(1) Mobile technologies have significant potential for m-health applications with over 4.6 billion users worldwide and phones that function as computers. (2) However, past technological innovations in electronic health records have faced challenges, such as delays, unreliable cost estimates, and security breaches compromising patient records. (3) Key principles for successful technology innovation include involving users in design, allowing co-evolution of technology and usage patterns, addressing organizational issues, and getting infrastructure right to support technology goals.