PostCSS is a tool for transforming CSS with JavaScript plugins. It allows developers to write CSS in a more modular fashion and use future CSS syntax today. PostCSS parses CSS into an abstract syntax tree, passes it through plugins for processing, and outputs new CSS. Popular PostCSS plugins include Autoprefixer for adding vendor prefixes, CSSNano for optimization, and CSSNext for future CSS syntax. PostCSS can be used with build tools like Grunt and Gulp and has a large ecosystem of over 200 plugins.