Digital transformation (DX) is becoming the journey towards autonomous operations across devices, equipment, business and process systems. The application of advanced intelligence and cognitive technologies across operations, supply chain planning / scheduling / distribution, engineering, field operations, and maintenance is enabling adaptive and dynamic responses to market changes and asset disturbances. It also enables real time self-optimization of processes. High levels of industrial autonomy require a strong automation base layer; procedure automation; use of more intelligent sensors; remote surveillance and inspection through traditional approaches and with robotics and drones; digital twins; artificial intelligence (AI), and other analytics to monitor, predict, and mitigate process and equipment failures. This presentation will provide an overview of the levels of industrial autonomy and applications. Furthermore, it will show what companies can do today and in the future to achieve autonomous operations.