tissue condenses around the developing brain (basal portion will
give rise to the cranial base, while the upper portion will give rise to the
calvaria).
• The cranial nerves, eyes, and blood vessels are already well underway in
their development before the appearance of the ectomeningeal capsule,
so the mesenchyme condenses around these pre‐existing structures,
creating the primitive skull base foramina
22. • Origins of Mesenchyme:
• The mesenchyme for the region anterior to the pituitary gland is
derived from the neural crest
• mesenchyme for the region posterior to the pituitary gland is of
paraxial mesenchyme
23. • The ectomeninx capsule consists of 2 layers.
• The inner layer ‐ will form the dura mater.
• The outer layer has both chondrogenic and osteogenic properties and will form
the cranial bones.
24. • This ectomeningeal mesenchyme will eventually produce 3 areas
• The neurocranium or desmocranium (the future calvaria), which surrounds and
protects the brain and is mainly ossified by intramembranous ossification the
chondrocranium or skull base, which is ossified by endochondral ossification
the viscerocranium, which will develop into the facial skeleton and is ossified
by both intramembranous and endochondral ossification .
25.
26. ii‐ Chondrification
• Chondrification of the ectomeningeal capsule starts in the seventh embryonic
week as cells within the ectomeningeal capsule differentiate
into chondroblasts. Chondrification of the skull base proceeds from
posterior to anterior. It begins to chondrify from 3 main pairs of cartilaginous
precursors:
• The Parachordal cartilage (posterior to the pituitary gland)
• The Hypophyseal cartilages (lateral to the pituitary gland) and
• The Prechordal cartilages (anterior to the pituitary gland)
27.
28. Prechordal Cartilages
• Laterally to Sella turcica, chondrification centres appear in the orbitosphenoid
cartilages, which will develop into the lesser sphenoid wings.
• The alisphenoid cartilages will form the greater sphenoid wings .
• An anterolateral extension of the orbitosphenoid cartilage arises near the orbital
portion of the developing frontal bone. This region, referred to as the sphenoet
hmoidal cartilage, forms the roof of the orbit.
• Anterior to the pituitary gland, the prechordal cartilages give rise to the nasal
capsule (ectethmoid), which chondrifies in the second foetal month.
29.
30. • The nasal capsule develops around the nasal sac and contributes to the format
ion of the ethmoid bone, the nasal septum, and the inferior nasal turbinate.
• The anterior prechordal region of the cranial base is derived from the neural
crest, whereas the parachordal region is of mesodermal origin .
• The boundary between these regions is marked by the future junction of the
basisphenoid and the basioccipital bones (the spheno‐occipital synchondrosis).
31.
32. • Although the skull base initially comprises discreet cartilaginous centres, by
the end of the 8th foetal week, it has fused into a single perforated basal
cartilaginous plate with the primitive neurovascular foramina.
• The developing brain is now situated in a shallow recess in the chondrocrani
um, and the central hypophyseal fossa is bounded by the presphenoid
cartilage, which forms the tuberculum sellae anteriorly, and by the
postsphenoid cartilage, which forms the dorsum sellae posteriorly.
33. Hypophyseal Cartilages
• A foramen persists in the skull base for Rathke’s pouch to ascend from th
underlying stomodeum, which will eventually form the anterior pituitary
gland.
• The cartilaginous area surrounding the foramen where the adenohypophy
sis will develop gives rise to the Sella turcica and the posterior body of
the sphenoid bone (Postsphenoid bone).
34. Parachordal Cartilage
• It arises along the margins of the cranial end of the notochord and is derived
from the occipital sclerotomes and the first cervical sclerotome (paraxial
mesenchyme origin).
• This sclerotome‐derived cartilage forms the boundaries of the foramen-
magnum. It appears first at the base of the future occipital bone and then
extends along the sides of the future foramen magnum.
• It also provides the mesenchymal anlagen for the future basilar and condylar
portions of the occipital bone.
35. • The otic capsules does not chondrify in humans, but fuses on either side with
the parachordal cartilage to form a single mass, petromastoid cartilages.
• Later ossification will give rise to the mastoid and petrous portions of the
temporal bones
36. iii‐ Ossification
• In the young foetus the entire cranial base from basion to nasion is a continuous
sheet of cartilage.
• In this cartilage, ossification centres for basioccipital, basisphenoid, and
presphenoid bones appears in the first half of foetal life.
• Fusion takes place between the presphenoid and basisphenoid centres shortly
before birth
37.
38. • The growth of the cranial base is highly uneven, in keeping with the
highly irregular shape it develops to accommodate the undulating
ventral surface of the brain.
• The uneven growth of the parts of the brain is reflected in adaption of
related parts of the cranial base as compartments or cranial fossae.
• The diencephalon is the most precocious in growth, the telencephaln
is next, and the rhombencephalon (with cerebellum) is slowest
growth.
39. • The anterior and posterior parts of the cranial base, demarcated at the
sella turcica, grow at different rates.
• Between the 10th and 40th weeks post conception,the anterior cranial
base increases its length and width sevenfold, but the posterior cranial
base grows only fivefold.
• Growth of the central ventral axis or the brain (the brain stem) and of
the related body of the sphenoid &basioccipital bones is slow, providing
a comparatively stable base.
40. • The anterior, middle, and posterior fossae of the cranial floor (related
respectively to the frontal and temporal lobes of the cerebrum and to
the cerebellum) expand enormously around this base, in keeping
with the high rate of growth of these parts of the brain
41. ETHMOID BONE
• The ethmoid bone ossifiesfrom3centres by endochondral ossification of
cartilage from the nasal capsule.
• One centre appears in the mesethmoid cartilage.
• One centre appears in each ethmoid labyrinth in the cartilage of the nasal
capsule.These labyrinthian centres appear during the fourth‐fifth foetal months,
and ossification spreads from each labyrinth into the ethmoid turbinates. At birth
,the labyrinths are partially ossified
42.
43. • The perpendicular plate ossifies from a median centre that appears in the first
year of life.
• The perpendicular plate fuses with the labyrinth in the second year of life.
44. • The cribriform plate is ossified from both the perpendicular plate and each
ethmoid labyrinth.
• The crista galli also ossifies in the second year. By 3 years of age, a single
ethmoid bone is formed, and because the ethmoid cells begin to form during the
third foetal month, these cells are present at birth.
45. Sphenoid bone:
• The sphenoid bone comprises up to 19 intramembranous and endochondral
ossification centres.
• These centres can be grouped into 8 areas
• the lesser wings
• the greater wings
• the pterygoid plates
• and the presphenoid and postsphenoid centres of the body.
46. • Early in the eighth foetal week: the Alisphenoid and Hamulus are the first sphen
oid elements to ossify. Initially, there is a suture between the Hamulus and the
remaining medial pterygoid plate.
47. • Week 8: Endochondral ossification centres develop in the Alisphenoid cartilag
es for the root of each greater sphenoid wing.
• The remainder of each greater wing ossifies in membrane, and ossification
then extends downward into the pterygoid plates.
• Ossification centres appear in the Orbitosphenoid cartilages, which eventually
become the lesser sphenoid wings.
• Intramembranous ossification centres appear for the medial and lateral
pterygoid plates. Each medial pterygoid plate also ossifies endochondrally
from secondary cartilages in their Hamulus
48.
49. • Month 4: A single median and 2 paired presphenoid ossification centres arise
in the anterior tuberculum sellae region.
• The postsphenoid portion of the sphenoid bone arises from 2 sets of paired
centres in the postsphenoid or basisphenoid cartilage on either side of the
upwardly projecting hypophyseal (Rathke’s) pouch.
50. • Near the cranial end of the basisphenoid, paired initially separate centres
develop (the bones of Bertini). After birth, these will become incorporated
into the sphenoid body; then, the sphenoid sinuses will eventually
extend into these centres
51. • Development of the Optic Canal happens in 3 stages:
• I. Formation of the cartilaginous optic foramen.
• II. Ossification of the cartilaginous foramen .
During the 12th‐17th foetal weeks, the cartilaginous optic foramen ossifies by
first forming its lateral border.
52. • III.Transformation of the bony foramen into a bony canal.
• canal begins to form during the fifth foetal month, but continues well into
childhood.
53. • The Sella develops in 4 stages:
• i.Chondrification .
• ii. Prenatal ossification .
• iii. Postnatal development of the planum sphenoidale .
• iv. Posterior growth of the planum sphenoidale.
54.
55. Cranial Base interrelations with craniofacial
development and malocclusion
• The cranial base or cranial floor’s function is to support and protect the brain
and spinal cord.
• It articulates with the vertebral column, the mandible and the maxillary
regions. (Moyers 1988)
• As such the growth and morphology of the Cranial Base should have an
influence on these related structures.
56. Influence of Cranial Base morphology on
adjacent structures
• Bjork noted that the shape of the brain case varies considerably in relation to
the shape of the cranial base (Björk 1955).
• A flattening of the cranial base is usually accompanied by reduced height of the
brain case, as measured from basion to bregma. On the other hand, the radius
of the brain case, measured from Sella to bregma, is greater, whereas the radius
from Sella to basion is greatly reduced. The posterior and median cranial fossae
arc therefore raised in relation to the anterior one.
57.
58. • Rotation of the brain case does not appear to cause any raising or lowering of the
anterior cranial fossa.
• This rotation of the bones of the brain case results in a rearward and upward
displacement of the foramen magnum and causes the foramen angle to widen.
• As the natural balance of the head on the spinal column depends on the location
of the foramen magnum, a flattening of the cranial base usually will have the
effect of tilting the face upward.(Björk 1955)
59. • The facial prognathism shows a reduction, as regards both the maxilla and the
mandible, when the cranial base flattens out.
• In retrognathic cases the cranial base is often found to by flattened with the
effect that the head is carried with the face tilted upward
60. • Facial pattern is also associated with cranial base morphology
• In Dolichocephalic individuals, the following is found
• The brain is horizontally long and relatively narrow. This sets up a cranial base
that is somewhat flatterthat is, the flexure between the middle cranial floor and
the anterior cranial floor is more open.
• It is also horizontally longer.
61. • These factors have several basic consequences for the pattern of the face.
• First, the whole nasomaxillary complex is placed in a more protrusive position
relative to the mandible because of the horizontally longer anterior and middle
segments of the cranial floor.
• Second, the whole nasomaxillary complex is lowered relative to the mandibular
condyle. This causes a downward and backward rotation of the entire mandible.
62. • Third, the occlusal plane becomes rotated into a downwardinclined alignment.
The two‐way forward placement of the maxilla and backward placement of the
mandibular corpus results in a tendency toward mandibular retrusion, and the
placement of the molars results in a tendency toward a Class II position.
• The profile tends to be retrognathic. Because of the more open cranial base an
gle and the resultant trajectory of the spinal cord into the cervical region, this t
ype of face is associated with individuals having a greater tendency toward a so
mewhat stooped posture and anterior inclination of the head and neck.
63.
64. • For people with a Brachycephalic facial pattern the following is found:
• Individuals with a brachycephalic head form have a rounder and wider brain. This
sets up a cranial base that is more upright and has a more closed flexure, which
decreases the effective horizontal dimension of the middle cranial fossa.
• The result is a relative retrusion of the nasomaxilla and a more forward relative
placement of the entire mandible. This causes a greater tendency toward a
prognathic profile and a Class Ill molar relationship.
65.
66. • The occlusal plane as well as the ramus of the mandible may be aligned upward,
but various compensatory processes usually result in either a perpendicular or
a downward‐inclined occlusal plane and slight backward rotation of the ramus.
• Because of the more upright middle cranial fossa and the more vertical trajectoy
of the spinal cord, individuals with all these various facial features also have a
tendency for a more erect posture with the head in a more "military" (at braced
attention) position.
67.
68. Influence of Cranial Base morphology on
malocclusion
• The cranial base angle is measured at three points antero‐posteriorly.
This measurement consists of two legs. The anterior leg, where the
maxilla is attached, extends from S‐N. The posterior leg, where the
mandible is attached, extends from S‐Ba. Therefore, any change in
the cranial base angle can affect the relationships of the maxilla and
mandible and influence the type of malocclusion.
69.
70. • The posterior leg of the cranial base angle (BaSN) may be tipped anteriorly/
posteriorly, whereas the anterior leg may also be tipped up or down anteriorly
by variation in either S or N vertically.
• Furthermore, variable lengths may compensate for any cranial deflection,such as
an acute posterior leg that places the mandible forward, and this action can be
negated by a long posterior leg that places both the basion and mandible
posteriorly and vice versa (Andria et al. 2004)
71. • The assessment of orthodontic anteroposterior skeletal discrepancy of the jaw
s and arches should also account for the role of the cranial base (Hopkin et al.
1968).
• The relationship of the cranial base with jaw position and classification of malo
cclusion has subsequently been examined extensively.
72. • Scott proposed one of the main factors that influence facial prognathism is the
opening of the cranial base angle.
• This angle has a large individual variation, with a 5° standard deviation, and is
markedly decreased in value from birth until the first year.
• It is also considered one of the craniofacial constants as it changes little during
growth from 5 to15 years (George 1978).
73. • Smaller linear and angular dimensions have been shown in class III patients, w
hereas class II subjects demonstrate an increased cranial base angle that leads
to a more posterior position of the mandible (Hopkin et al. 1968).
• The anterior cranial base and the middle cranial fossa have also been reported
to be longer in individuals with class II malocclusion (Cendekiawan et al. 2010)
However, many studies have shown that the etiological relationship between
the cranial base flexion and the type of malocclusion is not well supported.
74. • It therefore appears that the cranial base angle is not a pivotal factor in determi
ning malocclusion.
• Rather, the differential growth patterns and direction between the anterior crani
al base and posterior cranial base imply that length and inclination of the cranial
base are controlling factors of jaw position.
75. • Abnormalities of the posterior cranial base are related to mandibular prognathism
, and those of the anterior cranial base to retrusive maxilla.
• These relationships are probably explained by the glenoid fossa’s location in the
posterior cranial base; an elongated cranial base would bring the glenoid fossa
back and the mandible with it (Björk 1955)
76. • A compensating mechanism associated with cranial base flexure was first
described by Anderson and Popovich,in a study showing that the angle between
the posterior cranial base and the ramus of the mandible closes in a highly‐correl
ated way to compensate for the opening of the cranial base flexure.
• This phenomenon tends to maintain the angle between the ramus and the anteri
or cranial base. Therefore, with a more obtuse cranial base angle, the mandible
swings only slightly down and forward.
77. However, the difference between the anteroposterior positioning of the
maxilla and mandible is partly due to variation in the size of the jaws, and
partly due to variation in the length and flexure angle of the cranial base,
which are associated with the both jaws.
78. Cranial base abnormalities
• Due to the fact that the growth and development of the chondrocranium is
under strong genetic control, it is subject to minimal environmental influence.
• Conditions affecting defects in endochondral bone formation may be reflected
in abnormal Cranial Base development. (Sperber et al. 2010)
79. • Evidence is accumulating to indicate that thecartilaginous cranial base is primarily
involved in craniofacial anomalies; for example, the synchondroses of the skull
base are completely fused at birth in patients with Crouzon syndrome and show
early progressive fusion in Apert syndrome.
Abnormal development of the Cranial base is of clinical importance because of the
many vital structures that pass through the skull base.
80. • Cranial neuropathies can result from hypoplasia of skull base foramina
• As seen with achondroplasia, a small skull base can cause hydrocephalus
in infants and increased intracranial pressure in older children and adults.
81. • Deformity of the optic canals and superior orbital fissures may impair visual acuity
by compression of the optic nerve or ocular motility by compression of cranial ner
ves III, IV, and VI.(Tokumaru et al. 1996)
82. • Defective growth of cartilage will give rise to a shorter cranial base and an
increased angulation due to the loss of the “flattening” effects of growth at the
Spheno‐occipital Synchondrosis.
• This will lead to a “dished in” middle 1/3 of the face and a bulging neurocranium
• Premature closure of the synchondroses will lead to an underdeveloped middle
1/3 of the face, excessive cranial vaulting, exophthalmia and malocclusion (due
to decreased space for maxillary teeth). (Sperber et al. 2010)
83. CONCLUSION
• Knowing the basic growth and development of the Cranial Base and Calvaria is
of great importance for the clinician.
• By knowing the interactions of the various bones and structures that make up the
craniofacial complex he can better come to a diagnosis and treatment plan
for each patient, as well as know the underlying cause for the abnormality seen.
• Using the knowledge gained from studying the growth changes of the craniofacia
l region at different ages ,the clinician can know what patterns of development to
expect at certain timeframes during treatment, thereby providing a more
predictable treatment outcome
84. REFERENCES
• Premkumar, S., 2011. Textbook of Craniofacial Growth
• Proffit, W.R., Fields, H.W. & Sarver, D.M., 2013. Contemporary
orthodontics
• Som, P.M. & Naidich, T.P., 2013. Development of the Skull Base and Calvarium:
An Overview of the Progression from Mesenchyme to Chondrification to
Ossification
• Thiesen, G. et al., 2013. Comparative analysis of the anterior and posterior le
ngth and deflection angle of the cranial base, in individuals with facial Pattern
I, II and III. Dental press journal of orthodontics.